CN1546124A - Freeze-dried 'Shengmai' powder for injection and its preparing process - Google Patents
Freeze-dried 'Shengmai' powder for injection and its preparing process Download PDFInfo
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- CN1546124A CN1546124A CNA2003101159036A CN200310115903A CN1546124A CN 1546124 A CN1546124 A CN 1546124A CN A2003101159036 A CNA2003101159036 A CN A2003101159036A CN 200310115903 A CN200310115903 A CN 200310115903A CN 1546124 A CN1546124 A CN 1546124A
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Abstract
The invention discloses a freeze dried injection for restoring pulse beat and its preparation process which comprises, using red ginseng, ophiopogon root and schisandra fruit as principal raw material, employing water extraction method, removing impurities with settling agents, refining and decoloring through macroscopic adsorption resin column, filtering and refining, merging the obtained refined extract, forming solution, refining, split charging, and low-temperature freeze drying.
Description
Technical field:
The present invention improves the dosage form of existing SHENGMAI ZHUSHEYE, provides a kind of injection to give birth to the arteries and veins lyophilized powder, and its preparation method also is provided simultaneously, belongs to the injection Chinese medicine preparation technical field of treatment angina pectoris, myocarditis, shock.
Background technology:
Having used for many years clinically, is a kind of Chinese medicine of determined curative effect.But the dosage form of injection is a liquid at present, and less stable pH value often occurs behind the storage certain hour and changes, cause that appearance luster deepens, muddy even precipitation makes clarity defective, cause when injection, having to a certain degree pain and stimulation, even saponin content reduces curative effect decline.Because ampoule filling is stored for transportation and is made troubles.Shortcomings such as keeping life is short.
Summary of the invention:
The invention provides a kind of injection and give birth to the arteries and veins lyophilized powder, it is fast to drug absorption to have an active constituent content height, good stability, body, good effect. and transportation is stored convenient, and effect duration is long, safe and reliable characteristics.
Another task of the present invention provides the preparation method that above-mentioned injection is given birth to the arteries and veins lyophilized powder.
The present invention is the improvement to existing SHENGMAI ZHUSHEYE dosage form, is primary raw material with Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis, adopts following either party's method preparation: three kinds of raw materials are extracted respectively; With three kinds of raw material united extraction; Radix Ginseng Rubra and Fructus Schisandrae Chinensis united extraction, Radix Ophiopogonis are extracted separately.Three kinds of methods all adopt water extraction to extract, the precipitant removal of impurity, and the refining and decolouring with macroporous adsorbent resin, more after filtration, refining; The refining extract of 1～3 method gained is merged respectively, and wiring solution-forming gets injection through refining, packing, frozen drying and gives birth to the arteries and veins lyophilized powder respectively.
Chinese medicine preparation of the present invention is made by following parts by weight proportion raw material:
1 part of Radix Ginseng Rubra, 3.12 parts of Radix Ophiopogonis, 1.56 parts of Fructus Schisandrae Chinensis.
Preparation method of the present invention comprises following three kinds of concrete preparation methoies:
Method 1:
Get 1 part of Radix Ginseng Rubra, 3.12 parts, 1.56 parts of merging water boiling and extraction of Fructus Schisandrae Chinensis, comprise the steps:
(1) Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis are pulverized and are coarse powder, drop in the extraction pot, and add 0% to 95% pure liquid and extract 1 time, or once;
(2) merge each time extracting solution, relative density is 0.9-1.30 when being concentrated into 30 ℃-80 ℃, gets concentrated solution;
(3) add alcohol in the concentrated solution, make that pure content reaches 10%-95% in the solution, place, filter, reclaim ethanol, filter, filtrate;
(4) with filtrate by after the macroporous adsorptive resins I absorption, with 0%-40% alcohol eluting resin column, discard eluent, with 40%-100% concentration alcohol eluting, eluent;
(5) after eluent passes through resin column II, resin column III again, reclaim under reduced pressure alcohol, concentrated, dry, get dry powder, dry powder contains the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 80%.
(6) dry powder 0%-95% dissolve with ethanol solution is mixed with 5% total saponins solution, adds the medicinal carbon of 0.25%-2%, reflux 30 minutes to 2 hours; Filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and dryly must make with extra care dry powder (total saponin content reaches 85%)
(7) above-mentioned refining dry powder filling is penetrated water and be mixed with 5% aqueous solution, transfer PH to 7-7.5 with 1-10%NaOH solution, coarse filtration is with φ 0.20-0.80 micron filtering with microporous membrane; Filled with solution behind the fine straining, sterilization back lyophilizing must be given birth to the arteries and veins lyophilized injectable powder.The injection lyophilized powder contains the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 85%.
Method 2:
Get 1 part of Radix Ginseng Rubra, 3.12 parts of Radix Ophiopogonis, 1.56 parts of Fructus Schisandrae Chinensis, use water boiling and extraction respectively, comprise the steps:
(1) Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis pulverize separately are coarse powder, add 0% to 95% pure liquid respectively and extract 1 time, or once, get red ginseng extract, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extractive solution respectively;
(2) merge respectively red ginseng extract, Radix Ophiopogonis extract and Fructus Schisandrae Chinensis extractive solution separately each extracting solution, relative density is 0.9-1.20 when being concentrated into 30 ℃-80 ℃ respectively; Respectively Radix Ginseng Rubra concentrated solution, Radix Ophiopogonis concentrated solution and Fructus Schisandrae Chinensis concentrated solution;
(3) add alcohol in Radix Ginseng Rubra concentrated solution, Radix Ophiopogonis concentrated solution and the Fructus Schisandrae Chinensis concentrated solution respectively, make that pure content reaches 10%-95% in the solution, place, filter; Respectively Radix Ginseng Rubra filtrate, Radix Ophiopogonis filtrate and Fructus Schisandrae Chinensis filtrate;
(4) respectively with Radix Ginseng Rubra filtrate, Radix Ophiopogonis filtrate and Fructus Schisandrae Chinensis filtrate, respectively by after the macroporous adsorptive resins I absorption, use 0%-40% alcohol eluting resin column respectively, discard eluent, with 40%-100% concentration alcohol eluting, collect eluent, respectively Radix Ginseng Rubra eluent, Radix Ophiopogonis eluent and Fructus Schisandrae Chinensis eluent;
(5) respectively with Radix Ginseng Rubra eluent, Radix Ophiopogonis eluent and Fructus Schisandrae Chinensis eluent, behind resin column II, decolorizing resin post III, reclaim under reduced pressure alcohol respectively concentrates, dry, respectively Radix Ginseng Rubra dry powder, Radix Ophiopogonis dry powder and Fructus Schisandrae Chinensis dry powder.Three kinds of dry powder are merged mix homogeneously, mixed powder contains Radix Ginseng total saponins and Radix Ophiopogonis total saponins summation greater than 80%.
(6) mixed powder 0%-95% dissolve with ethanol solution is mixed with 5% total saponins solution, adds the medicinal carbon of 0.25%-2%, reflux 30 minutes to 2 hours; Filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and dryly must make with extra care mixed powder (total saponin content reaches 85%);
(7) above-mentioned refining mixed powder is added the injection water and be mixed with 5% aqueous solution, transfer PH to 7-7.5 with 1-10%NaOH solution, coarse filtration is with φ 0.20-0.80 micron filtering with microporous membrane; Filled with solution behind the fine straining, sterilization back lyophilizing must be given birth to the arteries and veins lyophilized injectable powder.The injection lyophilized powder contains the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 85%.
Method 3
Get 1 part of Radix Ginseng Rubra, 1.56 parts of merging of Fructus Schisandrae Chinensis water boiling and extraction respectively, Radix Ophiopogonis, 3.12 parts of independent water boiling and extraction comprised the steps:
(1) pulverizing of Radix Ginseng Rubra and Fructus Schisandrae Chinensis is a coarse powder for coarse powder merges, pulverize Radix Ophiopogonis, adds 0% to 95% pure liquid respectively and extracts 1 time, or once, get Radix Ginseng Rubra Fructus Schisandrae Chinensis extractive solution, Radix Ophiopogonis extract respectively;
(2) merge separately each time extracting solution of Radix Ginseng Rubra Fructus Schisandrae Chinensis extractive solution, Radix Ophiopogonis extract respectively, relative density is 0.9-1.20 when being concentrated into 30 ℃-80 ℃ respectively; Respectively Radix Ginseng Rubra Fructus Schisandrae Chinensis concentrated solution, Radix Ophiopogonis concentrated solution;
(3) add alcohol in Radix Ginseng Rubra Fructus Schisandrae Chinensis concentrated solution, the Radix Ophiopogonis concentrated solution respectively, make that pure content reaches 10%-95% in the solution, place, filter; Respectively Radix Ginseng Rubra Fructus Schisandrae Chinensis filtrate, Radix Ophiopogonis filtrate;
(4),, use 0%-40% alcohol eluting resin column respectively respectively by after the macroporous adsorptive resins I absorption respectively with Radix Ginseng Rubra Fructus Schisandrae Chinensis filtrate, Radix Ophiopogonis filtrate, discard eluent, with 40%-100% concentration alcohol eluting, collect eluent, respectively Radix Ginseng Rubra Fructus Schisandrae Chinensis eluent, Radix Ophiopogonis eluent;
(5) respectively with Radix Ginseng Rubra Fructus Schisandrae Chinensis eluent, Radix Ophiopogonis eluent, respectively by behind resin column II, the decolorizing resin post III, reclaim under reduced pressure alcohol respectively concentrates, dry, respectively Radix Ginseng Rubra Fructus Schisandrae Chinensis dry powder, Radix Ophiopogonis dry powder; With Radix Ginseng Rubra Fructus Schisandrae Chinensis dry powder and dry powder merging Radix Ophiopogonis mix homogeneously, get mixed powder, the summation that contains Radix Ginseng total saponins and Radix Ophiopogonis total saponins is greater than 80%.
(6) mixed powder 0%-95% dissolve with ethanol solution is mixed with 5% total saponins solution, adds the medicinal carbon of 0.25%-2%, reflux 30 minutes to 2 hours; Filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and dryly must make with extra care mixed powder (total saponin content reaches 85%);
(7) above-mentioned refining mixed powder is added the injection water and be mixed with 5% aqueous solution, transfer PH to 7-7.5 with 1-10%NaOH solution, coarse filtration is with φ 0.20-0.80 micron filtering with microporous membrane; Filled with solution behind the fine straining, sterilization back lyophilizing must be given birth to the arteries and veins lyophilized injectable powder.The injection lyophilized powder contains the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 85%.
Pure liquid described in the above-mentioned preparation method comprises other pure liquid solvents such as ethanol, methanol, butanols.
Described preparation method 1,2,3 is characterized in that: relative density is 0.9-1.20 when in the step (2) extracting solution being concentrated into 30 ℃-80 ℃.
Described preparation method 1,2,3 is characterized in that: add in the step (3) behind the ethanol that ethanol content is 40-85% in the solution.
Described preparation method 1,2,3 is characterized in that: in the step (4), macroporous adsorbent resin comprises models such as D21, AB-8, D101, and macroporous adsorptive resins continues and uses the 40-100% ethanol elution earlier with the 0-40% ethanol elution.
Described preparation method 1,2,3 is characterized in that: in the step (5), resin column II is the macropore cation resin post; Resin column III is the resin anion (R.A.) post.
For the step 4) or 5 in the preparation method 1,2,3) the refining extraction dry powder that obtains of macroporous resin column, can be made into solid preparation such as drop pill, tablet, the watered pill, aerosol, capsule etc.Also can mix by proper proportion, make the pharmaceutical composition that is applicable to the different dosage form that uses clinically with one or more pharmaceutically acceptable carriers or excipient.
Using method:
During intravenous drip: with using behind 5-10% glucose injection or the physiological saline solution, each 2-4 props up;
During intravenous injection: the glucose injection dilution back with 5-50% is used each 1;
During intramuscular injection: each 1, once-a-day.
Good effect of the present invention is: the less stable that has overcome present SHENGMAI ZHUSHEYE, the pH value change often appears after storing certain hour, cause that appearance luster deepens, muddiness even precipitation, make clarity defective, cause when injection, having to a certain degree pain and stimulation, even saponin content reduces curative effect decline; Also overcome present SHENGMAI ZHUSHEYE because ampoule filling is stored for transportation and made troubles.Shortcomings such as keeping life is short.
Good effect of the present invention also is to provide a kind of active constituent content height, good stability, and transportation is stored convenient, and effect duration, long injection was given birth to the arteries and veins lyophilized powder.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limit the present invention by any way, under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope that awaits the reply of the present invention.
Embodiment 1:
A. the extract separately for preparing Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis respectively
(1). get Radix Ginseng Rubra 10kg, Radix Ophiopogonis 31.2kg, Fructus Schisandrae Chinensis 15.6kg pulverize separately is a coarse powder, adds 20 times water respectively, heated and boiled three times.
(2) collect merging Radix Ginseng Rubra, Radix Ophiopogonis and the Fructus Schisandrae Chinensis water extract of gained separately respectively, being concentrated into 50 ℃ of relative densities respectively is 1.10;
(3) respectively with Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis concentrated solution separately, add ethanol to determining alcohol respectively and reach 80%, placed respectively 24 hours, filter, filtrate recycling ethanol, to there not being the alcohol flavor, dilution is filtered;
(4) respectively the filtrate of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis is adsorbed (D21 type) by macroporous adsorptive resins respectively, respectively with 10% ethanol-eluting resin column be eluted to eluent colourless after, discard eluent, use 85% concentration ethanol eluting resin column more respectively, collect eluent separately respectively;
(5) 85% ethanol elution of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis is respectively by cationic resin column and resin anion (R.A.) post, and reclaim under reduced pressure alcohol is condensed into extractum shape or dry powder respectively; Respectively Radix Panacis Quinquefolii dry powder, Radix Ophiopogonis dry powder and Fructus Schisandrae Chinensis dry powder; Three kinds of dry powder are merged mix homogeneously, mixed powder contains Radix Ginseng total saponins and Radix Ophiopogonis total saponins summation greater than 80%.B. prepare the injection lyophilized powder
(6) mixed powder water dissolution is mixed with 5% total saponins solution, adds 2% medicinal carbon, reflux 30 minutes to 2 hours; Filter while hot, fine straining again concentrates and dryly must make with extra care mixed powder (total saponin content reaches 85%);
(7) above-mentioned refining mixed powder is added the injection water and be mixed with 5% aqueous solution, transfer PH to 7-7.5 with 5%NaOH solution, coarse filtration is with φ 0.20-0.80 micron filtering with microporous membrane; Filled with solution behind the fine straining, sterilization back lyophilizing must be given birth to 1000 of arteries and veins lyophilized injectable powders.Injection is given birth to the arteries and veins lyophilized powder and is contained the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 85%.
Embodiment 2:
A. prepare Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis total extract
(1) gets Radix Ginseng Rubra 10kg, Radix Ophiopogonis 31.2kg, Fructus Schisandrae Chinensis 15.6kg and pulverize and be to merge coarse powder, add 20 times water, heated and boiled three times, each 1 hour.
(2) the each water extract that extracts gained of collection and merging, being concentrated into 70 ℃ of relative densities is 1.0;
(3) concentrated solution adds ethanol to determining alcohol and reaches 60%, places 24 hours, filter, filtrate recycling ethanol, to there not being the alcohol flavor, dilution is filtered, filtrate;
(4) with filtrate by macroporous adsorptive resins absorption (D21 type), use 20% ethanol-eluting resin column, be eluted to eluent colourless after, discard eluent, reuse 65% concentration ethanol eluting resin column, collection eluent;
(5) 65% ethanol elution are by cationic resin column and resin anion (R.A.) post, and reclaim under reduced pressure alcohol is condensed into dry powder;
B. prepare the injection lyophilized powder
(6) go up the dry powder water dissolution, be mixed with 5% total saponins solution, add 1% medicinal carbon, reflux 30 minutes to 2 hours; Filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and dryly must make with extra care dry powder (total saponin content reaches 85%);
(7) above-mentioned refining dry powder filling is penetrated water and be mixed with 5% aqueous solution, transfer PH to 7-7.5 with 5%NaOH solution, coarse filtration is with φ 0.20-0.80 micron filtering with microporous membrane; Filled with solution behind the fine straining, sterilization back lyophilizing must be given birth to 1000 of arteries and veins lyophilized injectable powders.Injection is given birth to the arteries and veins lyophilized powder and is contained the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 85%.
Embodiment 3:
A. get preparation Radix Ginseng Rubra and the extract of Fructus Schisandrae Chinensis united extraction thing and Radix Ophiopogonis respectively
(1). Radix Ginseng Rubra 10kg Fructus Schisandrae Chinensis 15.6kg united extraction, Radix Ophiopogonis, 31.2kg extracted separately, added 20 times water respectively, heated and boiled three times.
(2) collect each water extract of merging Radix Ginseng Rubra Fructus Schisandrae Chinensis and each water extract of Radix Ophiopogonis respectively, being concentrated into 50 ℃ of relative densities respectively is 1.10; Get Radix Ginseng Rubra Fructus Schisandrae Chinensis concentrated solution, the concentrated solution of Radix Ophiopogonis respectively,
(3) respectively with Radix Ginseng Rubra Fructus Schisandrae Chinensis concentrated solution, the concentrated solution of Radix Ophiopogonis, add ethanol to determining alcohol respectively and reach 75%, placed respectively 24 hours, filter, filtrate recycling ethanol, to there not being the alcohol flavor, dilution is filtered; Get Radix Ginseng Rubra Fructus Schisandrae Chinensis filtrate, the filtrate of Radix Ophiopogonis.
(4) respectively the Radix Ginseng Rubra Fructus Schisandrae Chinensis is mixed filtrate, the filtrate of Radix Ophiopogonis respectively by macroporous adsorptive resins absorption (D21 type), respectively with 10% ethanol-eluting resin column be eluted to eluent colourless after, discard eluent, use 85% concentration ethanol eluting resin column more respectively, collect eluent separately respectively;
(5) Radix Ginseng Rubra Fructus Schisandrae Chinensis eluent, Radix Ophiopogonis, eluent was respectively by cationic resin column and resin anion (R.A.) post, and reclaim under reduced pressure alcohol is condensed into dry powder respectively; Respectively Radix Ginseng Rubra Fructus Schisandrae Chinensis dry powder, Radix Ophiopogonis dry powder; Two kinds of dry powder are merged mix homogeneously, get mixed powder, contain Radix Ginseng total saponins and Radix Ophiopogonis total saponins summation greater than 80%.
B. prepare the injection lyophilized powder
(6) mixed powder water dissolution is mixed with 5% total saponins solution, adds 1% medicinal carbon, reflux 30 minutes to 2 hours; Filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and dryly must make with extra care mixed powder (total saponin content reaches 85%);
(7) above-mentioned refining mixed powder is added the injection water and be mixed with 5% aqueous solution, transfer PH to 7-7.5 with 5%NaOH solution, coarse filtration is with φ 0.20-0.80 micron filtering with microporous membrane; Filled with solution behind the fine straining, sterilization back lyophilizing must be given birth to 1000 of arteries and veins lyophilized injectable powders.Injection is given birth to the arteries and veins lyophilized powder and is contained the summation of Radix Ginseng total saponins and Radix Ophiopogonis total saponins greater than 85%.
Other project should meet 2000 editions lyophilized injectable powder projects of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 4
Take by weighing the living arteries and veins dry powder 1kg of gained among the embodiment 1～3 arbitrarily, medical starch 500g, mix homogeneously is used an amount of alcohol granulation, through the pelletizing machine granulate, tabletting, every 0.25g, oral, each 1-2 sheet, twice of every day.Other project should meet 2000 editions tablet projects of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 5
Take by weighing the living arteries and veins dry powder 500g of gained among the embodiment 1～3 arbitrarily, medical starch 500g, mix homogeneously, the 0# capsule of packing into, every 0.30g, each oral 1-2, twice of every day.Other project should meet 2000 editions capsule projects of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 6
Take by weighing the living arteries and veins dry powder raw material 100g of gained among the embodiment 1～3 arbitrarily, starch 1000g, Icing Sugar 400g, mix homogeneously is used an amount of alcohol granulation, and drying, granulate, packing are promptly.Oral, a 5g, twice on the one.Other project should meet 2000 editions granule projects of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 7
Get the living arteries and veins dry powder raw material 1kg of gained among the embodiment 1～3, make drop pill by the drop pill routine fashion, every 0.2g.Other project should meet 2000 editions drop pill projects of Pharmacopoeia of People's Republic of China relevant requirements.
Claims (8)
1. the preparation method of the living arteries and veins lyophilized powder of injection is that raw material extracts with Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis, it is characterized in that comprising the steps:
(1) Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis merging mixing are pulverized and are coarse powder, and add 0% to 95% pure liquid and extract 1 time, or once;
(2) merge each time extracting solution, relative density is 0.9-1.30 when being concentrated into 30 ℃-80 ℃, gets concentrated solution;
(3) add alcohol in the concentrated solution, make that pure content reaches 10%-95% in the solution, place, filter, reclaim ethanol, filter, filtrate;
(4) with filtrate by macroporous adsorptive resins absorption I after, with 0%-40% alcohol eluting resin column, discard eluent, with 40%-100% concentration alcohol eluting, eluent;
(5) after eluent passes through resin column II, resin column III again, reclaim under reduced pressure alcohol, concentrated, dry, get dry powder;
(6) with above-mentioned gained dry powder, be dissolved in 0%-95% alcohol water, the medicinal carbon that adds 0.25%-2%, reflux 30 minutes to 2 hours, cooling room temperature, be filtered to clear and bright, transfer PH to 7-7.5, coarse filtration, fine straining with 1-10%NaOH solution, be sub-packed in cillin bottle, the injection lyophilized powder that makes through frozen drying.
2, preparation method according to claim 1 is characterized in that: the Radix Ginseng Rubra in the step (1), Radix Ophiopogonis, Fructus Schisandrae Chinensis are that pulverize separately is a coarse powder, add 0% to 95% pure liquid and extract 1 time, or once;
3, preparation method according to claim 1 is characterized in that: water boiling and extraction is used in the merging of Radix Panacis Quinquefolii and Fructus Schisandrae Chinensis in the step (1), and use water boiling and extraction Radix Ophiopogonis separately, and add 0% to 95% pure liquid and extract 1 time, or once;
4, according to claim 2,3 or 4 described preparation methoies, it is characterized in that: in the step (4), macroporous adsorbent resin comprises D21, AB-8, D101 model, and macroporous adsorptive resins continues with 40-100% alcohol eluting earlier with 0-40% alcohol eluting.
5. according to claim 2,3 or 4 described preparation methoies, it is characterized in that: in the step (5), resin column II is a cationic resin column; Resin column III is the resin anion (R.A.) post.
6, the product that makes of claim 1～5 method.
7, the living arteries and veins dry powder of claim 1～5 preparation method production can be made into drop pill, tablet, the watered pill, aerosol, capsule on the pharmaceutics.
8, the living arteries and veins dry powder of claim 1～5 preparation method production is mixed in proportion with one or more pharmaceutically acceptable carriers or excipient, makes the pharmaceutical composition that is applicable to the different dosage form that uses clinically.
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| CN100418512C (en) * | 2005-11-23 | 2008-09-17 | 浙江京新药业股份有限公司 | 'Shengmai' infusion and its preparation process |
| CN101879270A (en) * | 2009-05-07 | 2010-11-10 | 天津天士力之骄药业有限公司 | Chinese medicinal injectable powder and quality control method thereof |
| CN101745003B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
| CN101745006B (en) * | 2008-12-05 | 2013-03-13 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100418512C (en) * | 2005-11-23 | 2008-09-17 | 浙江京新药业股份有限公司 | 'Shengmai' infusion and its preparation process |
| CN101745003B (en) * | 2008-12-05 | 2012-09-19 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
| CN101745006B (en) * | 2008-12-05 | 2013-03-13 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
| CN101745007B (en) * | 2008-12-05 | 2013-04-10 | 天津天士力之骄药业有限公司 | Extraction method of 'radix ophiopogonis/ginseng and schisandra chinensis' and preparation thereof |
| CN101745005B (en) * | 2008-12-05 | 2013-07-10 | 天津天士力之骄药业有限公司 | Extraction method of ophiopogon root, ginseng and shiandra and preparation thereof |
| CN101744988B (en) * | 2008-12-05 | 2013-10-16 | 天津天士力之骄药业有限公司 | Method for extracting ginseng, dwarf lilyturf tuber and schisandra chinensis and preparation thereof |
| CN101879270A (en) * | 2009-05-07 | 2010-11-10 | 天津天士力之骄药业有限公司 | Chinese medicinal injectable powder and quality control method thereof |
| CN101879270B (en) * | 2009-05-07 | 2014-02-12 | 天津天士力之骄药业有限公司 | Traditional Chinese medicine injectable powder and quality control method thereof |
| CN115707482A (en) * | 2021-08-19 | 2023-02-21 | 常熟雷允上制药有限公司 | Method for refining pulse-activating injection |
| CN115707482B (en) * | 2021-08-19 | 2024-04-26 | 常熟雷允上制药有限公司 | Refining method of Shengmai injection |
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