CN1836508A - Novel compound o-Phthalaldehyde microemusion sterilization composition - Google Patents
Novel compound o-Phthalaldehyde microemusion sterilization composition Download PDFInfo
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- CN1836508A CN1836508A CN 200510056769 CN200510056769A CN1836508A CN 1836508 A CN1836508 A CN 1836508A CN 200510056769 CN200510056769 CN 200510056769 CN 200510056769 A CN200510056769 A CN 200510056769A CN 1836508 A CN1836508 A CN 1836508A
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Abstract
The compound phthalaldehyde microemulsion germicide composition contains: phthalaldehyde 0.20-0.70 wt%, fatty alcohol A, fatty alcohol B1, chelant, quaternary ammonium salt, non-ionic surfactant, compound pH buffer system to ensure the germicide pH value of 7-10, defoaming agent compound to avoid foaming during circulation, and corrosion retardant to avoid metal corrosion. The compound phthalaldehyde microemulsion germicide composition has high sterilizing effect, stable physical and chemical properties, long preservation period, good compatibility, practical no toxicity and other features.
Description
Technical field
The present invention relates to a kind of novel compound o-Phthalaldehyde microemusion sterilization composition, be mainly used in the high level disinfection and the sterilization of hospital's precision instrument and equipment, public environment, similar with the use target and the method for glutaraldehyde, but performance and effect are more superior.
Background technology
Chemosterilant and bactericidal agent have crucial meaning in the application of medical industry, to prevent and prevent epiphytotics spread with cross-infection be a link of not replacing, be mainly used in hospital surgical apparatus, environment, accurate diagnostic equipment such as endoscope etc.The major product of using in nearly 50 years has sym-closene, Peracetic acid and glutaraldehyde etc., these products have been brought into play important effect for a long time, but long-term use finds that also there are many defectives in these products, and is excessive as the sym-closene smell, strong etc. to corrosion of metal; The pH of Peracetic acid is lower, thereby bigger to corrosion of metal, easily causes the loss to instrument in the disinfecting process of operating theater instruments, has limited its application; Glutaraldehyde uses the history in existing 40 years in hospital as high level disinfection agent and bactericidal agent, especially use as the sterilization of laparoscope precision equipment, characteristics with broad-spectrum high efficacy, but also found afterwards, glutaraldehyde is volatile, it has stronger spread effect to people's skin and respiratory apparatus, easily causes allergic, ulcer even cause cancer; Glutaraldehyde poor stability in addition, life cycle is short.Therefore, world many countries has been carried out the development of novel high level disinfection agent o-phthalaldehyde(OPA), especially the o-phthalaldehyde(OPA) high level disinfection agent with U.S. CIDEX has certain characteristics and influence, accomplishes the characteristics of sterilization high-efficiency broad spectrum, can kill all bacteriums except that gemma in 4 hours.It is little to have smell, characteristics such as excitant is low, life cycle is long, good stability, yet, the O-phthalaldehyde disinfectant brood cell's of CIDEX killing action is very poor, continuous action just can be finished and kill logarithm value greater than 5 in 32 hours, thereby can not can only use as the high level disinfection agent as bactericidal agent, the CIDEX O-phthalaldehyde disinfectant awaits further to strengthen to the omnibearing anti-corrosion capability of metal in addition.The restriction that this defective is serious o-phthalaldehyde(OPA) promote and use, especially the place of the processing that need sterilize at hospital's precision equipment, the medical worker is very prudent especially to its use, thus medical industry needs that the low smell of a kind of volatility is little, excitant is low, toxicity is little and good stability, life cycle are long sterilized dose precision instrument and equipment carried out sterilization treatment.
Summary of the invention
A main purpose of the present invention provides a kind of have high level disinfection and sterilization, the preparation that excitant and toxicity are low.
The mass percent (W/W) of a kind of novel compound o-Phthalaldehyde microemusion sterilization composition of the present invention is as follows:
O-phthalaldehyde(OPA) 0.20%-0.70%
Quaternary ammonium salt 0.1%-8%
Fatty alcohol A 3%-20%
Fatty alcohol B 0.1%-12%
A flat iron plate for making cakes mixture 0.1%-6%
Tween 0.1%-10%
Buffer solution 0.2%-7%
Foam inhibitor 0.2%--8%
Corrosion inhibiter 0.05%-5%
Organic acid 0.05%-6%
Bleeding agent 0.1%-8%
Deionized water 30%-80%
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition wherein comprises a kind of o-phthalaldehyde(OPA) compound, and as the disinfection composition, its shared mass percent is 0.20%-0.70%, is preferably 0.30%-0.60%.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition wherein comprises a kind of quaternary ammonium compound, and as the disinfection cleaning ingredients, its shared mass percent is 0.1%-8%, is preferably 0.20%-0.50%; Selected quaternary amine is single long chain hydrocarbon groups quaternary amine, two long chain hydrocarbon groups quaternary amine, is preferably two long chain hydrocarbon groups quaternary amines; Selected alkyl carbon atom quantity is C8-C24, and preferred alkyl carbon atom quantity is C8-C18.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition wherein comprises a kind of fatty alcohol category-A compound, and as solvent and cleaning ingredients, its shared mass percent is 3%-20%, is preferably 4%-15%; Selected fatty alcohol A is propane diols, butanediol, pentanediol, glycerine, polyethylene glycol-400, polyethylene glycol-600, is preferably glycerine.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of fatty alcohol category-B compound, as solvent, minimizing volatilization and synergy, increase dissolving and stabilization composition, its shared mass percent is 0.1%-12%, is preferably 3%-9%; Selected fatty alcohol B is ethylene glycol, 1-dodecanol 2-dodecanol, hexanol, amylalcohol, butanols, propyl alcohol, is preferably propyl alcohol.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of intercalating agent compounds, as the chelating composition of broad liquid system to metal ion, stablizing of favourable o-phthalaldehyde(OPA) solution system, its shared mass percent is 0.1%-6%, is preferably 0.5%-3%; Selected intercalating agent compound is sodium phosphate trimer, sodium citrate, ethylenediamine tetra-acetic acid, disodium ethylene diamine tetraacetate, tetrasodium ethylenediamine tetraacetate, sodium pyrophosphate, is preferably disodium ethylene diamine tetraacetate.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of tween compound, dispersion as solute, can play dispersion and emulsification composition to o-phthalaldehyde(OPA), the osmosis of the stable and reinforcement system of favourable o-phthalaldehyde(OPA) solution system, its shared mass percent is 0.1%-10%, is preferably 0.2%-2%; Selected non-ionic surface active compound is alkyl amine oxide, alkyl phenol ether, poly-alkyl glycoside, cocounut oil alkanolamide, and polysorbas20 is preferably poly-alkyl glycoside.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of buffer soln system, media as solute, can play the composition of the effect of stabilizing solution pH value to o-phthalaldehyde(OPA), the extraneous acid of antagonism, alkaloid substance are to the influence of disinfectant system, the stabilization that helps the o-phthalaldehyde(OPA) solution system, its shared mass percent is 0.2%-7%, is preferably 0.5%-6%.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of foam inhibitor, but soak branch as the disinfectant system, can play bubble and the steady bubble effect of pressing to the O-phthalaldehyde disinfectant system, reduce disinfectant and in the cyclic process of machine sterilization, produce bubble, disturb normal disinfection, improve the effectiveness and the reliability of work, its shared mass percent is 0.2%--8%, is preferably 0.5%-5%; Selected foam inhibitor is polyvinyl alcohol, polyethylene glycol, silicone oil, and oleic acid is preferably polyethylene glycol.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of corrosion inhibiter, as preventing and reducing the disinfectant system to the corrosion composition partly of metal in the apparatus, other compositions synergies of it and O-phthalaldehyde disinfectant system, so produced and played and reduced disinfectant infringement to machine in the cyclic process of machine sterilization, reduced the equipment use cost, prolonged the life-span of equipment, promote o-phthalaldehyde(OPA) sterilization and bactericidal agent compatibility to material, enlarged the scope of application of disinfectant, its shared mass percent is 0.05%-5%, is preferably 0.1%-3%.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of organic acid, regulate composition as the disinfectant system pH, and other composition Synergistic biocidal effects of it and O-phthalaldehyde disinfectant system, o-phthalaldehyde(OPA) sterilization and sterilizing activity have been improved, strengthened disinfectant stability, its shared mass percent is 0.05%-6%, be preferably 0.1%-2%, selected corrosion inhibitor compound is a petroleum sodium sulfonate, barium mahogany sulfonate, dithiocarbamate, mercapto-triazole, methylbenzotrazole, the ethyl BTA, zinc citrate, zinc sulphate is preferably mercapto-triazole.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of organic acid, regulate composition as the disinfectant system pH, and other composition Synergistic biocidal effects of it and O-phthalaldehyde disinfectant system, o-phthalaldehyde(OPA) sterilization and sterilizing activity have been improved, strengthened disinfectant stability, its shared mass percent is 0.05%-6%, is preferably 0.1%-2%; Selected organic acid is citric acid, lauric acid, malic acid, lactic acid, tartaric acid, linoleic acid, acetate, is preferably citric acid.
A kind of as mentioned above novel compound o-Phthalaldehyde microemusion sterilization composition, wherein comprise a kind of bleeding agent organic compound, strengthen infiltration, adsorption component as the disinfectant system, and other composition Synergistic biocidal effects of it and O-phthalaldehyde disinfectant system, strengthened the penetrating ability of disinfection composition, improved o-phthalaldehyde(OPA) sterilization and sterilizing activity, strengthened disinfectant stability bacterial cell, its shared mass percent is 0.1%-8%, is preferably 0.2%-6%; Selected bleeding agent organic compound is C7-C9 fatty alcohol oxirane ether, 1-ten alkyl-nitrogen Zhuo-2-ketone, N, dinethylformamide, 4-decyl oxazole-2-ketone, N-Methyl pyrrolidone, 2-methyl pyrrolidone, menthol are preferably C7-C9 fatty alcohol oxirane ether.
Embodiment
Embodiment 1: (W/W) is as follows for a kind of mass percent of novel compound o-Phthalaldehyde microemusion sterilization composition:
O-phthalaldehyde(OPA) 0.30%-0.60%
Cetrimonium bronmide 0.1%-8%
Butanediol 3%-20%
1-dodecanol 0.1%-12%
Ethylenediamine tetra-acetic acid 0.1%-6%
Alkyl phenol ether 0.1%-10%
Buffer solution 0.2%-7%
Polyvinyl alcohol 0.2%--8%
Mercapto-triazole 0.05%-5%
Citric acid 0.05%-6%
N-Methyl pyrrolidone 0.1%-8%
Deionized water 30%-80%
The present composition is by electron microscope observation breast grain average diameter≤90nm, and outward appearance is water white liquid, meets the feature of microemulsion solution.
Embodiment 2: (W/W) is as follows for a kind of mass percent of novel compound o-Phthalaldehyde microemusion sterilization composition:
O-phthalaldehyde(OPA) 0.25%-0.65%
The two domiphen 0.1%-6% of chlorination
Propane diols 3%-20%
Propyl alcohol 3%-8%
Disodium ethylene diamine tetraacetate 1%-6%
Cocounut oil alkanolamide 0.2%-8%
Buffer solution 0.3%-6%
Silicone oil 0.2%--8%
Methylbenzotrazole 0.1%-2%
Tartaric acid 0.1%-4%
1-dodecyl-nitrogen Zhuo-2-ketone 0.1%-8%
Deionized water 30%-80%
Optimize embodiment 1: (W/W) is as follows for a kind of mass percent of novel compound o-Phthalaldehyde microemusion sterilization composition:
O-phthalaldehyde(OPA) 0.35%-0.55%
Chlorination double hexadecyl dimethylamine 0.2%-4%
Glycerine 4%-15%
1-dodecanol 0.1%-12%
Disodium ethylene diamine tetraacetate 0.5%-3%
Poly-alkyl glycoside 0.2%-2%
Buffer solution 0.5%-6%
Polyethylene glycol 0.2%--8%
Mercapto-triazole 0.1%-2%
Citric acid 0.1%-2%
C7-C9 fatty alcohol oxirane ether 0.2%-6%
Deionized water 30%-80%
The present composition is by electron microscope observation breast grain average diameter≤90nm, and outward appearance is the liquid of yellow transparent slightly, and smell is very little, meets the basic standard of microemulsion solution.Optimize the experimental data that embodiment 1 in use obtains:
Table one present composition is at 37 ℃, content data before and after 90 days stability experiments
| The pH value | 37 ℃, content before and after 90 days stability experiments | ||
| 0 day content (%) | 90 days content (%) | Rate of descent (%) | |
| 6.0 | 0.5795 | 0.5453 | 5.9 |
| 7.0 | 0.5820 | 0.5500 | 5.5 |
| 8.0 | 0.5835 | 0.5520 | 5.4 |
| 9.0 | 0.5902 | 0.5571 | 5.6 |
| 10.0 | 0.5862 | 0.5510 | 6.0 |
Conclusion: PH o-phthalaldehyde(OPA) in the 6.0-10.0 scope is relatively stable, and active drug content rate of descent is lower than 10%, complies with the national standard requirements, and the shelf-life of product can reach 2 years.
Table two present composition is killed test to bacillus subtilis black variety gemma ATCC9372
| Effective content (mg/l) | The effect different time on average kill logarithm value (KL) | ||
| 20min | 30min | 40min | |
| 1/3 dilution | 2.60 | 2.85 | 3.5 |
| 2/3 dilution | 3.80 | 4.95 | ≥5 |
| Stoste | 4.90 | ≥5 | ≥5 |
Through evidence, in the present composition disinfectant 30min to bacillus subtilis black variety gemma ATCC9372 killing rate logarithm value greater than 5, can effectively kill bacillus subtilis black variety gemma.
Table three U.S. one composition is killed test to bacillus subtilis black variety gemma ATCC9372
| Effective content (mg/l) | The effect different time on average kill logarithm value (KL) | ||
| 15h | 25h | 32h | |
| 1/3 dilution | 2.50 | 2.95 | 3.20 |
| 2/3 dilution | 3.20 | 4.15 | ≥5 |
| Stoste | 3.80 | 4.60 | ≥5 |
Through evidence, in the U.S. one composition disinfectant 32h to bacillus subtilis black variety gemma ATCC9372 killing rate logarithm value greater than 5, can effectively kill bacillus subtilis black variety gemma, this data show U.S. product is compared with the present invention's combination, bactericidal activity has huge difference, demonstrates the outstanding feature of the present composition.
According to the method for Ministry of Public Health's disinfection technology working specification, soak stainless steel, carbon steel, copper, aluminium flake 72h with present composition disinfectant liquid, copper there is mild corrosion, stainless steel, carbon steel there are not corrosion, there is not corrosion to aluminium base.Therefore it can use sterilization and the sterilization with medical precision instrument.
Table four present composition toxicity and irritation test data
| Pilot project | The result |
| Main skin irritation test | Non-stimulated |
| Main eye irritation test | Moderate stimulates |
| Acute oral toxicity test (mouse) | LD 50＞5000mg/kg |
| Acute dermal toxicity test (rabbit) | LD 50＞2000mg/kg |
| The sensitization of skin effect | Non-sensitizing agent |
Result of the test shows that the excitant and the toxicity of the present composition is all very low, belongs to the actual nontoxic level of national standard, can be widely used in medical treatment and food industry, family etc.
Table five show with present composition compatibility material:
| Metal material | Macromolecular material |
| Carbon steel | NYLON610,66 |
| Brass | Polyvinyl chloride |
| Stainless steel | Merlon |
| Titanium | Polystyrene |
| Chromium steel | Polyacrylonitrile resin |
| Steel | Polyurethane |
| Vanadium steel | Poly-methyl acrylic acid fat |
| Nickel brass | Polyethylene |
| Plumbous | Polypropylene |
From above statistics, can illustrate that the present composition has compatibility widely to material, thereby make condition restriction that the present composition is subjected in the application facet of reality seldom that more applications can be arranged.
Claims (10)
1, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition is characterized in that, contains a certain proportion of o-phthalaldehyde(OPA) as main ingredient, reaches the composition of being made up of preparations such as one group of synergist and stabilizing agents, and its mass percentage content is:
O-phthalaldehyde(OPA) 0.20%-0.65%
Quaternary ammonium salt 0.1%-8%
Fatty alcohol A 3%-20%
Fatty alcohol B 1%-12%
A flat iron plate for making cakes mixture 0.1%-6%
Tween 0.1%-10%
Buffer solution 0.2%-7%
Foam inhibitor 0.2%--8%
Corrosion inhibiter 0.05%-5%
Organic acid 0.05%-6%
Bleeding agent 0.1%-8%
Deionized water 30%-80%
2, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind of carbochain alkyl quaternary ammonium salt, and its quality percentage composition is 0.1%-8%; It is between the 8-24 that its alkyl contains carbon number.
3, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind of aliphatic group alcohol A, and its quality percentage composition is 3%-20%; Its another feature is, contains a kind of aliphatic group alcohol B, and its quality percentage composition is 1%-12%, as the micro emulsion polar solvent.
4, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind of complexing of metal ion agent, and its quality percentage composition is 3%-20%; Selected complexing of metal ion agent is the polyphosphoric acids salt, pyrophosphate, ethylenediamine tetra-acetic acid and salt compounds thereof.
5, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind non-ionic surface active compound, and its quality percentage composition is 0.1%-10%.
6, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains pool of buffer liquid, and its quality percentage composition is 0.2%-7%, and the pH value of O-phthalic aldehyde compositions is remained between the 6-10.
7, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains one group of corrosion inhibiter that prevents metal erosion, and its quality percentage composition is 0.05%-5%; The corrosion inhibiter of institute's metal erosion is petroleum sodium sulfonate, barium mahogany sulfonate, coconut oleoyl amine, dithiocarbamate, mercapto-triazole, BTA, alkyl BTA, zinc citrate, zinc sulphate.
8, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind of froth breaking and presses down the alveolation compound, and its quality percentage composition is 0.2%--6%; It is water-soluble silicon oil, polyvinyl alcohol, polyethylene glycol, polyacrylic resin that selected froth breaking presses down the alveolation compound.
9, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind of bleeding agent compound, and its quality percentage composition is 0.1%-8%; Selected bleeding agent compound is dimethyl sulfoxide (DMSO), 1-ten alkyl-nitrogen Zhuo-2-ketone, N, dinethylformamide, N-Methyl pyrrolidone, 2-methyl pyrrolidone, menthol, 4-decyl oxazole-2-ketone, C7-C9 fatty alcohol oxirane ether.
10, a kind of novel compound o-Phthalaldehyde microemusion sterilization composition according to claim 1 is characterized in that, contains a kind of organic acid, and its quality percentage composition is 0.05%-6%; Selected organic acid is citric acid, malic acid, oxalic acid, lactic acid, acetate, gluconic acid.
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134979A2 (en) * | 2008-05-02 | 2009-11-05 | Ethicon, Inc. | Microemulsion germicidal composition |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
| WO2011053561A1 (en) | 2009-10-30 | 2011-05-05 | Ethicon, Inc. | Microemulsion sporicidal composition |
| CN102461499A (en) * | 2010-11-17 | 2012-05-23 | 民政部一零一研究所 | Disinfector for remains and preparation method thereof |
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN104521959A (en) * | 2014-12-23 | 2015-04-22 | 广东环凯微生物科技有限公司 | Novel disinfectant prepared from quaternary ammonium salt and alcohol |
| CN105379712A (en) * | 2015-12-15 | 2016-03-09 | 山东消博士消毒科技股份有限公司 | Phthalic dicarboxaldehyde disinfectant for endoscope cleaning and preparation technology thereof |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
| CN108184825A (en) * | 2017-11-27 | 2018-06-22 | 中国船舶重工集团公司第七八研究所 | A kind of compound ortho-phthalaldehyde nano-emulsion thimerosal and preparation method thereof |
| WO2020096890A1 (en) * | 2018-11-05 | 2020-05-14 | Medivators Inc. | Composition for cleaning and assessing cleanliness in real-time |
| CN112244020A (en) * | 2020-09-16 | 2021-01-22 | 山东利尔康医疗科技股份有限公司 | Low-foam low-odor phthalic dicarboxaldehyde formula and preparation method thereof |
| US10912296B2 (en) * | 2013-03-25 | 2021-02-09 | Kemira Oyj | Biocide formulation and method for treating water |
| US20210386278A1 (en) * | 2018-11-05 | 2021-12-16 | Mediators Inc. | Endoscope fluorescence inspection device |
| US11497581B2 (en) | 2018-11-05 | 2022-11-15 | Medivators Inc. | Endoscope cleaning and inspection system and method |
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2005
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134979A3 (en) * | 2008-05-02 | 2010-08-19 | Ethicon, Inc. | Microemulsion germicidal composition |
| RU2492650C2 (en) * | 2008-05-02 | 2013-09-20 | Этикон, Инк. | Microemulsion bactericidal composition |
| WO2009134979A2 (en) * | 2008-05-02 | 2009-11-05 | Ethicon, Inc. | Microemulsion germicidal composition |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
| WO2011053561A1 (en) | 2009-10-30 | 2011-05-05 | Ethicon, Inc. | Microemulsion sporicidal composition |
| CN102461499A (en) * | 2010-11-17 | 2012-05-23 | 民政部一零一研究所 | Disinfector for remains and preparation method thereof |
| CN102461499B (en) * | 2010-11-17 | 2014-06-18 | 民政部一零一研究所 | Disinfector for remains and preparation method thereof |
| US10912296B2 (en) * | 2013-03-25 | 2021-02-09 | Kemira Oyj | Biocide formulation and method for treating water |
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103636601B (en) * | 2013-12-10 | 2015-08-05 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN104521959A (en) * | 2014-12-23 | 2015-04-22 | 广东环凯微生物科技有限公司 | Novel disinfectant prepared from quaternary ammonium salt and alcohol |
| CN104521959B (en) * | 2014-12-23 | 2016-09-28 | 广东环凯微生物科技有限公司 | A kind of disinfectant solution utilizing quaternary ammonium salt and alcohol to prepare |
| CN105379712A (en) * | 2015-12-15 | 2016-03-09 | 山东消博士消毒科技股份有限公司 | Phthalic dicarboxaldehyde disinfectant for endoscope cleaning and preparation technology thereof |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
| CN108184825A (en) * | 2017-11-27 | 2018-06-22 | 中国船舶重工集团公司第七八研究所 | A kind of compound ortho-phthalaldehyde nano-emulsion thimerosal and preparation method thereof |
| WO2020096890A1 (en) * | 2018-11-05 | 2020-05-14 | Medivators Inc. | Composition for cleaning and assessing cleanliness in real-time |
| US20210386278A1 (en) * | 2018-11-05 | 2021-12-16 | Mediators Inc. | Endoscope fluorescence inspection device |
| US11497581B2 (en) | 2018-11-05 | 2022-11-15 | Medivators Inc. | Endoscope cleaning and inspection system and method |
| US11793601B2 (en) | 2018-11-05 | 2023-10-24 | Medivators Inc. | Endoscope cleaning and inspection system and method |
| CN112244020A (en) * | 2020-09-16 | 2021-01-22 | 山东利尔康医疗科技股份有限公司 | Low-foam low-odor phthalic dicarboxaldehyde formula and preparation method thereof |
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