CO4340691A1 - 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS . - Google Patents

2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS .

Info

Publication number
CO4340691A1
CO4340691A1 CO95006161A CO95006161A CO4340691A1 CO 4340691 A1 CO4340691 A1 CO 4340691A1 CO 95006161 A CO95006161 A CO 95006161A CO 95006161 A CO95006161 A CO 95006161A CO 4340691 A1 CO4340691 A1 CO 4340691A1
Authority
CO
Colombia
Prior art keywords
dipirido
diazepinas
heteroaril
dihidro
formula
Prior art date
Application number
CO95006161A
Other languages
English (en)
Inventor
Karl D Hargrave
R Patel Usha
R Kapadia Suresh
A Kelly Terence
Daniel W Mcneil
Mario G Cardozo
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO4340691A1 publication Critical patent/CO4340691A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1. UN COMPUESTO DE LA FORMULA 1 EN LA CUAL, Z ES UN ATOMO DE OXIGENO O DE AZUFRE, =NCN O UN GRUPO DE LA FORMULA =NOR10 EN LA CUAL R10 ES ALQUILO DE 1 A 3 ATOMOS DE CARBONO; R1 ES UN ATOMO DE HIDROGENO, ALQUILO DE 1 A 3 ATOMOS DE CARBONO, FLUOROALQUILO DE 1 A 3 ATOMOS DE CARBONO Y 1 A 2 ATOMOS DE FLUOR, CICLOPROPILO, ALILO, PROPARGILO, 2-HALO-2-PROPEN-1-ILO, MONO- O DIHALOVINILO, ALCANOILO O ALQUIL(TIO-CARBONILO) DE 2 A 3 ATOMOS DE CARBONO, ALQUILSULFONILO DE 1 A 2 ATOMOS DE CARBONO, MONO- O DI-ALQUILAMINOCARBONI- LO EN EL CUAL EL RESTO ALQUILO CONTIENE 1 A 2 ATO- MOS DE CARBONO, AMINOETILO, MONO- O DI-ALQUILAMI- NOETILO EN EL CUAL EL RESTO ALQUILO CONTIENE 1 A 2 ATOMOS DE CARBONO, ALQUILOXIALQUILO O ALQUILTIOAL- QUILO DE 2 A 3 ATOMOS DE CARBONO, O CIANOALQUILO EN EL CUAL ES RESTO ALQUILO CONTIENE 1 A 2 ATOMOS DE CARBONO; R2 ES UN ATOMO DE HIDROGENO, ALQUILO DE 1 A 4 ATO- MOS DE CARBONO, FLUORALQUILO DE 1 A 4 ATOMOS DE CARBONO Y 1 A 3 ATOMOS DE FLUOR, CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO, OXETANILO, TIETANILO, TETRAHIDROFURANILO, TETRAHIDROTIENILO, TETRAHIDRO- PIRANILO, TETRAHIDROTIOPIRANILO, ALQUENILMETILO O ALQUINILMETILO DE 3 A 4 ATOMOS DE CARBONO, ALQUIL- OXIALQUILO ALQUILTIOALQUILO DE 2 A 3 ATOMOS DE CARBONO, ALCANOILO O ALQUIL(TIOCARBONILO) DE 2 A 5 ATOMOS DE CARBONO, O CIANOALQUILO DE 2 A 3 ATOMOS DE CARBONO; R3 ES UN ATOMO DE HIDROGENO METILO O UN ATOMO DE HALOGENO; R4 ES UN ATOMO DE HIDROGENO, HIDROXI, AMINO, HI- DROXIMETILO, O AMINOMETILO; Y Ar ES UN GRUPO DE LA FORMULA I, II, III, IV, o V, EN LAS CUALES, R5 ES HIDROGENO, METILO, ETILO, ACETILO, AMINOCAR- BONILO, (N-ALQUIL) AMINOCARBONILO, O (N-N-DIAL- QUIL)AMINOCARBONILO, DONDE LOS RESTOS ALQUILO CON- TIENEN CADA UNO 1 A 2 ATOMOS DE CARBONO; R6, R7 Y R8 SON CADA UNO HIDROGENO; O UNO DE R6, R7 Y R8 ES METILO, HIDROXIMETILO, HI- DROXIETILO, TRIFLUOROMETILO, HALOGENO, ACETILO, METOXICARBONILO, ETOXICARBONILO, CARBOXI, MONO- O DIMETILMANIMOSULFONILO, AMINOSULFONILO, MONO- DIMETILAMINOCARBONILO, AMINOCARBONILO, METIL- O ETILSULFONILO, CIANO, O NITRO, Y LOS DOS SUSTITU- YENTES RESTANTES SON AMBOS HIDROGENO; A, B, D y E SON CADA UNO GRUPOS METINO, UNO DE LOS CUALES PUEDE ESTAR SUSTITUIDO OPCIONALMENTE CON R9; o, UNO DE A, B, D y E ES UN ATOMO DE NITROGENO, Y LOS RES RESTANTES DE A, B, D y E SON CADA UNO GRUPOS METINO, UNO DE CUYOS GRUPOS METILO PUEDE ESTAR SUSTITUIDO OPCIONALMENTE CON R9, Y, R9 ES ALQUILO O ALQUILOXI DE 1 A 3 ATOMOS DE CAR- BONO, AMINO, MONO, O DIMETILAMINO, HIDROXILO, ME- TILSULFONILAMINO, ACETILAMINO, ACETILOXI, AMINO- CARBONILO, MONO- O DIMETILAMINOCARBONILO, O HALO- GENO; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE AQUEL.
CO95006161A 1994-02-18 1995-02-17 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS . CO4340691A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19824294A 1994-02-18 1994-02-18
US35641594A 1994-12-14 1994-12-14

Publications (1)

Publication Number Publication Date
CO4340691A1 true CO4340691A1 (es) 1996-07-30

Family

ID=26893601

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95006161A CO4340691A1 (es) 1994-02-18 1995-02-17 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS .

Country Status (15)

Country Link
EP (1) EP0745083B1 (es)
JP (1) JPH09509179A (es)
KR (1) KR970701190A (es)
CN (1) CN1043347C (es)
AT (1) ATE166353T1 (es)
AU (1) AU690646B2 (es)
CA (1) CA2183571A1 (es)
CO (1) CO4340691A1 (es)
DE (1) DE69502587T2 (es)
DK (1) DK0745083T3 (es)
ES (1) ES2118575T3 (es)
PL (1) PL181323B1 (es)
RU (1) RU2142464C1 (es)
TW (1) TW327171B (es)
WO (1) WO1995022545A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
AU7726898A (en) * 1997-05-22 1998-12-11 G.D. Searle & Co. Pyrazole derivatives as p38 kinase inhibitors
US6716836B2 (en) * 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
KR20070030196A (ko) * 2004-04-13 2007-03-15 이카겐, 인코포레이티드 칼륨 이온 채널 조절제로서의 폴리시클릭 피리딘
ATE412651T1 (de) 2004-06-09 2008-11-15 Glaxo Group Ltd Pyrrolopyridinderivate
JP2009515984A (ja) 2005-11-15 2009-04-16 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤として有用なアザインダゾール
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN104884449A (zh) 2012-10-31 2015-09-02 拜尔农作物科学股份公司 作为害虫防治剂的新的杂环化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0410148T3 (da) * 1989-06-28 1994-08-08 Boehringer Ingelheim Pharma Hidtil ukendte 5,11-dihydro-6H-dipyrido(3,2-b:2,3-e)-(1,4)diazepin-6-oner og -thioner og deres anvendelse til forebyggelse eller behandling af AIDS
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
DE69213777T2 (de) * 1991-02-07 1997-03-13 Boehringer Ingelheim Pharma Pyridobenzodiazepine, Dipyrido-[3,2-b:2',3'-3] [1,4]-diazepine und deren Verwendung in der Vorbeugung und Behandlung von AIDS

Also Published As

Publication number Publication date
MX9603359A (es) 1998-07-31
JPH09509179A (ja) 1997-09-16
PL316006A1 (en) 1996-12-23
PL181323B1 (pl) 2001-07-31
WO1995022545A1 (en) 1995-08-24
DE69502587T2 (de) 1998-11-26
EP0745083B1 (en) 1998-05-20
ES2118575T3 (es) 1998-09-16
CN1043347C (zh) 1999-05-12
KR970701190A (ko) 1997-03-17
EP0745083A1 (en) 1996-12-04
RU2142464C1 (ru) 1999-12-10
AU690646B2 (en) 1998-04-30
TW327171B (en) 1998-02-21
CA2183571A1 (en) 1995-08-24
DE69502587D1 (de) 1998-06-25
ATE166353T1 (de) 1998-06-15
AU1845795A (en) 1995-09-04
CN1138861A (zh) 1996-12-25
DK0745083T3 (da) 1999-01-25

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