CO4340691A1 - 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS . - Google Patents
2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS .Info
- Publication number
- CO4340691A1 CO4340691A1 CO95006161A CO95006161A CO4340691A1 CO 4340691 A1 CO4340691 A1 CO 4340691A1 CO 95006161 A CO95006161 A CO 95006161A CO 95006161 A CO95006161 A CO 95006161A CO 4340691 A1 CO4340691 A1 CO 4340691A1
- Authority
- CO
- Colombia
- Prior art keywords
- dipirido
- diazepinas
- heteroaril
- dihidro
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1. UN COMPUESTO DE LA FORMULA 1 EN LA CUAL, Z ES UN ATOMO DE OXIGENO O DE AZUFRE, =NCN O UN GRUPO DE LA FORMULA =NOR10 EN LA CUAL R10 ES ALQUILO DE 1 A 3 ATOMOS DE CARBONO; R1 ES UN ATOMO DE HIDROGENO, ALQUILO DE 1 A 3 ATOMOS DE CARBONO, FLUOROALQUILO DE 1 A 3 ATOMOS DE CARBONO Y 1 A 2 ATOMOS DE FLUOR, CICLOPROPILO, ALILO, PROPARGILO, 2-HALO-2-PROPEN-1-ILO, MONO- O DIHALOVINILO, ALCANOILO O ALQUIL(TIO-CARBONILO) DE 2 A 3 ATOMOS DE CARBONO, ALQUILSULFONILO DE 1 A 2 ATOMOS DE CARBONO, MONO- O DI-ALQUILAMINOCARBONI- LO EN EL CUAL EL RESTO ALQUILO CONTIENE 1 A 2 ATO- MOS DE CARBONO, AMINOETILO, MONO- O DI-ALQUILAMI- NOETILO EN EL CUAL EL RESTO ALQUILO CONTIENE 1 A 2 ATOMOS DE CARBONO, ALQUILOXIALQUILO O ALQUILTIOAL- QUILO DE 2 A 3 ATOMOS DE CARBONO, O CIANOALQUILO EN EL CUAL ES RESTO ALQUILO CONTIENE 1 A 2 ATOMOS DE CARBONO; R2 ES UN ATOMO DE HIDROGENO, ALQUILO DE 1 A 4 ATO- MOS DE CARBONO, FLUORALQUILO DE 1 A 4 ATOMOS DE CARBONO Y 1 A 3 ATOMOS DE FLUOR, CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO, OXETANILO, TIETANILO, TETRAHIDROFURANILO, TETRAHIDROTIENILO, TETRAHIDRO- PIRANILO, TETRAHIDROTIOPIRANILO, ALQUENILMETILO O ALQUINILMETILO DE 3 A 4 ATOMOS DE CARBONO, ALQUIL- OXIALQUILO ALQUILTIOALQUILO DE 2 A 3 ATOMOS DE CARBONO, ALCANOILO O ALQUIL(TIOCARBONILO) DE 2 A 5 ATOMOS DE CARBONO, O CIANOALQUILO DE 2 A 3 ATOMOS DE CARBONO; R3 ES UN ATOMO DE HIDROGENO METILO O UN ATOMO DE HALOGENO; R4 ES UN ATOMO DE HIDROGENO, HIDROXI, AMINO, HI- DROXIMETILO, O AMINOMETILO; Y Ar ES UN GRUPO DE LA FORMULA I, II, III, IV, o V, EN LAS CUALES, R5 ES HIDROGENO, METILO, ETILO, ACETILO, AMINOCAR- BONILO, (N-ALQUIL) AMINOCARBONILO, O (N-N-DIAL- QUIL)AMINOCARBONILO, DONDE LOS RESTOS ALQUILO CON- TIENEN CADA UNO 1 A 2 ATOMOS DE CARBONO; R6, R7 Y R8 SON CADA UNO HIDROGENO; O UNO DE R6, R7 Y R8 ES METILO, HIDROXIMETILO, HI- DROXIETILO, TRIFLUOROMETILO, HALOGENO, ACETILO, METOXICARBONILO, ETOXICARBONILO, CARBOXI, MONO- O DIMETILMANIMOSULFONILO, AMINOSULFONILO, MONO- DIMETILAMINOCARBONILO, AMINOCARBONILO, METIL- O ETILSULFONILO, CIANO, O NITRO, Y LOS DOS SUSTITU- YENTES RESTANTES SON AMBOS HIDROGENO; A, B, D y E SON CADA UNO GRUPOS METINO, UNO DE LOS CUALES PUEDE ESTAR SUSTITUIDO OPCIONALMENTE CON R9; o, UNO DE A, B, D y E ES UN ATOMO DE NITROGENO, Y LOS RES RESTANTES DE A, B, D y E SON CADA UNO GRUPOS METINO, UNO DE CUYOS GRUPOS METILO PUEDE ESTAR SUSTITUIDO OPCIONALMENTE CON R9, Y, R9 ES ALQUILO O ALQUILOXI DE 1 A 3 ATOMOS DE CAR- BONO, AMINO, MONO, O DIMETILAMINO, HIDROXILO, ME- TILSULFONILAMINO, ACETILAMINO, ACETILOXI, AMINO- CARBONILO, MONO- O DIMETILAMINOCARBONILO, O HALO- GENO; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE AQUEL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19824294A | 1994-02-18 | 1994-02-18 | |
US35641594A | 1994-12-14 | 1994-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4340691A1 true CO4340691A1 (es) | 1996-07-30 |
Family
ID=26893601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO95006161A CO4340691A1 (es) | 1994-02-18 | 1995-02-17 | 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS . |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0745083B1 (es) |
JP (1) | JPH09509179A (es) |
KR (1) | KR970701190A (es) |
CN (1) | CN1043347C (es) |
AT (1) | ATE166353T1 (es) |
AU (1) | AU690646B2 (es) |
CA (1) | CA2183571A1 (es) |
CO (1) | CO4340691A1 (es) |
DE (1) | DE69502587T2 (es) |
DK (1) | DK0745083T3 (es) |
ES (1) | ES2118575T3 (es) |
PL (1) | PL181323B1 (es) |
RU (1) | RU2142464C1 (es) |
TW (1) | TW327171B (es) |
WO (1) | WO1995022545A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705499A (en) * | 1995-10-06 | 1998-01-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection |
US5747488A (en) * | 1996-01-30 | 1998-05-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
AU7726898A (en) * | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
US6716836B2 (en) * | 2001-03-22 | 2004-04-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
KR20070030196A (ko) * | 2004-04-13 | 2007-03-15 | 이카겐, 인코포레이티드 | 칼륨 이온 채널 조절제로서의 폴리시클릭 피리딘 |
ATE412651T1 (de) | 2004-06-09 | 2008-11-15 | Glaxo Group Ltd | Pyrrolopyridinderivate |
JP2009515984A (ja) | 2005-11-15 | 2009-04-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用なアザインダゾール |
WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
CN104884449A (zh) | 2012-10-31 | 2015-09-02 | 拜尔农作物科学股份公司 | 作为害虫防治剂的新的杂环化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0410148T3 (da) * | 1989-06-28 | 1994-08-08 | Boehringer Ingelheim Pharma | Hidtil ukendte 5,11-dihydro-6H-dipyrido(3,2-b:2,3-e)-(1,4)diazepin-6-oner og -thioner og deres anvendelse til forebyggelse eller behandling af AIDS |
CA2030056C (en) * | 1989-11-17 | 1995-10-17 | Karl D. Hargrave | 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection |
DE69213777T2 (de) * | 1991-02-07 | 1997-03-13 | Boehringer Ingelheim Pharma | Pyridobenzodiazepine, Dipyrido-[3,2-b:2',3'-3] [1,4]-diazepine und deren Verwendung in der Vorbeugung und Behandlung von AIDS |
-
1995
- 1995-02-17 WO PCT/US1995/001993 patent/WO1995022545A1/en active IP Right Grant
- 1995-02-17 CN CN95191228A patent/CN1043347C/zh not_active Expired - Fee Related
- 1995-02-17 CO CO95006161A patent/CO4340691A1/es unknown
- 1995-02-17 AU AU18457/95A patent/AU690646B2/en not_active Ceased
- 1995-02-17 JP JP7521920A patent/JPH09509179A/ja not_active Ceased
- 1995-02-17 KR KR1019960704495A patent/KR970701190A/ko active IP Right Grant
- 1995-02-17 DE DE69502587T patent/DE69502587T2/de not_active Expired - Fee Related
- 1995-02-17 DK DK95910286T patent/DK0745083T3/da active
- 1995-02-17 TW TW084101470A patent/TW327171B/zh active
- 1995-02-17 ES ES95910286T patent/ES2118575T3/es not_active Expired - Lifetime
- 1995-02-17 RU RU96118483A patent/RU2142464C1/ru active
- 1995-02-17 EP EP95910286A patent/EP0745083B1/en not_active Expired - Lifetime
- 1995-02-17 CA CA002183571A patent/CA2183571A1/en not_active Abandoned
- 1995-02-17 PL PL95316006A patent/PL181323B1/pl unknown
- 1995-02-17 AT AT95910286T patent/ATE166353T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX9603359A (es) | 1998-07-31 |
JPH09509179A (ja) | 1997-09-16 |
PL316006A1 (en) | 1996-12-23 |
PL181323B1 (pl) | 2001-07-31 |
WO1995022545A1 (en) | 1995-08-24 |
DE69502587T2 (de) | 1998-11-26 |
EP0745083B1 (en) | 1998-05-20 |
ES2118575T3 (es) | 1998-09-16 |
CN1043347C (zh) | 1999-05-12 |
KR970701190A (ko) | 1997-03-17 |
EP0745083A1 (en) | 1996-12-04 |
RU2142464C1 (ru) | 1999-12-10 |
AU690646B2 (en) | 1998-04-30 |
TW327171B (en) | 1998-02-21 |
CA2183571A1 (en) | 1995-08-24 |
DE69502587D1 (de) | 1998-06-25 |
ATE166353T1 (de) | 1998-06-15 |
AU1845795A (en) | 1995-09-04 |
CN1138861A (zh) | 1996-12-25 |
DK0745083T3 (da) | 1999-01-25 |
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