CN111642508B - Application of corydaline substances as herbicide - Google Patents
Application of corydaline substances as herbicide Download PDFInfo
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- CN111642508B CN111642508B CN202010382978.4A CN202010382978A CN111642508B CN 111642508 B CN111642508 B CN 111642508B CN 202010382978 A CN202010382978 A CN 202010382978A CN 111642508 B CN111642508 B CN 111642508B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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- Pest Control & Pesticides (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The application is a divisional application with the application number of 201711158169.X, the application date of 2017, 11 and 20 months, and the invention name of the application is 'application of isoquinoline alkaloids in the aspect of serving as herbicides'. The invention discloses application of corydaline substances as herbicides. The research of the invention finds that the corydaline substance, in particular the corydalis oridonin or dehydrocorydaline, has obvious weeding effect on a plurality of common weeds such as arabidopsis thaliana, mikania micrantha, eleusine indica, digitaria sanguinalis, bidens pilosa, feather cockscomb, duckweed and the like, is safe to the environment, has low toxicity to people and livestock, can be prepared into a herbicide for use, is used for preventing and removing weeds in actual production, and is environment-friendly and safe. In addition, the development of the weeding effect of the substances can promote the comprehensive utilization of resource plants, and the development prospect is wide.
Description
The application is a divisional application with the application number of 201711158169.X, the application date of 2017, 11 and 20 months, and the invention name of the application is 'application of isoquinoline alkaloids in the aspect of serving as herbicides'.
Technical Field
The invention belongs to the technical field of pesticide research and development. More particularly, relates to the application of the corydaline substances as herbicides.
Background
Herbicides (herbicide) refer to agents that cause complete or selective death of weeds, and are a class of substances used to destroy or inhibit plant growth. At present, the herbicide variety with high efficiency, low toxicity and broad spectrum plays an increasingly important role in agricultural production.
Alkaloids are a class of basic organic compounds containing nitrogen that are found in nature (mainly in plants, but sometimes also in animals). A great deal of literature reports the medical and agricultural effects of alkaloid compounds, and the alkaloid compounds have various functions, have wide application in daily life and play great roles in medicine and agriculture.
Further research and development of alkaloid substances have wide application prospect and obvious social significance. The research and development comprises two aspects, namely, the new application of the alkaloid substances with determined structures is further developed, the new alkaloid substances are researched and discovered, the physiological functions of the alkaloid substances are clarified, and good products for social production and people life service are developed.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the defects and shortcomings of the prior art and provide a corydaline substance with herbicidal activity, in particular to corydaline or dehydrocorydaline; the alkaloids have good herbicidal activity for Arabidopsis thaliana, mikania micrantha, goosegrass, digitaria sanguinea, bidens pilosa, feather cockscomb, duckweed and the like, are safe to environment, have low toxicity to human and livestock, and can be prepared into herbicide for use.
The invention aims to provide application of corydaline substances as herbicides.
Another object of the present invention is to provide a herbicide.
The above purpose of the invention is realized by the following technical scheme:
application of corydaline substances in preparation of herbicide is provided.
The corydaline substance is corydalis yanhusuo A or dehydrocorydaline.
Preferably, in the application, the herbicide acts on common important weeds such as arabidopsis thaliana, mikania micrantha, eleusine indica, crabgrass, bidens pilosa, feather cockscomb, duckweed, barnyard grass, green bristlegrass, alopecurus, bluegrass, cyperus rotundus, ageratum, purslane, amaranthus retroflexus, amaranthus receptaculus and/or cardamine filiformis.
A herbicide containing the corydaline substances is also within the protection scope of the invention.
The corydaline substances are corydalis yanhusuo A and/or dehydrocorydaline.
Preferably, the herbicide is a herbicide for common important weeds such as arabidopsis thaliana, mikania micrantha, eleusine indica, crabgrass, bidens pilosa, feather cockscomb, lemna minor, barnyard grass, setaria viridis, alopecurus, poa pratensis, bermudagrass, cyperus rotundus, ageratum, purslane, amaranthus retroflexus, amaranthus pallidum and/or cardamine hirsutella.
The above summary and application are based on the following research results of the subject group of the present inventors: in the research process of the subject group, multiple tests show that various corydaline substances have remarkable weeding effect on various weeds (including various invasive weeds). The corydalis alkaloid substance comprises the corydalis A or dehydrocorydaline. Through tests, the substances have obvious herbicidal activity on arabidopsis thaliana (wild type), mikania micrantha, eleusine indica, digitaria sanguinea, bidens pilosa, feather cockscomb, duckweed, barnyard grass, setaria viridis, alopecurus, poa pratensis, cynodon dactylon, cyperus rotundus, ageratum, purslane, amaranthus retroflexus, amaranthus and/or cardamine hirsutella.
The invention has the following beneficial effects:
the invention discloses a novel application of violaceine substances as a herbicide, the substances can obviously inhibit root growth or plant growth of weeds such as arabidopsis thaliana, mikania micrantha, goosegrass herb, digitaria sanguinea, bidens pilosa, feather cockscomb, barnyard grass, setaria viridis, alopecurus, poa pratensis, bermudagrass, cyperus rotundus, ageratum, purslane, amaranthus retroflexus, amaranthus pallidus and/or cardamine hirsutum, and the weeding effect is obvious.
In addition, the substances have wide sources, easily obtained raw materials and natural sources, have smooth degradation ways in the nature, and have no pollution, no residue and no environmental pollution.
In addition, most of the corydaline substances have certain insecticidal and antibacterial effects, and have control effects on crop pests and diseases while preventing and removing weeds, so that the effect of one medicine for multiple purposes is achieved.
Fourthly, the research and development of the weeding effect of the substances can promote the comprehensive development and utilization of plant resources containing the substances.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated. Unless otherwise indicated, reagents and materials used in the following examples are commercially available.
The following examples illustrate the herbicidal efficacy of several common weeds, and the data only show that the efficacy is significant.
Example 1 herbicidal Activity test for Mikania micrantha
1. Respectively preparing mother liquor with a certain concentration from nearly forty isoquinoline alkaloid substances, and then diluting the mother liquor to a concentration of 10mg/L by using Hoagland culture solution.
2. The herbicidal activity of the substances on mikania micrantha is measured by a small cup method by taking berberine as a reference, and the growth condition of plants is investigated after 7 days of growth.
3. The results show that 11 isoquinoline alkaloids shown in table 1, namely, methyl coptisine, berberine hydrochloride, tetrahydroberberine, dehydrocorydaline, dextrotetrahydropalmatine, corydalis saxatiline, rotundine, tetrahydrocoptisine, dihydroberberine, palmatine and corydaline all show good inhibition effects on mikania micrantha, and the root length inhibition rate of the mikania micrantha at a concentration of 10mg/L is more than 65%, and the fresh weight inhibition rate of the mikania micrantha is more than 70%.
Wherein, the root length inhibition rate and the fresh weight inhibition rate of the berberine hydrochloride, the methylpachyraline, the dehydrocorydaline and the tetrahydroberberine to mikania micrantha are all over 80 percent.
TABLE 1 inhibition of mikania micrantha
Note: the measured concentration of all the agents was 10 mg/L; the same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
Example 2 herbicidal Activity test on Bidens pilosa
1. The test method and the setting are the same as example 1, the test object is changed to bidens pilosa, the weeding activity of the substances on bidens pilosa is measured by a small cup method, and the plant growth condition is investigated after 7 days of growth.
2. The results show that the roots of the bidens pilosa seeds can not grow normally, and some roots are rotten; the 7 isoquinoline alkaloids shown in table 2, namely coptisine hydrochloride, tetrahydrocoptisine, dehydrocorydaline, palmatine, tetrahydroberberine, epiberberine and coptisine, show good herbicidal activity on bidens pilosa.
Wherein, the root length inhibition rate of the coptisine hydrochloride, the tetrahydrocoptisine and the dehydrocorydaline on the bidens pilosa is over 80 percent; the tetrahydrocoptisine and coptisine show good fresh weight inhibition activity on bidens pilosa, and the activity of the tetrahydrocoptisine and coptisine is obviously superior to that of berberine.
TABLE 2 inhibition of Bidens pilosa
Note: the measured concentration of all the agents was 10 mg/L; the same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
Example 3 herbicidal Activity test on Eleusine indica
1. The test method and the setting are the same as those of example 1, the test object is changed into goosegrass herb, the weeding activity of the goosegrass herb on the goosegrass herb is measured by a small cup method, and the plant growth condition is investigated after 7 days of growth.
2. The results show that 18 isoquinoline alkaloids shown in table 3, namely epiberberine, tetrahydrocoptisine, dehydrocorydaline, berberine hydrochloride, palmatine, tetrahydropalmatine, rotundine, berrubine, coptisine, dihydroberberine, allocryptopine, corydaline, methylpseptinine and african tetrandrine, have significant inhibition rate of the root length of the goosegrass herb, which exceeds 70%, mostly exceeds 80%, even exceeds 90%.
TABLE 3 inhibitory Effect on Eleusine indica
Note: the measured concentration of all agents was 10 mg/L. The same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
Example 4 herbicidal Activity test on crab grass
1. The test method and the setting are the same as those of example 1, the test object is changed to crabgrass, the weeding activity of the substances on the crabgrass is measured by a small cup method, and the plant growth condition is investigated 7 days after the growth.
2. The results show that 15 isoquinoline alkaloids shown in table 4, namely coptisine, methyl coptisine, dextro-tetrahydropalmatine, corydalis yanhusuo, coptisine hydrochloride, palmatine, epiberberine, corydalis amantadine, dehydrocorydaline, dihydroberberine, african tetrandrine, rotundine, sanguinarine hydrochloride, tetrahydroberberine and berrubine show root length inhibition and fresh weight inhibition effects on both digitaria sanguinalis, and the root length inhibition rate is over 50% and most of the compounds are over 80% under the treatment of a concentration of 10mg/L, which indicates that the root growth of monocotyledonous weeds digitaria sanguinalis can be inhibited. The totality shows that the substances have very remarkable control potential on the large crabgrass.
TABLE 4 inhibitory Effect on crab and Tang
Note: the measured concentration of all the agents was 10 mg/L; the same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
Example 5 herbicidal Activity test for feather cockscomb
1. The test method and the setting are the same as those of example 1, the test object is changed into feather cockscomb, the weeding activity of the substances on feather cockscomb is measured by adopting a small cup method, and the plant growth condition is investigated after 7 days of growth.
2. The results show that 11 isoquinoline alkaloids shown in table 5, namely demethyleneberberine, berberine hydrochloride, berberine oxide, sanguinarine hydrochloride, epiberberine, dihydroberberine, coptisine, palmatine, berrubine, dehydrocorydaline and corydalis saxicola bunting, all show root length inhibition and fresh weight inhibition on feather cockscomb, and the root length inhibition rate exceeds 50% under the treatment of 10mg/L concentration, wherein the inhibition rates of demethyleneberberine and coptisine hydrochloride are up to more than 90%, and excellent root growth inhibition is shown.
Wherein, the demethylene berberine, the berberine hydrochloride, the berberine oxide, the coptisine and the like have obvious inhibition on the fresh weight of the feather cockscomb, which shows that the feather cockscomb has inhibition effect on the growth of the feather cockscomb.
TABLE 5 inhibition of feather cockscomb
Note: the measured concentration of all the agents was 10 mg/L; the same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
Example 6 herbicidal Activity test for Arabidopsis thaliana
1. The test method and the setting are the same as those of example 1, the test object is changed into arabidopsis thaliana, the herbicidal activity of the substances on arabidopsis thaliana is measured by a small cup method, and the growth condition of plants is investigated after 7 days of growth.
2. The results show that 3 isoquinoline alkaloids shown in table 6, namely berberine hydrochloride, methyl berberine and dihydroberberine, have a significant inhibitory effect on arabidopsis thaliana, and arabidopsis thaliana grows very slowly, roots cannot grow normally, the root length inhibition rate exceeds 80%, and the arabidopsis thaliana shows good herbicidal activity.
TABLE 6 inhibitory Effect on Arabidopsis thaliana
Note: the measured concentration of all the agents was 10 mg/L; the same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
Example 7 herbicidal Activity test on Duckweed
1. The test method and the setting were the same as in example 1, the test object was changed to duckweed, the herbicidal activity of these substances on duckweed was measured by the hydroponic method, and the chlorophyll content was investigated after 7 days of growth.
2. The results show that 8 isoquinoline alkaloids shown in table 7, namely coptisine hydrochloride, methylpachyranine, dehydrocorydaline, dihydroberberine, coptisine, corydalis saxicola bunting, sanguinarine hydrochloride and sanguinarine, have obvious inhibition effects on synthesis of chlorophyll a, chlorophyll b and chlorophyll of duckweed, and indicate that the isoquinoline alkaloids can inhibit growth of aquatic weed duckweed.
Except for the corydalis saxicola bunting alkali, the inhibition rate of other substances on the duckweed chlorophyll is over 70%, most of the inhibition rate is over 80% or even over 90%, and the tested duckweed shows symptoms of withered and yellow, wilting and the like, so that the compounds have good effect of inhibiting the growth of the duckweed.
TABLE 7 inhibitory Effect on Duckweed
Note: the measured concentration of all the agents was 10 mg/L; the same column numbers followed by lower case letters in the table indicate no significant difference at the 0.05 level.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (1)
1. The application of the corydaline substances in the aspect of serving as or preparing herbicides is characterized in that the corydaline substances are corydalis A or dehydrocorydaline;
when the corydaline substance is dehydrocorydaline, the acting objects of the herbicide are mikania micrantha, bidens pilosa, eleusine indica, digitaria sanguinalis and feather cockscomb;
when the corydaline substance is corydaline, the herbicide can be Mikania micrantha, Eleusine indica and crab grass.
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| CN201711158169.XA CN107950546B (en) | 2017-11-20 | 2017-11-20 | Application of isoquinoline alkaloids as herbicide |
| CN202010382978.4A CN111642508B (en) | 2017-11-20 | 2017-11-20 | Application of corydaline substances as herbicide |
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| CN202010390208.4A Active CN111493080B (en) | 2017-11-20 | 2017-11-20 | Application of berberine compounds as herbicide |
| CN202010389612.XA Active CN111480654B (en) | 2017-11-20 | 2017-11-20 | Application of coptisine substances as herbicide |
| CN202010383789.9A Active CN111557303B (en) | 2017-11-20 | 2017-11-20 | Use of allocryptopine as herbicide |
| CN202010382978.4A Active CN111642508B (en) | 2017-11-20 | 2017-11-20 | Application of corydaline substances as herbicide |
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| CN202010389612.XA Active CN111480654B (en) | 2017-11-20 | 2017-11-20 | Application of coptisine substances as herbicide |
| CN202010383789.9A Active CN111557303B (en) | 2017-11-20 | 2017-11-20 | Use of allocryptopine as herbicide |
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| CN110787162B (en) * | 2019-12-09 | 2022-05-03 | 朱峰 | Use of methylprednisolone coptisine as JNK2 kinase inhibitor and for treating psoriasis |
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| CN111557303A (en) | 2020-08-21 |
| CN111642508A (en) | 2020-09-11 |
| CN111557303B (en) | 2021-02-19 |
| CN111493080B (en) | 2021-07-09 |
| CN107950546B (en) | 2021-01-26 |
| CN111480654A (en) | 2020-08-04 |
| CN107950546A (en) | 2018-04-24 |
| CN111480654B (en) | 2021-06-15 |
| CN111493080A (en) | 2020-08-07 |
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