CN101785460A - O-phthalaldehyde disinfectant and preparation method thereof - Google Patents
O-phthalaldehyde disinfectant and preparation method thereof Download PDFInfo
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- CN101785460A CN101785460A CN200910045997A CN200910045997A CN101785460A CN 101785460 A CN101785460 A CN 101785460A CN 200910045997 A CN200910045997 A CN 200910045997A CN 200910045997 A CN200910045997 A CN 200910045997A CN 101785460 A CN101785460 A CN 101785460A
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Abstract
The invention relates to an o-phthalaldehyde disinfectant and a preparation method thereof. The o-phthalaldehyde disinfectant comprises the following components in percentage by weight: 0.2 to 1 percent of o-phthalaldehyde, 0.1 to 0.5 percent of salicylic acid, 0.5 to 1.5 percent of dodecyldimethylbenzylammonium chloride, 1 to 10 percent of ethanol, 0.1 to 1 percent of disodium hydrogen phosphate, 1 to 10 percent of ethanol, 0.1 to 1 percent of sodium dihydrogen phosphate, 0.1 to 0.5 percent of inhibitor, 0.01 to 0.1 percent of ethylene diamine tetraacetic acid and the balance of water. The method for preparing the disinfectant comprises the steps of: adding the o-phthalaldehyde into the ethanol according to the content and component, stirring and mixing the materials; adding water into the materials and stirring the mixture; and adding the dodecyldimethylbenzylammonium chloride, the disodium hydrogen phosphate, the sodium dihydrogen phosphate, the inhibitor and the ethylene diamine tetraacetic acid into the mixture in sequence and stirring the mixed solution to allow the added materials to dissolve to obtain the o-phthalaldehyde disinfectant. The disinfectant has the advantages of no pungent smell, safety, low toxicity, stable property and convenient use, can be used for high-level disinfection of the heat-labile medical equipment and is particularly applicable to an endoscope automatic washing and disinfecting machine to perform high-level disinfection on an endoscope.
Description
Technical field
The present invention relates to disinfectant, relate in particular to a kind of O-phthalaldehyde disinfectant and preparation method thereof.
Background technology
At present clinically glutaral disinfectant solution is mainly adopted in the sterilization of thermo-labile medicine equipment.But glutaral disinfectant solution needs shortcomings such as activation, use inconvenience before existing poor stability, life cycle weak point, use, and glutaraldehyde is big to metal protection, need add the carcinogenic substance natrium nitrosum as corrosion inhibiter, just can alleviate it to the corrosion of metal effect.In addition, the easy volatility of glutaraldehyde has the obvious stimulation effect to people's eyes, skin, respiratory tract etc., harm medical worker's health.
O-phthalaldehyde(OPA) is a kind of novel aldehydes chemosterilant, has the advantages that corrosivity is low, not volatile, excitant is little, need not activate directly to use, and begins to use it for sterilizing endoscope in 1994 abroad, finds that it has good disinfection efficacy.O-phthalaldehyde(OPA) in 1999 have obtained the authentication of U.S. FDA, as a kind of high level disinfection agent, can be used for repeated treatments temperature-sensitive Medical Devices, can bring into play quick high level disinfection effect 20 ℃ of room temperatures.But o-phthalaldehyde(OPA) also exists significant disadvantages, mainly shows not ideal enough to the killing action of bacterium and gemma, and the character instability, and easy oxidized destruction has mild corrosion to metals such as carbon steel, aluminium.
Summary of the invention
The object of the invention provides a kind of O-phthalaldehyde disinfectant, by scientific formula combination, strengthens the kill efficiency to bacterium and gemma of o-phthalaldehyde(OPA), and improves the stability of disinfectant, reduces it to corrosion of metal.
A kind of O-phthalaldehyde disinfectant, it comprises each component of following each percetage by weight:
O-phthalaldehyde(OPA), 0.2-1;
Salicylic acid, 0.1-0.5;
Dodecyl dimethyl ammonium chloride, 0.5-1.5;
Ethanol, 1-10;
Sodium hydrogen phosphate, 0.1-1;
Sodium dihydrogen phosphate, 0.1-1;
Corrosion inhibiter, 0.1-0.5;
Disodium ethylene diamine tetraacetate, 0.01-0.1;
Water, surplus.
Described disinfectant, described corrosion inhibiter are that sodium metaphosphate or potassium metaphosphate or both share.
The preparation method of described disinfectant is: by described content and component, o-phthalaldehyde(OPA) is joined in the ethanol, mix; Add water again, stirring and dissolving; Add dodecyl dimethyl ammonium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate, corrosion inhibiter, disodium ethylene diamine tetraacetate successively, stirring and dissolving promptly gets described O-phthalaldehyde disinfectant.
Characteristics of the present invention are to be main sterilization component with o-phthalaldehyde(OPA), comprehensive utilization keratolytic, surfactant, diffusion promoter, soda acid buffering are to, corrosion inhibiter, chelating agent, by the scientific matching of each component, make o-phthalaldehyde(OPA) can bring into play more superior high level disinfection performance.The present invention adopts salicylic acid as keratolytic, can improve the permeability of bacteria cell wall, helps lend some impetus to o-phthalaldehyde(OPA) and penetrates into bacterial body, and salicylic acid has the assisting sterilisation effect simultaneously, strengthens Disinfection Effect.Dodecyl dimethyl ammonium chloride is a kind of cationic surface active agent, can improve the compatibility of o-phthalaldehyde(OPA) and bacterial body.Ethanol can improve the dissolubility of o-phthalaldehyde(OPA), and its infiltration diffusion is had facilitation.Sodium hydrogen phosphate and sodium dihydrogen phosphate are formed buffer system, keep the pH value of solution, improve the stability of disinfectant.O-phthalaldehyde(OPA) has the low characteristics of metal protection, and sodium metaphosphate and potassium metaphosphate can further reduce the metal protection of o-phthalaldehyde(OPA) as corrosion inhibiter, and can reach does not all have corrosion substantially to stainless steel, carbon steel, copper, aluminium.Disodium ethylene diamine tetraacetate is a kind of chelating agent, and the antioxygen synergistic effect is arranged, and can improve the stability of this disinfectant.
Embodiment
Below, in conjunction with specific embodiments, further specify the present invention:
A kind of O-phthalaldehyde disinfectant, it comprises each component of following each percetage by weight:
O-phthalaldehyde(OPA), 0.2-1;
Salicylic acid, 0.1-0.5;
Dodecyl dimethyl ammonium chloride, 0.5-1.5;
Ethanol, 1-10;
Sodium hydrogen phosphate, 0.1-1;
Sodium dihydrogen phosphate, 0.1-1;
Corrosion inhibiter, 0.1-0.5;
Disodium ethylene diamine tetraacetate, 0.01-0.1;
Water, surplus.
Described disinfectant, described corrosion inhibiter are that sodium metaphosphate or potassium metaphosphate or both share.
The preparation method of described disinfectant is: by described content and component, o-phthalaldehyde(OPA) is joined in the ethanol, mix; Add water again, stirring and dissolving; Add dodecyl dimethyl ammonium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate, corrosion inhibiter, disodium ethylene diamine tetraacetate successively, stirring and dissolving promptly gets described O-phthalaldehyde disinfectant.
Embodiment 1
O-phthalaldehyde(OPA) 3 grams are joined in ethanol 5 grams, mix; Add water 967.5 grams again, stirring and dissolving; Add dodecyl dimethyl ammonium chloride 10 grams, sodium hydrogen phosphate 5 grams, sodium dihydrogen phosphate 4 grams, sodium metaphosphate 5 grams, disodium ethylene diamine tetraacetate 0.5 gram successively, stirring and dissolving promptly gets described O-phthalaldehyde disinfectant.
Embodiment 2
O-phthalaldehyde(OPA) 5 grams are joined in ethanol 5 grams, mix; Add water 975.8 grams again, stirring and dissolving; Add dodecyl dimethyl ammonium chloride 5 grams, sodium hydrogen phosphate 2 grams, sodium dihydrogen phosphate 2 grams, potassium metaphosphate 5 grams, disodium ethylene diamine tetraacetate 0.2 gram successively, stirring and dissolving promptly gets described O-phthalaldehyde disinfectant.
Embodiment 3
O-phthalaldehyde(OPA) 10 grams are joined in ethanol 10 grams, mix; Add water 945 grams again, stirring and dissolving; Add dodecyl dimethyl ammonium chloride 15 grams, sodium hydrogen phosphate 8 grams, sodium dihydrogen phosphate 6 grams, sodium metaphosphate 2 grams, potassium metaphosphate 3 grams, disodium ethylene diamine tetraacetate 1 gram successively, stirring and dissolving promptly gets described O-phthalaldehyde disinfectant.
The foregoing description disinfectant there is no corrosion phenomenon to stainless steel substrates, carbon steel coupon, copper sheet, aluminium flake continuous dipping 14 days.Adopt the suspension quantitative disinfecting test, the killing effect to bacterium under 19-21 ℃ of condition sees Table 1.Accelerated stability test the results are shown in Table 2.
This O-phthalaldehyde disinfectant of table 1 is to the killing effect of bacterium
This O-phthalaldehyde disinfectant accelerated stability test of table 2 result
As the O-phthalaldehyde disinfectant that above-mentioned embodiment makes, product has no irritating odor, safety and low toxicity, and stable in properties, easy to use.This disinfectant can be used for the sterilization of medicine equipment, is specially adapted to the high level disinfection of thermo-labile medicine equipment, is particularly useful for scope automatically washing and sterilizing machine scope is carried out the high level disinfection processing.
Claims (3)
1. an O-phthalaldehyde disinfectant is characterized in that, it comprises each component of following each percetage by weight:
O-phthalaldehyde(OPA), 0.2-1;
Salicylic acid, 0.1-0.5;
Dodecyl dimethyl ammonium chloride, 0.5-1.5;
Ethanol, 1-10;
Sodium hydrogen phosphate, 0.1-1;
Sodium dihydrogen phosphate, 0.1-1;
Corrosion inhibiter, 0.1-0.5;
Disodium ethylene diamine tetraacetate, 0.01-0.1;
Water, surplus.
2. disinfectant according to claim 1 is characterized in that, described corrosion inhibiter is that sodium metaphosphate or potassium metaphosphate or both share.
3. the preparation method of disinfectant according to claim 1 and 2 is characterized in that: by described content and component, o-phthalaldehyde(OPA) is joined in the ethanol, mix; Add water again, stirring and dissolving; Add dodecyl dimethyl ammonium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate, corrosion inhibiter, disodium ethylene diamine tetraacetate successively, stirring and dissolving promptly gets described O-phthalaldehyde disinfectant.
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| CN 200910045997 CN101785460B (en) | 2009-01-23 | 2009-01-23 | O-phthalaldehyde disinfectant and preparation method thereof |
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| CN 200910045997 CN101785460B (en) | 2009-01-23 | 2009-01-23 | O-phthalaldehyde disinfectant and preparation method thereof |
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| CN101785460A true CN101785460A (en) | 2010-07-28 |
| CN101785460B CN101785460B (en) | 2013-12-18 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102197811A (en) * | 2011-04-12 | 2011-09-28 | 陈义平 | Compound orthophthalaldehyde disinfectant |
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103814894A (en) * | 2013-09-25 | 2014-05-28 | 陕西省蒲城美尔果农化有限责任公司 | Safety synergistic full-agent composition for pesticide containing heavy metal elements |
| CN104621104A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Disinfectant with low corrosiveness |
| CN104957134A (en) * | 2015-07-08 | 2015-10-07 | 北京中海诚达科贸有限公司 | Composite method of phthalic dicarboxaldehyde sterilizing agent for thermosensitive medical instrument |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
| CN108184825A (en) * | 2017-11-27 | 2018-06-22 | 中国船舶重工集团公司第七八研究所 | A kind of compound ortho-phthalaldehyde nano-emulsion thimerosal and preparation method thereof |
| CN115836681A (en) * | 2022-11-22 | 2023-03-24 | 利康医药科技江苏有限公司 | Phthalic dicarboxaldehyde disinfectant and preparation method thereof |
Families Citing this family (1)
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| CN112931505A (en) * | 2021-01-22 | 2021-06-11 | 海韵一剑大卫生科技有限公司 | Phthalic dicarboxaldehyde disinfectant, preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055822C (en) * | 1993-04-19 | 2000-08-30 | 李铁福 | Disinfectant |
| CN1613308A (en) * | 2004-09-24 | 2005-05-11 | 北京长江脉医药科技有限责任公司 | Antiseptics and preparation thereof |
| CN100569075C (en) * | 2004-12-31 | 2009-12-16 | 华中科技大学同济医学院 | A kind of anti-go mouldy medicament and application thereof |
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2009
- 2009-01-23 CN CN 200910045997 patent/CN101785460B/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102197811A (en) * | 2011-04-12 | 2011-09-28 | 陈义平 | Compound orthophthalaldehyde disinfectant |
| CN102197811B (en) * | 2011-04-12 | 2014-03-12 | 陈义平 | Compound orthophthalaldehyde disinfectant |
| CN103814894A (en) * | 2013-09-25 | 2014-05-28 | 陕西省蒲城美尔果农化有限责任公司 | Safety synergistic full-agent composition for pesticide containing heavy metal elements |
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103636601B (en) * | 2013-12-10 | 2015-08-05 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN104621104A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Disinfectant with low corrosiveness |
| CN104957134A (en) * | 2015-07-08 | 2015-10-07 | 北京中海诚达科贸有限公司 | Composite method of phthalic dicarboxaldehyde sterilizing agent for thermosensitive medical instrument |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
| CN108184825A (en) * | 2017-11-27 | 2018-06-22 | 中国船舶重工集团公司第七八研究所 | A kind of compound ortho-phthalaldehyde nano-emulsion thimerosal and preparation method thereof |
| CN115836681A (en) * | 2022-11-22 | 2023-03-24 | 利康医药科技江苏有限公司 | Phthalic dicarboxaldehyde disinfectant and preparation method thereof |
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| CN101785460B (en) | 2013-12-18 |
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