CN1836514A - Novel disinfection and slow-release composition containing BCDMH and its preparation method - Google Patents
Novel disinfection and slow-release composition containing BCDMH and its preparation method Download PDFInfo
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Abstract
The new type of slow released bromochloro disinfectant composition has dibromo Hydantoin or bromochloro Hydantoin as main component and polymer and forming agent as supplementary material and is prepared through conventional preparation process. It has the features of excellent control capacity of bactericidal factor release, long term stability, high bactericidal efficiency, broad bactericidal spectrum, high safety and environment friendship. It may be used in sterilizing and killing algae of water treating works, swimming pool, medical sewage treatment, fish pond, etc.
Description
Technical field
The present invention relates to a kind of novel disinfection and slow-release composition containing BCDMH and preparation method thereof.It relates to the quantification design of chlorine bromine sterilization slowly-releasing prescription, and the manufacturing processing method of tablet, granule and other solid slow-release product.
Background technology
Solid chloramines class antiseptic sterilization agent uses existing long history, it has the characteristics of broad-spectrum high efficacy, main employing chloramines compounds and organic decomposition agent reaction, dissolving forms and contains the hypochlorous high-effective disinfecting aqueous solution fast, the just present widely used chloride effervesce class disinfectant of this series products, has more use in medical industry, mainly be used in disinfecting of operating theater instruments etc., have certain scope of application and space, but exist application cost too high, in some other professional domain such as waste water treatment, running water is handled, there is the not too suitable problem of use simultaneously in aspects such as swimming sterilizing, the sterilization of these professional domains mostly needs the slowly disinfectant of release, accomplish that a medicine input reaches more permanent Disinfection Effect, has the saving labour, reduce the drug use amount, the characteristics that use cost is relatively low.Disinfectant research and development direction in recent years just develops towards low toxicity, direction efficient, easy to use, also more excellent bactericidal activity and stability have been shown with bromo for chlorine, bromine chlorine with the type product, can produce good synergy when bromine chlorine share, produce higher bactericidal activity; Hypochlorous in addition volatility is lower, only is hypochlorous 1/2, and the long retention time can be arranged, as the BCDMH compound, and chemical name: 3-bromo-1-chloro-5,5-dimethyl hydantoin.It can dissolve and then be decomposed to form hypochlorous acid and hypobromous acid sterilization factors in water in water, they are easier to the cellular plasm reaction bonded with microbial body, and then and protein molecule in nitrogen form nitrogen-bromine and nitrogen-chlorine chemistry key, thereby interference metabolic processes, finally cause microbial death, reach the purpose of sterilization.Another aspect, the toxicity of the compound of chlorine is stronger, and the biodegradation period in blood is long, and the toxicity of bromine compounds is relatively low, and the natural degradation speed in blood of human body is fast than chlorine, and toxicity is lower, more meets the requirement of contemporary safety and environmental protection.In addition the oxidisability of bromine a little less than, low to corrosion of metal than chlorine, be more suitable for using in the sterilization of instruments field.But present slow-release disinfection product both domestic and external mainly is composition with the TCCA (Trichloroisocyanuric acid), or be principal component with the BCDMH, add auxiliary material, the solid product of making by specific press device, find that in the control survey of use there are very big problem in this series products slowly-releasing and sustained release effect, mainly show the lability of release profiles, be subjected to the influence of external environment excessive, do not accomplish sustained release, thereby illustrate that stability of formulation also has problems, final formation in actual use is difficult to grasp input medication amount and hard case of blanking time.
Summary of the invention
Main purpose of the present invention provides a kind of compound BCDMH sustained-release tablet, has better bactericidal activity, composition selects for use BCDMH, C5H6Br2N2O2 and chlorinated isocyanuric acid to mix according to certain ratio, design by bromine compounds, chlorine compound and interact and balance, produce higher synergistic action effect, thereby produce bactericidal activity efficient, wide spectrum.
Another main purpose of the present invention provides a kind of stable, slow tablet of sustained release disinfection factor.Outside the main proportion of composing by the various main ingredient compositions of scientific and reasonable control, also to design auxiliary material and other additive of keeping the tablet ingredient stability, make tablet in water, can stablize, discharge reliably sterilization factors, can get rid of the influence of organic matter, alkaline matter and temperature etc. in the water in certain scope.
The main composition of the present composition (W/W) by mass percentage is as follows:
C5H6Br2N2O2 20%-85%
BCDMH 1%-15%
TCCA (Trichloroisocyanuric acid) 1%-10%
Silicate 0.1%-6%
Hydroxypropyl first 0.1%-5%
Rilanit special 0.1%-8%
Stearic acic derivative 0.5%-9%
Stearate 0.2%-8%
Sulphate 0.1%-6%
Carbonate 0.1%-2%
Alkyl sulfate 0.05%-6%
Ethylenediamine tetra-acetic acid 0.01%-2%
Polyvinyl alcohol 0.01%-6%
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH, contain a kind of C5H6Br2N2O2 compound, its quality percentage composition is 20%-75%, optimized amount is 40%-75%, mainly plays the effect of the brominated sterilization factors of slow release, because C5H6Br2N2O2 can be slightly soluble in water slowly in water, and in water, be decomposed into hypobromous acid, because the oxidisability of hypobromous acid is relatively poor than hypochlorous acid, the stability in water is better again, and it is stronger to resist organic ability.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH, contain a kind of BCDMH compound, its quality percentage composition is 1%-15%, optimized amount is 2%-10%, the BCDMH compound is a kind of important disinfecting drug composition that can slowly discharge hypochlorous acid and hypobromous acid in water, decompose the compound that comes out and in water, just continue again to interact, produced new bromo-chlorine compound, have stronger bactericidal activity.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of chlorinated isocyanuric acid compound, and its quality percentage composition is 0.1%-6%, and optimized amount is 0.5%-5%; Chlorinated isocyanuric acid can be monochlor(in)ate isocyanuric acid, dichloride isocyanuric acid, tri-chlorination isocyanuric acid, dichloride isocyanuric acid sodium etc., is preferably the tri-chlorination isocyanuric acid.Chlorinated isocyanuric acid is a kind of compound that is slightly soluble in water, is decomposed into hypochlorous acid behind the molten water and urea acid has produced bactericidal activity efficiently.By composite other synergist and stabilizing agent, make it can reach stable releasing effect.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of silicate compound, and its quality percentage composition is 1%-15%, and optimized amount is 2%-10%; Can select its calcium salt, magnesium salts, sodium salt, zinc salt, be preferably sodium salt, easily dissolving is apparent alkaline in water for silicate, and alkaline matter is as medicine dissolution promoter.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of hydroxypropyl methylcellulose derivative compound, and its quality percentage composition is 0.1%-5%, and optimized amount is 0.3%-3%; It is odorless white powder or particulate powder, and is fine and smooth loose, and good adhesion is arranged, and certain moisture is arranged, and is evenly distributed and not easily separated after particle mixes, and lubrication is good, unilateral smooth and beautiful appearance.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of rilanit special, and its quality percentage composition is 0.1%-8%, and optimized amount is 0.2%-4%; It can postpone the dispose procedure of water soluble drug as erodible framework material; Be used in combination with the stearic acid compound, the passing hole channel diffusion is separated control drug release with erosion.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of stearic acic derivative compound, and its quality percentage composition is 0.5%-9%, and optimized amount is 0.6%-6%; Can select to contain the stearic acid compound that carbon number is C8%-C22, be preferably the stearic acid compound of C10%-C20.It is odorless white powder or chip solid, and good adhesion is arranged, and is a kind of hydrophobic material, can with disinfection composition and the organic combination of auxiliary material, produce good controlled-release effect.
A kind of as mentioned above novel chlorine bromine sterilization slow releasing composition contains a kind of stearate compound, and its quality percentage composition is 0.2%-8%, and optimized amount is 0.5%-6%; Can select its sodium salt, sylvite, magnesium salts, calcium salt etc., be preferably sodium salt, it is white powder or chip solid, can be used as the auxiliary element of sustained release preparation.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of sulphate cpd, and its quality percentage composition is 0.1%-6%, and optimized amount is 0.5%-4%; Can select its sylvite, sodium salt, magnesium salts, calcium salt, zinc salt etc., be preferably calcium salt, it is white powder or crystalline solids, can be used as the moulding auxiliary element of sustained-release tablet.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of carbonate compound, and its quality percentage composition is 0.1%-2%, and optimized amount is 0.5%-4%; Can select its sylvite, sodium salt, magnesium salts, calcium salt, zinc salt etc., be preferably calcium salt, it is white powder or crystal, can be used as the sustained release and the moulding auxiliary element of sustained-release tablet.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of alkylsurfuric acid salt compound, and its quality percentage composition is 0.05%-6%, and optimized amount is 0.1%-4%; Can select its sylvite, sodium salt, magnesium salts, calcium salt, zinc salt etc., be preferably sodium salt, but it be the white hygroscopic powder, can be used as the stripping and the moulding auxiliary element of the sustained release of sustained-release tablet.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains the ethylenediamine tetra-acetic acid compound, and its quality percentage composition is 0.01%-5%, and optimized amount is 0.1%-3%; Can select its sylvite, sodium salt, magnesium salts, calcium salt, zinc salt etc., be preferably sodium salt, it is white powder or crystalline solid, can be used as the stable elements and the moulding auxiliary element of the sustained release of sustained-release tablet.
A kind of as mentioned above novel disinfection and slow-release composition containing BCDMH contains a kind of polyvinyl alcohol compound, and its quality percentage composition is 0.01%-6%, and optimized amount is 0.1%-4%; It is white or faint yellow particulate matter, has good chemical stability and insulating properties, film forming.Typical chemical property with polyalcohol can be carried out reactions such as esterification, etherificate and acetal.Water-soluble: the bin stability of polyvinyl alcohol water solution, the long-time preservation of polyvinyl alcohol water solution plays chemical change hardly.At ambient temperature, viscosity can raise gradually with the prolongation of standing time; Be transformed into gel at low temperatures, can become solution again after the heated and stirred.Cohesiveness: polyvinyl alcohol water solution and hydrophilic fibers have good cohesive force, and adhesion strength raises with the increase of the alcoholysis degree and the degree of polymerization.Surface chemistry character: polyvinyl alcohol has surface-active, can reduce the surface tension of water.Solvent resistance: polyvinyl alcohol can be dissolved in the polar solvent of hydroxyl, but easily is transformed into gel, generally is insoluble to non-polar organic solutions, also is insoluble to inorganic acid, and water is its best solvent.Can be used as the stable elements and the moulding auxiliary element of the sustained release of sustained-release tablet.
Embodiment
Embodiment 1:
C5H6Br2N2O2 20%-85%
BCDMH 1%-15%
DCCA 1%-10%
Magnesium silicate 0.1%-6%
Hydroxypropyl methylcellulose 0.1%-5%
Rilanit special 0.1%-8%
Stearic acid 0.5%-9%
Dolomol 0.2%-8%
Sodium sulphate 0.1%-6%
Calcium carbonate 0.1%-2%
Sodium tetradecyl sulfate 0.05%-6%
Disodium ethylene diamine tetraacetate 0.01%-2%
Polyvinyl alcohol 0.01%-6%
Embodiment 2:
C5H6Br2N2O2 20%-85%
BCDMH 1%-15%
TCCA (Trichloroisocyanuric acid) 1%-10%
Calcium silicates 0.1%-6%
Hydroxypropyl methylcellulose 0.1%-5%
Rilanit special 0.1%-8%
Stearic acid 0.5%-9%
Zinc stearate 0.2%-8%
Calcium sulphate 0.1%-6%
Calcium carbonate 0.1%-2%
Lauryl sodium sulfate 0.05%-6%
Disodium ethylene diamine tetraacetate 0.01%-2%
Polyvinyl alcohol 0.01%-6%
Optimize embodiment:
C5H6Br2N2O2 40%-75%
BCDMH 2%-10%
TCCA (Trichloroisocyanuric acid) 0.5%-5%
Sodium silicate 2%-10%
Hydroxypropyl methylcellulose 0.3%-3%
Rilanit special 0.2%-4%
C18 stearic acid 0.6%-6%
Odium stearate 0.5%-6%
Calcium sulphate 0.5%-4%
Calcium carbonate 0.5%-4%
Lauryl sodium sulfate 0.1%-4%
Disodium ethylene diamine tetraacetate 0.1%-3%
Polyvinyl alcohol 0.1%-4%
Burst size and the rate of release test data and the conclusion of disinfection and slow-release composition containing BCDMH of the present invention effective bromine in water body.
Put into the BCDMH sustained release tablets of 25 grams in the running water of 100 kilograms aerations, the effective bromine chlorinity (mg/L) with in the iodometric determination water body the results are shown in following table:
The result shows: present composition BCDMH sustained release tablets is the process of a slowly-releasing in water, effective bromine chlorinity in the water maintains 10mg/L～70mg/L all the time, and do not resemble the routine disinfection agent, usually in water after the dozens of minutes effectively bromine just descend, like this, after using the BCDMH sustained release tablets, water body can keep the sterilization state in long-time.
BCDMH at first discharges hypobromous acid and hypochlorous acid in water, kill microorganisms such as bacterium in the water and algae, thereby reaches the purpose of purification of water quality and sterilization.Subsequently, the bromine anion of inactivation is activated by active chlorine once more, fulfils the re-pasteurization mission.In addition, BCDMH is passed cell membrane easily and is directly destroyed intracellular enzyme, protein.The BCDMH efficient height of killing livestock is 20 times of chlorine, is 4 times of sodium dichloro cyanurate.This material solvability in water is very little, and tablet or the granule long period in water is just molten intact, and it is lasting to render a service, but its concentration of aqueous solution is as long as just there is enough disinfection power when 0.1%-1.0mg/l.After disengaging bromine, chlorine, residue descends 5, the 5-dimethyl hydantion, at first hydrolysis generates methylalanine, being decomposed into ammonia and carbonic acid gas by light, oxygen, microorganism in the short period under field conditions (factors) subsequently, can not producing that appoint can be residual, is a kind of as safe as a house and eco-friendly bactericide.
The checking of Disinfection Effect and other performance:
(1) disinfectant stability is measured
The variation of active constituent content in the experimental determination disinfectant is deposited is with the reference as definite this medicine storage term of validity.
According to " disinfection technology standard " 2002 editions 4.2.4, get packaged disinfectant and be positioned over respectively in 54 ℃ of insulating boxs 14 days, in 37 ℃ of insulating boxs 90 days, placing the forward and backward disinfectant bactericidal active ingredient content of measuring respectively.
Experimental data and result:
| Temperature (℃) | Content before placing | Place back content | Rate of descent |
| 54 ℃ (14 days) | 25.00％ | 23.80％ | 4.8％ |
| ?37℃ | 25.00％ | 23.85％ | 4.6％ |
The verification msg of present composition Disinfection Effect and other performances and result are according to Ministry of Public Health's " disinfection technology standard " (version in 2002) second portion " sterile products inspection technology standard ", to the checking of testing of performances such as the pH value of this product, stability, Disinfection Effect, anti-organic matter interference performance, metal protection, toxicity, excitant, its result is as follows:
(2) physicochemical property:
Bromine-chlorine-dimethyl hydantoin disinfectant 1500mg/l pH value average out to 6.5;
The effective bromine chlorinity of bromine-chlorine-dimethyl hydantoin disinfectant average out to 25%-85%;
Bromine-chlorine-dimethyl hydantoin disinfectant is effectively bromine chlorine average content decline 4.8% after 54 ℃ of constant temperature are deposited 14 days, 37 ℃ of constant temperature of bromine-chlorine-dimethyl hydantoin disinfectant are deposited effectively bromine chlorine average content decline 4.6% after 90 days, bromine-chlorine-dimethyl hydantoin disinfectant working concentration 2000mg/l soaks stainless steel, carbon steel, copper, aluminium flake 72h, copper, al stainless steel there is not corrosion substantially, to the carbon steel mild corrosion.
(3) Disinfection Effect
Bromine-chlorine-dimethyl hydantoin disinfectant concentration 1500mg/l effect 60min kills logarithm value greater than 5 to bar grass bacterium black mutation gemma ATCC9372's.
It is 3.26 that bromine-chlorine-dimethyl hydantoin disinfectant concentration 300mg/l effect 1min kills logarithm value to Escherichia coli 8099; It is 4.91 that effect 3min kills logarithm value to Escherichia coli 8099; Effect 5min kills logarithm value greater than 5 to Escherichia coli 8099.
It is 3.46 that bromine-chlorine-dimethyl hydantoin disinfectant concentration 300mg/l effect 1min kills logarithm value to staphylococcus aureus ATCC6538; It is 4.94 that effect 3min kills logarithm value to staphylococcus aureus ATCC6538; Effect 5min kills logarithm value greater than 5 to staphylococcus aureus ATCC6538
Bromine-chlorine-dimethyl hydantoin disinfectant concentration 300mg/l effect 1min, it is 3.18 that Candida albicans ATCC10231 is killed logarithm value; It is 4.84 that effect 3min kills logarithm value to Candida albicans ATCC10231; Effect 5min kills logarithm value greater than 5 toxicity checks to Candida albicans ATCC10231:
1, acute oral toxicity test: female, male mice per os LD
50＞5000mg/L, the nontoxic level in true border.
2, rabbit acute skin irritation test: the result is a nonirritant.
3, PCEMNR micronucleus test: result of the test is negative.
4, cumulative toxicity test (dosage escalation cumulative coefficient method): cumulative coefficient is the weak property accumulated greater than 5.
The preparation method of the present composition:
1, sterilization main ingredient composition is 65 ℃ of following dry for standby, takes by weighing main ingredient according to prescription and adds carbonate, silicate, sulphate, alkyl sulfate and phosphate successively by the equivalent incremental method and place the V-type blender, mixes about 30 minutes, must mixture I
2, the immersion soluble in water of the good hydroxymethyl-propyl cellulose of weighing more than 24 hours, is made the aqueous solution, add in the batch mixing, mediated 15 minutes.With 14 mesh sieve system particles, in the baking oven below 50, dry, get mixtures II
3, stearate is joined in the mixtures II that mixes, in the V-type blender, mixed 3 minutes.Get mixtures III.
4, the sampling of the mixtures III that obtains is tested, deliver to compressing tablet workshop compressing tablet after qualified.Finished product is criticized inspection, and index is qualified goes into warehouse for finished product.
Invention is summed up
(1) bromine has higher bactericidal activity than chlorine under the high pH value condition: at alkaline water body and containing in the ammoniacal liquor body, bromine has higher bactericidal activity than chlorine. The performance that it is found that bromine in the water system under the high pH condition surpasses chlorine. Sterilization speed is faster, is more suitable for artificial swimming pool, natural swimming place water pH value scope, but the active material hypobromous acid long period that is used for the water sterilization sterilization algae removal remain within the effective concentration range, prolonged action time, improved action effect.
(2) good stability: delivery systme has the losses such as the volatilization that reduces active material, loss, biochemical decomposition, delivery systme can improve the utilization rate of active material, reduce its injected volume, and then can reduce side effect, preferably the preparation active component is controlled in the safe concentration of regulation, has guaranteed water quality.
(3) concentration of release medicine is more stable, does not produce the zigzag fluctuation, can utilize most effectively medicine, has greatly reduced the medication number of times, is convenient to management, and is easy to use, improves the economy of lido sterilization. After the medium and high classes swimming place and hall used this compound sterilizing, Chi Shui was azure and limpid shinny, and pool wall is smooth without bur, and it is comfortable that the swimmer feels.
(4) safety and environmental protection: carrier easily decomposes in environment, and biological degradability is good, meets environmental requirement. Halogenated hydantoin uses 5,5-DMH as the disinfectant main carrier, and catabolite does not pollute environment in natural environment. In security, also there is significant effect the aspects such as reduction environmental pollution.
(5) sterilization algae removal is effective: active ingredient 1-2ppm is with regard to energy kill bacteria, fungi and algae in the water body.
(6) low toxicity, non-stimulated: LD50〉=5000mg/Kg.BW, working concentration is safe and harmless. On the other hand, from actual production and the analysis of life summarizes, China in recent years incidence of aquiculture disease is more and more higher, and diseased region is more and more wider, and the economic loss that causes is increasing. China from south to north, than coastal shallow sea, beach to landlocked pond, the large water surface, the nearly all breed variety of industrial aquaculture, the in various degree generation of disease is arranged, the disease of several that have even tens kinds occurs simultaneously, and existing common disease has again new disease. According to incompletely statistics, propagate the disease of the aquatic economic animal and plant such as fish, shrimp, shellfish, algae, crab, the frog artificially more than 200 kinds. Along with being on the rise of aquiculture disease, to slowly-releasing lozenge demand with increasing. Slowly-releasing BCDMH sterilization lozenge is used for culture fishery, and following advantage is arranged:
1, it is obvious to improve the water quality effect: comprise environmental improvement agent BCDMH etc. in the preparation, can kill bad algae, cultivate useful planktonic organism population, after solid pharmaceutical preparation is used for breeding water body, can reduce the water body pernicious gas, kill water and stop heterotroph, ammonifiers, sulfatereducting bacteria, Antifungi, part virus are effectively improved water quality condition.
2, drive away the body ecto-and endoparasites: the medicine that comprises in the preparation has the assistance Killing Microorganisms In Water, comprise protozoic effect, it also is the fish disinfectant, wherein sulfate, bicarbonate assist to kill or drive away external or endoparasite, and kill harmful invertebrate in the water body, also can treat the fish and water mildew.
3, sterilizing ability is not affected by water pH value: bactericidal activity does not reduce in alkaline medium.
4, improve the organism metabolism of cultivation object: to planktonic organism in the water body, the dissolved oxygen situation is improved effect; Aquatic livestock is not had strong and stimulating, be difficult for causing inflammation.
5, energy one medicine is multiplex: toxicity is little, can adopt hanging basket, the administration of hanging bag pesticide application technology, should be used for the dipping cultivation.
6, studies have shown that in a large number: the organochlorine disinfectant has carcinogenesis, Environmental Protection Agency of the United States Federal (USEPA) has forbidden independent dichloro, sym-closene are comprised that chlorine dioxide is used for fish culture, the halogenated hydantoin class disinfectants such as BCDMH are better substitutes, applied widely, residual little, be not subjected to the impact of ammonia nitrogen and pH value thereof.
Can substitute other high effect disinfectants-halogenated hydantoin of chlorine-containing agent, obtain breakthrough at preparation process at present. It is less that but halogenated hydantoin all is thinner powder and density; be difficult to be pressed into the solid pharmaceutical preparation of high strength integrality; there is very large problem in the preparation of the lozenge tablet of halogenated hydantoin; we adopt the slow control delivery of diffusion by take the non-toxic inexpensive macromolecule as carrier, and preparation process is simple; with low cost; easily commercialization, scale are a kind of novel, efficient, convenient, safe preparations, have solved the problems such as stability, security, convenience.
Slowly-releasing bromine chlorine composite slow release disinfectant preparation can be applicable to water for industrial use, drinking water, swimming pool and the sterilization of massage pond and aquaculture, for preventing the epidemic disease generation and spreading, makes drinking water disinfection in the flood fighting calamity.
Claims (9)
1, a kind of novel disinfection and slow-release composition containing BCDMH and preparation method, it is characterized in that, by reasonable compatibilities such as C5H6Br2N2O2, BCDMH, chlorinated isocyanurates and macromolecular material, forming agent and filling materials, good slow release disinfection factor, stability-enhanced effect have been produced.The component of the present composition unit of calculation (W/W) by percentage to the quality is as follows:
C5H6Br2N2O2 20%-85%
BCDMH 1%-15%
TCCA (Trichloroisocyanuric acid) 1%-10%
Silicate 0.1%-6%
Hydroxypropyl methylcellulose derivative 0.1%-5%
Rilanit special 0.1%-8%
Stearic acic derivative 0.5%-9%
Stearate 0.2%-8%
Sulphate 0.1%-6%
Carbonate 0.1%-2%
Alkyl sulfate 0.05%-6%
Ethylenediamine tetra-acetic acid and salt 0.01%-2%
Polyvinyl alcohol 0.01%-6%
According to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that 2, contain a kind of C5H6Br2N2O2 compound, its shared mass percent is 20%-85%.
3. according to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that contain a kind of BCDMH compound, its shared mass percent is 1%-15%.
According to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that 4, contain a kind of chlorinated isocyanuric acid compound, its shared mass percent is 1%-10%.
According to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that 5, contain a kind of silicate compound, its shared mass percent is 0.1%-6%; Contain a kind of sulphate, its shared mass percent is 0.1%-6%; Contain a kind of carbonate, its shared mass percent is 0.1%-2%; Contain a kind of ethylenediamine tetra-acetic acid and salt, its shared mass percent is 0.01%-2%; Contain a kind of alkyl sulfate, its shared mass percent is 0.05%-6%.
According to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that 6, contain a kind of hydroxypropyl methylcellulose derivative compound, its shared mass percent is 0.1%-5%; Containing its shared mass percent of a kind of stearic acic derivative is 0.5%-9%.
According to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that 7, contain a kind of rilanit special, its shared mass percent is 0.1%-8%.
8, according to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that, is to contain a kind of polyvinyl alcohol, and its shared mass percent is 0.01%-6%.
9, according to described a kind of novel disinfection and slow-release composition containing BCDMH of claim 1 and preparation method, it is characterized in that its composition and preparation method are as follows:
(1), sterilization main ingredient composition is pulverized the back 65 ℃ of following dry for standby.
Take by weighing main ingredient according to prescription and add carbonate, silicate, sulphate, alkyl sulfate and phosphate successively by the equivalent incremental method and place blender, mixed about 30 minutes, mixture I.
(2), the immersion soluble in water of the good hydroxymethyl-propyl cellulose of weighing more than 24 hours, is made the aqueous solution, add in the batch mixing, mediated 15 minutes,, in the baking oven below 50, dry with 14 mesh sieve system particles, must mixtures II.
(3), stearate is joined in the mixtures II that mixes, in blender, mixed 3 minutes, mixtures III.
(4), the sampling of the mixtures III that obtains is tested, deliver to compressing tablet workshop compressing tablet after qualified.
(5), finished product is criticized inspection, index is qualified goes into warehouse for finished product.
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| CN101817577A (en) * | 2010-04-21 | 2010-09-01 | 无锡美华化工有限公司 | Method for removing Microcystin-LR in water body by using bromides |
| CN101823790A (en) * | 2010-04-21 | 2010-09-08 | 无锡美华化工有限公司 | Method for killing algae in water area with bromide |
| CN103155944A (en) * | 2013-02-06 | 2013-06-19 | 第二炮兵工程设计研究院 | Biochemical decontamination agent and preparation method thereof |
| CN103891727A (en) * | 2012-12-25 | 2014-07-02 | 南京莱因医药科技有限公司 | Preparation method of stable compound halogen organic disinfectant |
| CN107162129A (en) * | 2017-06-02 | 2017-09-15 | 兴化市恒威生物技术有限公司 | A kind of water quality of aquaculture pond inorganic agent |
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2005
- 2005-03-25 CN CN 200510056772 patent/CN1836514A/en active Pending
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| CN101148634B (en) * | 2007-09-28 | 2010-06-02 | 广州市欧替克消毒剂生产有限公司 | Detergent containing bromochlorohydantoin |
| CN101817577A (en) * | 2010-04-21 | 2010-09-01 | 无锡美华化工有限公司 | Method for removing Microcystin-LR in water body by using bromides |
| CN101823790A (en) * | 2010-04-21 | 2010-09-08 | 无锡美华化工有限公司 | Method for killing algae in water area with bromide |
| CN103891727A (en) * | 2012-12-25 | 2014-07-02 | 南京莱因医药科技有限公司 | Preparation method of stable compound halogen organic disinfectant |
| CN103155944A (en) * | 2013-02-06 | 2013-06-19 | 第二炮兵工程设计研究院 | Biochemical decontamination agent and preparation method thereof |
| CN107162129A (en) * | 2017-06-02 | 2017-09-15 | 兴化市恒威生物技术有限公司 | A kind of water quality of aquaculture pond inorganic agent |
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