CO2020006523A2 - Compuestos moduladores de sting y métodos de elaboración y uso - Google Patents
Compuestos moduladores de sting y métodos de elaboración y usoInfo
- Publication number
- CO2020006523A2 CO2020006523A2 CONC2020/0006523A CO2020006523A CO2020006523A2 CO 2020006523 A2 CO2020006523 A2 CO 2020006523A2 CO 2020006523 A CO2020006523 A CO 2020006523A CO 2020006523 A2 CO2020006523 A2 CO 2020006523A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- manufacture
- sting
- modulating compounds
- sting modulating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente descripción proporciona moduladores/agonistas de STING y métodos de síntesis y métodos de uso para la profilaxis o el tratamiento del cáncer y otras enfermedades relacionadas con STING. La presente descripción se refiere a un compuesto representado por la Fórmula (I): donde cada símbolo es tal como se definió en la descripción, o una sal farmacéuticamente aceptable de este.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762584559P | 2017-11-10 | 2017-11-10 | |
US201862718613P | 2018-08-14 | 2018-08-14 | |
US201862754623P | 2018-11-02 | 2018-11-02 | |
PCT/IB2018/058846 WO2019092660A1 (en) | 2017-11-10 | 2018-11-09 | Sting modulator compounds, and methods of making and using |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2020006523A2 true CO2020006523A2 (es) | 2020-08-21 |
Family
ID=64604678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2020/0006523A CO2020006523A2 (es) | 2017-11-10 | 2020-05-28 | Compuestos moduladores de sting y métodos de elaboración y uso |
Country Status (17)
Country | Link |
---|---|
US (1) | US11542293B2 (es) |
EP (1) | EP3707151B1 (es) |
JP (1) | JP7195317B2 (es) |
KR (1) | KR20200098511A (es) |
CN (1) | CN111566119A (es) |
AU (1) | AU2018364708A1 (es) |
BR (1) | BR112020009126A2 (es) |
CA (1) | CA3082351A1 (es) |
CL (1) | CL2020001234A1 (es) |
CO (1) | CO2020006523A2 (es) |
EC (1) | ECSP20029790A (es) |
IL (1) | IL274570A (es) |
MX (1) | MX2020004858A (es) |
PE (1) | PE20210156A1 (es) |
SG (1) | SG11202004113VA (es) |
TW (1) | TW201922263A (es) |
WO (1) | WO2019092660A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
CA3084582A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
US10519187B2 (en) | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
KR20200140867A (ko) | 2018-04-06 | 2020-12-16 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 3'3'-사이클릭 다이뉴클레오티드 |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
AU2019371206A1 (en) | 2018-10-29 | 2021-05-27 | Venenum Biodesign, LLC | Novel sting agonists |
US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
AU2020310853A1 (en) | 2019-07-05 | 2022-01-27 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
JPWO2021206158A1 (es) | 2020-04-10 | 2021-10-14 | ||
JP2023537066A (ja) | 2020-08-07 | 2023-08-30 | タンボ・インコーポレイテッド | トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
PE20231947A1 (es) | 2020-11-09 | 2023-12-05 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco |
WO2023059695A1 (en) * | 2021-10-05 | 2023-04-13 | Sanegene Bio Usa Inc. | Polyhydroxylated cyclopentane derivatives and methods of use |
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-
2018
- 2018-11-09 BR BR112020009126-0A patent/BR112020009126A2/pt not_active Application Discontinuation
- 2018-11-09 CN CN201880073336.7A patent/CN111566119A/zh active Pending
- 2018-11-09 KR KR1020207016227A patent/KR20200098511A/ko not_active Application Discontinuation
- 2018-11-09 CA CA3082351A patent/CA3082351A1/en active Pending
- 2018-11-09 AU AU2018364708A patent/AU2018364708A1/en not_active Abandoned
- 2018-11-09 PE PE2020000488A patent/PE20210156A1/es unknown
- 2018-11-09 SG SG11202004113VA patent/SG11202004113VA/en unknown
- 2018-11-09 MX MX2020004858A patent/MX2020004858A/es unknown
- 2018-11-09 EP EP18814686.4A patent/EP3707151B1/en active Active
- 2018-11-09 US US16/762,710 patent/US11542293B2/en active Active
- 2018-11-09 JP JP2020526002A patent/JP7195317B2/ja active Active
- 2018-11-09 TW TW107139917A patent/TW201922263A/zh unknown
- 2018-11-09 WO PCT/IB2018/058846 patent/WO2019092660A1/en unknown
-
2020
- 2020-05-08 CL CL2020001234A patent/CL2020001234A1/es unknown
- 2020-05-10 IL IL274570A patent/IL274570A/en unknown
- 2020-05-28 CO CONC2020/0006523A patent/CO2020006523A2/es unknown
- 2020-06-08 EC ECSENADI202029790A patent/ECSP20029790A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2018364708A1 (en) | 2020-05-21 |
BR112020009126A2 (pt) | 2020-10-20 |
PE20210156A1 (es) | 2021-01-26 |
IL274570A (en) | 2020-06-30 |
US11542293B2 (en) | 2023-01-03 |
CA3082351A1 (en) | 2019-05-16 |
EP3707151A1 (en) | 2020-09-16 |
KR20200098511A (ko) | 2020-08-20 |
SG11202004113VA (en) | 2020-06-29 |
CL2020001234A1 (es) | 2020-12-04 |
ECSP20029790A (es) | 2020-09-30 |
TW201922263A (zh) | 2019-06-16 |
CN111566119A (zh) | 2020-08-21 |
MX2020004858A (es) | 2020-10-01 |
WO2019092660A1 (en) | 2019-05-16 |
JP7195317B2 (ja) | 2022-12-23 |
JP2021502383A (ja) | 2021-01-28 |
US20210171565A1 (en) | 2021-06-10 |
EP3707151B1 (en) | 2022-01-05 |
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