CN103005255A - Chitosan oligosaccharide-collagen peptide compound health food and preparation method thereof - Google Patents
Chitosan oligosaccharide-collagen peptide compound health food and preparation method thereof Download PDFInfo
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- CN103005255A CN103005255A CN2011102906604A CN201110290660A CN103005255A CN 103005255 A CN103005255 A CN 103005255A CN 2011102906604 A CN2011102906604 A CN 2011102906604A CN 201110290660 A CN201110290660 A CN 201110290660A CN 103005255 A CN103005255 A CN 103005255A
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Abstract
The invention relates to a chitosan oligosaccharide-collagen peptide compound health food and a preparation method thereof. The preparation method is characterized by comprising the following steps of: dissolving chitosan oligosaccharide in double distilled water at the temperature of 40-60 DEG C to prepare an aqueous solution with the mass fraction of 3-5 percent; dissolving collagen peptide in double distilled water to prepare a solution with the mass fraction of 3-5 percent; sufficiently stirring the two solutions in hot water bath at a 40-60 DEG C according to a certain proportion, sufficiently stirring for 30-60min to uniformly mix, and carrying out concentration and freeze drying to obtain the chitosan oligosaccharide-collagen peptide compound; and uniformly mixing the chitosan oligosaccharide-collagen peptide compound with vitamin C and vitamin E according to mass fractions of (50-80): (30-50): (10-30), adding a defined amount of auxiliaries and uniformly mixing to prepare any dosage form of capsules, tablets, granules or oral liquid. The chitosan oligosaccharide-collagen peptide compound health food is defined in ingredients, good in stability, free of toxic and side effects and remarkable in anti-oxidation and immunological enhancement functions, thereby being a health food which has the effects of resisting oxidation and enhancing immunity.
Description
Technical field
The present invention relates to the health care technology field, be specifically related to a kind ofly have anti-oxidant and strengthen the chitosan oligosaccharide of immunity-collagen peptide compound health food and preparation method thereof.
Background technology
Modern medicine thinks that the interior too much free radical of body is the arch-criminal who causes the human body various diseases, and the genesis mechanism of tumour, aging, inflammation, cardiovascular and cerebrovascular disease, blood disease etc. and interior free yl produce too much or the removing ability descends extremely close the contact.Under the human normal physiological status, generation and the removing of the free radical in the body are in a kind of poised state, when descending at immunity of organisms, antioxidase (superoxide dismutase (SOD), paddy takes off sweet skin peroxidase (GSH-px)) reduce or activity decreased, environmental pollution, ultraviolet irradiation, in the toxicant etc., under the inducing of extraneous factor, the generation of interior free yl is broken with the removing balance, cause the excessive free radical of cylinder accumulation, and and DNA, protein and polyunsaturated fatty acid effect, cause DNA chain oxidative damage, the protein-protein exchange, Protein-DNA crosslink and lipid peroxidation, thus various angiocardiopathies caused, cancer and aging phenomenon.For this reason, immunocompromised person, the elderly, radiation injury danger person need to take in a certain amount of antioxidant functional food outward by diet, keep body antioxidant system and immune stable and normal function, the increasing the weight of of prophylactic generation or existing disease.
Chitosan oligosaccharide (Chitosan oligosaccharide), also claim chitin oligo saccharide, formal name used at school is β-Isosorbide-5-Nitrae-oligomerization-gucosamine, take shitosan as raw material, the low molecular weight product that good water solubility, function are large, biologically active is high that forms through biotechnology degraded.Chitosan oligosaccharide is nearly 100% in the human body internal absorption factor, and its effect is the decades of times of shitosan.Studies have shown that: chitosan oligosaccharide has the human body of elimination Atomic oxygen radical anion, improves immunity of organisms, suppress the cancerous swelling Growth of Cells, promote liver spleen antibody to form, promote the absorption of calcium and mineral matter, the activation equipment body cell, reducing blood lipid, hypotensive, hypoglycemic, adjusting cholesterol, delay senility, the prevention AD suppresses the skin surface harmful bacteria and grows, etc. function, can be applicable to the fields such as medicine, functional food and daily use chemicals.
Collagen peptide is to adopt the technology such as advanced pacemaker enzyme is cut, sex change, drying, extraction, from collagen, extract the product that obtains, the mean molecule quantity of collagen peptide is about 1000Da, three grades of superhelixes of relative collagen complexity, the linear structure of collagen peptide make its digestibility up to 80% (collagen is＜=1%).Compare with the collagen of 30-50 ten thousand molecular weight, collagen peptide need not to decompose and can be absorbed by the body and utilize, thereby can significantly improve its bioavilability and biologically active.Scientific research shows, collagen peptide can more effectively resist oxyradical to the attack of DNA, improve many-sided activity such as cutaneous immunisation ability, antitumor, Angiotensin-converting enzyme inhibition (ACE).And can effectively infiltrate cuticula, skin corium, play and prolong the Skin Cell life-span, suppress the Cell membrane lipids peroxidating, improve skin water holding water holding capacity, promote the hyaluronic multiple efficacies such as synthetic of the synthetic and dermal cell of collagen.Therefore, collagen peptide also is a kind of good food, medicine and industrial chemicals.
In recent years, the research about collagen and shitosan compound has report more.Be used for the fresh-keeping of meat such as carragheen and collagen compound, gelatin and shitosan are made hybrid films and are had the functions such as hemostasis, moisturizing, promotion wound healing, are applicable to postoperative tissue repair and regeneration etc.Collagen peptide and chitosan oligosaccharide all have significant raising immunity and antioxidation activity, and are also embodying stronger potential advantages aspect the uvioresistant irradiation, and the related activity after both are composite may be improved because of synergy, and obtains good modified product.But at present, for the research of collagen peptide and chitosan oligosaccharide compound and anti-oxidant, improve the application of the aspects such as immunity of organisms and radioresistance with having no especially report.
Summary of the invention
First technical problem to be solved by this invention provides a kind of chitosan oligosaccharide-collagen peptide compound health food, and this health food can be used for improving antioxidant ability of organism and strengthens immunity.
First technical problem to be solved by this invention provides a kind ofly to be had anti-oxidant and strengthens the preparation method of the chitosan oligosaccharide of immunity-collagen peptide compound health food.
The present invention solves the technical scheme that above-mentioned first technical problem adopts: a kind of chitosan oligosaccharide-collagen peptide compound health food, it is characterized in that its component comprises chitosan oligosaccharide-50～80 parts of collagen peptide compounds, vitamin C 30-50 part, vitamin E 10-30 part, above-mentioned umber is mass fraction, and wherein the mass ratio of shitosan and collagen peptide is 7～9: 1 in chitosan oligosaccharide-collagen peptide compound.
As preferably, the molecular weight ranges of chitosan oligosaccharide and collagen peptide is all less than 3000Da in described chitosan oligosaccharide-collagen peptide compound.
The present invention solves the technical scheme that above-mentioned second technical problem adopt: the preparation method of a kind of chitosan oligosaccharide-collagen peptide compound health food is characterized in that step is followed successively by:
1) preparation chitosan oligosaccharide-collagen peptide compound: chitosan oligosaccharide is dissolved in 40 ℃～60 ℃ distilled waters configuration quality concentration 3%～5% aqueous solution; Collagen peptide is dissolved in 40 ℃～60 ℃ distilled waters, configuration quality concentration 3%～5% aqueous solution, be that 7～9: 1 ratio is mixed with above-mentioned two kinds of solution according to the mass ratio of shitosan and collagen peptide, in 40 ℃～60 ℃ hot baths, fully stir 30min～60min, make the mixing mixing, concentrated, freeze drying obtains chitosan oligosaccharide-collagen peptide compound;
2) get above-mentioned 1) in chitosan oligosaccharide-collagen peptide compound and vitamin C, vitamin E according to the ratio mixing of mass fraction 50～80: 30-50: 10-30, and add an amount of auxiliary materials and mixing, be prepared into any formulation in capsule, tablet, granule or the oral liquid.
As preferably, described step 1) molecular weight ranges of chitosan oligosaccharide and collagen peptide is all less than 3000Da in.
At last, the auxiliary material described step 2) is one or more mixture of the continuous or dextrin of starch, stearic acid.
Compared with prior art, the invention has the advantages that: chitosan oligosaccharide-collagen peptide compound and vitamin C, vitamin E are made by the science compatibility, have the anti-oxidant of excellence, improve the effect of immunity of organisms, can keep better human body body free radical balance, strengthen human body prevention of disease ability.Through experimental verification, take and to make ICR mouse MDA content 13.5% in one month; Make simultaneously superoxide dismutase (SOD) content and glutathione reroxidase (GSH-px) content rise respectively 16.3% and 6.7%, meet fully " health food check and assessment technique standard)) in (2003 editions) to the evaluation requirement of antioxidant functional food.Show by physicochemical property evaluation, toxicological assessment, functional experiment, health food definite ingredients of the present invention, good stability, have no side effect, anti-oxidant and to improve immunity function remarkable, it is a kind of health food anti-oxidant and the enhancing efficacy of immunity that has, and preparation technology is simple, easy to operate, is fit to suitability for industrialized production.
Description of drawings
Fig. 1 is to the effect curves of DPPH radicals scavenging power under embodiment of the invention chitosan oligosaccharide, collagen peptide and chitosan oligosaccharide-collagen peptide compound same concentrations.
The specific embodiment
Embodiment is described in further detail the present invention below in conjunction with accompanying drawing.
Embodiment 1
60 parts of chitosan oligosaccharides-collagen peptide compound; 40 parts of vitamin Cs; 20 parts of vitamin Es.
The preparation method of above-mentioned composition is:
(1) chitosan oligosaccharide is dissolved in 50 ℃ of distilled waters configuration 4% (mass fraction) aqueous solution; Collagen peptide is dissolved in 50 ℃ of distilled waters configuration 4% (mass fraction).The mass ratio of above-mentioned two kinds of solution according to 8: 1 mixed, and in stir 45min in 50 ℃ of hot baths, fully mixing concentrates, freeze drying gets chitosan oligosaccharide-collagen peptide compound.
(2) get vitamin C, vitamin E and chitosan oligosaccharide-collagen peptide compound according to 40: 20: 60 mass ratio mixing, and add that an amount of auxiliary material such as starch, stearic acid are continuous, one or more the mixture such as dextrin, mixing is prepared into any existing clinical applicable formulation in capsule, tablet, granule, the oral liquid.
Embodiment 2
80 parts of chitosan oligosaccharides-collagen peptide compound; 50 parts of vitamin Cs; 30 parts of vitamin Es.
The preparation method of above-mentioned composition is:
(1) chitosan oligosaccharide is dissolved in 50 ℃ of distilled waters configuration 5% (mass fraction) aqueous solution; Collagen peptide is dissolved in 50 ℃ of distilled waters configuration 5% (mass fraction).The mass ratio of above-mentioned two kinds of solution according to 9: 1 mixed, and in stir 30min in 60 ℃ of hot baths, fully mixing concentrates, freeze drying gets chitosan oligosaccharide-collagen peptide compound.
(2) get vitamin C, vitamin E and chitosan oligosaccharide-collagen peptide compound according to 50: 30: 80 mass ratio mixing, and add that an amount of auxiliary material such as starch, stearic acid are continuous, one or more the mixture such as dextrin, mixing is prepared into any existing clinical applicable formulation in capsule, tablet, granule, the oral liquid.
Embodiment 3
50 parts of chitosan oligosaccharides-collagen peptide compound; 30 parts of vitamin Cs; 0 part of vitamin e1.
The preparation method of above-mentioned composition is:
(1) chitosan oligosaccharide is dissolved in 50 ℃ of distilled waters configuration 3% (mass fraction) aqueous solution; Collagen peptide is dissolved in 50 ℃ of distilled waters configuration 3% (mass fraction).The mass ratio of above-mentioned two kinds of solution according to 7: 1 mixed, and in stir 60min in 40 ℃ of hot baths, fully mixing concentrates, freeze drying gets chitosan oligosaccharide-collagen peptide compound.
(2) get vitamin C, vitamin E and chitosan oligosaccharide-collagen peptide compound according to 30: 10: 50 mass ratio mixing, and add that an amount of auxiliary material such as starch, stearic acid are continuous, one or more the mixture such as dextrin, mixing is prepared into any existing clinical applicable formulation in capsule, tablet, granule, the oral liquid.
Why the present invention selects above-mentioned raw materials, is because they have following effect:
Chitosan oligosaccharide (Chitosan oligosaccharide): have the human body of elimination Atomic oxygen radical anion, improve immunity of organisms, suppress the cancerous swelling Growth of Cells, promote liver spleen antibody to form, promote the absorption of calcium and mineral matter, the activation equipment body cell, reducing blood lipid, hypotensive, hypoglycemic, adjusting cholesterol delay senility, the prevention AD suppresses the functions such as the skin surface harmful bacteria grows.
Collagen peptide: have the opposing oxyradical to the attack of DNA, improve many-sided activity such as cutaneous immunisation ability, antitumor, Angiotensin-converting enzyme inhibition (ACE).And can effectively infiltrate cuticula, skin corium, play and prolong the Skin Cell life-span, suppress the Cell membrane lipids peroxidating, improve skin water holding water holding capacity, promote the hyaluronic multiple efficacies such as synthetic of the synthetic and dermal cell of collagen.
Vitamin C: be to keep normal human's metabolism and the requisite material of physiological function, have anti-oxidant, promote that connective tissue forms, detoxifcation, promote neurotransmitter and carnitine synthetic, promote iron to absorb, improve immunologic function, the effect such as reduce artery sclerosis, prevent and control inflammation.
Vitamin E: be the most representative fat-soluble natural that is positioned film, the street cleaner of effective lipid peroxidation is by activity and the lipid peroxidation radical reaction inhibition lipid peroxidation of Tunization peroxylradicals.
Experiment showed, that the chitosan oligosaccharide that makes-collagen peptide compound health food takes and can make ICR mouse MDA content 13.5% in one month; Make simultaneously superoxide dismutase (SOD) content and glutathione reroxidase (GSH-px) content rise respectively 16.3% and 6.7%.Meet fully " health food check and assessment technique standard)) in (2003 editions) to the evaluation requirement of antioxidant functional food.
That the present invention has is anti-oxidant, strengthen the effect of immunity, and good stability, has no side effect, and wherein the combination of chitosan oligosaccharide-collagen peptide compound, vitamin and vitamin can be used for preparing in anti-oxidant, the medicine or health food that delay senility.
Claims (5)
1. chitosan oligosaccharide-collagen peptide compound health food, it is characterized in that its component comprises chitosan oligosaccharide-50～80 parts of collagen peptide compounds, vitamin C 30-50 part, vitamin E 10-30 part, above-mentioned umber is mass fraction, and wherein the mass ratio of shitosan and collagen peptide is 7～9: 1 in chitosan oligosaccharide-collagen peptide compound.
2. chitosan oligosaccharide according to claim 1-collagen peptide compound health food is characterized in that the molecular weight ranges of chitosan oligosaccharide and collagen peptide in described chitosan oligosaccharide-collagen peptide compound is all less than 3000Da.
3. the preparation method of chitosan oligosaccharide-collagen peptide compound health food is characterized in that step is followed successively by:
1) preparation chitosan oligosaccharide-collagen peptide compound: chitosan oligosaccharide is dissolved in 40 ℃～60 ℃ distilled waters configuration quality concentration 3%～5% aqueous solution; Collagen peptide is dissolved in 40 ℃～60 ℃ distilled waters, configuration quality concentration 3%～5% aqueous solution, be that 7～9: 1 ratio is mixed with above-mentioned two kinds of solution according to the mass ratio of shitosan and collagen peptide, in 40 ℃～60 ℃ hot baths, fully stir 30min～60min, make the mixing mixing, concentrated, freeze drying obtains chitosan oligosaccharide-collagen peptide compound;
2) get above-mentioned 1) in chitosan oligosaccharide-collagen peptide compound and vitamin C, vitamin E according to the ratio mixing of mass fraction 50～80: 30-50: 10-30, and add an amount of auxiliary materials and mixing, be prepared into any formulation in capsule, tablet, granule or the oral liquid.
4. preparation method according to claim 3 is characterized in that described step 1) in the molecular weight ranges of chitosan oligosaccharide and collagen peptide all less than 3000Da.
5. method according to claim 4 is characterized in that described step 2) in auxiliary material be one or more mixture of the continuous or dextrin of starch, stearic acid.
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Cited By (7)
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| CN103404765A (en) * | 2013-08-29 | 2013-11-27 | 青岛海百合生物技术有限公司 | Composite marine special dietary food for consumption of tumor patients |
| CN105495601A (en) * | 2015-12-29 | 2016-04-20 | 纪振洋 | Skin tendering and weight losing healthcare product |
| CN108085357A (en) * | 2017-12-28 | 2018-05-29 | 澳优乳业（中国）有限公司 | A kind of sheep breast lactalbumin immunomodulatory peptides and its compound and its application |
| CN112891518A (en) * | 2021-01-28 | 2021-06-04 | 曲词 | Compound containing non-denatured type II collagen and chitosan oligosaccharide and preparation method thereof |
| CN114209049A (en) * | 2021-12-20 | 2022-03-22 | 金日制药（中国）有限公司 | Marine prebiotic composition and preparation method and application thereof |
| CN115005352A (en) * | 2022-06-17 | 2022-09-06 | 日照壳美乐海洋生物科技有限公司 | Chitosan oligosaccharide and donkey-hide gelatin protein peptide composite and preparation method thereof |
| CN112998168B (en) * | 2021-04-23 | 2023-09-15 | 绿优品(福建)健康科技研发中心有限公司 | Hyaluronic acid composite polypeptide beverage and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404765A (en) * | 2013-08-29 | 2013-11-27 | 青岛海百合生物技术有限公司 | Composite marine special dietary food for consumption of tumor patients |
| CN105495601A (en) * | 2015-12-29 | 2016-04-20 | 纪振洋 | Skin tendering and weight losing healthcare product |
| CN108085357A (en) * | 2017-12-28 | 2018-05-29 | 澳优乳业（中国）有限公司 | A kind of sheep breast lactalbumin immunomodulatory peptides and its compound and its application |
| CN112891518A (en) * | 2021-01-28 | 2021-06-04 | 曲词 | Compound containing non-denatured type II collagen and chitosan oligosaccharide and preparation method thereof |
| CN112998168B (en) * | 2021-04-23 | 2023-09-15 | 绿优品(福建)健康科技研发中心有限公司 | Hyaluronic acid composite polypeptide beverage and preparation method thereof |
| CN114209049A (en) * | 2021-12-20 | 2022-03-22 | 金日制药（中国）有限公司 | Marine prebiotic composition and preparation method and application thereof |
| CN115005352A (en) * | 2022-06-17 | 2022-09-06 | 日照壳美乐海洋生物科技有限公司 | Chitosan oligosaccharide and donkey-hide gelatin protein peptide composite and preparation method thereof |
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Application publication date: 20130403 |