CO2021006970A2 - Anticuerpos biespecificos y su uso - Google Patents

Anticuerpos biespecificos y su uso

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Publication number
CO2021006970A2
CO2021006970A2 CONC2021/0006970A CO2021006970A CO2021006970A2 CO 2021006970 A2 CO2021006970 A2 CO 2021006970A2 CO 2021006970 A CO2021006970 A CO 2021006970A CO 2021006970 A2 CO2021006970 A2 CO 2021006970A2
Authority
CO
Colombia
Prior art keywords
cells
antibody
bispecific antibody
bispecific
high affinity
Prior art date
Application number
CONC2021/0006970A
Other languages
English (en)
Inventor
Qiang Li
Shixiang Jia
Lili Zhao
Guimin Zhang
Zhong Liu
Xinlu Ma
Yuan Yan
Zhenyu Li
Xingxia Hu
Yuhua Zhang
Bin Li
Original Assignee
Shandong New Time Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shandong New Time Pharmaceutical Co Ltd filed Critical Shandong New Time Pharmaceutical Co Ltd
Publication of CO2021006970A2 publication Critical patent/CO2021006970A2/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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Abstract

RESUMEN Un anticuerpo biespecífico, particularmente unido a la superficie del antígeno CD3 de las células inmunes y al antígeno BCMA en la superficie de las células tumorales, es capaz de unirse al CD3 humano con su alta afinidad, e incluye proliferación de células T, para mediar los efectos de eliminación de las células tumorales. El anticuerpo biespecífico puede ser utilizado para mediar la eliminación específica de células efectoras mediante células T en una prueba in vitro. El método para construir el anticuerpo biespecífico es simple, evitar la posibilidad de discrepancia entre dos grupos de cadenas ligeras y cadenas pesadas de los anticuerpos biespecíficos heterógenos, de este modo se reduce la dificultad de la purificación del anticuerpo y el anticuerpo obtenido tiene alta afinidad, bajos efectos adversos de citocina y alta seguridad.
CONC2021/0006970A 2018-11-01 2021-05-27 Anticuerpos biespecificos y su uso CO2021006970A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811294887 2018-11-01
PCT/CN2019/108057 WO2020088164A1 (zh) 2018-11-01 2019-09-26 双特异性抗体及其用途

Publications (1)

Publication Number Publication Date
CO2021006970A2 true CO2021006970A2 (es) 2021-07-30

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CN112996807B (zh) 2022-07-19
CN111138546B (zh) 2022-10-11
CA3118397A1 (en) 2020-05-07
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WO2020088403A1 (zh) 2020-05-07
US20210371526A1 (en) 2021-12-02
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CN111138544B (zh) 2022-06-28
JP2022512997A (ja) 2022-02-07
CN111138547A (zh) 2020-05-12
PE20211867A1 (es) 2021-09-21
WO2020088608A1 (zh) 2020-05-07
EP3875489A1 (en) 2021-09-08
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CA3118238C (en) 2023-12-19
CN112996810A (zh) 2021-06-18
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WO2020088164A1 (zh) 2020-05-07
CN111138546A (zh) 2020-05-12
AU2019370339A1 (en) 2021-06-10
CN111138542B (zh) 2022-09-23
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