CN104857506A - Traditional Chinese medicine for reducing blood fat and preparation method - Google Patents
Traditional Chinese medicine for reducing blood fat and preparation method Download PDFInfo
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- CN104857506A CN104857506A CN201510249279.1A CN201510249279A CN104857506A CN 104857506 A CN104857506 A CN 104857506A CN 201510249279 A CN201510249279 A CN 201510249279A CN 104857506 A CN104857506 A CN 104857506A
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Abstract
The invention belongs to the field of medicine production, in particular to a traditional Chinese medicine for reducing blood fat and a preparation method. The traditional Chinese medicine for reducing blood fat is prepared from raw materials in parts by weight as follows: 10-30 parts of natural hirudin, 8-20 parts of seafish oil preparations, 12-18 parts of danshen roots, 10-15 parts of cassia seeds, 5-10 parts of ginger powder, 3-8 parts of tartary buckwheat, 5-16 parts of hawthorn fruit and 5-10 parts of kudzuvine roots. The traditional Chinese medicine has the benefits and the technical effects as follows: the composition has better efficacy of blood fat reduction and is cheap, and the formula is simple; according to modern traditional Chinese medicine extraction, separation and preparation technologies, a reasonable preparation can be prepared from the traditional Chinese medicine composition; the traditional Chinese medicine can expand blood vessels, promote blood circulation, increase coronary perfusion flow and reduce myocardial oxygen consumption, and the treatment functions of auxiliary blood pressure reduction and blood fat reduction are comprehensively realized. The medicine composition is an elaborately-developed product in combination of traditional Chinese medicine medical skill and modern crafts in long-term practice and has a good effect on reduction of blood fat and blood pressure.
Description
Technical field
The invention belongs to field of medicine production, especially a kind of antilipemic Chinese herbal medicine and preparation method.
Background technology
Cardiovascular disease becomes a class disease of serious harm human health.Cardiovascular disease mainly comes from atherosclerosis, and the atherosclerosis of more than 80% is caused by hyperlipidemia.Due to the early stage no conscious sympton of hyperlipidemia, once find more difficult control and treatment.It is a process slowly that blood fat increases, and the harmful effect that blood fat is particularly eliminated in the adjustment of blood fat needs a lasting process too.
The much kinds more than 200 of blood fat reducing series products in the market, more than 80% of the Western medicine product exhibition market share based on Statins, although this kind of medicine instant effect, Most patients just can bring about tangible results in short several days, but, total institute is known, and hyperlipidemia is a kind of chronic disease, and its treatment needs long-term, take medicine even all the life, somewhat expensive, the most important thing is that many patients heavyly easily cause liver function damage taking, glutamate pyruvate transaminase raises, blood urea nitrogen raises, produce bad to human body, dependency is also stronger, is unfavorable for long-term taking.Chinese medicine class blood fat reducing series products many employings natural plant is produced, and has the advantages that side effect is little, is conducive to patient's long-term taking, more effective reduction " three-hypers ", controls blood fat and repeatedly raises.
At present, the blood fat reducing Chinese patent medicine on market is few, and existing medicine a bit belongs to finger and cures the symptoms, not the disease, and some is expensive, and some in use exists uncertain factor and makes to use interruption.
Summary of the invention
The technical problem to be solved in the present invention is: overcome deficiency of the prior art, provides a kind of and has no side effect, produces and antilipemic Chinese herbal medicine that use cost is low and preparation method.
For solving the problems of the technologies described above, the technical problem to be solved in the present invention is as follows:
A kind of antilipemic Chinese herbal medicine, described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 10-30 part, ocean fishes oil formulation 8-20 part, Radix Salviae Miltiorrhizae 12-18 part, Semen Cassiae 10-15 part, Rhizoma Zingiberis Recens powder 5-10 part, Radix Et Rhizoma Fagopyri Tatarici 3-8 part, Fructus Crataegi 5-16 part, Radix Puerariae 5-10 part.
Further, described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 12-25 part, ocean fishes oil 10-18 part processed, Radix Salviae Miltiorrhizae 13-16 part, Semen Cassiae 12-14 part, Rhizoma Zingiberis Recens powder 6-8 part, Radix Et Rhizoma Fagopyri Tatarici 4-6 part, Fructus Crataegi 6-15 part, Radix Puerariae 6-8 part.
Further, described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 20 parts, ocean fishes oil formulation 15 parts, Radix Salviae Miltiorrhizae 15 parts, Semen Cassiae 12 parts, Rhizoma Zingiberis Recens powder 8 parts, Radix Et Rhizoma Fagopyri Tatarici 6 parts, Fructus Crataegi 10 parts, Radix Puerariae 8 parts.
A preparation method for antilipemic Chinese herbal medicine, described preparation method comprises the following steps:
(1) natural hirudin 10-30 part, ocean fishes oil formulation 8-20 part, Radix Salviae Miltiorrhizae 12-18 part, Semen Cassiae 10-15 part, Rhizoma Zingiberis Recens powder 5-10 part, Radix Et Rhizoma Fagopyri Tatarici 3-8 part, Fructus Crataegi 5-16 part, Radix Puerariae 5-10 part;
(2) by the natural hirudin in step (1), ocean fishes oil formulation, Radix Salviae Miltiorrhizae, Semen Cassiae, Rhizoma Zingiberis Recens powder, Radix Et Rhizoma Fagopyri Tatarici, Fructus Crataegi, Radix Puerariae, add medical material weight 12 times of water and dehydrated alcohol 0.8 times, soak 2-3h, decoct 3h, filter, medicinal liquid is for subsequent use;
(3) medicinal residues that step (2) leaches are added medical material 6 and dehydrated alcohol 0.3 times of water again, decoct 2h, filter, obtain medicinal liquid;
(4) medicinal liquid of step (2), (3) gained is merged, staticly settle 8-12h, get supernatant centrifugal treating;
(5) by medicinal liquid obtained in step (4) 70-80 DEG C, concentrating under reduced pressure becomes the thick extractum of relative 1.20-1.30/60 DEG C under 0.08MPa condition;
(6) Rhizoma Zingiberis Recens is cleaned, dry, pulverize, cross 100 mesh sieves, obtain Rhizoma Zingiberis Recens powder;
(7) the thick extractum obtained in abovementioned steps and Rhizoma Zingiberis Recens powder are mixed in mixer, make granule, dry, obtain the Chinese medicinal powder of blood fat reducing;
(8) medicated powder of gained in step (7) to be incapsulated or common oral medicine dosage form made by other routine administration carriers or excipient.
Further, in described step (4), the medicinal liquid of step (2), (3) gained is merged, staticly settle 10h, get supernatant centrifugal treating.
Adopt Advantageous Effects of the present invention to be: this compositions has good blood fat reducing function, and prescription is simple, low price.Extract according to modern Chinese medicine, be separated, preparation technique, also can make Suitable formulations by this Chinese medicine composition.Energy blood vessel dilating, improves blood circulation, increases coronary flow, reduces myocardial oxygen consumption, comprehensively reaches aided blood pressure-lowering, the treatment function of blood fat reducing.This pharmaceutical composition be inventor in long-term practice to the result that TCM Recipe art is developed meticulously in conjunction with modern crafts, have fabulous effect to blood fat reducing blood pressure lowering.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of antilipemic Chinese herbal medicine, described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 10-30 part, ocean fishes oil formulation 8-20 part, Radix Salviae Miltiorrhizae 12-18 part, Semen Cassiae 10-15 part, Rhizoma Zingiberis Recens powder 5-10 part, Radix Et Rhizoma Fagopyri Tatarici 3-8 part, Fructus Crataegi 5-16 part, Radix Puerariae 5-10 part.
Further, described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 20 parts, ocean fishes oil formulation 15 parts, Radix Salviae Miltiorrhizae 15 parts, Semen Cassiae 12 parts, Rhizoma Zingiberis Recens powder 8 parts, Radix Et Rhizoma Fagopyri Tatarici 6 parts, Fructus Crataegi 10 parts, Radix Puerariae 8 parts.
Raw material composition data in embodiment 1-5 are in table 1.
| Composition | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Natural hirudin | 10 | 10 | 20 | 18 | 30 |
| Ocean fishes oil formulation | 8 | 10 | 15 | 18 | 20 |
| Radix Salviae Miltiorrhizae | 12 | 13 | 15 | 16 | 18 |
| Semen Cassiae | 10 | 12 | 12 | 14 | 15 |
| Rhizoma Zingiberis Recens powder | 5 | 6 | 8 | 8 | 10 |
| Radix Et Rhizoma Fagopyri Tatarici | 3 | 4 | 6 | 6 | 8 |
| Fructus Crataegi | 5 | 6 | 10 | 15 | 16 |
| Radix Puerariae | 5 | 6 | 8 | 8 | 10 |
Embodiment 3 is preferred forms.
The method preparing above-mentioned antilipemic Chinese herbal medicine comprises the following steps:
(1) natural hirudin 10-30 part, ocean fishes oil formulation 8-20 part, Radix Salviae Miltiorrhizae 12-18 part, Semen Cassiae 10-15 part, Rhizoma Zingiberis Recens powder 5-10 part, Radix Et Rhizoma Fagopyri Tatarici 3-8 part, Fructus Crataegi 5-16 part, Radix Puerariae 5-10 part;
(2) by the natural hirudin in step (1), ocean fishes oil formulation, Radix Salviae Miltiorrhizae, Semen Cassiae, Rhizoma Zingiberis Recens powder, Radix Et Rhizoma Fagopyri Tatarici, Fructus Crataegi, Radix Puerariae, add medical material weight 12 times of water and dehydrated alcohol 0.8 times, soak 2-3h, decoct 3h, filter, medicinal liquid is for subsequent use;
(3) medicinal residues that step (2) leaches are added medical material 6 and dehydrated alcohol 0.3 times of water again, decoct 2h, filter, obtain medicinal liquid;
(4) medicinal liquid of step (2), (3) gained is merged, staticly settle 8-12h, get supernatant centrifugal treating; Preferably staticly settle 10h;
(5) by medicinal liquid obtained in step (4) 70-80 DEG C, concentrating under reduced pressure becomes the thick extractum of relative 1.20-1.30/60 DEG C under 0.08MPa condition;
(6) Rhizoma Zingiberis Recens is cleaned, dry, pulverize, cross 100 mesh sieves, obtain Rhizoma Zingiberis Recens powder;
(7) the thick extractum obtained in abovementioned steps and Rhizoma Zingiberis Recens powder are mixed in mixer, make granule, dry, obtain the Chinese medicinal powder of blood fat reducing;
(8) medicated powder of gained in step (7) to be incapsulated or common oral medicine dosage form made by other routine administration carriers or excipient.
Blood fat reducing effect experiment:
Laboratory animal gets Wistar rat, and rat body weight is 160 ~ 180g, male and female half and half.The compositions that embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6 obtain is set to medicine 1, medicine 2, medicine 3, medicine 4, medicine 5 and medicine 6 respectively.
The preparation of high lipid food: get conventional foundation feedstuff powder 900g, net cholesterol 20g, lard stearin 75g, natrii tauroglycocholas 5g, mix homogeneously, makes granule.Get rat 80, male and female half and half, be divided into chow diet group (feeding normal diet), high lipid food group, medicine 1, medicine 2, medicine 3, medicine 4, medicine 5, medicine 6; Often organizing is 10, weighs, tail venous blood sampling, measures serum lipid concentrations.Respectively with the mixing of 3g and 1kg high lipid food, feed each group of rat by group, freely drink water, weigh 1 time every 10d.Successive administration is after 45 days, and put to death animal, abdominal vein gets blood, measures blood fat and hemorheology index.On automatic clinical chemistry analyzer, measure serum total cholesterol, triglyceride, HDL-C and low-density lipoprotein cholesterol content with enzyme process, Precipitation Determination, test kit builds up Bioengineering Research Institute purchased from Nanjing.
Experimental result
The serum TC (T-CHOL) of each group of rat, TG (triglyceride), HDL-C (HDL-C), and LDL-C (low-density lipoprotein cholesterol) changes of contents is in table 1.Result shows, the TC of high lipid food group rat blood serum, TG and LDL-C concentration is all significantly higher than chow diet group (P<0.01, P<0.05), HDL-C concentration is lower than chow diet group, but there was no significant difference (P>0.05) statistically.The serum TC of the rat of medicine 1, medicine 2, medicine 3, medicine 4, medicine 5 and medicine 6 groups, TG and LDL-C concentration is all starkly lower than high lipid food group; The concentration of HDL-C is apparently higher than high lipid food group (P<0.05).
Experimental result shows, antilipemic Chinese herbal medicine of the present invention has obvious effect for reducing blood fat.
Can learn from above-described embodiment and experimental data, antilipemic Chinese herbal medicine of the present invention has effect for reducing blood fat.
The above; be only the specific embodiment of the present invention, protection scope of the present invention is not limited thereto, and is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should define with claim is as the criterion.
Claims (5)
1. an antilipemic Chinese herbal medicine, it is characterized in that, described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 10-30 part, ocean fishes oil formulation 8-20 part, Radix Salviae Miltiorrhizae 12-18 part, Semen Cassiae 10-15 part, Rhizoma Zingiberis Recens powder 5-10 part, Radix Et Rhizoma Fagopyri Tatarici 3-8 part, Fructus Crataegi 5-16 part, Radix Puerariae 5-10 part.
2. a kind of antilipemic Chinese herbal medicine according to claim 1, is characterized in that: described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 12-25 part, ocean fishes oil 10-18 part processed, Radix Salviae Miltiorrhizae 13-16 part, Semen Cassiae 12-14 part, Rhizoma Zingiberis Recens powder 6-8 part, Radix Et Rhizoma Fagopyri Tatarici 4-6 part, Fructus Crataegi 6-15 part, Radix Puerariae 6-8 part.
3. a kind of antilipemic Chinese herbal medicine according to claim 1, is characterized in that: described antilipemic Chinese herbal medicine is made up of the raw material of following weight portion: natural hirudin 20 parts, ocean fishes oil formulation 15 parts, Radix Salviae Miltiorrhizae 15 parts, Semen Cassiae 12 parts, Rhizoma Zingiberis Recens powder 8 parts, Radix Et Rhizoma Fagopyri Tatarici 6 parts, Fructus Crataegi 10 parts, Radix Puerariae 8 parts.
4. a preparation method for a kind of antilipemic Chinese herbal medicine as claimed in claim 1, is characterized in that, described preparation method comprises the following steps:
(1) natural hirudin 10-30 part, ocean fishes oil formulation 8-20 part, Radix Salviae Miltiorrhizae 12-18 part, Semen Cassiae 10-15 part, Rhizoma Zingiberis Recens powder 5-10 part, Radix Et Rhizoma Fagopyri Tatarici 3-8 part, Fructus Crataegi 5-16 part, Radix Puerariae 5-10 part;
(2) by the natural hirudin in step (1), ocean fishes oil formulation, Radix Salviae Miltiorrhizae, Semen Cassiae, Rhizoma Zingiberis Recens powder, Radix Et Rhizoma Fagopyri Tatarici, Fructus Crataegi, Radix Puerariae, add medical material weight 12 times of water and dehydrated alcohol 0.8 times, soak 2-3h, decoct 3h, filter, medicinal liquid is for subsequent use;
(3) medicinal residues that step (2) leaches are added medical material 6 and dehydrated alcohol 0.3 times of water again, decoct 2h, filter, obtain medicinal liquid;
(4) medicinal liquid of step (2), (3) gained is merged, staticly settle 8-12h, get supernatant centrifugal treating;
(5) by medicinal liquid obtained in step (4) 70-80 DEG C, concentrating under reduced pressure becomes the thick extractum of relative 1.20-1.30/60 DEG C under 0.08MPa condition;
(6) Rhizoma Zingiberis Recens is cleaned, dry, pulverize, cross 100 mesh sieves, obtain Rhizoma Zingiberis Recens powder;
(7) the thick extractum obtained in abovementioned steps and Rhizoma Zingiberis Recens powder are mixed in mixer, make granule, dry, obtain the Chinese medicinal powder of blood fat reducing;
(8) medicated powder of gained in step (7) to be incapsulated or common oral medicine dosage form made by other routine administration carriers or excipient.
5. the preparation method of a kind of a kind of antilipemic Chinese herbal medicine as claimed in claim 1 according to claim 4, it is characterized in that: in described step (4), the medicinal liquid of step (2), (3) gained is merged, staticly settle 10h, get supernatant centrifugal treating.
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| CN106075189A (en) * | 2016-07-22 | 2016-11-09 | 钦州市中医医院 | A kind of Chinese medicine of blood fat reducing |
| CN106075343A (en) * | 2016-07-14 | 2016-11-09 | 高文广 | A kind of blood fat reducing Chinese-western medicine preparation and preparation method thereof |
| CN106334075A (en) * | 2016-11-07 | 2017-01-18 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine for preventing and treating intestinal diseases of fragrant pigs and preparation method thereof |
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| CN106334075A (en) * | 2016-11-07 | 2017-01-18 | 四会市恒星智能科技有限公司 | Traditional Chinese veterinary medicine for preventing and treating intestinal diseases of fragrant pigs and preparation method thereof |
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