CN1762380A - Nano selenium product and its preparation method - Google Patents
Nano selenium product and its preparation method Download PDFInfo
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- CN1762380A CN1762380A CN 200510104257 CN200510104257A CN1762380A CN 1762380 A CN1762380 A CN 1762380A CN 200510104257 CN200510104257 CN 200510104257 CN 200510104257 A CN200510104257 A CN 200510104257A CN 1762380 A CN1762380 A CN 1762380A
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Abstract
The invention relates to a nano selenium product and its preparing process, wherein the constituents include (based on mass portion, in each 100 portions of the solvent), nano selenium 0.003-0.008, vitamin C 0.5-2.0, vitamin E 6-16, and starch is used as the solvent.
Description
One, technical field
The present invention relates to a kind of nano selenium product and preparation method thereof, belong to nano selenium product and preparation method thereof technical field.
Two, background technology
Selenium is micro elements needed by human; it also is the important anticancer factor; be the active center composition that glutathion peroxidase, phospholipid hydroperoxide glutathione peroxidase, I type 5 ' take off enzyme such as iodine enzyme, have the important function of aspects such as removing free radical, prophylaxis of cancer, face nourishing antidebilitation, the liver protecting, opposing harmful heavy metal, radioprotective, immunomodulating.
Selenium is one of essential trace element in human life activity center, has multiple biological function:
1, selenium is the important composition composition of glutathion, its anti-radical action be vitamin E and ascorbic 300-500 doubly.Selenium can make virose peroxide be reduced to harmless material, makes peroxide breakdown, removes free radical, and protection cell mechanism and function are repaired the molecule damage location, enhancing human body immunity power.
2, selenium can promote multiple metabolic activity in the body.
3, selenium can promote the propagation and the lethal effect of T cell and neutrophilic granulocyte, promotes the synthetic and antibody of immunoglobulin to generate, and strengthens human virus's ability, suppresses complement activation, alleviates the immunologic injury that immune complex causes.Can also suppress the HIV (human immunodeficiency virus) activation, prevent apoptosis.
4, selenium is the normal composition of muscle, and scarce selenium can make skeletal muscle atrophy and be the canescence striped, and it is impaired that cardiac muscle takes place, and myocardial cell compactness changes, and lipid increases, and calcium deposition causes Keshan disease.
5, the selenium decapacitation prevents and treats outside Keshan disease, the Kaschin-Beck disease, can also antiviral, antiallergic, defying age, preventing from heavy metal poison (cadmium, hydrargyrum etc.), aspergillus flavus resisting toxin B1 and carcinogenesis such as benzanthracene, nitrosamine and the toxic and side effects that alleviates radiotherapy, chemotherapy.
6, selenium can be protected endotheliocyte, alleviates vascular remodeling, improves vascular function, brings high blood pressure down, and reduces the hypercoagulability that whole blood viscosity and platelet aggregation cause, microcirculation improvement reduces hypertension, evidence of coronary heart diseases and mortality rate.
When 7, suffering from systemic inflammatory response syndrome (SIRS) and multiple organs dysfunction syndrome (MOFS), selenium supplement can make the GSH-P activity increase, and suppresses cytokine and inflammatory mediator to histiocytic injury effect, improves symptom, reduces case fatality rate.
8, in various nutrients with immunoloregulation function effect, selenium is the nutrient that unique and viral infection have direct relation.
9, the light perception device makes photon conversion become the transformation process of the signal of telecommunication in the selenium participation eye.Thereby vision enhancing is prevented and treated oculopathy.
Selenium has remarkable effect to treatment hepatitis, arthritis, cataract, cardiovascular disease, lupus erythematosus, hemorrhagic fever, and selenium has tangible auxiliary treatment effect to the chemicotherapy of tumour patient.
But common selenium preparation has than mcroorganism toxicity, not too is suitable for clinical use.
A selenic marked feature is that scope is narrower between its nutrition dosage and the toxicity dose, therefore, develops the efficient selenium product of low toxicity, enjoys the attention of countries in the world.Compare with inorganic selenium, it is higher that the absorbing of organic selenium is worth, and acute toxicity is less, is considered to selenium product preferably, and organic selenium has replaced inorganic selenium gradually and has been used widely.But the efficient feature of the low toxicity of organic selenium has very strong advantage unlike inorganic selenium, even both subchronic toxicity dosage are approaching.
Traditional selenides shows stronger toxicity when human body is taken, biological effect can not reach people's expected effect.
Three, summary of the invention
The object of the present invention is to provide a kind of low toxicity health food efficiently---nano selenium product and preparation method thereof.
The objective of the invention is to be achieved through the following technical solutions: a kind of nano selenium product, special character is that its component includes solvent, nanometer selenium, vitamin C, vitamin E, according to the mass parts meter, join 0.003-0.008 part nanometer selenium, 0.5-2.0 part vitamin C, 6-16 part vitamin E in per 100 parts of solvents;
Further component solutions is, according to the mass parts meter, joins 0.004-0.007 part nanometer selenium, 0.7-1.8 part vitamin C, 8-14 part vitamin E in per 100 parts of solvents;
Further component solutions is according to the mass parts meter, to join 0.005-0.006 part nanometer selenium, 1.0-1.5 part vitamin C, 10-12 part vitamin E in per 100 parts of solvents again;
Solvent of the present invention is a starch; Vitamin C is a kind of antioxidant with antitumaous effect, and vitamin E has very strong antioxidation;
Nanometer selenium of the present invention is a red nano albumen selenium, with nanometer technology of preparing and bioseparation technology, sodium selenite is prepared into red nano albumen selenium in the ovalbumin system.
The preparation method of a kind of nano selenium product of the present invention, its special character be,
1, mass parts is as requested got each component, with spray gun liquid nanometer selenium is sprayed in the solvent starch, stirs while spraying, and has sprayed the back and continue to have stirred 10-30 minute, crosses 60 mesh sieves 2 times, guarantees its uniformity, puts 50 ℃ of oven dry in the baking oven, after 60 mesh sieves 1 time;
2, vitamin C, vitamin E are crossed 60 mesh sieves, with the mixture of above-mentioned solvent starch and nanometer selenium through 30 minutes mix homogeneously of three-dimensional mixer, obtain nano selenium product;
In order to reach the sterilization process requirement, the preparation method of nano selenium product of the present invention also increases following operation,
3, with above single-size, layering is inserted in the 1250MHz composited waveguide microwave machine, sterilizes 3-6 minute, takes out, and puts clean area material intermediate station, is up to the standards.
Nano selenium product of the present invention has not only possessed all health care and the treatment function of selenium to human body, and selenic particle diameter has reached below 100 nanometers, activity is very high, be easier to absorption of human body, accurate measurement, lowered the toxic and side effects of selenium, can more significantly improve the immune indexes of organism and significantly delay biological decay, made heavy dose of nanometer selenium treatment and prophylaxis of cancer used become possibility human body.
Carry out intensive research by structure and biological property to nanometer selenium, result of study explanation is compared with other form selenium, and nanometer selenium has the efficient advantage of stronger low toxicity, many index occupy current academic report.Aspect acute toxicity (LD50), inorganic selenium are 15mg/kg, and organic selenium is 30～40mg/kg, and nanometer selenium then is 113mg/kg.Aspect the slow toxicity in Asia, the content of inorganic selenium or organic selenium can cause rat body weight to descend and liver cirrhosis when 4～5ppm in the feedstuff; If nanometer selenium, above-mentioned phenomenon does not take place in Se content yet when 6ppm.Illustrate that thus nanometer selenium compares with organic selenium or inorganic selenium, toxicity obviously descends.Aspect biological effect, the external removing hydroxy radical of nanometer selenium efficient is 5 times of inorganic selenium, is 2.5 times of organic selenium.Nanometer selenium is promptly demonstrating under low dosage very and is suppressing tumor and immunomodulating health-care effect, and the inorganic selenium of corresponding low dosage there is no effect, the health-care effect of the nanometer selenium sensitive characteristics that shows abnormality.These low toxicities are characteristic efficiently, proves that once more nanoparticle character promptly is different from than its more atom, the molecule of microcosmic, also is different from than its macroscopic powder, block, but has unique character.
The present invention is a kind of little low toxicity of clinical good effect, side effect health food--selenium preparation efficiently that can be used in.Under identical dosage, nanometer selenium can more significantly improve the immune indexes of organism and significantly delay biological decay, and heavy dose of nanometer selenium of using makes prophylaxis of cancer become possibility.Because nanometer selenium is the small unit that several ten thousand selenium compounds form, thereby its antioxidation, to remove the free radical ability stronger, can better suppress the generation of the disease that causes because of radical damage.
Nano selenium product of the present invention has prophylaxis of cancer, slow down aging, immunomodulating, liver-protective health-care effect; Hepatitis, arthritis, cardiovascular disease there are good therapeutical effect, chemotherapy of tumors is also had the auxiliary treatment effect.
Four, the specific embodiment
With specific embodiment explanation the technology of the present invention solution, the present invention is not limited to embodiment below.
Embodiment 1: a kind of nano selenium product of present embodiment, and its component includes solvent, nanometer selenium, vitamin C, vitamin E, according to the mass parts meter, joins 0.003 part of nanometer selenium, 0.5 part of vitamin C, 6 parts of vitamin Es in per 100 parts of solvents;
The solvent of a kind of nano selenium product of present embodiment is a starch; Vitamin C is a kind of antioxidant with antitumaous effect, vitamin C can be blocked the formation of carcinogen nitrosamine, and the effect that suppresses tumor is arranged, and vitamin C also has good antioxidation, can suppress some chemical substance and be oxidized to carcinogen, can block carcinogenic activation; Vitamin E has very strong antioxidation, can prevent fatty compound, vitamin A, selenium, two kinds of sulfur aminoacid and ascorbic Oxidation; Therefore, vitamin C and vitamin E can have the effect of cooperation with active selenium at anticancer aspect, but when preserving the selenic stability of enhanced activity, in addition, vitamin C, vitamin E can promote selenic drainage, make itself with regard to low toxicity efficiently nanometer selenium be free from side effects.
Nanometer selenium is a red nano albumen selenium, with nanometer technology of preparing and bioseparation technology, in the ovalbumin system sodium selenite is prepared into red nano albumen selenium, and this red nano albumen selenium can be from buying ready-made product on the market;
The efficient sodium rice of the low toxicity of present embodiment selenium product has not only possessed all health care and the treatment function of selenium to human body, and lowered the toxic and side effects of selenium to human body, can more significantly improve the immune indexes of organism and significantly delay biological decay, make heavy dose of nanometer selenium treatment and prophylaxis of cancer used become possibility.
The preparation method of a kind of nano selenium product of present embodiment is:
1, mass parts is as requested got each component, with spray gun liquid nanometer selenium is sprayed in the solvent starch, stirs while spraying, and has sprayed the back and continue to have stirred 20 minutes, crosses 60 mesh sieves 2 times, guarantees its uniformity, puts 50 ℃ of oven dry in the baking oven, after 60 mesh sieves 1 time;
2, vitamin C, vitamin E are crossed 60 mesh sieves, with the mixture of above-mentioned solvent starch and nanometer selenium through 30 minutes mix homogeneously of three-dimensional mixer;
3, with above single-size, layering is inserted in the 1250MHz composited waveguide microwave machine, sterilizes 3-6 minute, takes out, and puts clean area material intermediate station, is up to the standards.
Embodiment 2: a kind of nano selenium product of present embodiment and preparation method thereof is with the difference of embodiment 1,
According to the mass parts meter, join 0.008 part of nanometer selenium, 2.0 parts of vitamin Cs, 16 parts of vitamin Es in per 100 parts of solvents in its component.
Embodiment 3: a kind of nano selenium product of present embodiment and preparation method thereof is with the difference of embodiment 1,
According to the mass parts meter, join 0.004 part of nanometer selenium, 0.7 part of vitamin C, 8 parts of vitamin Es in per 100 parts of solvents in its component.
Embodiment 4: a kind of nano selenium product of present embodiment and preparation method thereof is with the difference of embodiment 1,
According to the mass parts meter, join 0.007 part of nanometer selenium, 1.8 parts of vitamin Cs, 14 parts of vitamin Es in per 100 parts of solvents in its component.
Embodiment 5: a kind of nano selenium product of present embodiment and preparation method thereof is with the difference of embodiment 1,
According to the mass parts meter, join 0.005 part of nanometer selenium, 1.0 parts of vitamin Cs, 10 parts of vitamin Es in per 100 parts of solvents in its component.
Embodiment 6: a kind of nano selenium product of present embodiment and preparation method thereof is with the difference of embodiment 1,
According to the mass parts meter, join 0.006 part of nanometer selenium, 1.5 parts of vitamin Cs, 12 parts of vitamin Es in per 100 parts of solvents in its component.
More than each embodiment technical solution all can reach purpose of the present invention.
The present invention is a kind of little low toxicity of clinical good effect, side effect health food one selenium preparation efficiently that can be used in.Under identical dosage, nanometer selenium can more significantly improve the immune indexes of organism and significantly delay biological decay, and heavy dose of nanometer selenium of using makes prophylaxis of cancer become possibility.Because nanometer selenium is the small unit that several ten thousand selenium compounds form, thereby its antioxidation, to remove the free radical ability stronger, can better suppress the generation of the disease that causes because of radical damage.
Nano selenium product of the present invention has prophylaxis of cancer, slow down aging, immunomodulating, liver-protective health-care effect; Hepatitis, arthritis, cardiovascular disease there are good therapeutical effect, chemotherapy of tumors is also had the auxiliary treatment effect.
Through the following detection of Disease Prevention Control Center, Hubei Prov, reach a conclusion:
Enlarge three dosage groups of 10,20,30 times of designs according to daily crowd day recommended intake 0.5g/Kg.BW, establish the blank group simultaneously, adopt SPF level Kunming mouse, per os filling stomach gives continuously, begins experiment after 30 days.Experimental result shows: each dosage group and the comparison of blank group, the mice body weight, lymphatic organ/there are no significant for the body weight ratio difference.
1, middle and high dosage group can obviously strengthen the inductive mouse spleen lymphocyte competence for added value of ConA;
2, middle and high dosage group can obviously strengthen the inductive mice delayed allergy of dinitrofluorobenzene;
3, the high dose group mice serum hemolysin that can obviously raise;
4, middle and high dosage group can obviously strengthen Turnover of Mouse Peritoneal Macrophages and engulfs the chicken red blood cell function;
5, high dose group can obviously strengthen mice carbon and cleans up ability;
6, high dose group can obviously strengthen the antibody-producting cell ability;
7, each dosage group can obviously strengthen the NK cytoactive;
Conclusion: according to enhancing immunity function assessment process regulation, this is tried thing and is had the enhancing immunity function.
Claims (7)
1, a kind of nano selenium product is characterized in that its component includes solvent, nanometer selenium, vitamin C, vitamin E, according to the quality meter, joins 0.003-0.008 part nanometer selenium, 0.5-2.0 part vitamin C, 6-16 part vitamin E in per 100 parts of solvents.
2, according to the described a kind of nano selenium product of claim 1, it is characterized in that, join 0.004-0.007 part nanometer selenium, 0.7-1.8 part vitamin C, 8-14 part vitamin E in per 100 parts of solvents according to the quality meter.
3, according to the described a kind of nano selenium product of claim 1, it is characterized in that, join 0.005-0.006 part nanometer selenium, 1.0-1.5 part vitamin C, 10-12 part vitamin E in per 100 parts of solvents according to the quality meter.
4,, it is characterized in that described solvent is a starch according to the described a kind of nano selenium product of claim 1; Vitamin C is a kind of antioxidant with antitumaous effect, and vitamin E has very strong antioxidation; Nanometer selenium is a red nano albumen selenium.
5, according to the described a kind of nano selenium product of claim 1, it is characterized in that described nanometer selenium with nanometer technology of preparing and bioseparation technology, in the ovalbumin system, sodium selenite is prepared into red nano albumen selenium.
6, a kind of preparation method of nano selenium product is characterized in that,
(1) mass parts is as requested got each component, with spray gun liquid nanometer selenium is sprayed in the solvent starch, stirs while spraying, and has sprayed the back and continue to have stirred 10-30 minute, crosses 60 mesh sieves 2 times, guarantees its uniformity, puts 50 ℃ of oven dry in the baking oven, after 60 mesh sieves 1 time;
(2) vitamin C, vitamin E are crossed 60 mesh sieves, with the mixture of above-mentioned solvent starch and nanometer selenium through 30 minutes mix homogeneously of three-dimensional mixer, obtain nano selenium product.
7, according to the preparation method of the described a kind of nano selenium product of claim 1, it is characterized in that also increasing following operation,
(3) with above single-size, layering is inserted in the 1250MHz composited waveguide microwave machine, sterilizes 3-6 minute, takes out, and puts clean area material intermediate station, is up to the standards.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271353A (en) * | 2013-05-08 | 2013-09-04 | 天津市星河系科技有限公司 | Liver protecting and health care composition and preparation method thereof |
| CN103876158A (en) * | 2013-11-18 | 2014-06-25 | 国家***第三海洋研究所 | Elemental selenium and sugar compound and preparation method thereof |
| CN105815770A (en) * | 2009-01-23 | 2016-08-03 | 惠氏有限责任公司 | Multivitamin/mineral formulation without side effects of large-dose nutritious supplement |
| CN105941869A (en) * | 2016-05-26 | 2016-09-21 | 辽宁绿源生物肥业有限公司 | Selenium-enriched feed additive and production process thereof |
| CN109222108A (en) * | 2018-11-15 | 2019-01-18 | 湖北华龙西科生物科技有限公司 | A kind of active bio nanometer selenium nutriment and preparation method thereof |
| CN109809373A (en) * | 2019-01-23 | 2019-05-28 | 广东暨创硒源纳米研究院有限公司 | A kind of recovery method of nanometer selenium and application |
| CN110200287A (en) * | 2019-06-29 | 2019-09-06 | 华南理工大学 | A kind of oyster polypeptide-nano granules of selenium compound and the preparation method and application thereof with relieving alcoholism and protecting liver effect |
| CN112022873A (en) * | 2020-10-12 | 2020-12-04 | 烟台迈高国际生物科技有限公司 | Red nano-selenium compound and preparation method and application thereof |
| CN112385761A (en) * | 2020-11-18 | 2021-02-23 | 深圳市名之洋生物科技有限公司 | Selenium-enriched water and preparation method thereof |
| CN112915102A (en) * | 2021-01-22 | 2021-06-08 | 张超 | Nano-selenium comprehensive liquid formula for preventing and treating cancers |
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2005
- 2005-09-30 CN CN 200510104257 patent/CN1762380A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105815770A (en) * | 2009-01-23 | 2016-08-03 | 惠氏有限责任公司 | Multivitamin/mineral formulation without side effects of large-dose nutritious supplement |
| CN103271353A (en) * | 2013-05-08 | 2013-09-04 | 天津市星河系科技有限公司 | Liver protecting and health care composition and preparation method thereof |
| CN103271353B (en) * | 2013-05-08 | 2014-09-03 | 天津市星河系科技有限公司 | Liver protecting and health care composition and preparation method thereof |
| CN103876158A (en) * | 2013-11-18 | 2014-06-25 | 国家***第三海洋研究所 | Elemental selenium and sugar compound and preparation method thereof |
| CN103876158B (en) * | 2013-11-18 | 2016-09-28 | 国家***第三海洋研究所 | A kind of elemental selenium and sugared complex and preparation method thereof |
| CN105941869A (en) * | 2016-05-26 | 2016-09-21 | 辽宁绿源生物肥业有限公司 | Selenium-enriched feed additive and production process thereof |
| CN109222108A (en) * | 2018-11-15 | 2019-01-18 | 湖北华龙西科生物科技有限公司 | A kind of active bio nanometer selenium nutriment and preparation method thereof |
| CN109809373A (en) * | 2019-01-23 | 2019-05-28 | 广东暨创硒源纳米研究院有限公司 | A kind of recovery method of nanometer selenium and application |
| CN110200287A (en) * | 2019-06-29 | 2019-09-06 | 华南理工大学 | A kind of oyster polypeptide-nano granules of selenium compound and the preparation method and application thereof with relieving alcoholism and protecting liver effect |
| CN110200287B (en) * | 2019-06-29 | 2023-06-09 | 华南理工大学 | Oyster polypeptide-nano selenium particle compound with effects of dispelling effects of alcohol and protecting liver as well as preparation method and application thereof |
| CN112022873A (en) * | 2020-10-12 | 2020-12-04 | 烟台迈高国际生物科技有限公司 | Red nano-selenium compound and preparation method and application thereof |
| CN112385761A (en) * | 2020-11-18 | 2021-02-23 | 深圳市名之洋生物科技有限公司 | Selenium-enriched water and preparation method thereof |
| CN112915102A (en) * | 2021-01-22 | 2021-06-08 | 张超 | Nano-selenium comprehensive liquid formula for preventing and treating cancers |
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