CN1887101A - 一种减肥茶及其制备方法 - Google Patents
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- CN1887101A CN1887101A CN 200610083791 CN200610083791A CN1887101A CN 1887101 A CN1887101 A CN 1887101A CN 200610083791 CN200610083791 CN 200610083791 CN 200610083791 A CN200610083791 A CN 200610083791A CN 1887101 A CN1887101 A CN 1887101A
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Abstract
Description
动物品种 | 性别 | 动物(只) | 途径 | 剂量(mg/kg·bw) | 死亡数(只) | LD50(mg/kg·bw) |
小鼠小鼠 | 雌雄 | 1010 | 经口经口 | 2150021500 | 00 | >21500>21500 |
受试物 | 剂量(ug/皿) | TA97 | TA98 | TA100 | TA102 | ||||
+S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | ||
受试物 | 5000 | 143.7+7.4 | 153.3+4.6 | 33.3+1.5 | 37.3+2.1 | 178.3+5.5 | 164.3+6.1 | 291.3+10.5 | 275.7+10.5 |
l000 | 156.0±5.0 | 143.7±7.5 | 33.0±2.6 | 38.3±1.5 | 164.0±7.2 | 177.3±3.2 | 277.7±7.0 | 298.0±5.6 | |
200 | 159.3±5.1 | 145.3±9.5 | 38.7±1.5 | 33.3±1.5 | 175.0±6.6 | 164.7±7.4 | 276.7±5.0 | 297.7±5.1 | |
40 | 145.7±4.7 | 155.7±9.1 | 34.3±2.1 | 39.7±2.1 | 162.7±5.0 | 176.3±7.2 | 297.3±10.8 | 276.0±8.0 | |
8 | 156.3±5.5 | 148.0±2.0 | 40.0±2.6 | 34.3±2.1 | 173.7±8.1 | 160.7±8.1 | 275.3±5.0 | 296.7±5.7 | |
自发回变 | 157.7±8.5 | 144.3±7.1 | 33.0±1.0 | 40.0±4.6 | 160.7±4.0 | 174.0±7.2 | 297.0±7.8 | 279.7±13.1 | |
溶剂对照 | 144.3±9.7 | 158.0±9.2 | 39.7±3.1 | 33.7±2.1 | 163.7±7.8 | 176.7±8.4 | 274.3±12.0 | 299.7±7.8 | |
9-芴酮 | 0.2 | 1239.3±66.3 | 2248.3±47.5 | ||||||
NaN1 | 2.5 | 2294.7±53.1 | |||||||
1.8-二羟蒽醌 | 50.0 | 1054.3±68.1 | |||||||
MMC | 4.0 | 2057.5±83.7 | |||||||
2-AF | 10.0 | 1267.3±45.9 | 3169.3±44.5 | 2147.3±75.9 |
受试物 | 剂量(ug/皿) | TA97 | TA98 | TA100 | TA102 | ||||
+S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | ||
受试物 | 5000 | 155.3+11.2 | 145.7+10.4 | 34.0+2.0 | 41.7+3.5 | 161.0+7.8 | 176.0+7.0 | 279.0+15.6 | 296.0+9.5 |
1000 | 144.7±3.2 | 158.0±6.0 | 38.3±4.9 | 34.3±2.5 | 174.7±8.1 | 164.7±2.5 | 297.0±9.8 | 284.3±11.4 | |
200 | 155.0±10.8 | 147.0±7.9 | 34.3±1.5 | 38.7±2.5 | 160.3±9.7 | 174.3±6.8 | 281.7±7.0 | 295.7±12.0 | |
40 | 143.0±3.6 | 155.3±5.9 | 38.0±2.6 | 34.7±1.5 | 176.7±7.8 | 163.0±4.6 | 298.7±10.0 | 282.0±10.4 | |
8 | 147.0±7.8 | 155.7±7.5 | 41.0±3.0 | 34.0±2.6 | 161.3±7.2 | 177.0±7.9 | 281.7±6.4 | 298.0±9.6 | |
自发回变 | 155.3±7.5 | 144.7±7.1 | 34.7±1.5 | 40.7±4.0 | 176.0±8.9 | 163.0±5.6 | 296.0±12.2 | 283.7±8.5 | |
溶剂对照 | 146.3±7.4 | 155.3±7.5 | 41.0±2.6 | 33.7±2.1 | 163.3±6.1 | 176.7±8.1 | 279.7±7.2 | 299.3±7.4 | |
9-芴酮 | 0.2 | 1217.3±33.6 | 2254.3±95.1 | ||||||
NaN1 | 2.5 | 2320.0±96.7 | |||||||
1.8-二羟蒽醌 | 50.0 | 1038.0±45.0 | |||||||
MMC | 4.0 | 2169.3±29.4 | |||||||
2-AF | 10.0 | 1252.7±43.1 | 3125.0±97.5 | 2224.0±70.5 |
性别 | 剂量(mg/kg·bw) | 动物数(只) | 检查细胞数(个) | 微核数(个) | 微核率(‰) |
雄 | 10000500025001250040(cp) | 555555 | 500050005000500050005000 | 88878124 | 1.61.61.61.41.624.8 |
雌 | 10000500025001250040(cp) | 555555 | 500050005000500050005000 | 88788124 | 1.61.61.41.61.622.4 |
剂量(mg/kg.bw) | 动物数(只) | 受检***数(个) | ***畸形数(个) | ***畸形率(%) |
1000050002500040(cp) | 55555 | 50005000500050005000 | 989910695603 | 1.961.982.121.9012.06 |
性别 | 组别 | 体重(g) | ||||
实验前 | 第1周 | 第2周 | 第3周 | 第4周 | ||
雄 | 对照组低剂量组中剂量组高剂量组 | 91.50±6.1091.70±7.5291.30±7.9491.60±7.14 | 134.74±9.34132.40±8.25130.69±6.56131.59±7.24 | 173.77±11.20171.02±7.90170.70±8.30171.00±12.20 | 209.66±13.20206.74±12.40203.92±14.80206.00±13.90 | 248.89±15.00245.54±13.30242.13±20.20241.39±20.70 |
雌 | 对照组低剂量组中剂量组高剂量组 | 85.60±7.2685.50±6.3385.60±4.0685.50±5.88 | 119.42±9.18117.00±9.97115.85±8.57117.35±10.08 | 153.18±9.50152.21±13.50151.72±10.10152.70±11.80 | 181.14±11.60181.70±14.10181.18±12.30182.88±12.80 | 201.57±11.30199.21±14.80197.56±20.30195.41±17.20 |
性别 | 组别 | 体重增重(g) | 进食量(g) | 食物利用率(%) |
雄 | 对照组低剂量组中剂量组高剂量组 | 157.40±14.50154.21±8.80150.85±14.70149.80±14.80 | 535.80±20.30523.10±24.60531.50±25.20522.30±32.60 | 29.40±3.2029.60±2.5028.40±2.4028.80±3.10 |
雌 | 对照组低剂量组中剂量组高剂量组 | 115.90±7.00113.70±10.30111.97±19.00110.00±13.20 | 494.20±21.10483.20±17.70490.80±23.20477.20±25.50 | 23.50±1.5023.60±2.4022.80±3.3023.10±3.10 |
性别 | 组别 | 动物数(只) | 血红蛋白(g/L) | 红细胞总数(×1012/L) | 红细胞压积(L/L) | 血小板总数(×109/L) |
雄 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 167.40±19.27171.90±19.33163.20±20.98171.90±12.68 | 6.63±0.727.11±0.896.54±1.026.78±0.51 | 0.467±0.0540.489±0.0660.455±0.0700.493±0.037 | 299.3±45.8284.2±37.2294 8±62.5268.6±46.2 |
雌 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 175.40±11.63179.40±18.40179.90±8.67170.50±10.38 | 6.93±0.746.99±0.806.85±0.396.91±0.37 | 0.487±0.0430.502±0.0560.504±0.0220.502±0.034 | 270.9±45.9272.0±42.4292.8±65.9258.8±37.7 |
性别 | 组别 | 动物数(只) | 白细胞总数(×109/L) | 白细胞分类(%) | ||
淋巴 | 其他 | 中性 | ||||
雄 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 20.84±4.9620.35±2.9720.08±5.7721.71±5.48 | 65.10±6.6364.89±4.8365.23±4.7365.37±4.13 | 6.40±3.526.37±2.784.58±2.886.45±3.19 | 28.53±7.0428.74±4.8830.18±4.0428.18±5.96 |
雌 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 20.59±5.9121.32±4.7023.77±4.5620.29±2.87 | 64.34±7.6265.34±6.2768.90±7.7869.33±7.58 | 5.30±4.745.51±2.005.92±2.367.73±3.41 | 30.34±6.1429.14±6.3925.17±8.5222.95±9.73 |
性别 | 组别 | 动物数(只) | 谷丙转氨酶(U/L) | 谷草转氨酶(U/L) | 总蛋白(g/L) | 白蛋白(g/L) |
雄 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 29.13±3.2227.65±7.6730.43±4.6027.01±6.30 | 105.81±21.03109.23±11.7796.14±22.36102.85±18.49 | 71.50±2.2871.70±4.3271.10±3.3171.80±1.37 | 36.10±1.9538.04±3.5736.82±2.5636.42±2.52 |
雌 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 26.40±4.0727.40±5.8526.73±6.0725.95±6.27 | 101.30±17.83101.02±22.5298.93±19.68106.42±16.70 | 71.70±3.0272.70±4.1972.10±4.2471.80±3.09 | 38.80±3.0938.70±2.5837.52±2.8937.75±3.64 |
性别 | 组别 | 动物数(只) | 胆固醇(mmol/L) | 甘油三酯(mmol/L) | 尿素氮(mmol/L) | 血肌酐(μmol/L) | 血糖(mmol/L) |
雄 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 1.83±0.271.80±0.331.82±0.301.77±0.23 | 0.70±0.180.76±0.270.72±0.190.77±0.23 | 4.29±0.414.35±0.494.12±0.724.33±0.38 | 36.30±3.5837.20±3.8831.81±6.3435.35±2.48 | 3.59±0.503.66±0.513.51±0.933.65±0.59 |
雌 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 1.90±0.361.92±0.271.99±0.321.96±0.29 | 0.76±0.320.73±0.220.62±0.180.75±0.13 | 4.61±0.704.62±0.644.30±0.444.36±0.74 | 37.17±4.4439.49±2.6935.46±3.6037.86±4.14 | 3.88±0.933.66±0.413.78±0.443.71±0.27 |
性别 | 组别 | 动物数(只) | 肝/体(%) | 脾/体(%) | 肾/体(%) | 睾/体(%) |
雄 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 3.44±0.233.39±0.233.49±0.353.43±0.20 | 0.34±0.040.32±0.020.33±0.030.33±0.03 | 0.73±0.060.73±0.040.74±0.060.74±0.05 | 0.91±0.040.92±0.040.92±0.060.91±0.05 |
雌 | 对照组低剂量组中剂量组高剂量组 | 10101010 | 3.28±0.273.33±0.263.26±0.183.29±0.29 | 0.32±0.020.32±0.020.32±0.030.32±0.04 | 0.75±0.050.75±0.060.77±0.060.75±0.05 | ---------------- |
病变 | 雄鼠出现病变的动物数 | 雌鼠出现病变的动物数 | |||
高剂量组 | 对照组 | 高剂量组 | 对照组 | ||
肝细胞 | 变性坏死炎细胞浸润 | 0/102/100/10 | 0/101/100/10 | 1/101/100/10 | 1/101/100/10 |
间质 | 血管扩张炎细胞浸润纤维化 | 0/100/100/10 | 0/101/100/10 | 0/101/100/10 | 0/101/100/10 |
其他 | 0/10 | 0/10 | 0/10 | 0/10 |
病变 | 雄鼠出现病变的动物数 | 雌鼠出现病变的动物数 | |||
高剂量组 | 对照组 | 高剂量组 | 对照组 | ||
白髓 | 变性坏死炎细胞浸润 | 0/100/100/10 | 0/100/100/10 | 0/100/100/10 | 0/100/100/10 |
红髓 | 变性坏死炎细胞浸润 | 0/100/100/10 | 0/100/100/10 | 0/100/100/10 | 0/100/100/10 |
其他 | 0/10 | 0/10 | 0/10 | 0/10 |
病变 | 雄鼠出现病变的动物数 | 雌鼠出现病变的动物数 | |||
高剂量组 | 对照组 | 高剂量组 | 对照组 | ||
肾小球 | 变性坏死炎细胞浸润 | 0/100/100/10 | 0/100/100/10 | 0/100/100/10 | 0/100/100/10 |
肾小管 | 变性坏死炎细胞浸润 | 1/100/100/10 | 0/100/100/10 | 1/100/100/10 | 1/100/100/10 |
间质 | 血管扩张炎细胞浸润纤维化 | 0/101/100/10 | 0/102/100/10 | 0/100/100/10 | 0/102/100/10 |
其他 | 0/10 | 0/10 | 0/10 | 0/10 |
病变 | 雄鼠出现病变的动物数 | 雌鼠出现病变的动物数 | |||
高剂量组 | 对照组 | 高剂量组 | 对照组 | ||
粘膜 | 充血水肿出血坏死溃疡 | 0/102/100/100/100/10 | 0/102/100/100/100/10 | 0/101/100/100/100/10 | 0/101/100/100/100/10 |
间质 | 血管扩张炎细胞浸润纤维组织增生 | 0/101/100/10 | 0/100/100/10 | 0/101/100/10 | 0/101/100/10 |
其他 | 0/10 | 0/10 | 0/10 | 0/10 |
病变 | 雄鼠出现病变的动物数 | 雌鼠出现病变的动物数 | |||
高剂量组 | 对照组 | 高剂量组 | 对照组 | ||
粘膜 | 充血水肿出血坏死溃疡 | 0/102/100/100/100/10 | 0/101/100/100/100/10 | 0/101/100/100/100/10 | 0/101/100/100/100/10 |
间质 | 血管扩张炎细胞浸润纤维组织增生 | 0/101/100/10 | 0/101/100/10 | 0/101/100/10 | 0/101/100/10 |
其他 | 0/10 | 0/10 | 0/10 | 0/10 |
病变 | 出现病变的动物数 | ||
高剂量组 | 对照组 | ||
卵泡发育 | 良好一般差 | 10/100/100/10 | 10/100/100/10 |
黄体、白体、髓体 | 血管扩张细胞变性坏死炎细胞浸润 | 0/100/100/100/10 | 0/100/100/100/10 |
其他 | 0/10 | 0/10 |
病变 | 出现病变的动物数 | ||
高剂量组 | 对照组 | ||
曲精小管生精上皮 | 变性坏死炎细胞浸润 | 0/100/100/10 | 0/100/100/10 |
间质 | 血管扩张水肿炎细胞浸润 | 0/100/100/10 | 0/100/100/10 |
其他 | 0/10 | 0/10 |
检测项目 | 例数 | 试食前 | 试食后 |
总蛋白(g/L)白蛋白(g/L)谷丙转氨酶(U/L)尿素(mmol/L)血糖(mmol/L)肌酐(umol/L)尿酸(umol/L)总胆固醇(mmol/L)甘油三酯(mmol/L)血红蛋白(g/L)红细胞计数(×1012/L)白细胞计数(×109/L) | 323232323232323232323232 | 71.3±3.645.1±4.727.8±8.14.3±1.04.6±0.6103.1±24.3222.2±71.94.4±1.21.2±0.6118.9±18.84.1±0.56.4±2.2 | 71.1±2.244.0±3.328.4±6.04.5±0.94.8±0.598.2±23.9240.3±81.54.8±0.51.4±0.5128.3±16.74.3±0.47.3±1.9 |
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Effective date of registration: 20091113 Address after: Beijing City, Fangshan District Doudian Town Industrial District No. 1 Qiushi Patentee after: Beijing Aote Shuer Health Product Development Co., Ltd. Address before: Shandong province Ji'nan City Tianqiao District No. 32 No. 1-2-301 Patentee before: Zhao Yihong |