CN1709486A - Chinese medicine formulation for invigorating qi for tranquilization, and its preparing method - Google Patents

Chinese medicine formulation for invigorating qi for tranquilization, and its preparing method Download PDF

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CN1709486A
CN1709486A CN 200510031755 CN200510031755A CN1709486A CN 1709486 A CN1709486 A CN 1709486A CN 200510031755 CN200510031755 CN 200510031755 CN 200510031755 A CN200510031755 A CN 200510031755A CN 1709486 A CN1709486 A CN 1709486A
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radix
gained
preparation
honey
liquid
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王衡新
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Abstract

The present invention discloses a Chinese medicine preparation with the functions of supplementing qi and quieting spirit and its preparation method. Said Chinese medicine preparation can be made into dripping pills or micropills or soft capsule, and is made up by using 6 Chinese medicinal materials of biota seed, codonopsis root, astragalus root, ligusticum root, Chinese angelica root and poria as main raw material Besides, said invention also provides the concrete steps of its preparation method.

Description

Chinese medicine preparation of invigorating QI and tranquilization and preparation method thereof
Technical field:
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, relate in particular to Chinese medicine preparation of a kind of invigorating QI and tranquilization and preparation method thereof.
Background technology:
Drop pill in the Chinese medicine preparation or micropill or soft capsule, change dosage form and manage as new drug research according to the relevant laws and regulations of China's drug control as a kind of pharmaceutical dosage form.The existing dosage form of this product is a tablet, has listed the national drug ministry standard in.
The nourish heart technology features of sheet of the Chinese medicine preparation cedar seed of existing invigorating QI and tranquilization is got 13 flavors in the prescription, and Cortex Cinnamomi, Radix Codonopsis and Pinellia leaven 90g are ground into fine powder; Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Platycladi carry out percolation, make solvent with 70% ethanol, flood after 24 hours slowly percolation, collect the liquid of filtering, and reclaim ethanol; Fructus Schisandrae Chinensis, Radix Polygalae are solvent with 60% ethanol, carry out percolation, collect the liquid of filtering, and reclaim ethanol; Medicinal residues and the Radix Astragali, Radix Glycyrrhizae, Poria, Semen Ziziphi Spinosae behind remaining Pinellia leaven and the above-mentioned two kinds of percolation decoct with water secondary, and each 2 hours, collecting decoction filtered.Merge above each medicinal liquid, be condensed into thick paste, add fine powders such as Cortex Cinnamomi, mixing, drying, porphyrize adds Cinnabaris again, and mixing is made granule, and drying is pressed into 1000, sugar coating, promptly.
The Chinese medicine preparation cedar seed of existing invigorating QI and tranquilization nourish heart sheet exist disintegration long, carry and take shortcomings such as inconvenience, bioavailability is low.
Summary of the invention:
The purpose of this invention is to provide Chinese medicine preparation of a kind of invigorating QI and tranquilization and preparation method thereof, overcome the drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
The objective of the invention is to be achieved through the following technical solutions.
The Chinese medicine preparation of invigorating QI and tranquilization, it is that main component is nourish heart drop pill or micropill or a soft capsule of the cedar seed of Semen Platycladi, Radix Codonopsis, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), Pinellia leaven, Radix Glycyrrhizae (processed with honey), Cinnabaris.
Its preparation method is:
(1) medicine constituent and percentage by weight consumption thereof are as follows:
Semen Platycladi, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), each 1.6-4.8% of Radix Codonopsis, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, each 6.4-19% of Pinellia leaven, Poria 12.6-37.9%, Radix Glycyrrhizae (processed with honey) 0.7-1.9%, Cinnabaris 1.9-5.7%;
Medicine constituent optimum weight percentage ratio is:
Semen Platycladi, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), Radix Codonopsis each 3.2%, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, Pinellia leaven each 12.6%, Poria 25.3%, Radix Glycyrrhizae (processed with honey) 1.3%, Cinnabaris 3.8%;
(2) 40-90% that gets Cortex Cinnamomi, Radix Codonopsis and Pinellia leaven percentage by weight pulverizes, and gets mixing fine powders, and is standby;
(3) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Platycladi and carry out percolation, make solvent with 60-80% ethanol, flooded 12-36 hour, with the speed of per minute 0.5~5ml percolation slowly, collect the liquid of filtering, reclaim ethanol, gained medicinal liquid, medicinal residues are standby; Get Fructus Schisandrae Chinensis, Radix Polygalae is a solvent with 30-90% ethanol, carries out percolation, collects the liquid of filtering, and reclaims ethanol, gained medicinal liquid, medicinal residues are standby;
(4) all medicinal residues and the Radix Astragali, Radix Glycyrrhizae, Poria, the Semen Ziziphi Spinosae with remaining Pinellia leaven and (3) gained decocts with water secondary, and each 1-3 hour, collecting decoction filtered filtrate for later use;
(5) all medicinal liquids with (3) gained merge with (4) gained filtrate, are condensed into thick paste, add (2) gained mixing fine powders, mixing, and drying, porphyrize adds Cinnabaris again, and mixing gets mixed powder, and is standby;
The preparation method of drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the mixed powder that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of micropill is: get the mixed powder of (5) gained, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm;
Adjuvant is that following one or more combinations or other suitable adjuvant are used with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
The preparation of soft capsule method is: get the mixed powder of (5) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is that one or more combinations or other suitable adjuvant of following material used with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of Chinese medicine preparation of invigorating QI and tranquilization, it is that main component is nourish heart drop pill or micropill or a soft capsule of the cedar seed of Semen Platycladi, Radix Codonopsis, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), Pinellia leaven, Radix Glycyrrhizae (processed with honey), Cinnabaris.
Chinese medicine preparation of the present invention is mainly used in motive deficiency and coldness, palpitation and being susceptible to fright, and insomnia and dreamful sleep, forgetful.
The preparation method of Chinese medicine preparation of the present invention is:
(1) medicine constituent and weight consumption are as follows:
Semen Platycladi, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), each 32g of Radix Codonopsis, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, each 128g of Pinellia leaven, Poria 256g, Radix Glycyrrhizae (processed with honey) 13g, Cinnabaris 38g;
(2) get Cortex Cinnamomi, Radix Codonopsis and Pinellia leaven 90g and pulverize, get mixing fine powders, standby;
(3) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Platycladi and carry out percolation, make solvent, flooded 24 hours,, collect the about 1500ml of liquid that filters with the speed of per minute 1~3ml percolation slowly with 70% ethanol, recovery ethanol, gained medicinal liquid, medicinal residues are standby; Get Fructus Schisandrae Chinensis, Radix Polygalae is a solvent with 60% ethanol, carries out percolation, collects the about 320ml of liquid that filters, recovery ethanol, gained medicinal liquid, medicinal residues are standby;
(4) medicinal residues and the Radix Astragali, Radix Glycyrrhizae, Poria, the Semen Ziziphi Spinosae with remaining Pinellia leaven and (3) gained decocts with water secondary, and each 2 hours, collecting decoction filtered, filtrate for later use;
(5) all medicinal liquids with (3) gained merge with (4) gained filtrate, are condensed into thick paste, add (2) gained mixing fine powders, mixing, and drying, porphyrize adds Cinnabaris again, and mixing gets mixed powder, and is standby;
(6) the Chinese medicine preparation cedar seed of the invigorating QI and tranquilization drop pill that nourishes heart, its preparation method is a mixed powder of getting (5) gained, Polyethylene Glycol PEG6000 200g, stearic acid 80g, Poloxamer188 20g, treat that Polyethylene Glycol PEG6000, stearic acid, Poloxamer188 are heated to the mixed powder that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 80 ℃, at heat-retaining condition by splashing in the liquid paraffin, be condensed into ball, with the drop pill drop of molding to the greatest extent and the erasing liquor paraffin body, cold drying promptly.
(7) the Chinese medicine preparation cedar seed of the invigorating QI and tranquilization micropill that nourishes heart, its preparation method is a mixed powder of getting (5) gained, with 180g dextrin mix homogeneously, 5%PVP alcohol liquid is binding agent, at first prepare 60 purpose granules and make parent nucleus, be binding agent with 5%PVP alcohol liquid again, add the mixed powder amplification and make 40 purpose micropills, promptly.
(8) the Chinese medicine preparation cedar seed of the invigorating QI and tranquilization soft capsule that nourishes heart, its preparation method is to get (5) prepared mixed powder, behind water dissolution, the adding adjuvant is the combination of one or more different proportions in PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, the tween, suppresses or drips and make soft capsule;
Advantage of the present invention is:
Carry, taking convenience, the bioavilability height, controllability and good stability are conducive to improve curative effect.

Claims (3)

1, a kind of Chinese medicine preparation of invigorating QI and tranquilization is characterized in that it is that main component is nourish heart drop pill or micropill or a soft capsule of the cedar seed of Semen Platycladi, Radix Codonopsis, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), Pinellia leaven, Radix Glycyrrhizae (processed with honey), Cinnabaris;
2, a kind of preparation method of Chinese medicine preparation of invigorating QI and tranquilization, it is nourish heart drop pill or micropill or a preparation of soft capsule method of cedar seed, it is characterized in that:
(1) medicine constituent and percentage by weight consumption thereof are as follows:
Semen Platycladi, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), each 1.6-4.8% of Radix Codonopsis, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, each 6.4-19% of Pinellia leaven, Poria 12.6-37.9%, Radix Glycyrrhizae (processed with honey) 0.7-1.9%, Cinnabaris 1.9-5.7%;
(2) get the 40-90% of Pinellia leaven percentage by weight and Cortex Cinnamomi, Radix Codonopsis is pulverized, mixing fine powders, standby;
(3) get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Platycladi and carry out percolation, make solvent with 60-80% ethanol, flooded 12-36 hour, with the speed of per minute 0.5~5ml percolation slowly, collect the liquid of filtering, reclaim ethanol, gained medicinal liquid, medicinal residues are standby;
Get Fructus Schisandrae Chinensis, Radix Polygalae is a solvent with 30-90% ethanol, carries out percolation, collects the liquid of filtering, and reclaims ethanol, gained medicinal liquid, medicinal residues are standby;
(4) all medicinal residues and the Radix Astragali, Radix Glycyrrhizae, Poria, the Semen Ziziphi Spinosae with remaining Pinellia leaven and (3) gained decocts with water secondary, and each 1-3 hour, collecting decoction filtered filtrate for later use;
(5) all medicinal liquids with (3) gained merge with (4) gained filtrate, are condensed into thick paste, add (2) gained mixing fine powders, mixing, and drying, porphyrize adds Cinnabaris again, and mixing gets mixed powder, and is standby;
(6) get the mixed powder of (5) gained, add suitable adjuvant after, make drop pill or micropill or soft capsule;
The preparation method of drop pill is: with one or more of stearic acid or glyceryl monostearate or insect wax or Cera Flava or Polyethylene Glycol (PEG4000 or PEG6000) or sodium stearate or glycerin gelatine or polyoxyethylene monostearate (S-40) or Poloxamer188 or other suitable adjuvant, use with by arbitrary proportion, be heated to the mixed powder that adds (5) gained after whole fusions, be transferred in the liquid containing bottle rapidly after stirring, airtight and the insulation at 70-100 ℃, under heat-retaining condition, go in the liquid coolant (liquid paraffin or methyl-silicone oil or vegetable oil or water or ethanol) by dropping-pill machine, condensation cured becomes ball, with the drop pill drop of molding to the greatest extent and remove coolant, dry coationg promptly;
The preparation method of micropill is: get the mixed powder of (5) gained, add an amount of adjuvant, mix homogeneously is granulated, and coating or coating are not made the micropill of diameter less than 2.5mm;
Adjuvant is that following one or more combinations or other suitable adjuvant are used with by arbitrary proportion: ethyl cellulose (EC), the polypropylene polysiloxanes, the wax class, Polyethylene Glycol (PEG), stearic acid, Lac, acrylic resin, polyvinyl alcohol, polyvinylpyrrolidone (PVP), methylcellulose, hydroxypropyl cellulose, cellulose propionate, the acrylic resin aqueous dispersion, the pseudo-latex of ethyl cellulose, cellulose acetate-phthalate (CAP) latex, polyphenyl dioctyl phthalate vinyl acetate (PVAP) aqueous dispersion, propylene glycol, glycerol, triacetin, acetyl list monoglyceride, phthalic acid ester, polyoxyethylene sorbitan monoleate, sodium lauryl sulphate, lactose, fructose, sucrose;
The preparation of soft capsule method is: get the mixed powder of (5) gained, add suitable adjuvant, mix homogeneously is suppressed or is dripped and makes soft capsule;
Adjuvant is that one or more combinations or other suitable adjuvant of following material used with by arbitrary proportion: PEG400, vegetable oil, aromatic hydrocarbon esters, glycerol, isopropyl alcohol, tween;
3, the preparation method of the Chinese medicine preparation of a kind of invigorating QI and tranquilization according to claim 2 is characterized in that the optimum weight percentage ratio of its main constituent is:
Semen Platycladi, Radix Polygalae (system), Semen Ziziphi Spinosae, Cortex Cinnamomi, Fructus Schisandrae Chinensis (steaming), Radix Codonopsis each 3.2%, the Radix Astragali (processed with honey), Rhizoma Chuanxiong, Radix Angelicae Sinensis, Pinellia leaven each 12.6%, Poria 25.3%, Radix Glycyrrhizae (processed with honey) 1.3%, Cinnabaris 3.8%;
CN 200510031755 2005-06-24 2005-06-24 Chinese medicine formulation for invigorating qi for tranquilization, and its preparing method Pending CN1709486A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101433670B (en) * 2008-12-23 2010-12-08 杨永信 Medicament for treating network addiction caused by mental disorder
CN102614346A (en) * 2012-04-01 2012-08-01 吉林济邦洪德堂制药有限公司 Deer blood nerve soothing granules and preparation method thereof
CN104800376A (en) * 2014-01-26 2015-07-29 天津嘉创生物科技有限公司 Traditional Chinese medicinal oral liquid for treating mink self-biting disease and preparation method thereof
CN105168703A (en) * 2015-08-28 2015-12-23 江苏七O七天然制药有限公司 Traditional Chinese medicine gel plaster applied to acupoints to treat insomnia and preparation method thereof
WO2017048191A1 (en) * 2015-09-14 2017-03-23 Moleac Pte Ltd. Process for preparing herbal extracts
CN115227755A (en) * 2022-07-29 2022-10-25 重庆希尔安药业有限公司 Industrialized process of seven-ingredient heart-nourishing spleen-tonifying composition capsules

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101433670B (en) * 2008-12-23 2010-12-08 杨永信 Medicament for treating network addiction caused by mental disorder
CN102614346A (en) * 2012-04-01 2012-08-01 吉林济邦洪德堂制药有限公司 Deer blood nerve soothing granules and preparation method thereof
CN102614346B (en) * 2012-04-01 2013-12-04 吉林济邦洪德堂制药有限公司 Deer blood nerve soothing granules and preparation method thereof
CN104800376A (en) * 2014-01-26 2015-07-29 天津嘉创生物科技有限公司 Traditional Chinese medicinal oral liquid for treating mink self-biting disease and preparation method thereof
CN105168703A (en) * 2015-08-28 2015-12-23 江苏七O七天然制药有限公司 Traditional Chinese medicine gel plaster applied to acupoints to treat insomnia and preparation method thereof
WO2017048191A1 (en) * 2015-09-14 2017-03-23 Moleac Pte Ltd. Process for preparing herbal extracts
US10463707B2 (en) 2015-09-14 2019-11-05 Moleac Pte Ltd. Process for preparing herbal extracts
RU2723945C2 (en) * 2015-09-14 2020-06-18 Молеак Пте Лтд. Method of producing grass extracts
CN115227755A (en) * 2022-07-29 2022-10-25 重庆希尔安药业有限公司 Industrialized process of seven-ingredient heart-nourishing spleen-tonifying composition capsules
CN115227755B (en) * 2022-07-29 2023-10-13 重庆希尔安药业有限公司 Industrial process of seven-ingredient heart-nourishing spleen-strengthening composition capsules

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