MX2022002723A - Receptores de antigeno dimerico (dar) que se enlazan a bcma. - Google Patents
Receptores de antigeno dimerico (dar) que se enlazan a bcma.Info
- Publication number
- MX2022002723A MX2022002723A MX2022002723A MX2022002723A MX2022002723A MX 2022002723 A MX2022002723 A MX 2022002723A MX 2022002723 A MX2022002723 A MX 2022002723A MX 2022002723 A MX2022002723 A MX 2022002723A MX 2022002723 A MX2022002723 A MX 2022002723A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen receptors
- dar
- dimeric
- dimeric antigen
- antigen
- Prior art date
Links
- 102000006306 Antigen Receptors Human genes 0.000 title abstract 5
- 108010083359 Antigen Receptors Proteins 0.000 title abstract 5
- 101100425747 Mus musculus Tnfrsf17 gene Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 abstract 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 abstract 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/11—Antigen recognition domain
- A61K2239/13—Antibody-based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente divulgación proporciona construcciones de los receptores de los antígenos diméricos (DAR, por sus siglas en inglés) que se enlazan a un antígeno blanco de BCMA, en donde la construcción de DAR comprende una región de enlace de la cadena pesada en una cadena de polipéptido y una región de enlace de la cadena ligera en una cadena de polipéptido separada. Las dos cadenas de polipéptidos que componen los receptores de los antígenos diméricos se pueden dimerizar para formar un dominio de enlace al antígeno. Los receptores de los antígenos diméricos tienen propiedades similares a las de los anticuerpos, debido a que se enlazan de una forma específica a un antígeno blanco. Los receptores de los antígenos diméricos se pueden utilizar para la terapia celular dirigida.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962896190P | 2019-09-05 | 2019-09-05 | |
US201962896990P | 2019-09-06 | 2019-09-06 | |
US201962910341P | 2019-10-03 | 2019-10-03 | |
US201962943069P | 2019-12-03 | 2019-12-03 | |
US202063030145P | 2020-05-26 | 2020-05-26 | |
PCT/US2020/049538 WO2021046445A1 (en) | 2019-09-05 | 2020-09-04 | Dimeric antigen receptors (dar) that bind bcma |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022002723A true MX2022002723A (es) | 2022-03-22 |
Family
ID=74852154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022002723A MX2022002723A (es) | 2019-09-05 | 2020-09-04 | Receptores de antigeno dimerico (dar) que se enlazan a bcma. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220251168A1 (es) |
EP (1) | EP4025227A4 (es) |
JP (1) | JP2022546577A (es) |
KR (1) | KR20220057598A (es) |
CN (1) | CN114650829A (es) |
AU (1) | AU2020341712A1 (es) |
CA (1) | CA3149867A1 (es) |
IL (1) | IL291076A (es) |
MX (1) | MX2022002723A (es) |
WO (1) | WO2021046445A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112021016791A2 (pt) * | 2019-02-26 | 2021-11-16 | Sorrento Therapeutics Inc | Proteínas de ligação de antígenos que se ligam a bcma |
US20230167191A1 (en) | 2020-04-24 | 2023-06-01 | Sorrento Therapeutics, Inc. | Memory Dimeric Antigen Receptors (mDARs) |
TW202328192A (zh) * | 2021-09-06 | 2023-07-16 | 荷蘭商珍美寶公司 | 能結合cd27之抗體、彼之變異體及彼等之用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170051037A1 (en) * | 2014-05-02 | 2017-02-23 | Cellectis | Cs1 specific multi-chain chimeric antigen receptor |
CA2986030A1 (en) * | 2015-05-15 | 2016-11-24 | City Of Hope | Chimeric antigen receptor compositions |
US11173179B2 (en) * | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
IL258405B (en) * | 2015-10-23 | 2022-09-01 | Eureka Therapeutics Inc | Antibody/t-cell receptor chimeric structures and their uses |
WO2018237192A1 (en) * | 2017-06-21 | 2018-12-27 | Gsbio, Llc | BISPECIFIC ANTIBODIES HETERODIMERS |
WO2019173837A1 (en) * | 2018-03-09 | 2019-09-12 | Sorrento Therapeutics, Inc. | Dimeric antigen receptors (dar) |
BR112021016791A2 (pt) * | 2019-02-26 | 2021-11-16 | Sorrento Therapeutics Inc | Proteínas de ligação de antígenos que se ligam a bcma |
-
2020
- 2020-09-04 CN CN202080076523.8A patent/CN114650829A/zh active Pending
- 2020-09-04 JP JP2022514522A patent/JP2022546577A/ja active Pending
- 2020-09-04 AU AU2020341712A patent/AU2020341712A1/en active Pending
- 2020-09-04 EP EP20861409.9A patent/EP4025227A4/en active Pending
- 2020-09-04 KR KR1020227011203A patent/KR20220057598A/ko active Search and Examination
- 2020-09-04 MX MX2022002723A patent/MX2022002723A/es unknown
- 2020-09-04 CA CA3149867A patent/CA3149867A1/en active Pending
- 2020-09-04 WO PCT/US2020/049538 patent/WO2021046445A1/en unknown
-
2022
- 2022-03-02 IL IL291076A patent/IL291076A/en unknown
- 2022-03-03 US US17/686,261 patent/US20220251168A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022546577A (ja) | 2022-11-04 |
EP4025227A1 (en) | 2022-07-13 |
IL291076A (en) | 2022-05-01 |
KR20220057598A (ko) | 2022-05-09 |
CA3149867A1 (en) | 2021-03-11 |
AU2020341712A1 (en) | 2022-03-31 |
EP4025227A4 (en) | 2023-11-01 |
US20220251168A1 (en) | 2022-08-11 |
WO2021046445A1 (en) | 2021-03-11 |
CN114650829A (zh) | 2022-06-21 |
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