CO5190713A1 - Derivados de triazol e imidazol - Google Patents

Derivados de triazol e imidazol

Info

Publication number
CO5190713A1
CO5190713A1 CO00054541A CO00054541A CO5190713A1 CO 5190713 A1 CO5190713 A1 CO 5190713A1 CO 00054541 A CO00054541 A CO 00054541A CO 00054541 A CO00054541 A CO 00054541A CO 5190713 A1 CO5190713 A1 CO 5190713A1
Authority
CO
Colombia
Prior art keywords
lower alkyl
alkyl
pyridin
hydrogen
phenyl
Prior art date
Application number
CO00054541A
Other languages
English (en)
Inventor
Alexander Alanine
Bernd Buttelmann
Georg Jaeschke
Emmanuel Pinard
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5190713A1 publication Critical patent/CO5190713A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Un compuesto de la fórmula<EMI FILE="00054541_1" ID="1" IMF=JPEG >en dondeR1-R4 significa, independientemente, hidrógeno, -CF3, -OCF3, OCHF2, -OCH2F, alquilo inferior, alcoxilo inferior, halógeno, hidroxilo, fenilo, bencilo, amino, nitro, pirrol-l-ilo, alquil-sulfonilo inferior, alquil-sulfanilo inferior, ciano o benciloxilo; oR2 y R3 pueden ser, conjuntamente, -O-(CH2)2-O-, -O-CH2-O-, -O-(CH2)2-, -(CH2)3- o -CH=CH-CH=CH-;X significa -N=, -N(R8)- o -CH=;Y significa -N=, =N-, N(R8)- o -CH=; en donde uno de X o Y ha de ser nitrógeno;R5 significa el grupo<EMI FILE="00054541_2" ID="2" IMF=JPEG >en dondeR6 y R7 significan, independientemente uno de otro, hidrógeno, alquilo inferior, -C(O)- alquilo inferior, hidroxi-alquilo inferior, alquenilo inferior, -C(O)CH2OH oR6 y R7 pueden ser, junto con el átomo de N, -(CH2)n-, -(CH2)2-O-(CH2)2-, -CH2-CH=CH-CH2,-CH2-CH[OC(O)CH3]-(CH2)2, -CH2-CH[NHC(O)CH3]-(CH2)2, -O-(CH2)3-, -CH2-CH(OCH3)-(CH2)2-,-CH2-CH(halógeno)-(CH2)2-, -(CH2)2-CH(O-fenilo)-(CH2)2-, -(CH2)2-N(CHO)-(CH2)2-, -(CH2)2-N(COCH3)-(CH2)2, -CH2-CH(OH)-(CH2)3, -(CH2)2-CH(OH)-(CH2)2- o -(CH2)2- -N(bencilo)-CH2)2-;n significa 3 a 5; yR8 significa hidrógeno, alquilo inferior, alquenilo inferior, alquinilo inferior, -(CH2)m-O-alquilo inferior, -(CH2)m-OH, -(CH2)m-CHF2, -(CH2)m-CH2F, -(CH2)m-C(O)-alquilo inferior, -(CH2)m-C(O)O-alquilo inferior, -(CH2)m-CH(OH)-alquilo inferior, -(CH2)m-CH(OH)-(CH2)m-OH, -(CH2)m-C6H5, cuyo anillo de fenilo está opcionalmente sustituido por alquilo inferior, alcoxilo inferior o hidroxilo,-(CH2)m-C(=CH2)-alquilo inferior, -(CH2)m-cicloalquilo, -(CH2)m-CN, -(CH2)m-piridin-4-ilo, -(CH2)m-piridin-3-ilo o -(CH2)m-piridin-2-ilo;m significa = 0 a 4;y a sus sales de adición de ácido farmacéuticamente aceptables.
CO00054541A 1999-07-21 2000-07-19 Derivados de triazol e imidazol CO5190713A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99114313 1999-07-21

Publications (1)

Publication Number Publication Date
CO5190713A1 true CO5190713A1 (es) 2002-08-29

Family

ID=8238635

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00054541A CO5190713A1 (es) 1999-07-21 2000-07-19 Derivados de triazol e imidazol

Country Status (29)

Country Link
US (1) US6265426B1 (es)
EP (1) EP1070708B1 (es)
JP (1) JP3628946B2 (es)
KR (1) KR100383776B1 (es)
CN (1) CN1148357C (es)
AR (1) AR024790A1 (es)
AT (1) ATE257827T1 (es)
AU (1) AU773463B2 (es)
BR (1) BR0003075A (es)
CA (1) CA2314009C (es)
CO (1) CO5190713A1 (es)
DE (1) DE60007697T2 (es)
DK (1) DK1070708T3 (es)
ES (1) ES2211420T3 (es)
HR (1) HRP20000482A2 (es)
HU (1) HUP0002792A3 (es)
ID (1) ID26599A (es)
IL (1) IL137328A0 (es)
MA (1) MA26747A1 (es)
MX (1) MXPA00007069A (es)
NO (1) NO20003723L (es)
NZ (1) NZ505766A (es)
PE (1) PE20010349A1 (es)
PL (1) PL341616A1 (es)
PT (1) PT1070708E (es)
SG (1) SG98422A1 (es)
TR (1) TR200002097A3 (es)
UY (1) UY26253A1 (es)
ZA (1) ZA200003680B (es)

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US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
US7375136B2 (en) 2001-03-08 2008-05-20 Emory University pH-dependent NMDA receptor antagonists
US6951875B2 (en) * 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
CA2488117A1 (en) 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
US20060004088A1 (en) * 2002-10-22 2006-01-05 Oct Inc. Furan derivatives for preventing and curing osteoporosis and pharmaceutical compositions containing the same
US7084145B2 (en) * 2002-10-25 2006-08-01 Pfizer Inc. Triazole compounds useful in therapy
CN1747936A (zh) * 2003-02-12 2006-03-15 特兰斯泰克制药公司 作为治疗试剂的取代吡咯衍生物
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
GB0315111D0 (en) 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
DE602004027301D1 (de) * 2003-12-22 2010-07-01 Merck Sharp & Dohme Alpha-hydroxyamide als bradykininantagonisten oder inverse agonisten
NZ548208A (en) * 2004-02-12 2010-09-30 Transtech Pharma Inc Substituted azole derivatives, compositions, and methods of use
CN101374835B (zh) * 2006-01-30 2012-04-25 转化技术制药公司 作为PTPase抑制剂的取代的咪唑衍生物、组合物和使用方法
JO3019B1 (ar) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
EP2118077B1 (en) 2007-02-08 2014-12-24 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
EP2529623A3 (en) * 2007-04-03 2013-03-13 E. I. du Pont de Nemours and Company Substituted benzene fungicides
US20110158907A1 (en) * 2007-04-19 2011-06-30 The Trustees Of The Univeristy Of Pennsylvania Diphenyl-heteroaryl derivatives and their use for binding and imaging amyloid plaques
US8420680B2 (en) * 2007-06-29 2013-04-16 Emory University NMDA receptor antagonists for neuroprotection
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
RU2474579C2 (ru) 2007-10-18 2013-02-10 Янссен Фармацевтика Нв Тризамещенные 1,2,4-триазолы
AU2009226988B2 (en) 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
WO2009118187A1 (en) * 2008-03-27 2009-10-01 Evotec Neurosciences Gmbh Methods for treating disorders using nmda nr2b-subtype selective antagonist
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
RU2532394C1 (ru) * 2013-10-29 2014-11-10 Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") ПРИМЕНЕНИЕ БРОМИДА 1-β-ФЕНИЛЭТИЛ)-4-АМИНО-1,2,4-ТРИАЗОЛИЯ (ГИПЕРТРИЛ) КАК АКТИВНОЙ ОСНОВЫ ЛЕКАРСТВЕННЫХ СРЕДСТВ ДЛЯ КОРРЕКЦИИ НАРУШЕНИЙ ФУНКЦИОНИРОВАНИЯ НИТРОКСИДЕРГИЧЕСКОЙ СИСТЕМЫ ОРГАНОВ-МИШЕНЕЙ ПРИ ГОМОЦИСТЕИНЕМИИ И ОСТРЫХ НАРУШЕНИЯХ МОЗГОВОГО КРОВООБРАЩЕНИЯ
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Also Published As

Publication number Publication date
UY26253A1 (es) 2000-10-31
NO20003723L (no) 2001-01-22
TR200002097A2 (tr) 2001-02-21
ES2211420T3 (es) 2004-07-16
AU773463B2 (en) 2004-05-27
JP2001064263A (ja) 2001-03-13
CN1148357C (zh) 2004-05-05
ZA200003680B (en) 2001-01-22
CA2314009A1 (en) 2001-01-21
AU4865100A (en) 2001-01-25
EP1070708B1 (en) 2004-01-14
TR200002097A3 (tr) 2001-02-21
NZ505766A (en) 2002-03-28
KR100383776B1 (ko) 2003-05-12
PT1070708E (pt) 2004-05-31
NO20003723D0 (no) 2000-07-20
ID26599A (id) 2001-01-25
DK1070708T3 (da) 2004-05-10
KR20010049825A (ko) 2001-06-15
AR024790A1 (es) 2002-10-23
BR0003075A (pt) 2001-03-13
CN1281852A (zh) 2001-01-31
ATE257827T1 (de) 2004-01-15
SG98422A1 (en) 2003-09-19
HUP0002792A2 (hu) 2001-09-28
MA26747A1 (fr) 2004-12-20
US6265426B1 (en) 2001-07-24
IL137328A0 (en) 2001-07-24
DE60007697T2 (de) 2004-12-09
DE60007697D1 (de) 2004-02-19
EP1070708A1 (en) 2001-01-24
PE20010349A1 (es) 2001-03-26
MXPA00007069A (es) 2002-04-24
HU0002792D0 (en) 2000-09-28
PL341616A1 (en) 2001-01-29
JP3628946B2 (ja) 2005-03-16
CA2314009C (en) 2008-09-30
HUP0002792A3 (en) 2002-10-28
HRP20000482A2 (en) 2001-06-30

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