CN112641545A - Esophageal radiotherapy stent and preparation method thereof - Google Patents
Esophageal radiotherapy stent and preparation method thereof Download PDFInfo
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- CN112641545A CN112641545A CN202011489444.8A CN202011489444A CN112641545A CN 112641545 A CN112641545 A CN 112641545A CN 202011489444 A CN202011489444 A CN 202011489444A CN 112641545 A CN112641545 A CN 112641545A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
Abstract
The invention belongs to the technical field of medical instruments, and particularly relates to an esophageal radiotherapy support and a preparation method thereof, wherein the esophageal radiotherapy support comprises a support body, a first protective layer, a second protective layer and a drug-loaded layer, wherein the support body is used for supporting an esophagus, and the first protective layer is arranged on the periphery of the support body; the second protective layer is arranged on the periphery of the first protective layer; the drug-loaded layer is arranged on the periphery of the second protective layer and is used for loading the medicament and controlling the release of the medicament; the second protective layer is used for bonding the first protective layer and the drug-loaded layer. The esophageal radiotherapy support has the advantages of firm structure, difficult shedding and strong stability, and can prevent the occurrence of esophageal restenosis.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to an esophageal radiotherapy stent and a preparation method thereof.
Background
If the human esophagus is tumorous or cancerized, the esophagus can be blocked, and the ingestion of the patient into the real object can be affected. With the wide application of the esophageal stent in clinical practice, the esophageal stent can stretch the esophagus open to enlarge the diameter of the inner cavity of the diseased esophageal part, so that food can conveniently pass through. However, the currently clinically widely applied esophageal stents are single in rigidity, and due to the obvious difference between the rigidity of the esophageal stent and the rigidity of tumor tissues and healthy tissues in the coverage area of the stent, the esophageal stent is uncomfortable after implantation, and causes a plurality of medical problems such as soft tissue hyperplasia at two ends of the stent, esophageal restenosis and the like, and further influences the service life of the stent.
Disclosure of Invention
The invention mainly solves the technical problem that the implantation of an intuitive support causes the re-stricture of the esophagus, and provides an esophageal radiotherapy support and a preparation method thereof.
In order to solve the technical problems, the invention adopts a technical scheme that: the esophageal radiotherapy support comprises a support body, a first protective layer, a second protective layer and a drug-loaded layer, wherein the support body is used for supporting an esophagus, and the first protective layer is arranged on the periphery of the support body; the second protective layer is arranged on the periphery of the first protective layer; the drug-loaded layer is arranged on the periphery of the second protective layer and is used for loading the medicament and controlling the release of the medicament; the second protective layer is used for bonding the first protective layer and the drug-loaded layer.
The invention also comprises a second technical scheme, and a preparation method of the esophageal radiotherapy stent comprises the following steps: depositing a first protective layer on the stent body; synthesizing a second protective layer in situ on the first protective layer to obtain a composite structure of the bracket body/the first protective layer/the second protective layer; and placing the stent body/first protective layer/second protective layer composite structure in a drug-loaded agent solution, and drying to form the stent body/first protective layer/second protective layer/drug-loaded layer composite structure.
The invention has the beneficial effects that: different from the situation of the prior art, the esophageal radiotherapy stent provided by the embodiment of the invention has the advantages that the first protective layer is arranged on the surface of the stent body to protect the stent body, so that the generation of granulation caused by the difference between the rigidity of the stent body and the rigidity of the esophagus is improved, the tissue proliferation is prevented, the generation of granulation is reduced, the restenosis condition of the esophagus is improved, and the service life of the esophageal radiotherapy stent is prolonged. The embodiment of the invention is also provided with the second protective layer, so that the drug-loaded layer can be firmly combined with the first protective layer, the condition that the drug-loaded layer is not firmly combined with the bracket body and the first protective layer is improved, the drug-loaded layer is firmly combined with the first protective layer through the second protective layer, the falling probability of the drug-loaded layer is reduced, the drug-loaded layer is controlled to release the drug, and the drug acts on cells around the esophagus. The embodiment of the invention can improve the uniformity and stability of the drug-loaded layer by arranging the second protective layer. The esophageal radiotherapy support provided by the embodiment of the invention has the advantages of firm structure, difficulty in falling and strong stability, and the generation of restenosis can be further prevented by controlling the release of the medicament through the medicament-carrying layer.
Drawings
FIG. 1 is a scanning electron microscope image of a Ti-O layer formed on the surface of a Ti-Ni alloy stent body according to an embodiment of the present invention;
FIG. 2 is a scanning electron microscope of polydopamine produced on the surface of a Ti-O layer according to an embodiment of the present invention;
FIG. 3a is a transmission electron microscope image of an embodiment of a halloysite nanotube according to an embodiment of the invention;
FIG. 3b is a transmission electron microscope photograph of another embodiment of a halloysite nanotube according to an embodiment of the invention;
FIG. 4 is an atomic force microscope image of a halloysite nanotube according to an embodiment of the invention;
FIG. 5 is a scanning electron microscope image of a stent for esophageal radiotherapy according to an embodiment of the present invention;
fig. 6 is a partial sectional structure schematic view of an esophageal radiotherapy stent according to an embodiment of the invention.
Wherein, 1, the bracket body; 2. a first protective layer; 3. a second protective layer; 4. a drug-loaded layer.
Detailed Description
The embodiment of the invention provides an esophageal radiotherapy support, which comprises a support body 1, a first protective layer 2, a second protective layer 3 and a drug-loaded layer 4, wherein the support body 1 is used for supporting an esophagus, and the first protective layer 2 is arranged on the periphery of the support body 1; the second protective layer 3 is arranged on the periphery of the first protective layer 2; the drug-loaded layer 4 is arranged on the periphery of the second protective layer 3, and the drug-loaded layer 4 is used for loading a medicament and controlling the release of the medicament; the second protective layer 3 is used for bonding the first protective layer 2 and the drug-loaded layer 4.
According to the embodiment of the invention, the first protective layer 2 is arranged on the surface of the support body 1 to protect the support body 1, so that the generation of granulation caused by the difference between the rigidity of the support body 1 and the rigidity of the esophagus is improved, the tissue proliferation is prevented, the generation of the granulation is reduced, the restenosis condition of the esophagus is improved, and the service life of the esophageal radiotherapy support is prolonged. The embodiment of the invention is also provided with the second protective layer 3, so that the drug-loaded layer 4 can be firmly combined with the first protective layer 2, the condition that the drug-loaded layer 4 is not firmly combined with the bracket body 1 and the first protective layer 2 is improved, the drug-loaded layer 4 is firmly combined with the first protective layer 2 through the second protective layer 3, the falling probability of the drug-loaded layer 4 is reduced, the drug-loaded layer 4 is controlled to release the drug, and the drug acts on cells around the esophagus. The embodiment of the invention can improve the uniformity and stability of the drug-loaded layer 4 by arranging the second protective layer 3. The esophageal radiotherapy stent disclosed by the embodiment of the invention can further prevent the generation of restenosis by controlling the release of the medicament through the medicament-carrying layer 4.
In the embodiment of the invention, the bracket body 1 is made of metal or alloy; the first protective layer 2 is used to improve the biocompatibility of the stent body 1. In the embodiment of the invention, the stent body 1 is made of metal or alloy, wherein the metal or alloy has certain rigidity and can support the esophagus, so that the stent has a good supporting effect, and in other embodiments, the stent body 1 can also be made of rigid high polymer material. In the embodiment of the invention, the first protective layer 2 can improve the biocompatibility between the stent body 1 and the esophagus, so that the effect of resisting tissue hyperplasia can be achieved.
Specifically, the stent body 1 is a rigid support structure woven by a metal wire structure, and in the embodiment of the present invention, the stent body 1 is preferably integrally woven by monofilaments. In other embodiments, the stent body 1 may also be woven in other manners.
In the embodiment of the present invention, the first protective layer 2 is a compound layer containing an ionic bond of a metal and oxygen. The ionic bond is formed between metal and oxygen in the compound layer containing the ionic bond of metal and oxygen, so that the biocompatibility of the esophageal tissue and the metal stent can be improved.
In a preferred embodiment of the present invention, the stent body 1 is made of a titanium-nickel alloy, and the first protective layer 2 is a Ti — O layer. In the embodiment of the invention, the stent body 1 is made of the titanium-nickel alloy, so that the stent body 1 has certain biocompatibility and mechanical property, and in the embodiment of the invention, the first protective layer 2 is a Ti-O layer and a surface modification layer, so that the biocompatibility of the stent body 1 can be improved, and the biocompatibility of the titanium-nickel alloy can be further increased. In the embodiment of the invention, the stent body 1 can be a stent formed by interweaving a titanium-nickel alloy metal net structure. In other embodiments, the material of the stent body 1 may also be titanium. The Ti-O layer has an anticoagulation function and can prevent thrombosis to a certain extent; meanwhile, the stent has the functions of resisting tissue hyperplasia and the like, can reduce the generation of granulation, improves the soft tissue hyperplasia at two ends of the stent, and further improves the restenosis condition of the esophagus. Fig. 1 shows a scanning electron microscope image of the Ti — O layer prepared on the titanium-nickel alloy stent body 1.
In the embodiment of the invention, the Ti-O layer is plated on the bracket body 1 through plasma-assisted multi-arc ions. The plasma-assisted multi-arc ion plating technology has the advantages of simple process, no pollution, less energy consumption, high deposition rate, uniform and compact film formation, strong film-substrate binding force, low deposition temperature and good plating winding performance. The plasma-assisted multi-arc ion plating technology in the embodiment of the invention is characterized in that an ion source is additionally arranged on a traditional multi-arc ion plating system, so that the surface of the support body 1 is better treated, the activity of interface ions is improved, and the interface is better combined, so that a Ti-O layer and the support body 1 have more excellent film-base bonding force, the Ti-O layer has more excellent surface smoothness, and the formed film is uniform and compact. The problem of difficult film attachment on the stent body 1 can be solved, the film-based adhesive force is increased, and the film forming effect is improved.
In the embodiment of the present invention, the second protective layer 3 is a poly-dopamine layer. Dopamine is a biological adhesive with excellent performance, has a simple structure, is relatively environment-friendly, and can easily form a film due to the excellent structural property and adhesion of dopamine, and can be adhered to the surfaces of different materials such as metal, polymers, organic matters and the like. The polydopamine coating has strong stability, and the adhesion and uniformity of the polydopamine coating can effectively solve the problems of easy falling and non-uniformity of a medicine coating and are beneficial to improving the mechanical property of the coating. As shown in fig. 2, a scanning electron microscope image of a poly-dopamine layer formed on the surface of the Ti-O layer formed on the titanium-nickel alloy stent body 1 shows from fig. 1 and 2 that the surface of the Ti-O layer can be made relatively smooth and uniform by forming the poly-dopamine layer on the surface of the Ti-O layer.
In the embodiment of the present invention, the drug-loaded layer 4 includes nanotubes. In the embodiment of the invention, the nano tube is a tubular structure with the tube diameter of 1-100nm, and the hollow structure of the nano tube ensures that the nano tube has high surface adsorption performance, can adsorb medicaments and controls the release of the medicaments.
In the embodiment of the invention, the nanotube is a halloysite nanotube. The halloysite nanotube can improve the secondary performance of the coating and the controllability of drug release, and is beneficial to preparing a drug coating with more excellent functions. In the embodiment of the present invention, the controllability of the drug is controlled by controlling the amount of the drug-loaded layer 4, for example, in the embodiment of the present invention, the controllability of the drug is achieved by controlling the density of the halloysite nanotubes. As shown in fig. 3a and 3b, the diameter of the halloysite nanotube according to the embodiment of the invention is about 30nm, fig. 4 is an atomic force electron microscope image of the halloysite nanotube, and it can be illustrated that the halloysite according to the embodiment of the invention is a tubular structure in combination with fig. 4, 3a and 3b, which is beneficial to drug loading.
In the embodiment of the invention, the drug-loaded coating also comprises a sensitizer coating, and the sensitizer coating is loaded on the drug-loaded layer 4. In the embodiment of the invention, the drug coating comprises the sensitizer coating, and the sensitizer coating is borne on the drug-carrying layer 4. In the embodiment of the present invention, the sensitizer coating is a metal nano coating, more specifically, in the embodiment of the present invention, the metal nano coating is a gold nano coating, and in other embodiments, the sensitizer coating may also be other coatings. Fig. 5 shows a scanning electron microscope image of an esophageal radiotherapy stent containing a drug-loaded layer 4.
In a specific embodiment of the invention, the esophageal radiotherapy stent comprises a titanium-nickel alloy stent body 1 with a net structure formed by weaving silk threads, a Ti-O layer positioned on the surface of the titanium-nickel alloy stent body 1 is used as a first protective layer 2, a polydopamine layer positioned on the surface of the Ti-O layer is used as a second protective layer 3, and a halloysite nanotube layer positioned on the surface of the polydopamine layer is used as a drug-carrying layer 4; and the nano gold layer loaded on the surface of the drug-loaded layer 4 is used as a sensitizer; wherein the polydopamine layer is bonded between the Ti-O layer and the halloysite nanotube/nano-gold layer.
The esophageal radiotherapy stent provided by the embodiment of the invention is implanted into the esophagus of a patient with esophageal cancer, and in the process of radiotherapy, the esophageal radiotherapy stent provided by the embodiment of the invention can increase the sensitivity of a tumor near the esophageal radiotherapy stent to rays and can adjust the sensitivity of the tumor to the rays, so that a better treatment effect is achieved.
In the embodiment of the invention, a second technical scheme is also included, and the preparation method of the esophageal radiotherapy bracket comprises the following steps:
s110: depositing a first protective layer on the stent body;
in the embodiment of the invention, the stent body is integrally woven by metal monofilaments, and the smooth stent body is manufactured by electropolishing and a platinum ring manufacturing method. In other embodiments, the stent body may also be woven from multiple filaments, or the stent body may be obtained by direct purchase.
In the embodiment of the invention, the first protective layer is deposited on the stent body, so that the protective stent body can be increased, granulation generation caused by different rigidity between the stent body and the esophagus can be improved, tissue hyperplasia can be prevented, granulation generation can be reduced, and the restenosis condition of the esophagus can be improved.
More specifically, the first protective layer in the embodiment of the present invention may be a compound layer containing ionic bonds of metal and oxygen, and may be formed on the stent body by physical deposition, so as to improve the biocompatibility of the body. The first protective layer may be a metal oxide protective layer or a metal salt protective layer.
S120: and synthesizing a second protective layer on the first protective layer in situ to obtain a composite structure of the bracket body/the first protective layer/the second protective layer.
In the embodiment of the invention, the second protective layer is directly manufactured on the first protective layer by the in-situ synthesis technology, so that the formed second protective layer is compact and strong in uniformity, and the second protective layer is firmly combined with the first protective layer.
S130: and placing the stent body/first protective layer/second protective layer composite structure in a drug-carrying agent solution, and drying to form the stent body/first protective layer/second protective layer/drug-carrying layer composite structure.
In the embodiment of the invention, the stent body/first protective layer/second protective layer composite structure is directly placed in a drug-carrying agent solution, a drug-carrying layer can be rapidly deposited on the stent body/first protective layer/second protective layer composite structure, and an esophageal radiotherapy stent product is formed through drying treatment.
In the embodiment of the invention, the drying is drying, and in other embodiments, the drying can be performed at normal temperature.
As a preferred embodiment of the invention, the preparation method of the esophageal radiotherapy stent comprises the following steps:
s210: and sputtering a Ti-O layer on the bracket body by adopting plasma-assisted multi-arc ion plating to form a first protective layer.
In an embodiment of the present invention, the stent body is made of metal or alloy, more specifically, the stent body in the embodiment of the present invention adopts titanium-nickel alloy, and in other embodiments, the stent body may also adopt titanium metal or other metals. In the embodiment of the invention, a Ti-O layer is formed on the bracket body by sputtering through adopting plasma-assisted multi-arc ion plating to serve as a first protective layer. Specifically, under a vacuum condition, a titanium-nickel alloy stent body is placed into equipment, and Ti-O ions are deposited on the stent body by using a high-purity Ti-O target under a magnetic field to obtain a stent body/a first protection layer structure.
S220: copper sulfate and hydrogen peroxide are used as catalysts, dopamine or dopamine hydrochloric acid is used as a raw material, and polydopamine is synthesized in situ on the first protective layer and serves as a second protective layer.
And (3) soaking the support body/first protection layer structure manufactured in the step in dichloromethane, taking out after a plurality of times, placing the support body/first protection layer structure under a fume hood, placing the support body/first protection layer structure in an ultrasonic cleaner after the dichloromethane is volatilized, removing impurities on the surface of the support body/first protection layer structure, and drying for later use.
And (2) respectively dissolving copper sulfate and hydrogen peroxide serving as catalysts in a Tris solution, wherein the pH value of the Tris solution is 8.5, dissolving dopamine in the Tris solution of copper sulfate and hydrogen peroxide, and placing the cleaned stent body/first protective layer structure in the Tris solution of dopamine hydrochloride, copper sulfate and hydrogen peroxide to synthesize polydopamine in situ. And then taking out, drying and sterilizing for later use to obtain the composite structure of the bracket body/the first protective layer/the second protective layer.
S230: and placing the composite structure of the stent body/the first protective layer/the second protective layer in a drug-carrying agent solution containing the halloysite nanotube, and drying to form the composite structure of the stent body/the first protective layer/the second protective layer/the drug-carrying layer.
In the embodiment of the invention, the compound of the halloysite nanotube and the drug-loaded coating is dispersed in an organic solvent, for example, the compound of the halloysite nanotube and the drug-loaded coating is ultrasonically dispersed in a methanol solution, the cleaned stent body/first protective layer/second protective layer composite structure is placed in the methanol solution of the compound of the halloysite nanotube and the drug-loaded coating, then the stent body is taken out and dried, and the stent body/first protective layer/second protective layer/drug-loaded layer composite structure is obtained. In the embodiment of the invention, the compound of the halloysite nanotube and the drug-loaded coating is a compound of the halloysite nanotube and gold nanoparticles, and in other embodiments, the drug-loaded layer can be other coatings.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes performed by the present specification and drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. An esophageal radiotherapy stent, comprising:
the bracket body is used for supporting the esophagus;
the first protection layer is arranged on the periphery of the bracket body;
the second protective layer is arranged on the periphery of the first protective layer;
the drug-loaded layer is arranged on the periphery of the second protective layer and is used for loading a medicament and controlling the release of the medicament;
wherein the second protective layer is used for bonding the first protective layer and the drug-loaded layer.
2. The esophageal radiotherapy stent of claim 1, wherein the stent body is made of metal or alloy; the first protective layer is used for improving the biocompatibility of the stent body.
3. The esophageal radiation therapy stent of claim 2, wherein the first protective layer is a compound layer comprising ionic bonds of metal and oxygen.
4. The esophageal radiotherapy stent of claim 2, wherein the stent body is made of titanium or titanium-nickel alloy, and the first protective layer is a Ti-O layer; preferably, the Ti-O layer is plasma-assisted multi-arc ion plated on the stent body.
5. The esophageal radiation therapy stent of claim 1, wherein the second protective layer is a polydopamine layer.
6. The esophageal radiation therapy stent of any of claims 1-5, wherein the drug-loaded layer comprises nanotubes.
7. The esophageal radiation therapy stent of claim 6, wherein the nanotubes are halloysite nanotubes.
8. The esophageal radiotherapy stent of claim 1, comprising a sensitizer coating carried by the drug-carrying layer.
9. A preparation method of an esophageal radiotherapy stent is characterized by comprising the following steps:
depositing a first protective layer on the stent body;
synthesizing a second protective layer in situ on the first protective layer to obtain a composite structure of the bracket body/the first protective layer/the second protective layer;
and placing the stent body/first protective layer/second protective layer composite structure in a drug-loaded agent solution, and drying to form the stent body/first protective layer/second protective layer/drug-loaded layer composite structure.
10. The method for preparing a stent for esophageal radiotherapy according to claim 9, comprising the following steps:
sputtering a Ti-O layer on the bracket body by adopting plasma-assisted multi-arc ion plating to form a first protective layer;
copper sulfate and hydrogen peroxide are used as catalysts, dopamine or dopamine hydrochloric acid is used as a raw material, and polydopamine is synthesized in situ on the first protective layer and serves as a second protective layer;
and placing the composite structure of the stent body/the first protective layer/the second protective layer in a drug-carrying agent solution containing the halloysite nanotube, and drying to form the composite structure of the stent body/the first protective layer/the second protective layer/the drug-carrying layer.
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| CN202011489444.8A CN112641545A (en) | 2020-12-16 | 2020-12-16 | Esophageal radiotherapy stent and preparation method thereof |
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| CN202011489444.8A CN112641545A (en) | 2020-12-16 | 2020-12-16 | Esophageal radiotherapy stent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113908346A (en) * | 2021-11-12 | 2022-01-11 | 上海交通大学 | Radioactive lumen stent and preparation method thereof |
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| US20060229715A1 (en) * | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
| CN202387022U (en) * | 2011-11-03 | 2012-08-22 | 陆培华 | Controllable biodegradable drug slow-release membrane layer support |
| CN108969800A (en) * | 2017-06-05 | 2018-12-11 | 上海交通大学 | The preparation method of Wholly-degradable magnesium alloy bracket drug-carried coat with protective layer |
| WO2020246813A1 (en) * | 2019-06-05 | 2020-12-10 | 주식회사 오아이디 | Surface coating structure of surgical prosthesis, and method for modifying surface of surgical prosthesis by using same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113908346A (en) * | 2021-11-12 | 2022-01-11 | 上海交通大学 | Radioactive lumen stent and preparation method thereof |
| CN113908346B (en) * | 2021-11-12 | 2023-03-07 | 上海交通大学 | Radioactive lumen stent and preparation method thereof |
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