CN210665759U - Washing channel for chemiluminescence immunoassay - Google Patents
Washing channel for chemiluminescence immunoassay Download PDFInfo
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- CN210665759U CN210665759U CN201921588469.6U CN201921588469U CN210665759U CN 210665759 U CN210665759 U CN 210665759U CN 201921588469 U CN201921588469 U CN 201921588469U CN 210665759 U CN210665759 U CN 210665759U
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- 238000005406 washing Methods 0.000 title claims abstract description 29
- 238000003018 immunoassay Methods 0.000 title claims description 14
- 230000000903 blocking effect Effects 0.000 claims description 10
- 238000005192 partition Methods 0.000 claims description 6
- 239000006249 magnetic particle Substances 0.000 abstract description 18
- 238000001514 detection method Methods 0.000 abstract description 9
- 238000001179 sorption measurement Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
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Abstract
The utility model discloses a washing passageway for chemiluminescence immunodetection, including the passageway body, this internal cup strip draw-in groove that runs through to both ends tip along its length direction that is equipped with of passageway, cup strip draw-in groove both sides distribute has magnet, each the magnet includes the three magnetic path that distributes with halbach array mode respectively. Under the condition of adopting the magnet with the same volume, the magnet has the strongest magnetic field, and adsorbs magnetic particles in the reaction cup placed in the cup strip clamping groove, so that the magnetic particles keep stable posture in the washing process, the magnetic particle loss rate in the washing process is greatly reduced, the accuracy of a detection result is improved, meanwhile, the magnetic field is enhanced, the adsorption speed is accelerated, the washing speed is favorably improved, and the detection efficiency is improved.
Description
Technical Field
The utility model relates to a medical science chemiluminescence immunoassay detects technical field, concretely relates to a wash channel for chemiluminescence immunoassay.
Background
In an immunoassay experiment, a chemiluminescence immunoassay method is usually adopted for detecting and analyzing body fluid, in the detection process, an experimenter needs to adopt a special reaction cup to contain the body fluid to be detected, the experimenter puts the reaction cups in cup strips to realize the simultaneous detection operation of a plurality of reaction cups, thereby improving the detection efficiency, in the actual operation process, the cup strips with the reaction cups are usually put in a washing channel for washing operation, in the washing process, in order to prevent the magnetic particles from being lost, magnets are arranged at two sides of the channel to adsorb the magnetic particles, and the size of the channel structure is limited, the magnetic force provided by the arranged magnets is small, so that the generated adsorption force is insufficient, the loss rate is increased, the accuracy of the detection result is influenced, meanwhile, the magnetic particles are slowly adsorbed, and the magnetic particles can be tightly attached to the cup wall for a long time, the washing operation can be performed only thereafter, relatively increasing the step lag time, and lowering the washing efficiency.
SUMMERY OF THE UTILITY MODEL
In order to solve the problem, the utility model provides a washing passageway for chemiluminescence immunodetection changes the magnet structure, improves magnet magnetic force to improve detection efficiency and accuracy.
In order to achieve the above purpose, the utility model discloses technical scheme as follows:
the utility model provides a washing passageway for chemiluminescence immunodetection, includes the passageway body, this internal cup strip draw-in groove that runs through to both ends tip along its length direction that is equipped with of passageway, cup strip draw-in groove both sides distribute has the magnet, and its key lies in: each magnet comprises three magnetic blocks distributed in a Halbach array mode.
The structure above is adopted, constitute the magnet through the mode of halbach array for under the prerequisite that does not change traditional passageway body structure, can produce stronger magnetic field, produce the strongest magnetic field with the magnet of the same size promptly, in order to ensure that in the washing process, the magnetic particle in the reaction cup can be fast and all adsorb just to the lateral wall of one side of magnet on, reduce the magnetic particle loss rate, shorten washing needle reaction time simultaneously, be favorable to improving detection efficiency.
Preferably, the method comprises the following steps: the three magnetic blocks are a left magnetic block, a middle magnetic block and a right magnetic block from left to right in sequence, wherein the N pole of the middle magnetic block is opposite to the cup strip clamping groove, and the N poles of the left magnetic block and the right magnetic block are respectively opposite to the left side and the right side of the middle magnetic block. The structure provides a scheme that the magnetic blocks are arranged to form the Halbach array magnet, and the requirements of magnetic field strengthening and installation are met.
Further, the utility model provides a constitution mode of another magnet to supply more different designs or production demands, it is three the magnetic path is left magnetic path, middle magnetic path and right magnetic path from a left side to the right side in proper order, and wherein, the S utmost point of middle magnetic path is just to the cup strip draw-in groove, and the S utmost point of left magnetic path and right magnetic path is just to the left and right sides of middle magnetic path respectively.
Preferably, the method comprises the following steps: the magnets on the two sides of the cup strip clamping groove are distributed in a staggered mode along the length direction of the cup strip clamping groove. By adopting the scheme, when the cup strip moves in the cup strip clamping groove, the positions of the magnets facing the cup strip are changed in a staggered mode to form an attraction structure, so that the magnetic particles can be better ensured to be always in an attracted state, and the loss rate is reduced.
Preferably, the method comprises the following steps: the position that the passageway body bottom corresponds the magnet is equipped with the mounting groove that the opening is down, and every mounting groove all disposes the holding-down piece, the holding-down piece passes through screw and passageway body fixed connection. The installation of magnet is fixed through the mode that compresses tightly of pressing blade, and the later stage clearance of being convenient for is changed etc. and simple structure, the implementation of being convenient for.
Preferably, the method comprises the following steps: the channel body is detachably provided with an elastic limiting clamping strip on one side of the upper edge of the cup strip clamping groove, the elastic limiting clamping strip is arranged along the length direction of the channel body, one end of the elastic limiting clamping strip is fixed on the channel body, and the other end of the elastic limiting clamping strip is provided with a limiting bulge protruding towards the position right above the cup strip clamping groove. The scheme above adopting realizes that the cup strip put into the passageway carries out the axial spacing, and simultaneously, the spacing card strip of elasticity does not occupy the space of passageway side direction, makes two adjacent passageways hug closely and sets up side by side, shares the passageway body even, has improved the space utilization of equipment, increases analytical equipment's compactedness simultaneously.
Preferably, the method comprises the following steps: the channel body is provided with two cup strip clamping grooves which are arranged side by side, a separating part is arranged between the two cup strip clamping grooves, a blocking piece is fixedly supported on the separating part, the blocking piece is horizontally arranged along the length direction of the separating part, two sides of the blocking piece extend outwards, and at least part of the blocking piece is positioned right above the corresponding cup strip clamping grooves. By adopting the scheme, the height direction of the cup strips can be limited, the movement is prevented, and the stability of the cup strips in the channel is further improved.
Preferably, the method comprises the following steps: the two ends of the blocking piece are provided with an upward warped position-giving part. By adopting the scheme, the cup strip guiding device has the advantages that a certain guiding and yielding effect is achieved, and interference is reduced when the cup strips are placed into the cup strip clamping grooves or taken out of the cup strip clamping grooves.
Compared with the prior art, the beneficial effects of the utility model are that:
adopt the utility model provides a washing passageway for chemiluminescence immunodetection adopts under the magnet condition of equal volume, makes the magnet have strongest magnetic field to adsorb the magnetic particle in the reaction cup of putting into the cup strip draw-in groove, make it remain stable gesture in the washing process, greatly reduced washing process magnetic particle loss rate improves the accuracy of testing result, and magnetic field strengthens simultaneously, and adsorption rate accelerates, is favorable to improving washing speed, improves detection efficiency promptly.
Drawings
Fig. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic top view of the present invention;
FIG. 3 is a schematic diagram of an embodiment of a magnet;
FIG. 4 is a schematic structural view of another embodiment of a magnet;
fig. 5 is a schematic magnetic field diagram of the magnet structure of the embodiment shown in fig. 3.
Detailed Description
The present invention will be further described with reference to the following examples and accompanying drawings.
Referring to fig. 1 to 5, the washing channel for chemiluminescence immunoassay mainly includes a channel body 1, a cup strip slot 10 is arranged in the channel body 1 along a length direction of the channel body and penetrates through two ends of the channel body, a top of the cup strip slot 10 is open, the channel body is mainly used for fixing a cup strip 6 provided with a reaction cup 7 during washing, magnets 2 are distributed on two sides of the cup strip slot 10 on the channel body 1, the magnets 2 are used for adsorbing magnetic particles in the reaction cup 7 during washing and preventing loss, the main innovation point of the present application is that the magnets 2 include three magnetic blocks distributed in a halbach array, the maximum magnetic field strength is obtained with the minimum occupied volume, the purpose of fast and efficient adsorption is achieved, and the three magnetic blocks are a left magnetic block 20, a middle magnetic block 21 and a right magnetic block 22 in sequence from left to right and are both in a cuboid structure.
Referring to fig. 1, 3 and 5, a hollow arrow in the drawings indicates a magnetic induction line trend, and an implementation structure of the magnet 2 is proposed, that is, an N pole of the middle magnet block 21 faces the cup strip slot 10, an S pole is located at a side far from the cup strip slot 10, and is in a relative position with the cup strip 6 as shown in the drawing, and N poles of the left magnet block 20 and the right magnet block 22 face left and right sides of the middle magnet block 21, and form magnetic fields as shown in fig. 5, so that the magnetic field strength at the side wall position of the reaction cup 7 is sufficiently enhanced.
Referring to fig. 4, another embodiment of the magnet 2 of the present application is different in that the north and south poles of the magnet are reversed, as shown in the figure, in this embodiment, the S pole of the middle magnet 21 faces the cup bar slot 10, the N pole of the middle magnet is located at the side far from the cup bar slot 10, correspondingly, the S poles of the left magnet 20 and the right magnet 22 face the left side and the right side of the middle magnet 21, and the magnetic field distribution principle is the same as that described above.
It should be noted that, in the above two embodiments, in order to ensure that the high-intensity magnetic field forming the magnet 2 can sufficiently act on the side wall of the reaction cup 7, the size of the magnetic block should be selected according to the width of the reaction cup 7, as shown in the figure, the width of the middle magnetic block 21 is about 2/3-3/4 of the width of the reaction cup 7, and is opposite to the center of the width of the reaction cup 7, and both the left magnetic block 20 and the right magnetic block 22 are at least partially located within the width range of the reaction cup 7.
In addition, in order to prevent the magnetic particles from continuously adsorbing on one side wall of the reaction cup 7, the situation that the washing effect is affected occurs, so the magnets 2 are distributed in the two sides of the cup strip clamping groove 10 in a staggered manner along the length direction of the reaction cup, that is, when the cup strip 6 moves the width of one reaction cup 7 in the cup strip clamping groove 10, the magnet 2 corresponding to the reaction cup 7 is changed, so that the magnetic particles can be transferred from one side wall to be adsorbed on the other side wall, and the washing effect is improved by adsorption.
Magnet 2 in this application adopts detachable mounting means, as shown in fig. 1, the position that the bottom of passageway body 1 corresponds magnet 2 is equipped with mounting groove 11, mounting groove 11 size suits with magnet 2, mounting groove 11 has opening down simultaneously, and dispose compressing tablet 3, compressing tablet 3 can carry out length and width direction's at least part to the opening and shelter from, after mounting groove 11 is packed into to magnet 2, cover compressing tablet 3 in open position, magnet 2's lower extreme promptly, then pass through screw 30 with compressing tablet 3's both ends and carry out fixed connection with passageway body 1, compress tightly three magnetic path simultaneously in to magnet 2 through compressing tablet 3, and need not fix the magnetic path alone, be convenient for later stage dismouting change etc..
Referring to fig. 2, in order to fully improve the channel utilization ratio in this application, so have two cup strip draw-in grooves 10 that set up side by side on the channel body 1, two cup strip draw-in grooves 10 separate each other through partition 12, fixed support has the separation blade 5 that is lamellar structure on partition 12, separation blade 5 sets up along the length direction level of cup strip draw-in groove 10, its both sides are outwards extended along the width direction of channel body 1, and at least part is located directly over corresponding one side cup strip draw-in groove 10, like this after cup strip 6 puts into cup strip draw-in groove 10, its direction of height receives separation blade 5's restriction promptly, prevent the drunkenness, improve the stability of cup strip 6 relatively.
Meanwhile, the two ends of the blocking sheet 5 are warped upwards to form the position-giving part 50, so that the cup strips 6 are inserted into the position-giving part from the end parts of the cup strip clamping grooves 10, error interference is reduced, the cup strips 6 are ensured to smoothly enter and exit, faults are reduced, and the operation efficiency of the equipment is improved.
Similarly, the channel body 1 of the embodiment is detachably provided with the elastic limit strip 4 at one side of the upper edge of the cup strip clamping groove 10, the elastic limit strip 4 is integrally arranged along the length direction of the channel body 1, which comprises a rigid fixing part and an elastic abdication part, wherein the rigid fixing part is fixed on the channel body 1, the elastic abdication part extends along the length direction of the upper edge of the cup strip clamping groove 10, the end part of the cup strip clamping groove is provided with a limiting bulge 40 which protrudes towards the right upper part of the cup strip clamping groove 10, the size of the limiting bulge 40 is matched with the limiting groove 60 at the end part of the cup strip 6, as shown in the figure, the two ends of the cup strip 6 are respectively provided with a limiting groove 60, correspondingly, two elastic limiting clamping strips 4 are arranged on the channel body 1 corresponding to each cup strip clamping groove 10 in the embodiment, the two elastic limiting clamping strips 4 are located on one side far away from the partition part 12, and the two elastic limiting clamping strips 4 are symmetrically arranged.
Thus, after the cup strip 6 enters the cup strip clamping groove 10, at least one of the limiting grooves 60 at the two ends of the cup strip can be ensured to be matched with the limiting bulge 40 corresponding to the elastic limiting clamping strip 4, the limiting in the length direction is realized, and the position stability of the cup strip 6 is relatively improved.
Referring to fig. 1 to 5, during installation, the magnets 2 are first combined according to the arrangement shown in fig. 3 or 4, and then the magnets 2 are installed in the installation grooves 11 of the channel body 1 and fixed.
In the use process, the cup strip 6 with the reaction cups 7 is horizontally inserted into the cup strip clamping groove 10, the limiting groove 60 at one end of the cup strip is matched and clamped with the limiting protrusion 40 corresponding to the elastic limiting clamping strip 4, meanwhile, the magnets 2 corresponding to two adjacent reaction cups 6 are positioned on different two sides of the cup strip clamping groove 10, magnetic particles in the reaction cups 7 are quickly adsorbed to one side where the magnets 2 are positioned, the washing operation can be carried out, after one washing action is completed, the cup strip 6 moves by the width of one reaction cup 7, the positions of the magnets 2 corresponding to the reaction cups 7 are changed, the magnetic particles are quickly moved to the other side of the reaction cups 7, the washing is carried out again, the washing effect is greatly improved, and the loss rate of the magnetic particles is reduced.
Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and the scope of the present invention.
Claims (8)
1. The utility model provides a washing passageway for chemiluminescence immunodetection, includes passageway body (1), be equipped with in passageway body (1) and run through to cup strip draw-in groove (10) of both ends tip along its length direction, cup strip draw-in groove (10) both sides distribute has magnet (2), its characterized in that: each magnet (2) comprises three magnetic blocks distributed in a Halbach array mode.
2. The wash channel for chemiluminescent immunoassay of claim 1, wherein: the three magnetic blocks are a left magnetic block (20), a middle magnetic block (21) and a right magnetic block (22) from left to right in sequence, wherein the N pole of the middle magnetic block (21) is opposite to the cup strip clamping groove (10), and the N poles of the left magnetic block (20) and the right magnetic block (22) are respectively opposite to the left side and the right side of the middle magnetic block (21).
3. The wash channel for chemiluminescent immunoassay of claim 1, wherein: the three magnetic blocks are a left magnetic block (20), a middle magnetic block (21) and a right magnetic block (22) from left to right in sequence, wherein the S pole of the middle magnetic block (21) is opposite to the cup strip clamping groove (10), and the S poles of the left magnetic block (20) and the right magnetic block (22) are respectively opposite to the left side and the right side of the middle magnetic block (21).
4. The wash channel for chemiluminescent immunoassay of any one of claims 1 to 3, wherein: the magnets (2) on the two sides of the cup strip clamping groove (10) are distributed in a staggered mode along the length direction of the cup strip clamping groove.
5. The wash channel for chemiluminescent immunoassay of any one of claims 1 to 3, wherein: the position that passageway body (1) bottom corresponds magnet (2) is equipped with mounting groove (11) that the opening is down, and every mounting groove (11) all disposes compressing tablet (3), compressing tablet (3) pass through screw (30) and passageway body (1) fixed connection.
6. The wash channel for chemiluminescent immunoassay of claim 1, wherein: the elastic limiting clamping strip (4) is detachably arranged on one side of the upper edge of the cup strip clamping groove (10) of the channel body (1), the elastic limiting clamping strip (4) is arranged along the length direction of the channel body (1), one end of the elastic limiting clamping strip is fixed on the channel body (1), and the other end of the elastic limiting clamping strip is provided with a limiting bulge (40) protruding towards the position right above the cup strip clamping groove (10).
7. The wash channel for chemiluminescent immunoassay of claim 1 or 6, wherein: the novel cup strip channel is characterized in that two cup strip clamping grooves (10) arranged side by side are formed in the channel body (1), a partition part (12) is arranged between the cup strip clamping grooves (10), a blocking piece (5) is fixedly supported on the partition part (12), the blocking piece (5) is horizontally arranged along the length direction of the partition part (12), two sides of the blocking piece extend outwards, and at least part of the blocking piece is located right above the corresponding cup strip clamping grooves (10).
8. The wash channel for chemiluminescent immunoassay of claim 7, wherein: the two ends of the baffle sheet (5) are provided with an upwardly warped relief part (50).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921588469.6U CN210665759U (en) | 2019-09-24 | 2019-09-24 | Washing channel for chemiluminescence immunoassay |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921588469.6U CN210665759U (en) | 2019-09-24 | 2019-09-24 | Washing channel for chemiluminescence immunoassay |
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| Publication Number | Publication Date |
|---|---|
| CN210665759U true CN210665759U (en) | 2020-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201921588469.6U Active CN210665759U (en) | 2019-09-24 | 2019-09-24 | Washing channel for chemiluminescence immunoassay |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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2019
- 2019-09-24 CN CN201921588469.6U patent/CN210665759U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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