CN1686498A - Jiangzhitongmai Chinese medicine for treating high blood fat disease - Google Patents

Abstract

A Chinese medicine for treating hyperlipemia, hypercholesterolemia, etc is prpeared from 12 Chinese-medicinal materials including haw, rhubarb, red sage root, fleece flower root, astragalus root, etc.

Description

The lowering fat to dredge vessels Chinese medicine of treatment hyperlipidemia

Technical field

The present invention relates to a kind of lowering fat to dredge vessels Chinese medicine for the treatment of the hyperlipidemia disease.

Background technology

Along with the raising of people's living standard, but the dietary structure collocation is unreasonable, and food rich in fat is taken on the high side, and hyperlipidemia disease sickness rate is high among the crowd, and the trend of rejuvenation is arranged.Hyperlipidemia can promote atherosclerosis, easily causes cardiovascular and cerebrovascular disease.Formation is with cerebral infarction, and coronary heart disease is pathological changes and then make the patient senilism occur in advance such as the blood capillary ischemic change of representative, disables, the soldier is dead, symptoms such as dead, vascular dementia early.The control hyperlipidemia has become the important topic of medical circle, and up to now, the technical agent of treatment hyperlipidemia is more, and some western drug has lipid-lowering effect preferably, but the course of treatment is long, and need take for a long time could the stabilised blood lipid level.And also have certain toxic and side effects, also do not occur the gratifying preparation of effect in the Chinese medicine.

Summary of the invention

The present invention is directed to the deficiencies in the prior art part, a kind of blood circulation promoting and blood stasis dispelling that has is provided, rush down the medicine of the treatment hyperlipidemia of turbid lipid-reducing function.

Medicine of the present invention is by being medicine with sovereign right with Fructus Crataegi, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Rhizoma Curcumae Longae, Radix Polygoni Multiflori, Semen Cassiae, Radix Puerariae; Be aided with Rhizoma Alismatis, Ganoderma, Rhizoma dioscoreae (parched), Rhizoma Chuanxiong, Radix Astragali composition.The each component weight proportion is:

3～5 parts in 8～12 portions of Rhizoma Curcumae Longaes of 3～5 parts of Radix Salviae Miltiorrhizaes of 2～8 parts of Radix Et Rhizoma Rhei of Fructus Crataegi

3～5 parts of 3～5 parts of Semen Cassiaes of 2～3 parts of Rhizoma dioscoreae (parched)s of 3～5 parts of Rhizoma Chuanxiongs of Ganoderma

3～5 parts of 3～5 portions of Rhizoma Alismatis of 3～5 parts of Radixs Astragali of 2～3 parts of Radix Puerariaes of Radix Polygoni Multiflori

The lowering fat to dredge vessels Chinese medicine of treatment hyperlipidemia of the present invention, formulated by following materials of weight proportions:

5 parts of 5 parts of Radix Et Rhizoma Rhei of 12 portions of Rhizoma Curcumae Longaes of 6 parts of Radix Salviae Miltiorrhizaes of Fructus Crataegi

5 parts of 3 parts of Rhizoma dioscoreae (parched)s of 5 parts of Rhizoma Chuanxiongs of 5 portions of Ganodermas of Rhizoma Alismatis

5 parts of 5 parts of Radixs Astragali of 3 parts of Radix Puerariaes of 5 parts of Radix Polygoni Multiflori of Semen Cassiae

Radix Salviae Miltiorrhizae, Fructus Crataegi, Radix Puerariae activating blood circulation to dissipate blood stasis are monarch drug in the prescription; Radix Et Rhizoma Rhei, Rhizoma Alismatis, Rhizoma Curcumae Longae removing mass stagnate, blood stasis expelling blood, rush down turbid blood fat reducing and be minister altogether; Ganoderma, the Radix Astragali, Rhizoma dioscoreae (parched) spleen invigorating are regulated the flow of vital energy, and enrich and benefit essence and blood helps the power of monarch, ministerial drug, and modern study can improve the function of apolipoprotein, is adjuvant drug altogether; Semen Cassiae, polygonum multiflorum tonic Liver and kidney reduce the messenger drug that is absorbed as of intestinal lipid.Have blood circulation promoting and blood stasis dispelling, rush down the merit of turbid blood fat reducing.

The concrete processing technology of this patent medicine is:

1, the selected prepared slices of Chinese crude drugs is screened, rejects impurity (immature, go mouldy, damage by worms).

2, concoct decoction pieces:

1. Radix Et Rhizoma Rhei: with genuine Radix Et Rhizoma Rhei with 10 times to the yellow wine spray of its weight and moistening 20 minutes, divide again to be placed in the container, steam to fry with slow fire and deepened to color in 30 minutes, flame-out back took out in vexed 30 minutes dry standby.

2. Radix Polygoni Multiflori: the mixed extractive that Semen sojae atricolor 10kg is added water 25kg is to 10kg, then with 10 times of weight in the mixed of got Radix Polygoni Multiflori and mix thoroughly, steamed Radix Polygoni Multiflori 30 minutes with slow fire again, to sepia for degree, dry standby.

3. Rhizoma Alismatis: the edible salt water with 2.5% is mixed thoroughly, with the little Huang degree of being of reaching of slow fire stir-fry.

4. Rhizoma Dioscoreae: the little Huang that reaches with the stir-fry of intense fire Testa Tritici is advisable.

3, pulverize: do not have heating plektron crushing screening with SF-230 type sorting type pulverizer, reach No. 9 sieves and be no less than 95% powder.

4, the powder made from above-mentioned Chinese medicine is mixed thoroughly with the equivalent method of progressively increasing.

5, Ganoderma coarse powder extractive as the bonding stirring medicated powder of wetting agent, is made the plastotype agglomerate.

6, use WZM-15A Chinese medicine pellet processing machine, the pharmacy bar is cut apart rubbing, makes No. 8 benchmark labels of the Φ 6-Φ watered pill.

7, oven dry: carry out air-dry, oven dry with the far infrared electric oven, guarantee that dries quantity is to guarantee drug effect.

The present invention is through clinical treatment 300 routine patients, and clinic control 75 examples account for 25%; Produce effects 107 examples account for 35.6%; Effective 111 examples account for 37%; Invalid 7 examples account for 2.4%; Total effective rate 97.6%.This medicine can obviously reduce blood triglyceride, T-CHOL and low density lipoprotein, LDL, high density lipoprotein increasing level; And can significantly improve the sings and symptoms of hyperlipemia, do not see that this medicine causes any toxic and side effects simultaneously.This medical instrument has instant effect, good effect, cheap, the characteristics that have no side effect substantially, in the value that is having research and development and applying aspect the treatment hyperlipidemia.

Be incorporated into hyperlipemia 400 examples of selecting standard from the outpatient service selector, be divided into experimental group 300 examples at random, matched group 100 examples.Its concrete outcome can be with reference to following tabulation:

Table 1 patient ordinary circumstance and main complication distribution table.

Group	The example number	The man	The woman	Age	Hypertension	Coronary heart disease	Diabetes	Fat	The first merit is low
										Matched group	??100	??57	??33	?55.1±16.4	????19	????7	????5	??37	????3
Test group	??300	??189	??111	?54.3±15.2	????63	????19	????14	??124	????8

Table 2 patient blood fat clinical classification table (%)

Group example number	Hypercholesterolemia	The mixed type hyperlipidemia	Hypertriglyceridemia	End density lipoprotein mass formed by blood stasis
					Matched group 100	????18(1.0)	????32(32.0)	????44(44.0)	????6(6.0)
Test group 300	????59(19.7)	????104(34.7)	????12(4)	????16(5.3)

The table 3 patient course of disease and symptom Signs are amassed distribution table (X ± SD)

Group	The example number	The course of disease (year)	Integration
				Matched group	????100	????6.25±5.10	????44.61±3.87
Test group	????300	????6.30±4.05	????45.02±3.82

Table 4 patient traditional Chinese medical science symptom classification chart

Group	The example number	Expectorant is turbid to check disease (%)	Congestion retardance disease (%)
				Matched group	100 examples	????64(64.0)	????36(36.0)
Test group	300 examples	????176(58.7)	????124(41.3)

Table 5 symptom and Signs total effects

Project example number	Clinic control (%)	Produce effects (%)	Effectively (%)	Invalid (%)	Total effective rate (%)
						Matched group 100	?30(30.0)	????19(19.0)	??30(30.0)	??21(21.0)	????79.0
Test group 300	?184(61.3)	????65(21.7)	??22(7.3)	??29(9.7)	????90.3 *

Annotate: compare with matched group: ^*P＜0.05

Table 6 blood fat lab testing total effects

Group	The example number	Clinic control (%)	Produce effects (%)	Effectively (%)	Invalid (%)	Total effective rate
							Matched group	100	????9(9.0)	21(21.0)	?47(47.0)	????23(23.0)	????77.0
Test group	300	????48(16.0)	90(30.0)	134(44.7)	????28(9.3)	????90.7

Table 7 safety results

Group		Cardiac function	Liver function	Renal function	Irritated	Other
							Matched group	Unusual after the cure of abnormalities before the treatment	??18 ??11	????47 ????25	????0 ????0	????0 ????0	????0 ????0
Test group	Unusual after the cure of abnormalities before the treatment	??51 ??18	????15 ????4	????19 ????6	????0 ????0	????0 ????0

All more than 96%, symptom and sign total effective rate reach 90.3% to this product of comprehensive analyse shows to the total effective rate of hyperlipidemia treatment; Total effective rate to blood lipid level reaches 96.7%, and does not see any untoward reaction.Its flavour of a drug are formed rationally, and the tool activating blood circulation to dissipate blood stasis dries and rushes down turbid merit.It is evident in efficacy to be used for the treatment of the turbid accumulation type hyperlipidemia of congestion, clinical research through 300 routine patients shows this medicine obviously triglyceride reducing, T-CHOL and low-density albumen, increasing high density protein level, and can improve the sings and symptoms of hyperlipemic patients significantly, its blood fat reducing total effective rate is not seen any toxic and side effects that this guiding drug rises simultaneously more than 96%.

Model case 1: the Meng XX, the man, 57 years old, on May 4th, 2002 went to a doctor because of coronary heart disease.Its symptom is dizziness uncomfortable in chest, obviously weak, looks into ECG ST section and reduces TC5.9mmol/L, TG2.3mmol/L, HDL-C0.6mmol/L.Take lowering fat to dredge vessels granule that this prescription makes after one month, it is normal that electrocardiogram recovers, TC3.4mmol/L, TG1.5mmol/L, HDL-C0.99mmol/L, the recovery from illness that disappears substantially of all diseases.

Model case 2: Guo XX, the woman, 59 years old, on May 1st, 2002 went to a doctor because of myocardial ischemia.Patient's dizziness, nose heave, sensation of oppression over the chest with shortness of breath, cardiopalmus, weak obvious are looked into reduction in ST segment depression, TC6.9mmol/L, TG2.5mmol/l, HDL-C0.5mmol/L.Took the lowering fat to dredge vessels granule one month, treatment finishes the whole signs of back patient and disappears, and it is normal that electrocardiogram recovers, TC4.6mmol/L, TG1.7mmol/L, HDL-C0.99mmol/L, recovery from illness.

Model case 3: Yin X, the woman, 46 years old, excuse was dizzy, abdominal distention was gone to a doctor on May 2nd, 2002, and patient's obesity is dizzy in this year, accidental sensation of oppression over the chest with shortness of breath, cardiopalmus, weak, numb limbs and tense tendons, nausea and vomiting, abdominal distention.Look into triglyceride, T-CHOL, the rising of low-density lipoprotein white level, the S-T section descends, and takes the lowering fat to dredge vessels granule therapy then, and the symptomatology sign disappears after one month, and it is normal that physico-chemical examination recovers, and fully recover.

The specific embodiment

Embodiment 1:

Choose prepared slices of Chinese crude drugs Fructus Crataegi 10g, Radix Salviae Miltiorrhizae 12g,, Rhizoma Curcumae Longae 5g, Rhizoma Alismatis 5g, Ganoderma 5g, Rhizoma Chuanxiong 3g, Rhizoma dioscoreae (parched) 3g, Semen Cassiae 5g, Radix Polygoni Multiflori 8g, Radix Puerariae 5g, Radix Astragali 5g, Radix Et Rhizoma Rhei 5g.Institute's Chinese medicine of getting is rejected impurity through screening.Radix Et Rhizoma Rhei drenched to steam with slow fire with yellow wine again fry 30 fens, dry standby then to color depth; Radix Polygoni Multiflori and the decoction of black soybean that boils mixed thoroughly again steamed 30 minutes,, dry standby to sepia with slow fire; Rhizoma Alismatis is mixed thoroughly with the slow fire stir-fry to little Huang with 2.5% saline solution; Rhizoma Dioscoreae is fried to little Huang with intense fire Testa Tritici.All medical materials are pulverized in the lump, make the watered pill.Be used for hypertriglyceridemia.

Embodiment 2:

Choose prepared slices of Chinese crude drugs Fructus Crataegi 5g, Radix Salviae Miltiorrhizae 10g, Rhizoma Curcumae Longae 4g, Rhizoma Alismatis 5g, Ganoderma 4g, Rhizoma Chuanxiong 3g, Rhizoma dioscoreae (parched) 4g, Semen Cassiae 5g, Radix Polygoni Multiflori 3g, Radix Puerariae 4g, Radix Astragali 4g, Radix Et Rhizoma Rhei 5g.

Institute's Chinese medicine of getting is rejected impurity through screening.Radix Et Rhizoma Rhei drenched to steam with slow fire with yellow wine again fry 30 fens, dry standby then to color depth; Radix Polygoni Multiflori and the Semen sojae atricolor that boils mixed thoroughly again steamed 30 minutes,, dry standby to sepia with slow fire; Rhizoma Alismatis is mixed thoroughly with the slow fire stir-fry to little Huang with 2.5% saline solution; Rhizoma Dioscoreae is fried to little Huang with intense fire Testa Tritici.All medical materials are pulverized in the lump, make the watered pill.Be used for the mixed type hyperlipidemia.

Claims (2)

1, a kind of lowering fat to dredge vessels Chinese medicine for the treatment of hyperlipidemia is characterized in that being formed by the preparation of raw material of following weight ratio:

8～12 parts of 2～8 parts of Radix Salviae Miltiorrhizaes of Fructus Crataegi

3～5 parts of 3～5 parts of Radix Et Rhizoma Rhei of Rhizoma Curcumae Longae

3～5 parts of 3～5 portions of Ganodermas of Rhizoma Alismatis

3～5 parts of 2～3 parts of Rhizoma dioscoreae (parched)s of Rhizoma Chuanxiong

2～3 parts of 3～5 parts of Radix Polygoni Multiflori of Semen Cassiae

3～5 parts of 3～5 parts of Radixs Astragali of Radix Puerariae

2, ask the lowering fat to dredge vessels Chinese medicine of 1 described treatment hyperlipidemia according to right, it is characterized in that forming by the preparation of raw material of following weight ratio:

5 parts of 5 parts of Radix Et Rhizoma Rhei of 12 portions of Rhizoma Curcumae Longaes of 6 parts of Radix Salviae Miltiorrhizaes of Fructus Crataegi

5 parts of 3 parts of Rhizoma dioscoreae (parched)s of 5 parts of Rhizoma Chuanxiongs of 5 portions of Ganodermas of Rhizoma Alismatis

5 parts of 5 parts of Radixs Astragali of 3 parts of Radix Puerariaes of 5 parts of Radix Polygoni Multiflori of Semen Cassiae