CO2017004932A2 - Métodos para seleccionar una línea de células t y donador de la misma para terapia celular adoptiva - Google Patents

Métodos para seleccionar una línea de células t y donador de la misma para terapia celular adoptiva

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Publication number
CO2017004932A2
CO2017004932A2 CONC2017/0004932A CO2017004932A CO2017004932A2 CO 2017004932 A2 CO2017004932 A2 CO 2017004932A2 CO 2017004932 A CO2017004932 A CO 2017004932A CO 2017004932 A2 CO2017004932 A2 CO 2017004932A2
Authority
CO
Colombia
Prior art keywords
selecting
methods
donor
cell line
adoptive
Prior art date
Application number
CONC2017/0004932A
Other languages
English (en)
Inventor
Richard J O'reilly
Ekaterina Doubrovina
Guenther Koehne
Aisha N Hasan
Susan E Prockop
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CO2017004932A2 publication Critical patent/CO2017004932A2/es

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Abstract

La presente invención se refiere a métodos para seleccionar una línea de células T alogénicas para administración terapéutica a un paciente que tiene o se sospecha que tiene un patógeno o cáncer. También se describen métodos para seleccionar un donador de quién se deriva una línea de células T alogénicas para administración terapéutica a un paciente que tiene o se sospecha que tiene un patógeno o cáncer.
CONC2017/0004932A 2014-11-05 2017-05-17 Métodos para seleccionar una línea de células t y donador de la misma para terapia celular adoptiva CO2017004932A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462075856P 2014-11-05 2014-11-05
PCT/US2015/058939 WO2016073550A1 (en) 2014-11-05 2015-11-04 Methods of selecting t cell line and donor thereof for adoptive cellular therapy

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CO2017004932A2 true CO2017004932A2 (es) 2017-08-31

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US (2) US11173205B2 (es)
EP (1) EP3215165B1 (es)
JP (2) JP7018316B2 (es)
KR (1) KR102395528B1 (es)
CN (2) CN113768952A (es)
AR (1) AR102538A1 (es)
AU (1) AU2015343239B2 (es)
CA (1) CA2966351A1 (es)
CL (2) CL2017001110A1 (es)
CO (1) CO2017004932A2 (es)
ES (1) ES2846747T3 (es)
FR (1) FR23C1015I1 (es)
IL (1) IL252087B (es)
MX (1) MX2017005707A (es)
MY (1) MY189857A (es)
NZ (1) NZ731321A (es)
PE (1) PE20171135A1 (es)
PH (1) PH12017500787A1 (es)
RU (1) RU2734784C2 (es)
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TW (1) TWI673365B (es)
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Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
JP7018316B2 (ja) 2014-11-05 2022-02-10 メモリアル スローン ケタリング キャンサー センター 養子細胞療法のためのｔ細胞株及びそのドナーの選択方法
CN107835690A (zh) * 2015-05-12 2018-03-23 纪念斯隆-凯特林癌症中心 通过t细胞疗法治疗埃巴病毒相关淋巴细胞增生性病症的方法
AU2016324479B2 (en) 2015-09-18 2022-12-01 Baylor College Of Medicine Immunogenic antigen identification from a pathogen and correlation to clinical efficacy
CA3023820A1 (en) * 2016-05-25 2017-11-30 The Council Of The Queensland Institute Of Medical Research Methods of immunotherapy
CA3037002A1 (en) 2016-09-23 2018-03-29 Memorial Sloan Kettering Cancer Center Generation and use in adoptive immunotherapy of stem cell-like memory t cells
WO2018148183A1 (en) 2017-02-07 2018-08-16 Memorial Sloan Kettering Cancer Center Use of immune checkpoint modulators in combination with antigen-specific t cells in adoptive immunotherapy
WO2018217203A1 (en) 2017-05-25 2018-11-29 Oreilly Richard John Use of the il-15/il-15ra complex in the generation of antigen-specific t cells for adoptive immunotherapy
WO2019083866A1 (en) 2017-10-23 2019-05-02 Atara Biotherapeutics, Inc. METHODS FOR ADJUSTING IMMUNOTHERAPY MANAGEMENT TUMORAL FLOOD MANAGEMENT
WO2019136379A1 (en) * 2018-01-08 2019-07-11 Atara Biotherapeutics, Inc. Systems and methods for distributing cell therapies
US20210000874A1 (en) 2018-03-14 2021-01-07 Memorial Sloan Kettering Cancer Center Methods of selecting t cell line for adoptive cellular therapy
US20210213066A1 (en) * 2018-05-18 2021-07-15 Children's National Medical Center Improved cell therapy compositions for hematopoietic stem cell transplant patients
CA3149145A1 (en) * 2019-07-29 2021-02-04 Baylor College Of Medicine Antigen-specific t cell banks and methods of making and using the same therapeutically
WO2021154882A1 (en) * 2020-01-27 2021-08-05 H. Lee Moffitt Cancer Center And Research Institute Inc. Hdac6-inhibited human regulatory t cells
US11191827B1 (en) * 2020-12-09 2021-12-07 Tevogen Bio Inc. COVID-19 peptide specific T-cells and methods of treating and preventing COVID-19
WO2023004335A1 (en) * 2021-07-22 2023-01-26 Board Of Regents, The University Of Texas System Selection of viral-specific cytotoxic t-cell lines for the management of viral infections
KR102631682B1 (ko) * 2021-12-02 2024-02-28 (주)에스엠티바이오 면역 세포 공여자의 선별 방법

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3201610B2 (ja) 1995-03-17 2001-08-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍を処置する方法
CN1237909A (zh) 1996-10-11 1999-12-08 加利福尼亚大学董事会 联合使用肿瘤细胞与混合淋巴细胞的癌症免疫治疗
WO1998033891A1 (en) * 1997-01-31 1998-08-06 Hemosol Inc. Method for the production of selected lymphocytes
AU7256498A (en) * 1997-04-25 1998-11-24 Wistar Institute Of Anatomy And Biology, The Cytolytic t-cell clones against colorectal carcinoma and methods of use thereof
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
AU9796998A (en) 1997-10-10 1999-05-03 Regents Of The University Of California, The Implants comprising combinations of allogeneic cells for use in cancer treatment
CA2438652A1 (en) 2001-02-19 2002-09-06 Merck Patent Gesellschaft Mit Beschraenkter Haftung Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
RU2303264C2 (ru) * 2001-02-19 2007-07-20 Мерк Патент Гмбх Способ идентификации эпитопов т-клеток и его применение для получения молекул со сниженной иммуногенностью
US7763243B2 (en) * 2001-08-17 2010-07-27 Roger Williams Medical Center In situ immunization
US20050181459A1 (en) * 2002-06-11 2005-08-18 Matthew Baker Method for mapping and eliminating T cell epitopes
CA2496888A1 (en) 2002-09-06 2004-03-18 Mannkind Corporation Epitope sequences
US7163685B2 (en) 2003-04-16 2007-01-16 City Of Hope Human cytomegalovirus antigens expressed in MVA and methods of use
WO2009155535A2 (en) 2008-06-20 2009-12-23 Duke University Compositions, methods and kits for eliciting an immune response
US8467973B2 (en) * 2009-07-28 2013-06-18 Promising Future, Llc Pairing processes for preparing alloreactive cytotoxic T cells
CN102596209A (zh) * 2009-08-17 2012-07-18 国立大学法人东京大学 含有短暂性存活ctl的医药品组合物
US20140086888A1 (en) 2010-09-01 2014-03-27 Helen E. Heslop Ebv-specific cytotoxic t-lymphocytes for the treatment of locoregional nasopharyngeal carcinoma (npc)
ES2635335T3 (es) 2010-09-20 2017-10-03 Biontech Cell & Gene Therapies Gmbh Receptores de células T específicos de antígeno y epítopos de células T
WO2013006050A1 (en) 2011-07-06 2013-01-10 Isa Pharmaceuticals B.V. Peptides inducing or enhancing an immune response against prostate-specific membrane protein (PSMA)
JP7018316B2 (ja) 2014-11-05 2022-02-10 メモリアル スローン ケタリング キャンサー センター 養子細胞療法のためのｔ細胞株及びそのドナーの選択方法
US20210000874A1 (en) 2018-03-14 2021-01-07 Memorial Sloan Kettering Cancer Center Methods of selecting t cell line for adoptive cellular therapy

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