CN200977327Y

CN200977327Y - Composition type knitting medical nanometer radioactive metal internal frame

Info

Publication number: CN200977327Y
Application number: CNU2006200486769U
Authority: CN
Inventors: 徐怀德
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-12-07
Filing date: 2006-12-07
Publication date: 2007-11-21
Anticipated expiration: 2016-12-07

Abstract

The utility model is a complex type knitting medical use nanometer radio active metal inner support, which comprises a knitting reticulation metal inner support and a multiplex polyurethane membrane of the support. The utility model is characterized in that a carbon 60 nanometer pipe CNTs is compounded on the polyurethane membrane to form a composite material which is compounded the polyurethane and the 60 nanometer pipe, and the composite material is accompanied by radioactive source material of phosphor 32 or iodine 125. The composite material is spray coated a biological medication material of a paclitaxel and a magnetic material of nanometer Fe3 O4. The utility model has the advantages that the nanometer material carbon 60 nanometer pipes has been used on a radioactivity blood vessel support and a esophagus support, the radioactivity leakage has been reduced, the radioactivity leakage is lower than zero point one percent, the mechanical property and the organism compatibility of the support polyurethane membrane has been improved, making the medical use inner support no longer is a tool of the pampered treatment, but has real cure effect and prevent the second obstruction of the cavity organ and the blood vessel.

Description

Compound knitted medical nanometer radioactive metal inner support

Technical field

This utility model relates to a kind of medical stent, particularly discloses a kind of compound knitted medical nanometer radioactive metal inner support.

Background technology

Medical internal metal rack is one of advanced in the world at present medical apparatus and instruments, medically, has a lot of diseases or operation to cause some luminal stenosis, infraction, and unhealthful, severe patient increases the weight of disease, even threat to life.For this reason, people once used various apparatuses or air bag to expand in the affected part or support, but work more complicated, and may produce other complication, NiTi contains golden support and not only has the favorable tissue compatibility, but also has unique shape memory characteristic, utilize this characteristic that support is implanted, simple to operate, be easy to grasp, this support is specially adapted to the cavity tumor, the patient of unsuitable open surgery, it is reported that at present, nick-eltitanium alloy stent can be used for treating the urethral obstruction due to the prostatic hyperplasia, esophagus, tracheal stenosis, as a kind of new palliative therapy means, in clinical, receive effect preferably.At present, the blood vessel that human body causes because of tumor disease, intestinal, esophagus, tracheal stenosis or block, must be studied medical internal metal rack for this reason.

Summary of the invention

The purpose of this utility model is to make that support no longer is a kind of instrument of palliative therapy, and has real therapeutical effect, strive for more valuable treatment time for cancer patient simultaneously, improve end-stage patients' quality of life, make medical support become one of standard approach of tract pipe cancer patient Comprehensive Treatment.

This utility model is achieved in that a kind of compound knitted medical nanometer radioactive metal inner support, comprise knitting netted internal metal rack and the compound polyurethane film of support, it is characterized in that: also be compounded with carbon 60 nanotube CNTs on the described polyurethane film, form polyurethane and the bonded composite of carbon 60 nanotubes, described composite has phosphorus 32 or iodine 125 radiation source material with infusion method.

Sprayed biological drug material paclitaxel and nanometer Fe on the described composite ₃O ₄Magnetic material.

The beneficial effects of the utility model are: radioactivity intravascular stent and esophageal stents appear, nano material carbon 60 nanotubes are moved to support, reduced escape of radioactivity, escape of radioactivity is lower than 0.1%, improve the mechanical property and the biocompatibility of support polyurethane coating film, making medical stent no longer is a kind of instrument of palliative therapy, and has real therapeutical effect.

Description of drawings

Accompanying drawing is this utility model structural representation.

Among the figure: 1, polyurethane film; 2, internal metal rack; 3, carbon 60 nanotube CNTs; 4, P ³²Or I ¹²⁵5, medication coat paclitaxel; 6, Fe ₃O ₄Magnetic material.

The specific embodiment

With reference to the accompanying drawings, knitting netted internal metal rack 2, the compound polyurethane film 1 of support also is compounded with carbon 60 nanotube CNTs 3 on the polyurethane film 1, form polyurethane and the bonded composite of carbon 60 nanotubes, and composite is enclosed P with infusion method ³²(phosphorus 32) or I ¹²⁵(iodine 125) 4 radiation source material, sprayed biological drug material paclitaxel forms medication coat 5, spraying nanometer Fe on the composite ₃O ₄ Magnetic material 6.

Based on the enlightenment and the research experience of development radioactivity blood vessel double nano support inhibition vascular smooth muscle cell, the radioactivity composite Nano support that draws through the material improvement will provide best treatment means.This type of support combines the physical support effect of interior radiation characteristic medicine, heat energy and the support of radioactive substance, to kill cancerous cell when opening tract, suppress tumor tissue growth, thereby farthest alleviate due to the lumen malignant tumor narrowly, and postpone the time of tract restenosis.

This research intends selecting P ³²(phosphorus 32) or I ¹²⁵(iodine 125) is that support is in conjunction with radioactive source.P ³²Only launch the β ray, I ¹²⁵The emission gamma-rays, its average energy is 0.695MeV, and the mean range in tissue is 4mm, 1.7cm, and its energy all absorbs at dense poly-position, and local organization is produced radiation damage.Tumor cell is responsive to the β ray, can accept enough radiation dose and is damaged and suppresses, thereby utilize P ³²Or I ¹²⁵Local irradiation destroy tumor DNA and suppress growth of tumor, relief of symptoms is to reach the purpose of treatment.

Another outstanding problem of the medical support of band film is at present, and the membrane material mechanical strength that is adopted is also not high, and polyurethane commonly used degradation with aging and calcification may occur in vivo, and then makes material damage.Therefore, adopt suitable method that polyurethane material is improved and be with the intensity and the biocompatibility of film tract and intravascular stent, the multi-function action that performance is filmed, patient's therapeutic effect be can further improve, and certain social benefit and economic benefit produced.

As the very important a member in the nano material, carbon 60 nanotubes are CNTs extremely everybody concern owing to have excellent performance.Proper C NTs is spiked into the tensile strength that can improve material in the polyurethane material, improves the performance of support, obtains more superior support.Early-stage Study shows, the axial modulus of elasticity of CNT from theory estimate and measuring all near in addition above graphene film, at 1TPa between the 1.8TPa.Because after CNT process chemical modification and ultrasonic cut were handled, its contraction in length was about the hundreds of nanometer, and the good dispersion property in polyurethane, behind composite carbon nanometer tube in polyurethane, can obtain the functional polyurethane film that is evenly distributed.Because CNTs excellent biological compatibility and antioxygenic property improve polyurethane material with CNTs, improve the biocompatibility and the antioxidation degradation property of rack surface membrane material.The more important thing is,, can also reduce the radioactivity leakage rate of support owing to the specific performance of nano material own.Thereby this research will attempt CNTs is spiked into and be prepared into composite in the polyurethane, sprayed biological drug material paclitaxel and can only nano magnetic material Fe on composite ₃O ₄, under external magneticaction, produce 42 temperature and treat enhanced sensitivity, and directly destroy tumor DNA key to improve radiochemotherapy.Be applied to the requirement of radioactivity compound rest around it, to its biocompatibility, mechanical property and possible reduction radioactivity are revealed effect and are prevented mainly that cavity tumor and blood vessel implant frame secondary from blocking and conduct a research.

Studies show that:

The technical specification of this utility model medical stent is as follows:

I. rack surface maximum activity degree is 2mCi/cm;

II. the leakage rate that soaks in normal saline after 10 days of support is lower than 0.1%;

III. rack surface understands that the good uniformity of radioactive substance is in 20%;

IV. the tensile strength of rack surface coating material improves more than 50%.

P has successfully been developed in the development of this utility model radioactivity intravascular stent and esophageal stents appear ³²Or I ¹²⁵Radioactivity Fe ₃O ₄The nano material coating-film support is applied to nano material-CNT on the radioactivity plated film, has reduced the radioactivity leakage, has improved the mechanical property and the biocompatibility of filming.The Esophageal Stent quality of the method preparation that employing is filmed is good, soaks back radioactivity leakage and be lower than 0.1% in normal saline.This support carries out preliminary experiment and has obtained certain experience in zoopery.This utility model applicant has obtained achievement at nano material, particularly fullerene and CNT in the research of biological medicine crossing domain, accumulated abundant working experience, is willing to make contributions for human health.

Claims

1. compound knitted medical nanometer radioactive metal inner support, comprise knitting netted internal metal rack and the compound polyurethane film of support, it is characterized in that: also be compounded with carbon 60 nanotube CNTs on the described polyurethane film, form polyurethane and the bonded composite of carbon 60 nanotubes, described composite has phosphorus 32 or iodine 125 radiation source material with infusion method.

2. compound knitted medical nanometer radioactive metal inner support according to claim 1 is characterized in that: sprayed biological drug material paclitaxel and nanometer Fe on the described composite ₃O ₄Magnetic material.