CN1824078A - 一种青柏洁身泡藤颗粒制剂 - Google Patents
一种青柏洁身泡藤颗粒制剂 Download PDFInfo
- Publication number
- CN1824078A CN1824078A CN 200510135339 CN200510135339A CN1824078A CN 1824078 A CN1824078 A CN 1824078A CN 200510135339 CN200510135339 CN 200510135339 CN 200510135339 A CN200510135339 A CN 200510135339A CN 1824078 A CN1824078 A CN 1824078A
- Authority
- CN
- China
- Prior art keywords
- dry extract
- lactose
- ethanol
- granular preparation
- disintegrating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 20
- 239000002245 particle Substances 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims description 35
- 241000902900 cellular organisms Species 0.000 title claims description 4
- 239000003814 drug Substances 0.000 claims abstract description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 62
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 48
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 28
- 239000008187 granular material Substances 0.000 claims description 28
- 239000000284 extract Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 18
- 239000008101 lactose Substances 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 235000015165 citric acid Nutrition 0.000 claims description 16
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 14
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000007779 soft material Substances 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 238000007908 dry granulation Methods 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 241000345998 Calamus manan Species 0.000 claims 8
- 235000012950 rattan cane Nutrition 0.000 claims 8
- 239000000463 material Substances 0.000 abstract description 3
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 244000089698 Zanthoxylum simulans Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 239000006210 lotion Substances 0.000 description 9
- 206010013786 Dry skin Diseases 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 239000013543 active substance Substances 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001033 granulometry Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
干浸膏粉 | 400 | 400 | 400 | 400 | 400 | 400 | 400 | 400 | 400 | 400 |
乳糖 | 460 | 420 | 380 | 340 | 300 | 460 | 420 | 380 | 340 | 300 |
枸橼酸 | 70 | 90 | 110 | 130 | 150 | |||||
酒石酸 | 70 | 90 | 110 | 130 | 150 | |||||
碳酸氢钠 | 70 | 90 | 110 | 130 | 150 | 70 | 90 | 110 | 130 | 150 |
乙醇(ml) | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 | 220 |
六 | 37.2° | 4.8 | 9.7 |
七 | 33.6° | 3.5 | 6.0 |
八 | 35.3° | 3.1 | 8.2 |
九 | 34.7° | 2.7 | 7.5 |
十 | 33.1° | 1.9 | 6.4 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005101353393A CN100411657C (zh) | 2005-12-30 | 2005-12-30 | 一种青柏洁身泡藤颗粒制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005101353393A CN100411657C (zh) | 2005-12-30 | 2005-12-30 | 一种青柏洁身泡藤颗粒制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1824078A true CN1824078A (zh) | 2006-08-30 |
CN100411657C CN100411657C (zh) | 2008-08-20 |
Family
ID=36935019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005101353393A Expired - Fee Related CN100411657C (zh) | 2005-12-30 | 2005-12-30 | 一种青柏洁身泡藤颗粒制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100411657C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100417409C (zh) * | 2006-12-28 | 2008-09-10 | 西安仁仁药业有限公司 | 治疗妇女生殖***炎症的中药外用洗剂 |
CN102793828A (zh) * | 2012-08-09 | 2012-11-28 | 西安太极药业有限公司 | 一种治疗女性外阴炎和***炎的外用洗液及其制备方法 |
CN102961556A (zh) * | 2011-08-31 | 2013-03-13 | 肖凡 | 防治妇科炎症的外用洗液 |
-
2005
- 2005-12-30 CN CNB2005101353393A patent/CN100411657C/zh not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100417409C (zh) * | 2006-12-28 | 2008-09-10 | 西安仁仁药业有限公司 | 治疗妇女生殖***炎症的中药外用洗剂 |
CN102961556A (zh) * | 2011-08-31 | 2013-03-13 | 肖凡 | 防治妇科炎症的外用洗液 |
CN102961556B (zh) * | 2011-08-31 | 2014-01-29 | 肖凡 | 防治妇科炎症的外用洗液 |
CN102793828A (zh) * | 2012-08-09 | 2012-11-28 | 西安太极药业有限公司 | 一种治疗女性外阴炎和***炎的外用洗液及其制备方法 |
CN102793828B (zh) * | 2012-08-09 | 2014-04-16 | 西安太极药业有限公司 | 一种治疗女性外阴炎和***炎的外用洗液及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100411657C (zh) | 2008-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1824078A (zh) | 一种青柏洁身泡藤颗粒制剂 | |
CN1226033C (zh) | 一种中药浓缩丸的制备方法 | |
CN1895462A (zh) | 一种治疗***炎的男康软胶囊 | |
CN1813936A (zh) | 小儿热速清泡腾片及其制备方法 | |
CN1698851A (zh) | 香砂养胃分散片及其制备方法 | |
CN1857650A (zh) | 一种清热解毒,软坚散结,活血化瘀,行气止痛的中药复方制剂及其制备方法 | |
CN1813860A (zh) | 一种脑心清分散片及其制备工艺 | |
CN1895398A (zh) | 一种小儿清热止咳泡腾颗粒的生产方法 | |
CN1505523A (zh) | 造粒物和锭剂的制造方法 | |
CN100350897C (zh) | 中药双相硬胶囊 | |
CN104857305B (zh) | 一种胃康灵微丸及其制备方法和应用 | |
CN100341489C (zh) | 一种具有补肾壮骨作用的仙灵骨葆滴丸及其制备方法 | |
CN1233401C (zh) | 藿香正气胶囊及其制备方法 | |
CN1268324C (zh) | 一种中药软胶囊制剂及其制备工艺 | |
CN1067256C (zh) | 一种浓缩中药制剂及其制法 | |
CN1368292A (zh) | 纳米温中止泻制剂药物及其制备方法 | |
CN1931337A (zh) | 金刚藤微丸及其制备方法 | |
CN1931250A (zh) | 妇乐丸微丸及其制备方法 | |
CN1850196A (zh) | 一种排毒养颜颗粒及其制备方法 | |
CN103494894A (zh) | 一种具有降低血糖功效的中药组合物及其制备方法和应用 | |
CN1695713A (zh) | 一种治疗糖尿病的药物及其制备方法 | |
CN1368151A (zh) | 纳米海龙蛤蚧制剂药物及其制备方法 | |
CN1814071A (zh) | 一种障眼明胶囊及其制备工艺 | |
CN1569178A (zh) | 一种治疗妇科炎症的中药口服制剂及其制备方法 | |
CN1857576A (zh) | 银丹心脑通药物制剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: JIUQUAN DADELI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HAN BO Effective date: 20090612 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090612 Address after: No. 6, deli Road, hi tech Industrial Park, Jiuquan, China Patentee after: Jiuquan great profit Pharmaceutical Co., Ltd. Address before: Room 1708G, Qingyun contemporary building, No. 43 West Third Ring Road, Beijing, Haidian District Patentee before: Han Bo |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080820 Termination date: 20141230 |
|
EXPY | Termination of patent right or utility model |