CO4770883A1 - PROCEDURE FOR PREPARING L-ASCORBIC ACID - Google Patents

PROCEDURE FOR PREPARING L-ASCORBIC ACID

Info

Publication number
CO4770883A1
CO4770883A1 CO98045322A CO98045322A CO4770883A1 CO 4770883 A1 CO4770883 A1 CO 4770883A1 CO 98045322 A CO98045322 A CO 98045322A CO 98045322 A CO98045322 A CO 98045322A CO 4770883 A1 CO4770883 A1 CO 4770883A1
Authority
CO
Colombia
Prior art keywords
acid
preparing
procedure
process according
ascorbic acid
Prior art date
Application number
CO98045322A
Other languages
Spanish (es)
Inventor
Fechtel Ulrich
Bechmann Klaus
Wolfgang Heinz
Walter Kuhn
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CO4770883A1 publication Critical patent/CO4770883A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para preparar ácido L-ascórbico, caracterizado porque se hace reaccionar el ácido 2-ceto-L-gulónico con un ácido mineral concentrado a una temperatura comprendida entre 40 y 80°C. Procedimiento según la reivindicación 1, caracterizado porque la reacción se lleva a cabo a temperaturas comprendidas entre 50 y 70°C. Procedimiento según la reivindicación 1 ó 2, caracterizado porque la relación entre el ácido 2-ceto-L-gulónico y el ácido mineral es de 1:3. Procedimiento según una de las reivindicaciones 1 a 3, caracterizado porque en calidad de ácido mineral se emplea el ácido clorhídrico concentrado. Procedimiento según una de las reivindicaciones 1 a 4, caracterizado porque se lleva una mezcla compuesta por ácido 2-ceto-L-gulónico y ácido mineral concentrado a la temperatura de reacción deseada.Procedure for preparing L-ascorbic acid, characterized in that 2-keto-L-gulonic acid is reacted with a concentrated mineral acid at a temperature between 40 and 80 ° C. Process according to claim 1, characterized in that the reaction is carried out at temperatures between 50 and 70 ° C. Process according to claim 1 or 2, characterized in that the ratio of 2-keto-L-gulonic acid to mineral acid is 1: 3. Process according to one of claims 1 to 3, characterized in that concentrated hydrochloric acid is used as mineral acid. Process according to one of Claims 1 to 4, characterized in that a mixture consisting of 2-keto-L-gulonic acid and concentrated mineral acid is brought to the desired reaction temperature.

CO98045322A 1997-08-07 1998-08-06 PROCEDURE FOR PREPARING L-ASCORBIC ACID CO4770883A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19734086A DE19734086C1 (en) 1997-08-07 1997-08-07 L-ascorbic acid preparation

Publications (1)

Publication Number Publication Date
CO4770883A1 true CO4770883A1 (en) 1999-04-30

Family

ID=7838185

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98045322A CO4770883A1 (en) 1997-08-07 1998-08-06 PROCEDURE FOR PREPARING L-ASCORBIC ACID

Country Status (12)

Country Link
EP (1) EP1001952A2 (en)
JP (1) JP2001512722A (en)
KR (1) KR20010022595A (en)
CN (1) CN1265655A (en)
AR (1) AR010938A1 (en)
AU (1) AU9156298A (en)
BR (1) BR9811855A (en)
CA (1) CA2299364A1 (en)
CO (1) CO4770883A1 (en)
DE (1) DE19734086C1 (en)
ID (1) ID25547A (en)
WO (1) WO1999007691A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19904821C1 (en) * 1999-02-05 2000-07-06 Merck Patent Gmbh Preparation of L-ascorbic acid from 2-keto- or 2,3-4,6-diacetone-2-keto-L-gulonic acid
DE19919203A1 (en) 1999-04-28 2000-11-02 Basf Ag Process for the preparation of L-ascorbic acid
DE19954511A1 (en) 1999-11-12 2001-05-17 Basf Ag Process for the preparation of alkali salts of L-ascorbic acid
DE10022518A1 (en) * 2000-05-10 2001-11-15 Basf Ag Preparation of L-ascorbic acids by reacting 2-keto-L-gulonic acids or melt of 2-keto-L-gulonic acid alkyl esters under acid catalysis using water-miscible solvent(s)
WO2002051827A1 (en) 2000-12-22 2002-07-04 Eastman Chemical Company Process for producing ascorbic acid in the presence of a sulfit
EP1351949B1 (en) 2000-12-22 2005-05-18 Eastman Chemical Company Continuous process for producing l-ascorbic acid
WO2002083739A2 (en) * 2001-04-10 2002-10-24 Danisco Usa, Inc. Polymerization of mono and disaccharides with monocarboxylic acids and lactones
US6740762B2 (en) 2001-08-24 2004-05-25 Eastman Chemical Company Process for ascorbic acids using alkaline earth silicate catalysts
US6716997B1 (en) 2001-10-09 2004-04-06 Eastman Chemical Company Systems and methods for generation of ascorbic acid with reduced color
CN111018815A (en) * 2019-12-29 2020-04-17 安徽丰原发酵技术工程研究有限公司 Method for preparing vitamin C by increasing concentration of hydrochloric acid through solvent extraction
CN111087373A (en) * 2019-12-29 2020-05-01 安徽丰原发酵技术工程研究有限公司 Method for preparing vitamin C by acid method
CN114369075B (en) * 2022-02-14 2023-09-29 河北乐开节能科技股份有限公司 Method for preparing VC crystal by using aqueous solution of 2-keto-L-gulonic acid in one step

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2462251A (en) * 1945-05-16 1949-02-22 Merck & Co Inc Process for preparing ascorbic acids
DD141832A1 (en) * 1978-10-31 1980-05-21 Joachim Schmidt METHOD AND DEVICE FOR PREPARING L-ASCORBIN ACID
CN86105960A (en) * 1985-08-09 1987-05-13 鲁布里佐尔公司 Under substantially anhydrous conditions, prepare the L-xitix from 2-ketone-L-gulonic acid
DE3819045C2 (en) * 1987-06-08 1997-06-19 Takeda Chemical Industries Ltd Production of L-ascorbic acid

Also Published As

Publication number Publication date
WO1999007691A2 (en) 1999-02-18
BR9811855A (en) 2000-08-15
KR20010022595A (en) 2001-03-26
AR010938A1 (en) 2000-07-12
AU9156298A (en) 1999-03-01
CA2299364A1 (en) 1999-02-18
ID25547A (en) 2000-10-12
DE19734086C1 (en) 1998-08-13
CN1265655A (en) 2000-09-06
EP1001952A2 (en) 2000-05-24
JP2001512722A (en) 2001-08-28
WO1999007691A3 (en) 1999-04-08

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