CN1781516A - 制备大叶蒟提取物的方法、提取物及其应用 - Google Patents
制备大叶蒟提取物的方法、提取物及其应用 Download PDFInfo
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- CN1781516A CN1781516A CNA2004100847917A CN200410084791A CN1781516A CN 1781516 A CN1781516 A CN 1781516A CN A2004100847917 A CNA2004100847917 A CN A2004100847917A CN 200410084791 A CN200410084791 A CN 200410084791A CN 1781516 A CN1781516 A CN 1781516A
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- China
- Prior art keywords
- extract
- piper laetispicum
- piper
- laetispicum
- percolation
- Prior art date
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- 239000000284 extract Substances 0.000 title claims abstract description 75
- 241000746610 Piper laetispicum Species 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims abstract description 35
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- 238000005325 percolation Methods 0.000 claims description 22
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 20
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- 239000000287 crude extract Substances 0.000 claims description 12
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
样品号 | 药材 | 前处理方式 | 有机溶剂 | 提取方式 | 精制方式 |
1 | 根、根茎 | 切制 | 乙醇 | 渗漉 | 大孔树脂 |
2 | 根、根茎 | 切制 | 乙醇 | 渗漉 | 大孔树脂 |
3 | 藤茎、叶 | 打粉 | 乙醇 | 渗漉 | 醇提水沉法 |
4 | 全草 | 切制 | 酸水 | 浸渍 | 酸提碱沉法 |
5 | 根、根茎 | 切制 | 甲醇 | 渗漉 | - |
6 | 根、藤茎 | 打粉 | *** | 浸渍 | 聚酰胺柱 |
7 | 根、根茎 | 切制 | 氯仿 | 渗漉 | 离子交换 |
8 | 根、藤茎 | 打粉 | 氯仿 | 渗漉 | - |
9 | 全草 | 打粉 | 乙酸乙酯 | 渗漉 | 大孔树脂 |
10 | 根 | 切制 | 碱水 | 浸渍 | 有机溶剂提取 |
11 | 根、根茎 | 打粉 | 乙醇 | 回流 | 大孔树脂 |
12 | 全草 | 切制 | 超临界流体萃取 |
药物* | 剂量(mg/kg/d) | n | 累计不动时间(s)X±SE |
CK- | - | 10 | 83.94±6.89 |
CK+ | 20 | 10 | 21.87±4.56** |
1 | 10 | 10 | 18.76±2.41** |
1 | 20 | 10 | 28.45±4.43** |
1 | 40 | 10 | 11.98±3.12** |
5 | 40 | 10 | 36.32±6.54** |
11 | 10 | 10 | 92.73±3.07 |
11 | 20 | 10 | 37.07±12.53* |
11 | 40 | 10 | 51.66±6.74* |
4 | 40 | 10 | 33.52±3.63** |
药物* | 剂量(mg/kg) | n | 累计电击数X±SE |
CK- | - | 8 | 4.80±1.63 |
CK+ | 1 | 8 | 12.78±2.05** |
2 | 100 | 8 | 8.64±2.14* |
2 | 50 | 8 | 7.43±1.32* |
3 | 100 | 8 | 7.56±2.12 |
8 | 100 | 8 | 6.87±1.69 |
11 | 100 | 8 | 5.98±1.05 |
6 | 100 | 8 | 8.05±2.11* |
药物* | 剂量(mg/kg) | n | 累计爬格子数X±SE |
CK- | - | 8 | 167.38±8.70 |
CK+ | 100 | 8 | 136.43±6.86* |
1 | 100 | 8 | 133.87±9.41* |
1 | 50 | 8 | 154.74±10.23 |
7 | 100 | 8 | 149.78±9.61 |
11 | 100 | 8 | 151.33±5.72 |
9 | 100 | 8 | 157.31±9.22 |
药物* | 剂量(mg/kg) | n | 累计扭体次数X±SE |
CK- | - | 8 | 29.25±2.62 |
CK+ | 50 | 8 | 9.89±1.09** |
2 | 100 | 8 | 10.34±1.44** |
2 | 50 | 8 | 14.25±2.47* |
10 | 100 | 8 | 16.25±0.90* |
11 | 100 | 8 | 20.97±1.23 |
12 | 100 | 8 | 19.13±2.82* |
Claims (10)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100847917A CN100356940C (zh) | 2004-12-01 | 2004-12-01 | 制备大叶蒟提取物的方法、提取物及其应用 |
KR1020077012090A KR20070085519A (ko) | 2004-12-01 | 2005-11-28 | 대엽구약 추출물을 제조하는 방법, 추출물 및 그 용도 |
CA2589013A CA2589013C (en) | 2004-12-01 | 2005-11-28 | Method to prepare piper laetispicum c.dc. extract, the extract and the application thereof |
PCT/CN2005/002034 WO2006058487A1 (fr) | 2004-12-01 | 2005-11-28 | Extrait de piper laetispicum c.dc., procédé d'élaboration et applications |
US11/720,616 US8062678B2 (en) | 2004-12-01 | 2005-11-28 | Extractive of Piper laetispicum C.DC., its process and its uses |
RU2007120255/15A RU2385160C2 (ru) | 2004-12-01 | 2005-11-28 | ЭКСТРАКТ Piper Laetispicum C.DC., СПОСОБ ЕГО ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ |
EP05813062A EP1829582B1 (en) | 2004-12-01 | 2005-11-28 | An extract of piper laetispicum c.dc., its method for preparation and its uses |
JP2007543681A JP2008521839A (ja) | 2004-12-01 | 2005-11-28 | 大葉(叶)蒟抽出物の調製方法、抽出物及びその応用 |
HK07111709.2A HK1107038A1 (en) | 2004-12-01 | 2007-10-30 | An extract of piper laetispicum c.dc., its method for preparation and its uses |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100847917A CN100356940C (zh) | 2004-12-01 | 2004-12-01 | 制备大叶蒟提取物的方法、提取物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1781516A true CN1781516A (zh) | 2006-06-07 |
CN100356940C CN100356940C (zh) | 2007-12-26 |
Family
ID=36564755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100847917A Active CN100356940C (zh) | 2004-12-01 | 2004-12-01 | 制备大叶蒟提取物的方法、提取物及其应用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8062678B2 (zh) |
EP (1) | EP1829582B1 (zh) |
JP (1) | JP2008521839A (zh) |
KR (1) | KR20070085519A (zh) |
CN (1) | CN100356940C (zh) |
CA (1) | CA2589013C (zh) |
HK (1) | HK1107038A1 (zh) |
RU (1) | RU2385160C2 (zh) |
WO (1) | WO2006058487A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102429962A (zh) * | 2010-09-29 | 2012-05-02 | 王全福 | 大叶蒟提取物的制备方法、提取物及其应用 |
CN102475746A (zh) * | 2010-11-23 | 2012-05-30 | 天津天士力制药股份有限公司 | 大叶蒟有效组分的制备方法 |
CN107759710A (zh) * | 2017-09-19 | 2018-03-06 | 广东中烟工业有限责任公司 | 大叶白麻提取物的制备方法及其在烟草方面的应用 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012165888A2 (ko) * | 2011-05-31 | 2012-12-06 | 씨제이제일제당(주) | 파이퍼 레트로프락텀 열매추출물을 유효성분으로 포함하는 항비만, 항당뇨 및 근육량 증대및 운동력 향상용 조성물 |
CN103063789B (zh) * | 2011-10-19 | 2016-06-08 | 天士力制药集团股份有限公司 | 同时检测大叶蒟中12个酰胺类生物碱的液相分析方法 |
EP2767174B2 (de) | 2013-02-16 | 2020-07-01 | Symrise AG | Orale Zubereitungen |
CN113209165A (zh) * | 2017-11-01 | 2021-08-06 | 苏州颐华生物医药技术股份有限公司 | 一种大叶蒟提取物及其制备方法与应用 |
US11485725B2 (en) | 2017-12-15 | 2022-11-01 | Auransa Inc. | Derivatives of piperlongumine and uses thereof |
CN115006314B (zh) * | 2022-07-11 | 2023-07-11 | 科乐美(广州)生物科技有限公司 | 一种卡瓦胡椒提取物及其制备方法和应用 |
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CN1137702C (zh) | 2000-07-14 | 2004-02-11 | 复旦大学 | 中草药大叶蒟乙酸乙酯抽提物在制备精神类药物中的应用 |
CN1389462A (zh) * | 2002-07-12 | 2003-01-08 | 复旦大学 | 大叶蒟素及其同系物,和在制备药物组合物中的应用 |
CN100436407C (zh) * | 2003-03-20 | 2008-11-26 | 蒋毅 | 大叶蒟有效部位的制备及其在医疗、保健领域的应用 |
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2004
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- 2005-11-28 EP EP05813062A patent/EP1829582B1/en active Active
- 2005-11-28 KR KR1020077012090A patent/KR20070085519A/ko active Search and Examination
- 2005-11-28 RU RU2007120255/15A patent/RU2385160C2/ru active
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102429962A (zh) * | 2010-09-29 | 2012-05-02 | 王全福 | 大叶蒟提取物的制备方法、提取物及其应用 |
CN102475746A (zh) * | 2010-11-23 | 2012-05-30 | 天津天士力制药股份有限公司 | 大叶蒟有效组分的制备方法 |
CN102475746B (zh) * | 2010-11-23 | 2015-05-06 | 天士力制药集团股份有限公司 | 大叶蒟有效组分的制备方法 |
CN107759710A (zh) * | 2017-09-19 | 2018-03-06 | 广东中烟工业有限责任公司 | 大叶白麻提取物的制备方法及其在烟草方面的应用 |
CN107759710B (zh) * | 2017-09-19 | 2020-05-29 | 广东中烟工业有限责任公司 | 大叶白麻提取物的制备方法及其在烟草方面的应用 |
Also Published As
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HK1107038A1 (en) | 2008-03-28 |
EP1829582A4 (en) | 2009-07-29 |
RU2007120255A (ru) | 2009-01-10 |
KR20070085519A (ko) | 2007-08-27 |
CA2589013C (en) | 2016-12-13 |
US20090297642A1 (en) | 2009-12-03 |
WO2006058487A1 (fr) | 2006-06-08 |
JP2008521839A (ja) | 2008-06-26 |
CN100356940C (zh) | 2007-12-26 |
CA2589013A1 (en) | 2006-06-08 |
EP1829582A1 (en) | 2007-09-05 |
US8062678B2 (en) | 2011-11-22 |
RU2385160C2 (ru) | 2010-03-27 |
EP1829582B1 (en) | 2012-10-17 |
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