CN1857421A - Preparing method of total corydaline extract and corydalis preparation - Google Patents
Preparing method of total corydaline extract and corydalis preparation Download PDFInfo
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- CN1857421A CN1857421A CN 200610049743 CN200610049743A CN1857421A CN 1857421 A CN1857421 A CN 1857421A CN 200610049743 CN200610049743 CN 200610049743 CN 200610049743 A CN200610049743 A CN 200610049743A CN 1857421 A CN1857421 A CN 1857421A
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Abstract
The present invention relates to preparation process of total corydalis alkaloid and various kinds of total corydalis alkaloid preparations for treating acute and chronic pains, insomnia and depression. The preparation process of total corydalis alkaloid with high extracting rate and high active extract component content includes the following steps: grinding corydalis material, soaking in 5-10%concentration Na2CO3, NaHCO3 or NaOH solution, extracting with 10%-85% concentration alcohol solution, decompression concentrating, acidifying the concentrated solution with 1%-10% concentration HCl or H2SO4 solution, resin column chromatographic separation and 0-90% concentration alcohol solution elution, concentrating eluted solution, and freeze drying to obtain the total corydalis alkaloid powder. The total corydalis alkaloid powder is further prepared into various preparations.
Description
Technical field
The present invention relates to a kind of preparation method and all kinds of preparation thereof of Chinese medicine extract, specifically be from Rhizoma Corydalis, to prepare the method for total alkali extract and all kinds of preparations that prepare with this total alkali extract, be used for the treatment of acute, chronic various pains, calmness, hypnosis, depression.
Background technology
Rhizoma Corydalis is the tuber of papaveraceae plant corydalis Corydalis yanhusuo W.T.Wang.Bitter in the mouth warm in nature, promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving.Contain alkaloid in the Rhizoma Corydalis, it is about 0.65% wherein to belong to tertiary amines person's content, belongs to quaternary amines person about 0.3%.Separated at present the alkaloid of three kinds of structure types surplus nearly 20, wherein have: d-corydaline (d-C-orydaline is a Rhizoma Corydalis first element), dl-Tetrahydropalmatine (dl-Tetrahydropalmatine is a tetrahydropalmatine), unit's Opium alkali (Protopine is Rhizoma Corydalis third element), 1-Tetrahydrocoptisine (1-Tetrahydrocoptisine is a Rhizoma Corydalis fourth element), dl-Tetrahydrocoptisine (being Rhizoma Corydalis penta element), 1-tetrahydrocolumbamine (1-Tetrahydrocolumbamine is that Rhizoma Corydalis is own plain), corybulbine (Corybulbine is a Rhizoma Corydalis element in heptan), β-homochelidonie (β-Homoch-elidonine is a Rhizoma Corydalis element in the third of the twelve Earthly Branches), coptisine (Coptisine), 13-Methylpalmatine (Dehydrocorydaline is a dehydrogenation Rhizoma Corydalis first element).(-)-Corydalmine (Corydalmine), dehydrogenation Rhizoma Corydalis amine (Dehydrocorydalmine) and Columbamine (Columbamine), and d-boldine dimethyl ether (d-Glaucine) etc.Studies have shown that Rhizoma Corydalis total alkaloids has analgesic activity, syngignoscism, calm, stable effect, antiarrhythmic effect, antiulcer action.
At present Rhizoma Corydalis is that corydalis tuber is cut into small pieces as medicinal main mode, separates out behind its active component orally by the patient then with the method for decocting in water, perhaps makes oral formulations.The defective of the medicinal mode of this kind is: the mode of 1, taking is single, does not have other modes such as injection, thereby its range of application is subjected to bigger restriction; 2, the active substance that extracts from corydalis tuber of decocting in water mode is limited, and not only the activity substance content in the preparation is low, has influenced therapeutic effect, and raw material is not fully utilized, and has caused the wasting of resources.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned the deficiencies in the prior art, all kinds of preparations that a kind of total alkali preparation method of extract are provided and prepare with the total alkali extract, the method that is provided should have the active good effectiveness of composition of perfect technology, total alkali extract rate height, extract; The preparation that is provided is should dosage form complete, can need to select required drug formulation at patient's difference treatment, to improve therapeutic effect.
Technical scheme provided by the invention is:
The preparation method of total corydaline extract is: Rhizoma Corydalis is ground into coarse granule, adopts 5～10%Na
2CO
3Or NaHCO
3Or NaOH soaks alkalization, extracts with 10%～85% ethanol again, and extracting solution concentrating under reduced pressure, concentrated solution are used 1%～10%HCl or 1%～10%H again
2SO
4Acidify, acidifying solution carries out the resin column chromatography, and adopts 0～90% ethanol elution, the eluent concentrating under reduced pressure, lyophilization gets total alkaloids dry powder.
The preparation method of total corydaline extract, operation according to the following steps successively:
1, Rhizoma Corydalis is ground into coarse granule, and fineness is the 5-10 order;
2, use 5-10%Na
2CO
3, NaHCO
3, NaOH soaks alkalization, time 3-4 hour;
3, the ethanol extraction three times that adds 10%-85% adds alcoholic acid weight at every turn and is 5 times of Rhizoma Corydalis weight, extracts temperature 85-90 ℃ 1 hour at every turn;
4, merge extractive liquid,, concentrating under reduced pressure, temperature is 50-60 ℃, pressure is-5 to-10pa;
5, concentrated solution is with 1%-10%HCl or 1%-10%H
2SO
4Carry out acidify, PH=3-3.5, acidificatoin time 2-3 hour;
6, acidifying solution carries out the resin column chromatography, adopts the 0-95% ethanol elution, the eluent concentrating under reduced pressure, and temperature is 50-60 ℃, pressure is-5 to-10pa;
7, lyophilization gets total alkaloids dry powder.
Described resin column material is D
101Or AB-8 or HP-20 or ion exchange resin.
The injection that is provided, its preparation method is: Rhizoma Corydalis total alkaloids 10～200mg adds a certain amount of dissolving of water for injection, with HCl adjust pH 3～4, filter depyrogenation, membrane filtration or ultrafiltration, add a certain amount of antioxidant, fill feeds nitrogen and seals, sterilized 30 minutes, 105 ℃～120 ℃, check, every of finished product contains 5～100mg Rhizoma Corydalis total alkaloids.
The freeze-dried powder that is provided, its preparation method is:
Rhizoma Corydalis total alkaloids 5～100mg with certain amount stent material, adds a certain amount of water for injection dissolving, filters, and depyrogenation, fill, lyophilization, gland is made every and is contained 5～100mg total alkaloids.
The tablet that is provided, its preparation method is:
Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of medical starch, Icing Sugar, and micropowder silica gel, magnesium stearate is granulated, and tabletting or coating are made every tablet of tablet that contains 5～100mg.
The capsule that is provided, its preparation method is:
Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of medical starch, Icing Sugar, and sodium carboxymethyl cellulose, micropowder silica gel is granulated, granulate, fill is made every capsules and is contained 5～100mg.
The soft capsule that is provided, its preparation method is:
Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of refining Oleum Glycines, and the heating mix homogeneously is the gum base of substrate with the gelatin, the glue sheet, and the compacting soft capsule, every soft capsule contains Rhizoma Corydalis total alkaloids 5～100mg.
The drop pill that is provided, its preparation method is:
Rhizoma Corydalis total alkaloids 2～20mg adds a certain amount of Polyethylene Glycol, and the heating mix homogeneously is used the drop pill machine, the preparation drop pill, and the drop pill of the heavy 30mg～80mg of every ball is made in sterilization, and every ball contains Rhizoma Corydalis total alkaloids 2mg～20mg.
The oral liquid that is provided, its preparation method is:
Rhizoma Corydalis total alkaloids 10～100mg adds a certain amount of water for injection, and adjust pH 4～5 adds solubilizing agent, flavoring agent, and sweeting agent, mix homogeneously filters, and fill is sterilized, and makes the oral liquid of 10ml～100ml, and every contains Rhizoma Corydalis total alkaloids 10mg～100mg.
Useful technique effect of the present invention is: the total alkali preparation method of extract that is provided, not only can be more up hill and dale from Rhizoma Corydalis, extract the alkaloid component of various structure types, and make resource obtain using more fully; And the purity of the total alkaloids that is extracted is higher, can reach 10-96%, therefore can be made into required all kinds of preparations.In addition, because made all kinds of preparation formulations are complete, thereby can satisfy various needs of medical treatment.
The specific embodiment
The preparation method of total corydaline extract, operation according to the following steps successively:
1, Rhizoma Corydalis is ground into coarse granule, and fineness is the 5-10 order;
2, use 5-10%Na
2CO
3, NaHCO
3, NaOH soaks alkalization, time 3-4 hour;
3, the ethanol extraction three times that adds 10%-85% adds alcoholic acid weight at every turn and is 5 times of Rhizoma Corydalis weight, extracts temperature 85-90 ℃ 1 hour at every turn;
4, merge extractive liquid,, concentrating under reduced pressure, temperature is 50-60 ℃, pressure is-5 to-10pa;
5, concentrated solution is with 1%-10%HCl or 1%-10%H
2SO
4Carry out acidify, PH=3-3.5, acidificatoin time 2-3 hour;
6, acidifying solution carries out the resin column chromatography, adopts the 0-95% ethanol elution, the eluent concentrating under reduced pressure, and temperature is 50-60 ℃, pressure is-5 to-10pa;
7, lyophilization gets total alkaloids dry powder.
The embodiment of total corydaline extract preparation method:
Embodiment 1: fumitory coarse powder 10kg, and the 5%NaOH alkalization with 70% ethanol extraction, was extracted 1 hour at every turn, extracts three times, merge extractive liquid,, concentrating under reduced pressure, concentrated solution 5%HCl transfers pH=3～4, macroporous resin D on the acid solution
101Post, with the water flushing, then with 85% ethanol elution, the eluent concentrating under reduced pressure, lyophilization gets total alkaloids 128g.
Embodiment 2: fumitory coarse powder 10kg, 3%NaHCO
3Alkalization, with 75% alcohol reflux three times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure, concentrated solution 5%H
2SP
4Transfer pH=3～4, ion exchange resin column on the acid solution, with the water flushing, then with 70% ethanol elution, the eluent concentrating under reduced pressure, lyophilization gets total alkaloids 116g.
Embodiment 3: fumitory coarse powder 10kg, 5%NaHCO
3Alkalization, with 80% alcohol reflux three times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure, concentrated solution 5%HCl transfers pH=3～4, and macroporous resin AB-8 on the acid solution washes with water, 80% ethanol elution, the eluent concentrating under reduced pressure, lyophilization gets total alkaloids 112g.
Embodiment 4: fumitory coarse powder 10kg, 5%Na
2CO
3Alkalization, with 85% alcohol reflux three times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure, concentrated solution 5%H
2SO
4Transfer pH=3～4, macroporous resin HP-20 on the acid solution, with the water flushing, 85% ethanol elution, the eluent concentrating under reduced pressure, lyophilization gets total alkaloids 109g.
Utilize total corydaline extract, can be made into following all kinds of preparation:
One, injection
Rhizoma Corydalis total alkaloids 10～200mg adds a certain amount of dissolving of water for injection, with HCl adjust pH 3～4, filters, and depyrogenation, membrane filtration or ultrafiltration add a certain amount of antioxidant (as NaHSO
3Deng), fill feeds nitrogen to seal, sterilization (30 minutes, 105 ℃～120 ℃), and check, finished product 5～100mg Rhizoma Corydalis total alkaloids/only.
The embodiment of injection preparation method:
Embodiment 1: get Rhizoma Corydalis total alkaloids 5.0g, add water for injection 2000ml dissolving, with HCl adjust pH 3.5, filter, membrane filtration (0.22 μ m), fill, every 2ml feeds nitrogen, seal, 1000 injections are made in sterilization (120 ℃), and every contains Rhizoma Corydalis total alkaloids 5mg.
Embodiment 2: get Rhizoma Corydalis total alkaloids 20.0g, add water for injection 5000ml dissolving, with HCl adjust pH 4.0, filter ultrafiltration (molecular cut off＞10,000), filtrate, fill, every 5ml feeds nitrogen, seal, 1000 injections are made in sterilization (105 ℃), and every contains Rhizoma Corydalis total alkaloids 20mg.
Two, freeze-dried powder
Rhizoma Corydalis total alkaloids 5～100mg is with certain amount stent material (Na
2HPO
4Or glucose or galactose or dextran or mannitol, or any two kinds of stent material that adjuvant mixes with certain proportion wherein), add a certain amount of water for injection dissolving, filter depyrogenation, fill, lyophilization, gland is made every and is contained 5～100mg total alkaloids.
The embodiment of freeze-dried powder preparation method:
Embodiment 1: gets Rhizoma Corydalis total alkaloids 5.0g, adds the 4.0g dextran, add the dissolving of 2000ml water for injection, filter, and depyrogenation, degerming, fill, every 2ml, lyophilization, gland is made every lyophilized formulations that contains the Rhizoma Corydalis total alkaloids of 5mg.
Embodiment 2: gets Rhizoma Corydalis total alkaloids 10.0g, adds 8.2g mannitol, add the dissolving of 5000ml water for injection, filter, and depyrogenation, degerming, fill, every 5ml, lyophilization, gland is made every lyophilized formulations that contains the Rhizoma Corydalis total alkaloids of 10mg.
Three, tablet
Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of medical starch, Icing Sugar, and micropowder silica gel, magnesium stearate is granulated, and tabletting or coating are made every tablet of tablet that contains 5～100mg.
The embodiment of method for preparing tablet thereof:
Embodiment 1: get Rhizoma Corydalis total alkaloids 30.0g, add medical starch 23.0g, Icing Sugar 6.0g, micropowder silica gel 4.0g, cross 16 mesh sieve mixing granulations, drying is crossed 12 mesh sieve granulate, add 2.0g magnesium stearate mixed pressuring plate, make 1000, every contains Rhizoma Corydalis total alkaloids 30mg.
Embodiment 2: get Rhizoma Corydalis total alkaloids 100.0g, add medical starch 52.0g, Icing Sugar 10.0g adds sodium carboxymethyl cellulose 5.0g, add starch slurry, cross 16 mesh sieve mixing granulations, drying is crossed 12 mesh sieve granulate, add 5.0g magnesium stearate tabletting, make 1000, every contains Rhizoma Corydalis total alkaloids 100mg.
Four, capsule
Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of medical starch, Icing Sugar, and sodium carboxymethyl cellulose, micropowder silica gel is granulated, granulate, fill is made every capsules and is contained 5～100mg.
The embodiment of capsule preparation method thereof:
Embodiment 1: get Rhizoma Corydalis total alkaloids 50.0g, add medical starch 36.0g, Icing Sugar 8.0g, sodium carboxymethyl cellulose 6.0g, mix homogeneously, add starch slurry, mix, cross 14 mesh sieve mixing granulations, drying, cross 12 mesh sieve granulate, the dress capsule is made 1000, and every contains Rhizoma Corydalis total alkaloids 50mg.
Embodiment 2: get Rhizoma Corydalis total alkaloids 60.0g, add medical starch 48.0g, lactose 15.0g, micropowder silica gel 4.0g, mix homogeneously adds starch slurry and mixes, and crosses 14 mesh sieve mixing granulations, drying, cross 12 mesh sieve granulate, the dress capsule is made 1000, and every contains Rhizoma Corydalis total alkaloids 60mg.
Five, soft capsule
Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of refining Oleum Glycines, and the heating mix homogeneously is the gum base of substrate with the gelatin, glue sheet, compacting soft capsule.
The embodiment of soft capsule preparation method;
Embodiment 1: gets Rhizoma Corydalis total alkaloids 50.0g, adds the refining Oleum Glycines of 500ml, and Methyl p-hydroxybenzoate 5g, propylparaben 2.5g, the heating mix homogeneously is the film of substrate with the gelatin, and the compacting soft capsule is made 1000 soft capsules, and every contains Rhizoma Corydalis total alkaloids 50mg.
Embodiment 2: gets Rhizoma Corydalis total alkaloids 100.0g, adds the refining Oleum Glycines of 500ml, and Methyl p-hydroxybenzoate 5g, propylparaben 2.5g, the heating mix homogeneously is the film of substrate with the gelatin, and the compacting soft capsule is made 1000 soft capsules, and every contains Rhizoma Corydalis total alkaloids 100mg.
Six, drop pill
Rhizoma Corydalis total alkaloids 2～20mg adds a certain amount of Polyethylene Glycol (1500～20000), and the heating mix homogeneously is used the drop pill machine, the preparation drop pill, and the drop pill of the heavy 30mg～80mg of every ball is made in sterilization, whenever contains Rhizoma Corydalis total alkaloids 2mg～20mg.
The embodiment of method for preparing drop pills:
Embodiment 1: get Rhizoma Corydalis total alkaloids 5.0g, add the 35.0g polyethylene glycol 6000, the heating mix homogeneously is equipped with drop pill with drop pill mechanism, and sterilization is made 1000.Every contains Rhizoma Corydalis total alkaloids 5mg, makes the heavy 40mg of every ball.
Embodiment 2: get Rhizoma Corydalis total alkaloids 20.0g, add the 20.0g polyethylene glycol 6000, the heating mix homogeneously is equipped with drop pill with drop pill mechanism, and sterilization is made 1000.Every contains Rhizoma Corydalis total alkaloids 20mg, makes the heavy 40mg of every ball.
Seven, oral liquid
Rhizoma Corydalis total alkaloids 10～100mg adds a certain amount of water for injection, and adjust pH 4～5 adds solubilizing agent, flavoring agent, and sweeting agent, mix homogeneously filters, and fill is sterilized, and makes the oral liquid of 10ml～100ml, and every contains Rhizoma Corydalis total alkaloids 10mg～100mg.
The embodiment of oral liquor:
Embodiment 1: get Rhizoma Corydalis total alkaloids 50.0g, add 9.8 liters of waters for injection, transfer pH4.5, add Tween 80-100ml, add Folium Stevlae Rebaudianae general glycoside 5.0g, mix homogeneously filters, fill, and 1000 oral liquids are made in sterilization, and every 10ml contains Rhizoma Corydalis total alkaloids 50mg.
Embodiment 2: get Rhizoma Corydalis total alkaloids 100.0g, add 9.7 liters of waters for injection, transfer pH 3.5, add Tween 80-100ml, add refining Mel 200ml, mix homogeneously filters, fill, and 1000 oral liquids are made in sterilization, and every 10ml contains Rhizoma Corydalis total alkaloids 100mg.
It should be noted that the production technology of described all kinds of preparations is common process.
Claims (10)
1, the preparation method of total corydaline extract, it is characterized in that this method is: Rhizoma Corydalis is ground into coarse granule, adopts 5～10%Na
2CO
3Or NaHCO
3Or NaOH soaks alkalization, extracts with 10%～85% ethanol again, and extracting solution concentrating under reduced pressure, concentrated solution are used 1%～10%HCl or 1%～10%H again
2SO
4Acidify, acidifying solution carries out the resin column chromatography, and adopts 0～90% ethanol elution, the eluent concentrating under reduced pressure, lyophilization gets total alkaloids dry powder.
2, the preparation method of total corydaline extract according to claim 1 is characterized in that the operation according to the following steps successively of this preparation method:
One, Rhizoma Corydalis is ground into coarse granule, and fineness is the 5-10 order;
Two, use 5-10% Na
2CO
3, NaHCO
3, NaOH soaks alkalization, time 3-4 hour;
Three, the ethanol extraction three times that adds 10%-85% adds alcoholic acid weight at every turn and is 5 times of Rhizoma Corydalis weight, extracts temperature 85-90 ℃ 1 hour at every turn;
Four, merge extractive liquid,, concentrating under reduced pressure, temperature is 50-60 ℃, pressure is-5 to-10pa;
Five, concentrated solution is with 1%-10%HCl or 1%-10%H
2SO
4Carry out acidify, PH=3-3.5, acidificatoin time 2-3 hour;
Six, acidifying solution carries out the resin column chromatography, adopts the 0-95% ethanol elution, the eluent concentrating under reduced pressure, and temperature is 50-60 ℃, pressure is-5 to-10pa;
Seven, lyophilization gets total alkaloids dry powder.
3, the preparation method of total corydaline extract according to claim 1 and 2 is characterized in that described resin column material is D
101Or AB-8 or HP-20 or ion exchange resin.
4, the injection of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 10～200mg adds a certain amount of dissolving of water for injection, with HCl adjust pH 3～4, filter depyrogenation, membrane filtration or ultrafiltration, add a certain amount of antioxidant, fill feeds nitrogen and seals, sterilized 30 minutes, 105 ℃～120 ℃, check, every of finished product contains 5～100mg Rhizoma Corydalis total alkaloids.
5, the freeze-dried powder of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 5～100mg, with certain amount stent material, add a certain amount of water for injection dissolving, filter depyrogenation, fill, lyophilization, gland is made every and is contained 5～100mg total alkaloids.
6, the tablet of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of medical starch, Icing Sugar, micropowder silica gel, magnesium stearate, granulate, tabletting or coating are made every tablet of tablet that contains 5～100mg.
7, the capsule of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 5～100mg adds a certain amount of medical starch, Icing Sugar, sodium carboxymethyl cellulose, micropowder silica gel is granulated, granulate, fill is made every capsules and is contained 5～100mg.
8, the soft capsule of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 5～100mg, add a certain amount of refining Oleum Glycines, the heating mix homogeneously, with the gelatin is the gum base of substrate, the glue sheet, the compacting soft capsule, every soft capsule contains Rhizoma Corydalis total alkaloids 5～100mg.
9, the drop pill of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 2～20mg, add a certain amount of Polyethylene Glycol, the heating mix homogeneously, use the drop pill machine, the preparation drop pill, the drop pill of the heavy 30mg～80mg of every ball is made in sterilization, and every ball contains Rhizoma Corydalis total alkaloids 2mg～20mg.
10, the oral liquid of the total corydaline extract of method preparation according to claim 1, its preparation method is: Rhizoma Corydalis total alkaloids 10～100mg adds a certain amount of water for injection, adjust pH 4～5, add solubilizing agent, flavoring agent, sweeting agent, mix homogeneously, filter fill, sterilization, make the oral liquid of 10ml～100ml, every contains Rhizoma Corydalis total alkaloids 10mg～100mg.
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| CN101406527B (en) * | 2008-11-27 | 2011-12-07 | 黑龙江中医药大学 | Method for preparing salts of Corydalis ambigua total alkaloid and use thereof as medicament for treating cardiovascular disease |
| CN103083408A (en) * | 2011-10-27 | 2013-05-08 | 中国中医科学院中药研究所 | Composition of traditional Chinese medicine extracts, and preparation method and application thereof |
| CN103191198A (en) * | 2013-04-03 | 2013-07-10 | 中国中医科学院中药研究所 | Rhizoma corydalis extract as well as preparation method and use thereof |
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| CN101406527B (en) * | 2008-11-27 | 2011-12-07 | 黑龙江中医药大学 | Method for preparing salts of Corydalis ambigua total alkaloid and use thereof as medicament for treating cardiovascular disease |
| CN103083408A (en) * | 2011-10-27 | 2013-05-08 | 中国中医科学院中药研究所 | Composition of traditional Chinese medicine extracts, and preparation method and application thereof |
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| CN103191198A (en) * | 2013-04-03 | 2013-07-10 | 中国中医科学院中药研究所 | Rhizoma corydalis extract as well as preparation method and use thereof |
| CN104547053A (en) * | 2015-01-25 | 2015-04-29 | 王小华 | Application of rhizoma-corydalis extract in preparing medicine for treating rheumatoid arthritis |
| CN104644762A (en) * | 2015-01-25 | 2015-05-27 | 汪甬娜 | Application of rhizoma corydalis in treatment of gall-stone |
| CN104547054A (en) * | 2015-01-25 | 2015-04-29 | 汪甬娜 | External application of rhizoma corydalis composition for treating pain of gall-stone |
| CN108519450A (en) * | 2017-06-05 | 2018-09-11 | 广州市药品检验所 | Corydalis tuber reference extract and its preparation method and application |
| CN111642508A (en) * | 2017-11-20 | 2020-09-11 | 华南农业大学 | Application of corydaline substances as herbicide |
| CN111642508B (en) * | 2017-11-20 | 2021-09-24 | 华南农业大学 | Application of corydaline substances as herbicide |
| CN108057064A (en) * | 2018-01-19 | 2018-05-22 | 浙江中医药大学 | A kind of Corydalis ambigua total alkaloid gastric floating tablet |
| CN108057064B (en) * | 2018-01-19 | 2020-11-03 | 浙江中医药大学 | Corydalis tuber total alkaloid gastric floating tablet |
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