CN213172392U

CN213172392U - Hemorrhagic fever vaccine apparatus for producing

Info

Publication number: CN213172392U
Application number: CN202021626864.1U
Authority: CN
Inventors: 周琪; 陈韦韦; 周鸿飞; 李影
Original assignee: ROYAL (WUXI) BIO-PHARMACEUTICAL CO LTD
Current assignee: ROYAL (WUXI) BIO-PHARMACEUTICAL CO LTD
Priority date: 2020-08-07
Filing date: 2020-08-07
Publication date: 2021-05-11
Anticipated expiration: 2030-08-07

Abstract

The utility model discloses a hemorrhagic fever vaccine apparatus for producing, include: a storage mechanism for holding a culture medium; a cell factory in communication with the storage mechanism, the storage mechanism delivering a culture medium to the cell factory; the cell factory observation device comprises an observation mechanism, wherein a fixed column of the observation mechanism is provided with a first guide rail, the first guide rail is provided with a sliding block, the sliding block is provided with a connecting block, the connecting block is pivotally connected with the sliding block through a rotating shaft, and the connecting block is provided with a CCD (charge coupled device) camera which can shoot and observe the cell factory. It can enlarge the vaccine production and can be observed in time in the production process.

Description

Hemorrhagic fever vaccine apparatus for producing

Technical Field

The utility model relates to a bacterin production field, specifically a hemorrhagic fever bacterin apparatus for producing.

Background

At present, the main production mode of the blood heat vaccine is the rotary bottle production. At present, the number of rotating bottles for cell culture required by a batch of vaccines produced by a company is as much as 875 bottles, 10 cell culture personnel are provided, the constant-temperature factory area required by the cell culture is 40m2, the manual operation intensity is high, the technical requirement is high, bacteria are easy to infect, and the difference between the bottles is difficult to control.

The cell factory culture technology has obvious advantages for large-scale culture of adherent cells, and has little one-time investment, no need of large-scale expensive equipment and no need of complex pipeline design. In addition, the cell factory culture process can flexibly arrange the production scale according to market demands, and meets the requirements of companies for producing vaccines.

The cell factory is a cell culture device with exquisite design, utilizes the culture surface to the utmost extent in the limited space, thereby saving a large amount of factory space and realizing the purpose of enlarging the productivity without any factory reconstruction. Can be used for industrial scale production such as vaccine, monoclonal antibody or biological pharmacy, is especially suitable for culture of adherent cells, does not change the kinetic condition of cell growth when being amplified from laboratory scale, has 5 specifications of 1, 2, 5, 10 and 40 layers, and makes amplification simple and easy.

Traditional process vs cell factory:

SUMMERY OF THE UTILITY MODEL

In order to overcome the defect among the prior art, the embodiment of the utility model provides a hemorrhagic fever vaccine apparatus for producing, it can enlarge vaccine production, can in time observe in the production process.

In order to achieve the above object, the embodiment of the present application discloses a hemorrhagic fever vaccine production apparatus, including:

a storage mechanism for holding a culture medium;

a cell factory in communication with the storage mechanism, the storage mechanism delivering a culture medium to the cell factory;

the cell factory observation device comprises an observation mechanism, wherein a fixed column of the observation mechanism is provided with a first guide rail, the first guide rail is provided with a sliding block, the sliding block is provided with a connecting block, the connecting block is pivotally connected with the sliding block through a rotating shaft, and the connecting block is provided with a CCD (charge coupled device) camera which can shoot and observe the cell factory.

Preferably, the storage mechanism is an acid bottle.

Preferably, the storage mechanism is provided with a two-way cover, the two-way cover is respectively connected with a rubber tube and a bag type filter, and the rubber tube is communicated with a liquid adding port of the cell factory.

Preferably, a peristaltic pump is arranged on the rubber tube and pumps the culture medium in the storage mechanism into the cell factory.

Preferably, the rubber tube is provided with a plurality of T-shaped connectors and is connected with a liquid adding port of a plurality of cell factories through the T-shaped connectors.

Preferably, the rubber tube is connected to a filling port of the cell factory by a connector.

Preferably, a bag filter is connected to the other port of the cell factory.

Preferably, the first guide rail is spiral and can be sleeved on the periphery of the cell factory.

The utility model has the advantages as follows:

1. the vaccine is produced by using a cell factory, and a culture surface is utilized to the maximum extent in a limited space, so that a large amount of factory space is saved, and the purpose of expanding the capacity can be realized without any factory reconstruction;

2. the observation mechanism is simple and easy to operate, is convenient to take and place, can directly overlap from the top of cell factory and establish around the cell factory, the CCD camera can be in through the slider slide on the first guide rail, has reached the effect of adjusting the position of CCD camera, makes the CCD camera can 360 observe the cell factory.

In order to make the aforementioned and other objects, features and advantages of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a schematic structural view of a hemorrhagic fever vaccine production apparatus according to an embodiment of the present invention;

FIG. 2 is a schematic structural view of an observation mechanism of the apparatus for producing a vaccine against hemorrhagic fever in the embodiment of the present invention;

reference numerals of the above figures:

1. a storage mechanism; 11. a two-way cover; 12. a hose; 13. a peristaltic pump; 14. a T-shaped connector; 15. a bag filter; 16. a connector;

2. a cell factory;

3. fixing a column; 31. a first guide rail; 32. a slider; 33. connecting blocks; 34. a rotating shaft; 35. a CCD camera.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature.

In order to achieve the purpose, the utility model provides a hemorrhagic fever vaccine production device.

In this embodiment, referring to fig. 1, the apparatus for producing a hemorrhagic fever vaccine includes a storage mechanism 1, a cell factory 2, and an observation mechanism.

In this embodiment, referring to fig. 1, the storage mechanism 1 is an acid bottle, a two-way cover 11 is disposed on the storage mechanism 1, and a rubber tube 12 and a bag filter 15 are connected to the two-way cover 11 respectively.

In this embodiment, referring to fig. 1, a peristaltic pump 13 is disposed on the rubber tube 12, and the peristaltic pump 13 pumps the culture medium in the storage mechanism 1 into the cell factory 2.

In this embodiment, referring to fig. 1, three T-shaped connectors 14 are disposed on the rubber tube 12, and the rubber tube 12 is connected to one filling opening of three cell factories 2 through the three T-shaped connectors 14.

In this embodiment, referring to FIG. 1, a bag filter 15 is connected to the other port of the cell factory 2.

In this embodiment, referring to fig. 2, the observation mechanism fixes the column 3, the first guide rail 31 is disposed on the fixed column 3, the slider 32 is disposed on the first guide rail 31, the slider 32 is disposed with the connection block 33, the connection block 33 and the slider 32 are pivotally connected through the rotation shaft 34, and the CCD camera 35 is disposed on the connection block 33.

In the present embodiment, referring to fig. 2, the first guide rail 31 is spiral, and the first guide rail 31 can be sleeved on the periphery of the cell factory 2. The CCD camera 35 can slide on the first guide rail 31 via a slider 32, so that information of various angles of the cell factory 2 can be collected.

The connecting block 33 is connected with the sliding block 32 through a rotating shaft 34, the connecting block 33 is always in a state of being vertical to the horizontal plane under the action of gravity, and the CCD camera 35 is further ensured to be in a state of being vertical to the horizontal plane.

The observation mechanism is easy to operate, is convenient to take and place, can be directly sleeved on the periphery of the cell factory 2 from the upper part of the cell factory 2, and the CCD camera 35 can slide on the first guide rail 31 through the sliding block 32, so that the effect of adjusting the position of the CCD camera 35 is achieved.

The present invention has been explained by using specific embodiments, and the explanation of the above embodiments is only used to help understand the method and the core idea of the present invention; meanwhile, for the general technical personnel in the field, according to the idea of the present invention, there are changes in the specific implementation and application scope, to sum up, the content of the present specification should not be understood as the limitation of the present invention.

Claims

1. A hemorrhagic fever vaccine production apparatus characterized by comprising:

a storage mechanism for holding a culture medium;

2. The apparatus for producing a hemorrhagic fever vaccine as recited in claim 1, wherein the storage mechanism is an acid bottle.

3. The apparatus for producing a hemorrhagic fever vaccine as claimed in claim 2, wherein the storage mechanism is provided with a two-way cover, the two-way cover is respectively connected with a rubber tube and a sac filter, and the rubber tube is communicated with a charging port of the cell factory.

4. The apparatus for producing a hemorrhagic fever vaccine as recited in claim 3, wherein a peristaltic pump is provided on the hose, and the peristaltic pump pumps the culture medium in the storage mechanism into the cell factory.

5. The apparatus for producing a hemorrhagic fever vaccine as claimed in claim 3, wherein the hose is provided with a plurality of T-shaped connectors, and the hose is connected with a plurality of charging ports of cell factories through the plurality of T-shaped connectors.

6. The apparatus for producing a hemorrhagic fever vaccine as claimed in claim 3, wherein the connection between the rubber tube and a charging port of the cell factory is made by a connector.

7. The apparatus for producing a hemorrhagic fever vaccine as claimed in claim 1, wherein a sac filter is connected to the other port of the cell factory.

8. The apparatus for producing a vaccine against hemorrhagic fever as recited in claim 1, wherein the first guide rail has a spiral shape and is capable of fitting around the outer periphery of the cell factory.