CN206208903U - A kind of colloid gold test paper adaptive background high resolution detection circuit - Google Patents
A kind of colloid gold test paper adaptive background high resolution detection circuit Download PDFInfo
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- CN206208903U CN206208903U CN201621298931.5U CN201621298931U CN206208903U CN 206208903 U CN206208903 U CN 206208903U CN 201621298931 U CN201621298931 U CN 201621298931U CN 206208903 U CN206208903 U CN 206208903U
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Abstract
The utility model provides a kind of colloid gold test paper adaptive background high resolution detection circuit, it includes light emitting diode, luminous tube driver element circuit, photodiode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplifies and low-pass filter unit circuit, AD conversion unit circuit and microcontroller, the light emitting diode sends light irradiation on test paper, the reflected light of light source is received by photodiode, the luminous tube driver element circuit is connected with light emitting diode, the photodiode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplifies and low-pass filter unit circuit, AD conversion unit circuit and microcontroller are sequentially connected, the microcontroller is connected with self-adaptative adjustment element circuit.Detection error can be reduced by the detection circuit, accuracy in detection, accuracy of detection and repeatable accuracy is improved.
Description
Technical field
The utility model is related to the hardware circuit design technical field of detecting instrument, and specially a kind of colloid gold test paper is adaptive
Answer background high resolution detection circuit.
Background technology
At present, POCT real-time tests (point-of-care testing) industry market quickly grows, and colloid gold test paper is fast
Fast diagnostic techniques is built upon EUSA, latex agglutination experiment, monoclonal antibody technique and immune colloid gold mark
With collaurum as label in note technical foundation, the new technology of observed result is reacted using specific antibody antigen binding, can be extensive
Live Quantitative detection is applied to, colloid gold test paper detecting instrument also arises at the historic moment as a kind of rapid in-vitro diagnostic device,
And its function, performance are constantly being lifted.
The detection process of colloid gold test paper detector：Quantitative prepare liquid is instilled at the dripping hole of colloid gold test paper, is led to
Cross chromatography effect and enter pad, be combined into immune complex with the colloid payment acceptor on pad, this complex logistics pernitric acid
Antibody on cellulose membrane, with film be combined into brownish red chromogenic line include nature controlling line and detection line, they can with test strips in
Obvious aberration is formed at the background of centre, when such test paper reaction time point is reached, test paper is inserted the optical detection system of detector
In system, monochromatic light exposure is sent on test paper by luminous tube, detection line correspond to prepare liquid concentration to the reflected light power of light source
Size, detector equidistantly scanned to the display window where detection line, nature controlling line, the simulation letter for converting optical signals into
Number analog-to-digital conversion is carried out, be converted into digital quantity signal, quantized result is drawn by computing.
The problem that common detection technique is present：
The general method using standard color comparison card of calibration of detector, and also deposited between colloid gold test paper and standard color comparison card
Different in certain light reflection difference, light change of reflection then influences the change of electric signal, makes the range of electric signal larger, that is, need
Expand the range ability of collection Guangxin number, and range extension then reduces accuracy of detection；
Difference between batch and batch internal difference, subject matter individual difference to be measured and optical system that the manufacture craft of colloid gold test paper is brought
Mechanical movement error of presence etc. make its can produce in practice with batch, it is of the same race, even with bar test paper repeated detection when occur inspection
The phenomenon of the larger error of result is surveyed, accuracy in detection and repeatable accuracy are have impact within the specific limits；
Clear, the muddy situation of prepare liquid is different, the background area that test paper display window is contrasted with detection line, nature controlling line
Color is different, or even some prepare liquid haemolysises, causes whole display window all in general red situation, due to mixing for color
Stacked on situation of stating is calculated by the fixed value method that standard color comparison card is demarcated, and the situation of result error occurs, reduces inspection
Survey the degree of accuracy.
Utility model content
The purpose of this utility model is to provide a kind of colloid gold test paper adaptive background high resolution detection circuit, maximum limit
The reduction collaurum detector of degree detection error in actual applications, improves accuracy in detection, accuracy of detection and repeatable accuracy.
The utility model is realized by following proposal：
A kind of colloid gold test paper adaptive background high resolution detection circuit, including：Light emitting diode, luminous tube drive single
First circuit, photodiode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplify and low-pass filter unit
Circuit, AD conversion unit circuit and microcontroller, it is characterised in that：The light emitting diode sends light irradiation in test paper
On, the reflected light of light source is received by photodiode, and the luminous tube driver element circuit is connected with light emitting diode, the light
Electric diode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplify and low-pass filter unit circuit, modulus
Conversion unit circuit and microcontroller are sequentially connected, and the microcontroller is connected with self-adaptative adjustment element circuit.
Preferably, the luminous tube driver element circuit includes constant current drive device, resistance and electric capacity.
Preferably, the photoelectric conversion unit circuit includes operational amplifier and feedback resistance.
Preferably, the self-adaptative adjustment element circuit is made up of 4 substitutional resistance R of operational amplifier and periphery.
Preferably, the signal amplifies and low-pass filter unit circuit is by operational amplifier, resistance R1, resistance R2, resistance
R3, resistance R4, electric capacity C1 and electric capacity C2 composition.
Beneficial effect：
1. the utility model takes background signal with peak signal relative quantity as calibration and basis, effective to reduce
The bands such as the mechanical movement error that colloid gold test paper difference between batch and batch internal difference, subject matter individual difference to be measured and optical system are present
The detection error come, improves accuracy in detection and repeatable accuracy.
2. the utility model takes the technical method that adaptive background is adjusted, and the target of the different range abilities of detection all may be used
Ensure high-resolution, accuracy of detection is ensure that while range extension scope.
Brief description of the drawings
Fig. 1 is the schematic diagram of colloid gold test paper adaptive background high resolution detection circuit described in the utility model.
Fig. 2 is the opto-electronic conversion list of colloid gold test paper adaptive background high resolution detection circuit described in the utility model
The schematic diagram of first circuit.
Fig. 3 is the self-adaptative adjustment of colloid gold test paper adaptive background high resolution detection circuit described in the utility model
The schematic diagram of element circuit.
Fig. 4 be colloid gold test paper adaptive background high resolution detection circuit described in the utility model signal amplify and
The schematic diagram of low-pass filter unit circuit.
Fig. 5 is the analog-to-digital conversion list of colloid gold test paper adaptive background high resolution detection circuit described in the utility model
The schematic diagram of first circuit and microcontroller.
Specific embodiment
The technical scheme in the utility model embodiment is carried out below in conjunction with the accompanying drawing in the utility model embodiment
Clearly and completely describe, it is clear that described embodiment is only a part of embodiment of the utility model, rather than whole
Embodiment.Based on the embodiment in the utility model, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment for being obtained, belongs to the scope of the utility model protection.
With reference to Fig. 1, a kind of colloid gold test paper adaptive background high resolution detection circuit, including：It is light emitting diode, luminous
Pipe driver element circuit, photodiode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplify and low pass
Filter unit circuit, AD conversion unit circuit and microcontroller, the light emitting diode send light irradiation on test paper,
The reflected light of light source is received by photodiode, and the luminous tube driver element circuit is connected with light emitting diode, the photoelectricity
Diode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplify and low-pass filter unit circuit, modulus turn
Change element circuit and microcontroller is sequentially connected, the microcontroller is connected with self-adaptative adjustment element circuit.
The luminous tube driver element circuit includes constant current drive device, resistance and electric capacity.Luminous tube driver element circuit
The electric current of stabilization is provided for light emitting diode, makes its luminous homogeneous constant, it is to avoid because current break causes violent light source
Light and shade changes, so as to be impacted to testing result.Can select discrete component or integrated chip composition luminous tube driver element electricity
Road, preferably integrated chip.
With reference to Fig. 2, the photoelectric conversion unit circuit includes operational amplifier and feedback resistance.Photodiode is in reflection
Under the irradiation of light, there is photogenerated current in its internal generation light Electrical change, and this electric current is the other signal of microampere order, need to be carried out preliminary
Amplify, the I-V change-over circuits being made up of operational amplifier OA and feedback resistance RF, by this faint current signal be converted to compared with
Big initial voltage signal VORI.
With reference to Fig. 3, Fig. 3 is self-adaptative adjustment element circuit, and it is a differential amplifier circuit, by operational amplifier OA and
4 substitutional resistance R compositions of periphery, " empty short " and " void is disconnected " concept according to operational amplifier, can calculate this amplifying circuit
The VMID and initial voltage signal VORI of output and the relation of reference voltage VREF are VMID=VREF-VORI, are subtracted by this
Method circuit is the function of being capable of achieving self-adaptative adjustment, and adjustment process is as follows：Background area first to display window is scanned, such as
Shown in Fig. 5, microcontroller carries out modulus by controlling AD conversion unit circuit to the analog voltage signal value of VMID first
Conversion is quantified as data signal, if background color is shallower, corresponding VORI values are smaller, then VMID values are bigger, now microcontroller
Device MCU controls reference voltage VREF is adjusted, and VREF is diminished, then the value of VMID reduces, when it is reached close to analog-to-digital conversion
VREF now is fixed during a certain numerical value of element circuit reference voltage zero point, then whole display window is carried out equidistantly uniformly to sweep
Retouch, amplified by signal as shown in Figure 4 and low-pass filter unit circuit, by the VMID signals of scanning be amplified and filtering at
Reason output VOUT is sent to the AD conversion unit circuit shown in Fig. 5, is reflected background area, detection line and the nature controlling line of scanning
Less digital quantity and larger digital quantity be voltage signal excursion all almost all effectively fall in analog-digital converter
Reference voltage range within, can so increase range ability, and in turn ensure that the actually active high-resolution of analog-digital converter
Scope, improves accuracy of detection, by average and the relative difference of the peak value of detection line to background area, obtains detection knot
Really, accordingly even when background area, detection line, nature controlling line are subject to different color additions interference to cause the value of each VREF may be
Difference, but take the relative difference of the average of background area and the peak value of detection line and then ensure that accuracy in detection and repeatable accuracy；
Similarly in the case of background color relatively depth then with the above method similarly, make VREF become it is big by achieve the goal.By this adaptive
The method for answering background area to adjust reference voltage can effectively improve detection quality.
With reference to Fig. 4, Fig. 4 show signal and amplifies and low-pass filter unit circuit, wherein, by operational amplifier OA and resistance
R1, R2 and electric capacity C1, C2 composition second order active low-pass filter circuit, because the light source for using is constant monochromatic light, so this
Circuit is suitable for filtering invalid HF noise signal；Operational amplifier OA and resistance R3, R4 composition amplifying circuit, to VMID
Further amplify, its excursion major part is all fallen in the range of AD conversion unit circuit reference voltage, it is ensured that high
Resolution ratio, improves accuracy in detection.
By above-mentioned detection circuit, described problem can be prevented effectively from, improve accuracy in detection, the inspection of collaurum detector
Survey precision and repeatable accuracy.
Above to a kind of colloid gold test paper adaptive background high resolution detection circuit provided by the utility model, carry out
It is discussed in detail, specific case used herein is set forth to principle of the present utility model and implementation method, above reality
The explanation for applying example is only intended to help and understands method of the present utility model and its core concept；Simultaneously for the general of this area
Technical staff, according to thought of the present utility model, will change in specific embodiments and applications, to sum up institute
State, this specification content should not be construed as to limitation of the present utility model.
Claims (5)
1. a kind of colloid gold test paper adaptive background high resolution detection circuit, including：Light emitting diode, luminous tube driver element
Circuit, photodiode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplify and low-pass filter unit electricity
Road, AD conversion unit circuit and microcontroller, it is characterised in that：The light emitting diode sends light irradiation on test paper,
The reflected light of light source is received by photodiode, and the luminous tube driver element circuit is connected with light emitting diode, the photoelectricity
Diode, photoelectric conversion unit circuit, self-adaptative adjustment element circuit, signal amplify and low-pass filter unit circuit, modulus turn
Change element circuit and microcontroller is sequentially connected, the microcontroller is connected with self-adaptative adjustment element circuit.
2. circuit is detected according to claim 1, it is characterised in that：The luminous tube driver element circuit drives including constant current
Device, resistance and electric capacity.
3. circuit is detected according to claim 1, it is characterised in that：The photoelectric conversion unit circuit includes operational amplifier
And feedback resistance.
4. circuit is detected according to claim 1, it is characterised in that：The self-adaptative adjustment element circuit is by operational amplifier
And 4 substitutional resistances composition of periphery.
5. circuit is detected according to claim 1, it is characterised in that：The signal amplifies and low-pass filter unit circuit is by transporting
Calculate amplifier, resistance R1, resistance R2, resistance R3, resistance R4, electric capacity C1 and electric capacity C2 composition.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621298931.5U CN206208903U (en) | 2016-11-30 | 2016-11-30 | A kind of colloid gold test paper adaptive background high resolution detection circuit |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621298931.5U CN206208903U (en) | 2016-11-30 | 2016-11-30 | A kind of colloid gold test paper adaptive background high resolution detection circuit |
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| CN206208903U true CN206208903U (en) | 2017-05-31 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117074666A (en) * | 2023-08-18 | 2023-11-17 | 杭州宣航科技有限公司 | Test strip negative-positive identification method and device, electronic equipment and storage medium |
-
2016
- 2016-11-30 CN CN201621298931.5U patent/CN206208903U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117074666A (en) * | 2023-08-18 | 2023-11-17 | 杭州宣航科技有限公司 | Test strip negative-positive identification method and device, electronic equipment and storage medium |
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