CN220485585U - Protein purification device - Google Patents
Protein purification device Download PDFInfo
- Publication number
- CN220485585U CN220485585U CN202320493285.1U CN202320493285U CN220485585U CN 220485585 U CN220485585 U CN 220485585U CN 202320493285 U CN202320493285 U CN 202320493285U CN 220485585 U CN220485585 U CN 220485585U
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- CN
- China
- Prior art keywords
- rectangular
- heat preservation
- protein purification
- frame
- heating
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- 238000001742 protein purification Methods 0.000 title claims abstract description 34
- 238000010438 heat treatment Methods 0.000 claims abstract description 43
- 238000004321 preservation Methods 0.000 claims abstract description 34
- 239000004065 semiconductor Substances 0.000 claims description 28
- 230000017525 heat dissipation Effects 0.000 claims description 12
- 230000033228 biological regulation Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 abstract description 16
- 102000004169 proteins and genes Human genes 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 238000001816 cooling Methods 0.000 description 12
- 238000009413 insulation Methods 0.000 description 10
- 238000005057 refrigeration Methods 0.000 description 5
- 239000002184 metal Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 208000001034 Frostbite Diseases 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000012774 insulation material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
The application provides a protein purification instrument, in particular to a protein purification device, which comprises a protein purification instrument, wherein a rectangular heat preservation frame is arranged at the front side of the protein purification instrument, a heat preservation door is arranged on the rectangular heat preservation frame, a temperature regulating device is arranged in the rectangular heat preservation frame, and the temperature regulating device comprises a refrigerating element, a heating element and a plurality of temperature controllers; the utility model seals the elements for purifying the protein through the rectangular heat preservation frame and the heat preservation door, refrigerates or heats the periphery of the elements for purifying the protein through the heating element and the refrigerating element, and keeps the periphery temperature of the elements for purifying the protein at the temperature required by protein purification through the digital display intelligent full-automatic temperature control switch, so as to ensure the activity of the protein.
Description
Technical Field
The disclosure specifically discloses a protein purification device.
Background
The protein purifier is designed for full-automatic two-step affinity purification of protein with His-Tagged peptide mark and GSTtagged peptide mark. The existing protein purifying instrument integrates all reagent bottles, component collecting pipes, sample pipes and the like together and is arranged on the same vertical plane to form an independent system. Such as a protein purifier model HASS 150.
The utility model with the publication number of CN218465724U discloses a multichannel protein purifier, which comprises a shell, an installation block and a base, wherein the top end of the base is provided with the shell, two ends of a second limiting plate and a first limiting plate are respectively provided with a side plate, and two sides of a threaded rod are respectively provided with an installation plate.
Although the utility model limits the test tube to prevent the test tube from shifting during processing, the temperature of protein purification cannot be changed as in the existing protein purification instrument, the tolerance temperature of different proteins is different, the protein activity can be protected only by purifying at a proper temperature, and the temperature of the purification process cannot be changed by the existing protein purification instrument. In view of this, we propose a protein purification device.
Disclosure of Invention
In view of the above-described drawbacks or deficiencies of the prior art, the present application is directed to a protein purification device.
The technical scheme adopted by the utility model is as follows:
the protein purification device comprises a protein purification instrument, wherein a rectangular heat preservation frame is arranged at the front side of the protein purification instrument, and a heat preservation door is arranged at one side of the rectangular heat preservation frame;
the temperature adjusting device is arranged in the rectangular heat preservation frame and comprises a plurality of refrigerating elements, a plurality of heating elements and a plurality of temperature controllers, wherein the semiconductor refrigerating sheets in the refrigerating elements and one of the temperature controllers are connected with each other through power lines, and the heating sheets in the heating elements and one of the temperature controllers are connected with each other through the power lines.
As a preferred technical scheme of the utility model: the refrigerating element is arranged at the upper end of the rectangular heat preservation frame, and the heating element is arranged at the lower end of the rectangular heat preservation frame.
As a preferred technical scheme of the utility model: the refrigerating element is composed of a semiconductor refrigerating sheet, the refrigerating surface of the semiconductor refrigerating sheet faces downwards, and the heating element is composed of a heating sheet.
As a preferred technical scheme of the utility model: the mesh enclosure is installed to the below of semiconductor refrigeration piece and the top of heating plate, the mesh enclosure with rectangle frame inner wall fixed connection in the rectangle heat preservation frame.
As a preferred technical scheme of the utility model: the upper side of semiconductor refrigeration piece is installed the radiating box, the radiating box install in the top of rectangle heat preservation frame.
As a preferred technical scheme of the utility model: the heat dissipation box is composed of a rectangular box, the rectangular box is fixedly connected with a rectangular frame in the rectangular heat preservation frame, one side of the rectangular box is provided with a heat dissipation hole, and the other side of the rectangular box is provided with two fans.
As a preferred technical scheme of the utility model: the rectangular heat preservation frame is composed of a rectangular frame, a plurality of rectangular through holes are formed in the upper side of the rectangular frame, and a plurality of heating grooves are formed in the inner bottom surface of the rectangular frame.
As a preferred technical scheme of the utility model: the heating element is arranged in the heating groove, and the refrigerating element is arranged in the rectangular perforation.
The beneficial effects are that:
the utility model seals the elements for purifying the protein through the rectangular heat preservation frame and the heat preservation door, refrigerates or heats the periphery of the elements for purifying the protein through the heating element and the refrigerating element, and keeps the periphery temperature of the elements for purifying the protein at the temperature required by protein purification through the digital display intelligent full-automatic temperature control switch, so as to ensure the activity of the protein.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the detailed description of non-limiting embodiments, made with reference to the following drawings, in which:
FIG. 1 is a schematic diagram of the overall structure of the present utility model;
FIG. 2 is a schematic view, partially in section, of the present utility model;
FIG. 3 is a schematic view of a rectangular heat preservation frame structure of the present utility model;
FIG. 4 is a partial sectional view showing the location structure of the heat dissipating box and the refrigerating element of the present utility model
FIG. 5 is a schematic diagram of a heating element according to the present utility model.
In the figure:
1. a rectangular heat preservation frame; 11. a rectangular frame; 12. a heating tank; 13. rectangular perforation;
2. a protein purification instrument;
3. a thermal insulation door;
4. a heat dissipation box; 41. a rectangular box; 42. a fan; 43. a heat radiation hole;
5. a mesh enclosure;
6. a refrigerating element; 61. a semiconductor refrigeration sheet; 62. a lower fin; 63. an upper radiating fin I;
7. a heating element; 71. a heating sheet; 72. and a second upper radiating fin.
Detailed Description
The present application is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the utility model and are not limiting of the utility model. It should be noted that, for convenience of description, only the portions related to the utility model are shown in the drawings.
It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
As shown in FIGS. 1-5, the preferred embodiment of the present utility model provides a protein purification apparatus comprising a protein purification instrument 2, wherein a rectangular heat-insulating frame 1 is fixedly installed on one side of the protein purification instrument 2, on which a protein purification element is installed, the rectangular heat-insulating frame 1 is composed of a rectangular frame 11, two heating grooves 12 are provided on the inner bottom surface of the rectangular frame 11, and two rectangular perforations 13 are provided on the upper side surface of the rectangular frame 11
In this embodiment, the front side of the rectangular frame 11 is rotatably provided with the thermal insulation door 3, the rectangular thermal insulation frame 1 and the thermal insulation door 3 are made of thermal insulation materials, and magnets are fixedly installed at the contact positions of the rectangular thermal insulation frame 1 and the thermal insulation door 3 and used for stably closing the thermal insulation door 3 on the rectangular thermal insulation frame 1 and isolating the temperature between the rectangular thermal insulation frame 1 and the thermal insulation door 3 from the external temperature.
In this embodiment, a temperature adjusting device is installed in the rectangular heat preservation frame 1, the temperature adjusting device includes a cooling element 6 and a heating element 7, the cooling element 6 is installed at the upper end of the rectangular heat preservation frame 1, the heating element 7 is installed at the lower end of the rectangular heat preservation frame, the cooling element 6 is composed of a semiconductor cooling sheet 61, the cooling surface of the semiconductor cooling sheet 61 faces downwards, the heating element 7 is composed of a heating sheet 71, and the heating sheet 71 is fixedly installed on the inner bottom surface of the rectangular heat preservation frame 1.
The reason why the refrigerating element 6 is mounted on the upper end of the rectangular heat-insulating frame 1 and the heating element 7 is mounted on the lower end is that the hot air generated by heating the heating element 7 expands, the density becomes small, the hot air is increased to be filled between the rectangular heat-insulating frame 1 and the heat-insulating door 3, the cold air cooled by the refrigerating element 6 contracts, the air density becomes large, the cold air is decreased to be filled between the rectangular heat-insulating frame 1 and the heat-insulating door 3, and the air heated above the semiconductor refrigerating sheet 61 becomes small, and the density becomes high.
In this embodiment, the mesh enclosure 5 is installed below the semiconductor cooling plate 61 and above the heating plate 71, for preventing the hands from touching the semiconductor cooling plate 61 and the heating plate 71 directly, preventing scalding or frostbite, the mesh enclosure 5 is made of a material with poor thermal conductivity, and has many holes for air to pass through, and the mesh enclosure 5 is fixedly connected with the inner wall of the rectangular frame 11.
In this embodiment, the upper side of the semiconductor refrigeration sheet 61 is provided with the heat dissipation box 4, the heat dissipation box 4 is formed by a rectangular box 41, the top ends of the rectangular box 41 and the rectangular frame 11 are fixedly installed, one side of the rectangular box 41 is provided with a heat dissipation hole 43, the other side of the rectangular box 41 is fixedly provided with two fans 42, the two fans 42 and the heat dissipation hole 43 correspond to each other and are used for accelerating the flow of air on two sides, the rectangular box 41 is fixedly provided with a storage battery, the storage battery is connected with the fans 42 through a power line, after the fans 42 are started, the air in the heat dissipation box 4 can be driven to flow rapidly, and the heat produced by the upper side of the semiconductor refrigeration sheet 61 can be dissipated quickly.
It should be added that the storage battery is also connected with the semiconductor refrigerating sheet 61 and the heating sheet 71 through the power lines, and the circuit of the semiconductor refrigerating sheet 61 and the storage battery and the circuit of the heating sheet 71 and the storage battery are all connected with the temperature controller through the power lines, and the temperature controller is a digital display intelligent full-automatic temperature control switch of the model SCWD.
It should be noted that, the semiconductor cooling fin 61 is fixedly installed in the rectangular through hole 13, the upper side of the semiconductor cooling fin 61 is fixedly installed with the first upper radiating fin 63, the lower side of the semiconductor cooling fin 61 is fixedly installed with the second upper radiating fin 72, the heating fin 71 is fixedly installed with the second upper radiating fin 72, the first lower radiating fin 62, the first upper radiating fin 63 and the second upper radiating fin 72 are all composed of a plurality of metal sheets with high thermal conductivity, the plurality of metal sheets are installed in a scattered manner, two ends of gaps among the plurality of metal sheets in the first upper radiating fin 63 are opposite to the fan 42 and the radiating hole 43 respectively, and the temperature at two sides of the semiconductor cooling fin 61 and the temperature at the second upper radiating fin 72 can be accelerated to be transferred to the air outwards by the first lower radiating fin 62, the first upper radiating fin 63 and the second upper radiating fin 72;
in this embodiment, the heat-preserving door 3 is closed on the rectangular heat-preserving frame 1, the temperature between the protein purification instrument 2, the rectangular heat-preserving frame 1 and the heat-preserving door 3 is isolated from the external temperature, then the heat above the semiconductor refrigerating sheet 61 is transferred into the rectangular box 41 by the first heat-radiating sheet 63, and under the condition of protecting the activity of protein, the circuit on the heating element 7 or the heat-producing element 6 is selectively opened, so that the protein purification instrument 2, the rectangular heat-preserving frame 1 and the heat-preserving door 3 can be cooled or heated, meanwhile, the transfer of the temperature of the refrigerating surface below the semiconductor refrigerating sheet 61 can be accelerated by the lower heat-radiating sheet 62 which expands downwards, the transfer of the temperature above the heating sheet 71 can be accelerated, because the refrigerating speed below the semiconductor refrigerating sheet 61 is fast and the heat above the heat-radiating sheet is fast and relevant, the first heat-radiating sheet 63 which expands upwards can transfer the heat above the semiconductor refrigerating sheet 61 into the rectangular box 41, and under the working condition, the high-temperature air in the rectangular box 41 can be driven to flow out fast, and the temperature of the air in the rectangular box 41 can be led into the space between the heat-preserving frame 1 and the heat-preserving door 3, thereby the temperature of the protein can be cooled by the intelligent heat-preserving door 3, and the heat-preserving door 3 can be cooled by the heat-preserving door.
The foregoing description is only of the preferred embodiments of the present application and is presented as a description of the principles of the technology being utilized. It will be appreciated by persons skilled in the art that the scope of the utility model referred to in this application is not limited to the specific combinations of features described above, but it is intended to cover other embodiments in which any combination of features described above or equivalents thereof is possible without departing from the spirit of the utility model. Such as the above-described features and technical features having similar functions (but not limited to) disclosed in the present application are replaced with each other.
Claims (8)
1. A protein purification device comprising a protein purification instrument (2), characterized in that: a rectangular heat preservation frame (1) is arranged at the front side of the protein purification instrument (2), and a heat preservation door (3) is arranged at one side of the rectangular heat preservation frame (1);
the temperature regulation device is arranged in the rectangular heat preservation frame (1), and comprises a plurality of refrigerating elements (6), a plurality of heating elements (7) and a plurality of temperature controllers, wherein the semiconductor refrigerating sheets (61) in the refrigerating elements (6) and one temperature controller are connected with each other through power lines, and the heating sheets (71) in the heating elements (7) and one temperature controller are connected with each other through the power lines.
2. The protein purification apparatus of claim 1, wherein: the refrigerating element (6) is arranged at the upper end of the rectangular heat preservation frame (1), and the heating element (7) is arranged at the lower end of the rectangular heat preservation frame (1).
3. The protein purification apparatus of claim 1, wherein: the refrigerating element (6) is composed of a semiconductor refrigerating sheet (61), the refrigerating surface of the semiconductor refrigerating sheet (61) faces downwards, and the heating element (7) is composed of a heating sheet (71).
4. A protein purification apparatus according to claim 3, wherein: the mesh enclosure (5) is arranged below the semiconductor refrigerating sheet (61) and above the heating sheet (71), and the mesh enclosure (5) is fixedly connected with the inner wall of the rectangular frame (11) in the rectangular heat preservation frame (1).
5. A protein purification apparatus according to claim 3, wherein: the upper side of the semiconductor refrigerating sheet (61) is provided with a heat dissipation box (4), and the heat dissipation box (4) is arranged at the top end of the rectangular heat preservation frame (1).
6. The protein purification apparatus of claim 5, wherein: the heat dissipation box (4) is composed of a rectangular box (41), the rectangular box (41) is fixedly connected with a rectangular frame (11) in the rectangular heat preservation frame (1), one side of the rectangular box (41) is provided with a heat dissipation hole (43), and the other side of the rectangular box is provided with two fans (42).
7. The protein purification apparatus of claim 1, wherein: the rectangular heat preservation frame (1) is composed of a rectangular frame (11), a plurality of rectangular through holes (13) are formed in the upper side of the rectangular frame (11), and a plurality of heating grooves (12) are formed in the inner bottom surface of the rectangular frame (11).
8. The protein purification apparatus of claim 7, wherein: the heating element (7) is arranged in the heating groove (12), and the refrigerating element (6) is arranged in the rectangular perforation (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320493285.1U CN220485585U (en) | 2023-03-15 | 2023-03-15 | Protein purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320493285.1U CN220485585U (en) | 2023-03-15 | 2023-03-15 | Protein purification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220485585U true CN220485585U (en) | 2024-02-13 |
Family
ID=89832333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320493285.1U Active CN220485585U (en) | 2023-03-15 | 2023-03-15 | Protein purification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220485585U (en) |
-
2023
- 2023-03-15 CN CN202320493285.1U patent/CN220485585U/en active Active
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| GR01 | Patent grant |