CN1733020A - Chinese medicinal preparation for soothing liver, strengthening spleen, nourishing blood and normalizing menstruation and its preparation process - Google Patents
Chinese medicinal preparation for soothing liver, strengthening spleen, nourishing blood and normalizing menstruation and its preparation process Download PDFInfo
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- CN1733020A CN1733020A CN 200510031936 CN200510031936A CN1733020A CN 1733020 A CN1733020 A CN 1733020A CN 200510031936 CN200510031936 CN 200510031936 CN 200510031936 A CN200510031936 A CN 200510031936A CN 1733020 A CN1733020 A CN 1733020A
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Abstract
The invention relates to a Chinese medicinal preparation for soothing liver, strengthening spleen, nourishing blood and normalizing menstruation and its preparation process, wherein the preparation can be made into drop pills or microcapsules having the main constituents of Bupleurum root, Chinese angelica root, root of herbaceous peony, white atractylodes rhizome, poria cocos, mentha, fresh ginger and licorice root.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to a kind of soothing liver and strengthening spleen, Chinese medicine preparation of nourishing blood for regulating menstruation and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or pellet capsule, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is watered pill, honey pill agent, concentrated pill, mixture, granule, has all listed the national drug standards in.
Existing soothing liver and strengthening spleen, the technology features of the carefree concentrated pill of Chinese medicine preparation of nourishing blood for regulating menstruation is to get Radix Bupleuri, Radix Angelicae Sinensis 50g, Herba Menthae, Rhizoma Zingiberis Recens extraction volatile oil, the medicinal residues and the Rhizoma Atractylodis Macrocephalae, Poria decoct with water secondary, each 2 hours, collecting decoction, filter, it is 1.35～1.40 thick paste that filtrate is condensed into relative density, and the Radix Paeoniae Alba and residue Radix Angelicae Sinensis powder are broken into fine powder.The about 20g of extracting liquorice is ground into fine powder, and the residue Radix Glycyrrhizae is made extractum, with above-mentioned cream, powder and volatile oil and an amount of mixing of maltose, and pill, drying, polishing, promptly.
Existing carefree concentrated pill exists to carry takes shortcomings such as inconvenience, disintegration is long, bioavailability is low.
Existing soothing liver and strengthening spleen, the technology features of the carefree watered pill of Chinese medicine preparation of nourishing blood for regulating menstruation are to get that the seven flavor medicine material is ground into fine powder in the prescription, sieve, and mixing, other gets Rhizoma Zingiberis Recens and decocts with water, and filters, and gets above-mentioned powder with the general ball of decocting liquid, drying, promptly.
Existing soothing liver and strengthening spleen, the technology features of the carefree big honeyed pills of Chinese medicine preparation of nourishing blood for regulating menstruation are to get that the seven flavor medicine material is ground into fine powder in the prescription, sieve, and mixing adds the refined honey pill, promptly.
The existing carefree watered pill, big honeyed pills exist to carry takes shortcomings such as inconvenience, dose is big, disintegration is long, bioavailability is low, quality is wayward.
Existing soothing liver and strengthening spleen, the technology features of the carefree mixture of Chinese medicine preparation of nourishing blood for regulating menstruation are that Herba Menthae, the Rhizoma Atractylodis Macrocephalae and Radix Angelicae Sinensis extract volatile oil, and the aqueous solution after distillation device is in addition collected; Radix Angelicae Sinensis medicinal residues, the Radix Paeoniae Alba and Rhizoma Zingiberis Recens are collected the liquid of filtering according to the percolation under fluid extract and the extractum item, reclaim ethanol, and be standby; The medicinal residues of the Herba Menthae and the Rhizoma Atractylodis Macrocephalae and Radix Bupleuri, Poria, Radix Glycyrrhizae decoct with water secondary, and collecting decoction filters, and the aqueous solution after filtrate and the distillation merges, and concentrates, merge with the above-mentioned liquid of filtering, leave standstill, filter, filtrate concentrates, and the adding antiseptic is an amount of, put coldly, add volatile oil, stir evenly, promptly.
Existing carefree mixture exists to carry takes shortcomings such as inconvenience, dose is big, stability is bad.
Existing soothing liver and strengthening spleen, the technology features of the Chinese medicine preparation XIAOYAO KELI of nourishing blood for regulating menstruation are that Herba Menthae is extracted volatile oil, and the aqueous solution after distillation device is in addition collected; Other gets Rhizoma Zingiberis Recens and Six-elements such as above-mentioned medicinal residues and all the other Radix Bupleuri decoct with water secondary, and collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, and it is an amount of to concentrate adding sucrose, dextrin and ethanol, makes granule, and drying sprays into Herba Menthae Haplocalycis volatile oil, mixing, promptly.
Existing XIAOYAO KELI exist dose big, carry inconvenience, need boiled water to take after mixing it with water, shortcoming such as diabetics can not use, stability is bad.
Summary of the invention:
The purpose of this invention is to provide a kind of soothing liver and strengthening spleen, Chinese medicine preparation of nourishing blood for regulating menstruation and preparation method thereof overcomes the drawback of prior art, improves quality and the curative effect and the bioavailability of product, satisfies the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
A kind of soothing liver and strengthening spleen, Chinese medicine preparation of nourishing blood for regulating menstruation and preparation method thereof, it is that main constituent is carefree drop pill or the pellet capsule of Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Herba Menthae, Radix Glycyrrhizae (processed with honey).
Its preparation method is:
(1) medicine constituent and percentage by weight thereof are as follows:
Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria each 10～20%, Radix Glycyrrhizae 7～15%, Herba Menthae 1～5%;
Medicine constituent optimum weight percentage ratio is:
Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria each 16.67%, Radix Glycyrrhizae 13.33%, Herba Menthae 3.33%.
(2) Herba Menthae is extracted volatile oil, and volatile oil is standby; Aqueous solution, medicinal residues after the distillation are standby;
(3) get with the Rhizoma Zingiberis Recens of weight such as Radix Bupleuri and Herba Menthae medicinal residues and Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Radix Glycyrrhizae and decoct with water 1～3 time, each 1～3 hour, collecting decoction, filter, the aqueous solution after filtrate and the Herba Menthae distillation merges, and concentrates, be dried to drug particles, standby;
(4) get the drug particles of (3) gained, spray into the volatile oil of (2) gained, mix homogeneously, get hybrid medicine, again one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable auxiliary material are used with by arbitrary proportion, add in the hybrid medicine of above-mentioned gained after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly.
(5) get the drug particles of (3) gained, add an amount of adjuvant, mix homogeneously is granulated, and sprays into the volatile oil of (2) gained, and coating or coating are not made the micropill of diameter less than 2.5mm; Maybe, incapsulate, promptly get pellet capsule the micropill that makes.
Adjuvant is following one or more combinations or other suitable adjuvant, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of soothing liver and strengthening spleen, Chinese medicine preparation of nourishing blood for regulating menstruation and preparation method thereof, it is that main constituent is carefree drop pill or the pellet capsule of Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Herba Menthae, Radix Glycyrrhizae (processed with honey).
Chinese medicine preparation of the present invention mainly can soothing liver and strengthening spleen, nourishing blood for regulating menstruation.Be used for gloomy due to the stagnation of liver-QI with deficiency of the spleen and do not relax, distending pain in the chest and hypochondrium is had a dizzy spell, loss of appetite, menoxenia.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption are as follows:
Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), each 143g of Poria, Radix Glycyrrhizae 114.4g, Herba Menthae 28.6g;
(2) Herba Menthae is extracted volatile oil, and volatile oil is standby; Aqueous solution, medicinal residues after the distillation are standby;
(3) get 100g Rhizoma Zingiberis Recens and Herba Menthae medicinal residues and Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Radix Glycyrrhizae decocts with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and the aqueous solution after filtrate and the Herba Menthae distillation merges, concentrate drying gets drug particles, and is standby;
(4) a kind of soothing liver and strengthening spleen, the Chinese medicine preparation drop pill of nourishing blood for regulating menstruation is carefree drop pill, its preparation method is a drug particles of getting (3) gained, sprays into the volatile oil of (2) gained, gets hybrid medicine; Polyethylene Glycol PEG6000 108g, stearic acid 56g, Poloxamer188 60g, treat to add above-mentioned hybrid medicine after Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(5) a kind of soothing liver and strengthening spleen, the Chinese medicine preparation micropill of nourishing blood for regulating menstruation or pellet capsule are carefree pellet capsules, and its preparation method is a drug particles of getting (3) gained, with 120g dextrin mix homogeneously, with 5%PVP alcohol liquid is binding agent, at first preparing 60 purpose granules and make parent nucleus, is binding agent with 5%PVP alcohol liquid again, adds the mixed powder amplification and makes 40 purpose micropills, spray into the volatile oil of (2) gained, make micropill, incapsulate, promptly get pellet capsule.
Advantage of the present invention is:
Carry, taking convenience, the bioavilability height, controllability and good stability are conducive to improve curative effect.
Claims (3)
1, a kind of soothing liver and strengthening spleen, the Chinese medicine preparation of nourishing blood for regulating menstruation is characterized in that it is that main constituent is carefree drop pill or the pellet capsule of Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Herba Menthae, Radix Glycyrrhizae (processed with honey).
2, a kind of soothing liver and strengthening spleen, the preparation method of the Chinese medicine preparation of nourishing blood for regulating menstruation, it is the preparation method of carefree drop pill or pellet capsule, it is characterized in that:
(1) medicine constituent and percentage by weight thereof are as follows:
Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria each 10～20%, Radix Glycyrrhizae 7～15%, Herba Menthae 1～5%;
(2) Herba Menthae is extracted volatile oil, and volatile oil is standby; Aqueous solution, medicinal residues after the distillation are standby;
(3) get with the Rhizoma Zingiberis Recens of weight such as Radix Bupleuri and Herba Menthae medicinal residues and Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria, Radix Glycyrrhizae and decoct with water 1～3 time, each 1～3 hour, collecting decoction, filter, the aqueous solution after filtrate and the Herba Menthae distillation merges, and concentrates, be dried to drug particles, standby;
(4) get the drug particles of (3) gained, add suitable adjuvant after, mixing is granulated, and sprays into the volatile oil of (2) gained, hybrid medicine, make drop pill or pellet capsule again;
The preparation method of its drop pill is: one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable auxiliary material are used with by arbitrary proportion, add in the hybrid medicine of (4) gained after being heated to whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70～100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of pellet capsule is: get the drug particles of (3) gained, add an amount of adjuvant, mix homogeneously is granulated, and sprays into the volatile oil of (2) gained, and coating or coating are not made the micropill of diameter less than 2.5mm; To make micropill, incapsulate, promptly get pellet capsule;
Adjuvant is following one or more combinations or other suitable adjuvant, uses with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose.
3, a kind of soothing liver and strengthening spleen according to claim 2, the preparation method of the Chinese medicine preparation of nourishing blood for regulating menstruation is characterized in that the optimum weight percentage ratio of its main constituent is:
Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae (stir-fry), Poria each 16.67%, Radix Glycyrrhizae 13.33%, Herba Menthae 3.33%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031936 CN1733020A (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for soothing liver, strengthening spleen, nourishing blood and normalizing menstruation and its preparation process |
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| CN 200510031936 CN1733020A (en) | 2005-07-29 | 2005-07-29 | Chinese medicinal preparation for soothing liver, strengthening spleen, nourishing blood and normalizing menstruation and its preparation process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396545B (en) * | 2007-09-26 | 2011-12-07 | 北京亚东生物制药有限公司 | Detection method of ditional Chinese medicine composition for treating disharmony between the liver and the spleen |
| CN102294003A (en) * | 2011-08-26 | 2011-12-28 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of ease pill |
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2005
- 2005-07-29 CN CN 200510031936 patent/CN1733020A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396545B (en) * | 2007-09-26 | 2011-12-07 | 北京亚东生物制药有限公司 | Detection method of ditional Chinese medicine composition for treating disharmony between the liver and the spleen |
| CN102294003A (en) * | 2011-08-26 | 2011-12-28 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of ease pill |
| CN102294003B (en) * | 2011-08-26 | 2013-04-17 | 太极集团重庆涪陵制药厂有限公司 | Preparation method of ease pill |
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