CN1839807A - Solution for disinfection and feet-protection - Google Patents
Solution for disinfection and feet-protection Download PDFInfo
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- CN1839807A CN1839807A CN 200610045765 CN200610045765A CN1839807A CN 1839807 A CN1839807 A CN 1839807A CN 200610045765 CN200610045765 CN 200610045765 CN 200610045765 A CN200610045765 A CN 200610045765A CN 1839807 A CN1839807 A CN 1839807A
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Abstract
Disclosed is a sterilizing food care liquid for treating skin diseases caused by fungus and various bacteria, wherein the percentage by weight of the ingredients include, DP300 0.2-0.5%, alcohol 15-25%, methyl glycol 55-70%, glycerin 2.5-4%, gourmet powder 0.5-1.5%, and distilled water 10-20%. The invention also discloses the process for its preparation.
Description
Technical field: the invention relates to a kind of medicinal liquid, in particular for treating by the sufficient liquid of protecting of fungus and various bacterial dermopathic sterilizations.
Background technology: " fungus " this fearful name, may become most of people and know because the various dermatosiss that cause by its deep already poisoning all kinds of crowds, the result that it brings not only be that " sufferings " two words just can describe.It not only brings not to the utmost worry to me, also can infect to around the crowd, allow everybody is in distress to share, consequence is well imagined.Therefore killing fungus has been instant major issue.At present, treatment dermopathic medicines such as " funguses " is more on the market, but DeGrain mostly.
Summary of the invention: the purpose of the invention provides a kind of treatment is had significant curative effect by antibacterial and fungus-caused dermatosis solution for disinfection and feet-protection; The purpose of the invention is achieved through the following technical solutions:
Solution for disinfection and feet-protection: its prescription and percentage by weight are:
Triclosan 0.2～0.5%;
Ethanol 15～25%;
Propylene glycol 55～70%;
Glycerol 2.5～4%;
Essence 0.5～1.5%;
Distilled water 10～20%.
Its processing technology is: triclosan is dissolved in the ethanol, with propylene glycol and glycerol mixing and stirring, two kinds of mixed liquors are dissolved in the distilled water again, stir, add essence again, stir.
Its technology preparation principle is; this utility model is to be main component with the triclosan aqueous solution; it is formulated to add Derma-Guard and essence etc. again; triclosan; powder with aroma type white is soluble in multiple organic solvent, and strong acid and strong base and heat are had high stability, are not infected with skin and product; kill widely and inhibitory action causing that infection or pathogenicity Gram-positive and negative bacterium, fungus, yeast and virus etc. all have, to the skin nonirritant.Ethanol, water white transparency, flammable liquid is made solvent in this agent.1, the 2-propylene glycol, colourless viscous liquid, little have acid, and easily the moisture absorption is under normal circumstances stable, but easily generates propionic aldehyde, lactic acid, acetone acid and acetic acid when high temperature, can mix with water, acetone and chloroform, can be dissolved in ether, is used as antibacterial in this product.Glycerol is commonly called as glycerol, is the pleasantly sweet thick liquid of no color or smell, can be miscible with water, also can be dissolved in organic solvents such as ether, chloroform, have strong hygroscopicity, in this product be solvent be again lubricant.Essence as additive, is used to change this agent fragrance, and kind is selected as required.Vertically shake up earlier before using, take off bottle cap then, can send out product forth by opening part.
The advantage of the invention is: owing to adopt the triclosan aqueous solution as main component, it is formulated to add Derma-Guard and essence etc. again, wherein triclosan is killed and inhibitory action widely to causing that infection or pathogenicity Gram-positive and negative bacterium, fungus, yeast and virus etc. all have, therefore to dermatosis on fungus and the various germ foot, as beriberi, curing tinea pedis obvious effects is arranged, is 93.43% as originally protecting sufficient liquid to the average bacteriostasis rate of staphylococcus aureus, is 91.43% to the oidiomycetic average bacteriostasis rate of white; Can prevent that with originally protecting sufficient vacuole foot split foot, foot freeze; This product is applied to the foot affected part in right amount can be antipruritic rapidly, eliminates pustule and have the effect that prevents courses of infection; This product evenly is sprayed on suppresses skin superficial fungi on the shoe pad and grow, and can eliminate sweaty foot and foot odor.
The specific embodiment: solution for disinfection and feet-protection: its prescription and percentage by weight are:
Triclosan 0.2～0.5%;
Ethanol 15～25%;
Propylene glycol 55～70%;
Glycerol 2.5～4%;
Essence 0.5～1.5%;
Distilled water 10～20%
Its Recipe is: produced preceding 20 minutes, the preparation workshop will be carried out once comprehensively with the ultraviolet sterilizer sterilization, and the workman puts on aseptic clothes and enters sterile workshop and prepare afterwards, and used distilled water is through behind the sedimentation and filtration, after the sterilization of far infrared sterilization machine, can use.
Its concrete example of making: 100 kilograms are protected sufficient liquid finished product is example:
1,0.4 kilogram of triclosan is dissolved in 19 kilograms of the ethanol and stir evenly, 60.6 kilograms of propylene glycol are mixed stirring evenly with glycerol for 3 kilograms, again two kinds of mixed liquors are dissolved in 16 kilograms of the distilled water and stir, add 1 kilogram in essence at last, stir promptly.
2, pure as jade clear 0.2 kilogram is dissolved in 15 kilograms of the ethanol and stirs evenly, 60 kilograms of propylene glycol are mixed stirring evenly with glycerol for 4 kilograms, again two kinds of mixed liquors are dissolved in 19.5 kilograms of the distilled water and stir, add 1.5 kilograms in essence at last, stir promptly.
3, pure as jade clear 0.5 kilogram is dissolved in 16.5 kilograms of the ethanol and stirs evenly, 70 kilograms of propylene glycol are mixed stirring evenly with glycerol for 2.5 kilograms, again two kinds of mixed liquors are dissolved in 10 kilograms of the distilled water and stir, add 0.5 kilogram in essence at last, stir promptly.
4, pure as jade clear 0.5 kilogram is dissolved in 20 kilograms of the ethanol and stirs evenly, 65 kilograms of propylene glycol are mixed stirring evenly with glycerol for 3 kilograms, again two kinds of mixed liquors are dissolved in 10 kilograms of the distilled water and stir, add 1.5 kilograms in essence at last, stir promptly.
5, pure as jade clear 0.3 kilogram is dissolved in 25 kilograms of the ethanol and stirs evenly, 55 kilograms of propylene glycol are mixed stirring evenly with glycerol for 3.5 kilograms, again two kinds of mixed liquors are dissolved in 15 kilograms of the distilled water and stir, add 1 kilogram in essence at last, stir promptly.
6, pure as jade clear 0.5 kilogram is dissolved in 20 kilograms of the ethanol and stirs evenly, 55 kilograms of propylene glycol are mixed stirring evenly with glycerol for 4 kilograms, again two kinds of mixed liquors are dissolved in 20 kilograms of the distilled water and stir, add 0.5 kilogram in essence at last, stir promptly.
The resulting solution for disinfection and feet-protection of above-mentioned example, to treating by antibacterial and fungus-caused dermatosis, has significant curative effect, especially be 93.43% to staphylococcus aureus bacteriostasis rate average rate, to the oidiomycetic average bacteriostasis rate of white is 91.43%, protect to prevent split foot, Pig's feets in aspic with this product, antipruritic etc.
This product operation instruction: add 20 times warm water dilution back foot bath 20 minutes by the weight of protecting sufficient liquid.
Provide examining report below:
Solution for disinfection and feet-protection stability is measured (bacteriostasis property):
1, test strain title, bacterial strain number, the unit of providing and cultivate algebraically: staphylococcus aureus (Staphylococcusaureus) AS 1.2465; ATCC; The 6th～7 generation of=ATCC 6538 (China Committee for Culture Collection of Microorganisms common micro-organisms center).
2, prescription: 0.4 kilogram of triclosan, 19 kilograms of ethanol, 60.6 kilograms of propylene glycol, 3 kilograms of glycerol, 16 kilograms of distilled water, 1 kilogram in essence.
3, detect foundation:
State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002;
2.1.11.3.4 (1) .2 of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002)) and 2.1.1.2.3 (1).
4, preservation condition:
The test method accelerated test
Package encapsulation situation Packing Sound
Preserve 54 ℃ ± 1 ℃ of ambient temperature
Preserve envionmental humidity 75% ± 5%
14 days standing times
5, the temperature of testing environment and relative humidity:
19 ℃ ± 2 ℃ of testing environment room temperatures
Testing environment relative humidity 45% ± 5%
6, bacteriostatic test:
Test specimen stock solution
20 ℃ ± 1 ℃ of test temperature
Test repeats 3 times
7, test
Test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Deposit back (accelerated test: 54 ℃ ± 1 ℃ of laying temperature, relative humidity 75% ± 5%, 14 days standing times), solution for disinfection and feet-protection effective ingredient, concentration are stock solution, be 10min action time, is 91.86% to the average bacteriostasis rate of staphylococcus aureus.
The fungistatic effect of contrast test before and after preserving
| Deposit situation | The test sequence number | The average bacteriostasis rate (%) of effect different time (min) | The average clump count of positive controls (cfu/ml) | |||
| 2 | 5 | 10 | 20 | |||
| Before depositing | 1 | 83.34 | 88.91 | 93.11 | 95.69 | 4.80×10 4 |
| 2 | 84.15 | 86.77 | 94.90 | 97.34 | 5.90×10 4 | |
| 3 | 82.68 | 87.70 | 92.64 | 96.52 | 4.10×10 4 | |
| Meansigma methods | 83.40 | 87.66 | 93.43 | 96.42 | 4.60×10 4 | |
| After depositing | 1 | 80.64 | 84.94 | 91.10 | 96.62 | 4.80×10 4 |
| 2 | 82.42 | 85.75 | 91.45 | 94.93 | 3.80×10 4 | |
| 3 | 81.05 | 86.23 | 93.53 | 95.05 | 5.60×10 4 | |
| Meansigma methods | 81.34 | 85.62 | 91.86 | 95.45 | 4.70×10 4 | |
8, conclusion
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Deposit back (accelerated test: 54 ℃ ± 1 ℃ of laying temperature, relative humidity 75% ± 5%, 14 days standing times), solution for disinfection and feet-protection effective ingredient, concentration are stock solution, be 10min action time, is 91.86% to the average bacteriostasis rate of staphylococcus aureus.Has strong bacteriostasis.
Solution for disinfection and feet-protection is to the staphylococcus aureus bacteriostatic test:
1, test strain title, bacterial strain number, the unit of providing and cultivate algebraically: staphylococcus aureus (Staphylococcusaureus) AS 1.2465; ATCC; The 5th～6 generation of=ATCC 6538 (China Committee for Culture Collection of Microorganisms common micro-organisms center).
2, prescription: 0.4 kilogram of triclosan, 19 kilograms of ethanol, 60.6 kilograms of propylene glycol, 3 kilograms of glycerol, 16 kilograms of distilled water, 1 kilogram in essence.
3, detect foundation:
State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002;
The 2.1.1.2.3 (1) of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002).
4, testing conditions:
20 ℃ ± 1 ℃ of test temperature
5, test
Test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Sterilization is antipruritic to protect sufficient liquid effective ingredient, concentration is stock solution, and be 10min action time, is 92.84% to the average bacteriostasis rate of staphylococcus aureus.
| The test sequence number | The average bacteriostasis rate (%) of effect different time (min) | The average clump count of positive controls (cfu/ml) | |||
| 2 | 5 | 10 | 20 | ||
| 1 | 82.15 | 88.94 | 92.10 | 94.63 | 3.80×10 4 |
| 2 | 83.61 | 86.77 | 94.93 | 97.03 | 5.90×10 4 |
| 3 | 82.38 | 88.31 | 92.85 | 96.58 | 4.60×10 4 |
| Meansigma methods | 82.38 | 88.31 | 92.84 | 96.58 | 4.10×10 4 |
6, conclusion
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Solution for disinfection and feet-protection effective ingredient, concentration are stock solution, and be 10min action time, are 92.84% to the average bacteriostasis rate of staphylococcus aureus.Has strong bacteriostasis.
Solution for disinfection and feet-protection is to the Candida albicans bacteriostatic test:
1, test strain title, bacterial strain number, the unit of providing and cultivate the 6th～7 generation of algebraically: Candida albicans (Candidaalbicans) ATCC 10231 (China Committee for Culture Collection of Microorganisms common micro-organisms center).
2, prescription: 0.4 kilogram of triclosan, 19 kilograms of ethanol, 60.6 kilograms of propylene glycol, 3 kilograms of glycerol, 16 kilograms of distilled water, 1 kilogram in essence.
3, detect foundation:
State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002:
The 2.1.1.9.3 (1) of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002).
4, testing conditions:
20 ℃ ± 1 ℃ of test temperature
5, test
Test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Solution for disinfection and feet-protection effective ingredient, concentration are stock solution, and be 10min action time, are 91.43% to the oidiomycetic average bacteriostasis rate of white.
| The test sequence number | The average bacteriostasis rate (%) of effect different time (min) | The average clump count of positive controls (cfu/ml) | |||
| 2 | 5 | 10 | 20 | ||
| 1 | 74.63 | 82.16 | 92.54 | 95.24 | 5.40×10 4 |
| 2 | 78.53 | 82.54 | 91.55 | 96.10 | 6.10×10 4 |
| 3 | 76.45 | 84.95 | 90.28 | 97.56 | 4.90×10 4 |
| Meansigma methods | 76.56 | 83.34 | 91.43 | 96.13 | 5.20×10 4 |
8, conclusion
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Solution for disinfection and feet-protection effective ingredient, concentration are stock solution, and be 10min action time, are 91.43% to the oidiomycetic average bacteriostasis rate of white.Has strong bacteriostasis.
Claims (1)
1, solution for disinfection and feet-protection: it is characterized in that: solution for disinfection and feet-protection prescription and percentage by weight are:
Triclosan 0.2～0.5%;
Ethanol 15～25%;
Propylene glycol 55～70%;
Glycerol 2.5～4%;
Essence 0.5～1.5%;
Distilled water 10～20%,
Its processing technology is: triclosan is dissolved in the ethanol, with propylene glycol and glycerol mixing and stirring, two kinds of mixed liquors are dissolved in the distilled water again, stir, add essence again, stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610045765 CN1839807A (en) | 2006-01-26 | 2006-01-26 | Solution for disinfection and feet-protection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610045765 CN1839807A (en) | 2006-01-26 | 2006-01-26 | Solution for disinfection and feet-protection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1839807A true CN1839807A (en) | 2006-10-04 |
Family
ID=37029114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610045765 Pending CN1839807A (en) | 2006-01-26 | 2006-01-26 | Solution for disinfection and feet-protection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1839807A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655259A (en) * | 2013-11-14 | 2014-03-26 | 青岛安信医疗器械有限公司 | Foot care solution |
-
2006
- 2006-01-26 CN CN 200610045765 patent/CN1839807A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655259A (en) * | 2013-11-14 | 2014-03-26 | 青岛安信医疗器械有限公司 | Foot care solution |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |