CN1824320A - 含有钙通道阻滞剂和b族维生素的药物组合物及其用途 - Google Patents
含有钙通道阻滞剂和b族维生素的药物组合物及其用途 Download PDFInfo
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- CN1824320A CN1824320A CNA200610000693XA CN200610000693A CN1824320A CN 1824320 A CN1824320 A CN 1824320A CN A200610000693X A CNA200610000693X A CN A200610000693XA CN 200610000693 A CN200610000693 A CN 200610000693A CN 1824320 A CN1824320 A CN 1824320A
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- folic acid
- amlodipine
- vitamin
- hypertension
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Abstract
Description
组别 | 剂量(mg/kg) | 动物数(只) | 降压幅度(mmHg) | 24h尿α1微球蛋白(ug) |
正常组模型组叶酸维生素B6维生素B12氨氯地平氨氯地平氨氯地平+叶酸氨氯地平+VitB6氨氯地平+VitB12 | 等容量等容量0.0410.10.30.50.3+0.040.3+10.3+0.1 | 12181919182020201920 | -2.1±4.0-10.5±6.3-6.9±8.6-12.0±5.1-7.3±5.215.0±5.9**20.4±10.8**23.9±6.9**▲▲17.9±4.6**20.9±3.6**▲ | 29.8±6.9102.4±31.085.5±19.696.6±27.495.3±27.578.7±20.4*68.2±26.9**54.9±20.4**▲▲60.4±17.6**▲64.8±15.8**▲ |
组别 | 剂量(mg/kg) | 动物数(只) | 降压幅度(mmHg) | 24h尿α1微球蛋白(ug) |
正常组模型组叶酸维生素B6维生素B12尼群地平尼群地平尼群地平+叶酸尼群地平+VitB6尼群地平+VitB12 | 等容量等容量0.0410.12.03.02.0+0.042.0+12.0+0.1 | 12192020181920201920 | -1.8±5.0-8.3±3.8-5.2±3.4-7.0±4.9-10.3±6.635.0±8.4**44.4±9.5**48.9±7.0**▲▲42.9±7.6**▲43.0±5.2**▲ | 14.3±6.080.9±20.365.5±13.076.9±17.373.0±14.058.7±10.6*48.2±14.6**44.9±13.6**▲▲46.4±12.2**▲▲50.8±7.6**▲ |
组别 | 剂量(mg/kg) | 动物数(只) | 降压幅度(mmHg) |
正常组模型组叶酸硝苯地平硝苯地平硝苯地平+叶酸 | 等容量等容量0.081.01.51.0+0.08 | 101515151515 | 1.8±3.21.5±3.73.5±2.825.0±7.8**33.8±6.2**32.2±5.0**▲ |
组别 | 剂量(mg/kg) | LVEDP(mmHg) | T(ms) | 左心重/体重(mg/g) |
正常组模型组叶酸马米酸左旋氨氯地平马来酸左旋氨氯地平马米酸左旋氨氯地平+叶酸 | --0.080.510.5+0.08 | 2.0±1.822.9±4.918.9±4.810.4±3.8**7.2±3.4**6.8±3.4**▲ | 4.8±0.919.8±4.017.1±3.613.0±4.6**8.8±3.5**9.5±3.7**▲ | 1.90±0.242.99±0.292.68±0.342.05±0.37**2.07±0.39**2.01±0.27** |
组别 | 剂量(mg/kg) | 数量(n) | NO(mmol/L) | ET(pg/L) |
正常组高血压组氨氯地平氨氯地平+叶酸叶酸 | --0.50.5+0.040.5+0.080.5+0.160.5+0.50.08 | 1210121111111212 | 115.4±25.851.1±17.2**64.5±13.2▲72.9±21.8▲85.0±30.3▲▲★81.5±21.3▲▲★84.9±15.4▲▲★69.2±21.1▲ | 113.8±21.9167.3±31.2**137.6±19.5▲132.4±14.1▲▲124.8±17.1▲▲★130.3±20.4▲▲122.4±17.5▲▲★149.5±22.2 |
组别 | 剂量(mg/kg) | 动物数 | α1-微球蛋白浓度(μg/ml) | 24h尿量(ml) | 24hα1-微球蛋白(μg) |
正常组高血压组氨氯地平氨+叶酸叶酸 | --0.50.5+0.040.5+0.080.5+0.160.5+0.50.08 | 1210121111111212 | 0.42±0.271.87±0.79**1.16±0.46▲▲0.83±0.23▲▲★0.81±0.45▲▲★0.94±0.54▲▲0.88±0.77▲▲1.49±0.71 | 20.6±7.523.8±6.423.3±4.323.7±5.121.7±7.920.9±8.822.3±6.323.8±9.0 | 7.4±3.742.0±14.3**26.0±9.0▲▲19.3±5.9▲▲★15.1±6.0▲▲★★16.2±5.6▲▲★★18.1±6.7▲▲★32.3±9.8▲ |
组别 | 剂量(mg/kg) | 动物数 | 尿蛋白浓度(μg/ml) | 24h尿量(ml) | 尿蛋白(mg) |
正常组高血压组氨氯地平氨+叶酸叶酸 | --0.50.5+0.040.5+0.080.5+0.160.5+0.50.08 | 1210121111111212 | 396.6±145.41587.5±358.1**1226.9±294.3▲▲1188.2±299.3▲▲921.3±212.6▲▲★★938.0±354.7▲▲1002.9±274.0▲▲1593.9±398.3 | 17.6±4.219.0±3.018.8±4.217.3±5.016.4±4.317.8±4.219.6±3.818.2±4.6 | 7.1±3.430.2±7.9**22.6±6.3▲19.9±5.4▲▲15.1±5.0▲▲★★16.3±6.1▲▲★★17.6±5.2▲▲28.4±9.0 |
组别 | 剂量(mg/kg) | 动物数 | Scr(μmol/L) | 24h尿肌酐(mmol) | Ccr(ml/min) | BUN(mmol/L) |
正常组高血压组氨氯地平氨+叶酸叶酸 | --0.50.5+0.040.5+0.080.5+0.160.5+0.50.08 | 1210111111111212 | 92.8±10.799.3±24.689.1±10.191.0±27.186.0±17.793.4±13.498.1±9.494.4±19.4 | 49.0±16.615.4±4.528.9±7.034.1±9.537.3±12.339.9±4.520.6±7.322.7±9.7 | 0.364±0.1100.121±0.033**0.226±0.049▲▲0.270±0.068▲▲0.297±0.071▲▲★0.301±0.052▲▲★★0.315±0.080▲▲★0.166±0.052 | 7.28±0.797.74±0.467.21±0.307.65±0.447.10±0.217.01±0.337.30±0.917.36±0.46 |
组别 | LVSP(mmHg) | LVEDP(mmHg) | +dp/dtmax(×103,mmHg/s) | -dp/dtmax(×103,mmHg/s) |
正常组高血压组0.5+0.040.5+0.080.5+0.160.5+0.5氨0.5叶酸0.08 | 129.6±12.6183.2±22.4**144.3±15.5▲▲133.8±8.9▲▲★136.7±15.8▲▲★138.9±16.4▲▲148.7±9.5▲▲176.4±16.0 | -0.92±4.139.6±22.2**16.3±4.8▲▲★15.8±4.7▲▲★13.1±5.0▲▲★★11.6±10.7▲▲★21.7±4.8▲▲32.4±24.2 | 12.4±3.06.3±1.6**9.6±2.6▲▲11.1±2.8▲▲★10.5±2.0▲▲★11.9±2.1▲★8.5±1.7▲▲7.1±2.0 | 15.1±4.34.9±1.1**7.6±1.1▲▲★7.3±1.3▲▲7.2±1.9▲▲6.8±1.3▲▲6.4±1.2▲▲5.1±1.6 |
实验分组 | 动物数 | 病变组织 | 各组病理程度及动物数 | |||
病变显著 | 病变轻度 | 病变不明显 | ||||
正常组 | 12 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 100011 | 100012 | 10121212109 |
高血压组 | 10 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 877865 | 223243 | 010002 |
氨氯地平(0.5mg/kg) | 12 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 633533 | 447553 | 252246 |
氨氯地平+叶酸 | 11 | 心 | 心肌细胞肥大 | 2 | 8 | 1 |
组(0.5+0.04mg/kg) | 肾脾脑 | 心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 14521 | 55554 | 52146 | |
氨氯地平+叶酸组(0.5+0.08mg/kg) | 11 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 234322 | 543535 | 444364 |
氨氯地平+叶酸组(0.5+0.16mg/kg) | 11 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 113331 | 545446 | 563444 |
氨氯地平+叶酸组(0.5+0.5mg/kg) | 12 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 323442 | 545344 | 464546 |
叶酸组(0.08mg/kg) | 12 | 心肾脾脑 | 心肌细胞肥大心冠状动脉硬化肾小球萎缩或肥大肾细小动脉硬化间质纤维化中央动脉硬化小动脉硬化微血管增生 | 758665 | 362454 | 212213 |
组别 | 剂量(mg/kg) | 动物数 | 观察样本数 | 病变显著数 | 病变轻度数 | 病变不明显数 |
正常组高血压氨氯地平氨+叶酸叶酸 | --0.50.5+0.040.5+0.080.5+0.160.5+0.50.08 | 1210121111111212 | 7260726666667272 | 341231516121837 | 416283225282524 | 653211925262911 |
组别 | 剂量(mg/kg) | 数量(n) | NO(mmol/L) | ET(pg/L) |
正常组模型组氨氯地平+叶酸硝苯地平+叶酸尼群地平+叶酸非洛地平+叶酸地尔硫卓+叶酸 | --0.5+0.083+0.083+0.081+0.086+0.08 | 16131515131412 | 138.8±38.257.7±18.4**105.4±20.3▲▲74.5±13.2▲★82.9±21.8▲★86.0±19.7▲▲68.8±14.1▲★★ | 234.6±42.7366.8±65.5**216.5±57.4▲▲288.2±76.6▲★253.3±64.5▲▲234.8±47.1▲▲309.5±62.9★★ |
组别 | 剂量(/kg) | N | SOD(NkU/L) | MDA(umol/L) | 血小板聚集率(%) | |
最大聚集率 | 平均聚集率 | |||||
正常组模型组氨氯地平+叶酸硝苯地平+叶酸尼群地平+叶酸非洛地平+叶酸地尔硫卓+叶酸 | --0.5+0.083+0.083+0.081+0.086+0.08 | 16131515131412 | 201.3±46.4113.4±30.5**174.6±34.3▲▲138.8±26.8▲★154.3±31.2▲▲150.2±19.7▲▲★135.8±35.6★ | 0.46±0.102.56±0.52**1.25±0.42▲▲1.64±0.41▲▲★1.72±0.53▲▲★1.62±0.48▲▲★1.85±0.69▲★ | 13.2±3.135.3±5.3**24.5±4.9▲▲33.2±6.7★★30.5±5.8▲▲★28.4±8.4▲▲30.6±5.6★★ | 6.2±3.127.3±4.6**16.5±5.6▲▲22.4±6.6★★23.9±6.6★★18.3±5.5▲▲22.1±7.9 |
组别 | 剂量(mg/kg) | 动物数 | 尿蛋白(mg) | Ccr(ml/min) | 24hα1-微球蛋白(μg) |
正常组模型组氨氯地平+叶酸硝苯地平+叶酸尼群地平+叶酸非洛地平+叶酸地尔硫卓+叶酸 | --0.5+0.083+0.083+0.081+0.086+0.08 | 16131515131412 | 14.3±6.8106.8±37.4**49.6±10.7▲▲82.8±20.2▲★★69.9±16.9▲▲★★65.9±12.6▲▲★68.6±21.4▲▲★ | 0.454±0.1130.218±0.045**0.412±0.033▲▲0.283±0.056▲▲★0.338±0.077▲▲★0.347±0.110▲▲0.316±0.064▲▲★ | 20.8±10.4103.6±41.4**47.3±20.1▲▲70.3±24.9▲★69.3±15.4▲▲★65.1±18.8▲▲★80.5±24.5★★ |
组别 | LVSP(mmHg) | LVEDP(mmHg) | +dp/dtmax(×103,mmHg/s) | -dp/dtmax(×103,mmHg/s) |
正常组模型组氨氯地平+叶酸硝苯地平+叶酸尼群地平+叶酸非洛地平+叶酸地尔硫卓+叶酸 | 133.4±21.5213.3±26.4**140.6±18.7▲▲164.6±17.9▲▲★★156.7±15.8▲▲★158.9±26.4▲▲168.7±30.6▲▲★★ | -3.23±6.754.8±21.0**22.7±6.8▲▲30.4±7.5▲▲★★33.1±10.0▲▲★★30.6±10.7▲▲★41.7±4.8★★ | 14.8±3.95.4±2.9**12.5±4.8▲▲7.5±2.4▲★8.8±3.3▲▲★10.9±3.6▲▲6.8±2.7★★ | 16.1±2.96.6±2.112.2±3.2▲▲8.7±2.4▲▲★★8.2±2.6▲▲★★9.0±2.3▲▲★★5.4±3.2★★ |
组别 | 剂量(mg/kg) | 动物数 | 观察样本数 | 病变显著数 | 病变轻度数 | 病变不明显数 |
正常组模型组氨氯地平+叶酸硝苯地平+叶酸尼群地平+叶酸非洛地平+叶酸地尔硫卓+叶酸 | --0.5+0.083+0.083+0.081+0.086+0.08 | 16131515131412 | 96789090788472 | 3602748403643 | 6133030223320 | 875331216159 |
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CN110882249A (zh) * | 2019-11-08 | 2020-03-17 | 北京吾为尔创科技有限公司 | 含苯磺酸左氨氯地平水合物的组合物及其制备方法 |
CN110882249B (zh) * | 2019-11-08 | 2021-04-30 | 北京吾为尔创科技有限公司 | 含苯磺酸左氨氯地平水合物的组合物及其制备方法 |
WO2021088672A1 (zh) * | 2019-11-08 | 2021-05-14 | 施慧达药业集团(吉林)有限公司 | 含苯磺酸左氨氯地平水合物的组合物及其制备方法 |
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