CN105832925A - Traditional Chinese medicine composition for treating hyperlipidaemia - Google Patents

Traditional Chinese medicine composition for treating hyperlipidaemia Download PDF

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CN105832925A
CN105832925A CN201610321399.2A CN201610321399A CN105832925A CN 105832925 A CN105832925 A CN 105832925A CN 201610321399 A CN201610321399 A CN 201610321399A CN 105832925 A CN105832925 A CN 105832925A
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medicine composition
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李晓维
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/884Alismataceae (Water-plantain family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating hyperlipidaemia. The traditional Chinese medicine composition is prepared from seven kinds of Chinese herbal medicine materials, and is characterized by being prepared from, by weight, 30 parts of rhizoma alismatis, 15 parts of hawthorn, 15 parts of cassia occidentalis, 15 parts of the roots of red-rooted salvia, 15 parts of polygonum multiflorum, 15 parts of radix astragali and 10 parts of fructus Lycii.

Description

A kind of Chinese medicine composition treating hyperlipemia
Technical field
The invention belongs to one and treat lipid metabolism disease technical field, it is former for being specifically related to seven kinds of Chinese herbal medicine The Chinese medicine composition for treating hyperlipemia made by material.
Background technology
Hyperlipemia doctor trained in Western medicine clinical status:
In blood plasma, TL amount or part are referred to as hyperlipemia when exceeding normal high limit, can directly cause The disease of serious harm health, such as atherosclerosis, coronary heart disease, pancreatitis etc..Hyperlipemia can It is divided into constitutional and Secondary cases two class.Constitutional is agnogenio, and many genus are attribute, most and congenital and something lost Pass relevant, participate in lipoprotein transhipment and the receptor of metabolism, enzyme or apolipoprotein caused by abnormal, or due to environment Factor (diet, nutrition, medicine) and the mechanism by the unknown cause.Secondary cases is multiple, and to be born in metabolic disorderly Random disease (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, Adrenal cortex function is hyperfunction), or with other factor age, sex, season, drink, smoking, diet, Physical exertion, psychentonia, emotional activity etc. are relevant.The clinical manifestation of hyperlipemia is mainly lipid very Intradermal deposition caused by xanthoma and lipid blood vessel endothelium deposit caused by arteriosclerosis.Although high fat Mass formed by blood stasis can cause xanthoma, but its incidence rate the highest;And atherosclerotic generation and development are The most progressive a kind of process.The most under normal conditions, most of patients non-evident sympton and abnormal sign. Many people are just to draw owing to other reasons carries out just being found to have blood plasma lipoprotein level rising when blood biochemical is checked Rise and pay attention to.The western medical treatment of hyperlipemia, first, Drug therapy, medicine with reduce serum total cholesterol and Low-density lipoprotein cholesterol is main path, its secondary motion exercise, controls body weight, and sports are not only Cardio-pulmonary function can be strengthened, improve insulin resistant and glucose tolerance, but also can lose weight, reduce Plasma triglyceride, cholesterol levels and high density lipoprotein increasing level.Additionally give up bad life Custom: if smoking cessation, wine etc. are also good methods, meanwhile, in blood plasma, lipid is mainly derived from food, Research shows, by keeping on a diet, blood plasma cholesterol level can be made to reduce by 5%~10%.For major part blood fat The blood lipid regulation that abnormal patient all can reach more satisfactory by adjusting diet with mode of making the life better Effect.Also there is only a few blood lipid the highest, be more common in the patient that gene genetic is abnormal, Ke Yitong Cross plasma purification treatment, surgical intervention.
Hyperlipemia tcm clinical practice present situation:
Hyperlipemia belongs to the categories such as " phlegm syndrome ", " deficient ", " thoracic obstruction " of the traditional Chinese medical science, " dizziness ".The traditional Chinese medical science is thought Its etiology and pathogenesis is mainly closely related with the imbalance of taste hepato-biliary function.The spleen has the function to transport and transform nutrients, due to eating and drinking without temperance, Surfeit delicious food savoury, impairing the spleen and stomach, dysfunction of the spleen in transportation, raw in phlegm-damp, it is mixed among blood vessels, makes venation block, Hematogenous blockage and send out primary disease.Kidney storing essence, main water liquid, body is empty with age, kidney qi degradation, and insufficiency of kidney-YANG can not temperature Warm spleen soil and derivative phlegm retention fat is turbid;Deficiency of the kidney yin then can heat fire-transformation, refining liquid is expectorant, and enduring blood is fat.Liver master dredges Letting out, gallbladder is the mansion of middle essence, can secrete refined juice, clean esterified turbid.If internal injury caused by excess of seven emotions, feelings will is melancholy, or for a long time Direct stimulation, makes depression of liver-QI, and catharsis is neglected one's duty, and courage is strongly fragrant holds back the most peace and quiet incapability, the turbid difficultyization of fat;Edema with the liver involved is taken advantage of Soil then transformation and transportation of the spleen and stomach obstacle, abnormal ascending-descending of QI, pure and impure difficulty is divided.Additionally, natural endowment is different, some heredity because of Element is also one of reason causing hyperlipemia.Tcm clinical practice is treated, and increases owing in blood, lipid components is abnormal Height is the various common pathological change of hyperlipemia, so the common method for the treatment of that blood fat reducing is each type, from disclosed Data is seen, the traditional Chinese medical science to the clinic of hyperlipemia by following five type determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs:
The most insufficiency of the spleen phlegm stagnation syndrome type: addiction delicious food usually, sitting drowsiness, obesity, often sense is dizzy not well, breast Gastral cavity painful abdominal mass is vexed, and indolent and listless weak, limbs are heavy, white and greasy fur or thick greasy, pulse condition stringy and rolling pulse.This type is real with the turbid mark of expectorant Be main, be more common in hyperlipemia just, mid-term.Treatment: spleen invigorating helps fortune, expelling phlegm and resolving turbidity.The conventional seven taste Rhizoma Atractylodis Macrocephalaes Dissipate and close phlegm-removing decoction plus-minus.
2. the stagnant blood stasis blocking type of expectorant: see that the feeling of stuffiness in chest is vexed swollen, have a dull ache, or aching as needle stabbing and fix, cardiopalmus suffocated breathing, White and greasy fur, purplish tongue or have petechia, pulse condition is deep and slow and puckery or knot generation.This type often merges coronary heart disease, the heart Angor.Treatment: eliminate the phlegm dredging collateral, a surname's numbness of invigorating blood circulation.Conventional: Gualou Xiebai Banxia Tang closes Chinese drugs plus-minus.
3. liver-yang type of phlegm fire: ferritic excess of liver-YANG, feeling of fullness in the head jumping pain, being irritable and getting angry easily, bitter taste is vexed, dream drowsirness Few, thick fur is greasy or sallow and thick, pulse condition string strength and slide.The normal complicated hypertension of this type, owing to liver-yang rises suddenly and sharply May result in apoplexy.Treatment: suppressing the hyperactive liver and subsiding YANG, clearing and dissipating phlegm-heat.It is conventional with TIANMA GOUTENG YIN, Bolus for Clearing Heat and Phlegm Side.
4. yang deficiency of spleen and stomache: disease sees spiritlessness and weakness, pale white complexion, coldness of the body with chills. face limb edema, poor appetite is just Half congealed, soreness of the waist and knees, light red tongue is fat, while there is indentation, pulse condition sinks weak or heavy.Secondary cases hyperlipemia is more common in by this type Disease.During being common in hypothyroidism or chronic nephropathy.Treatment: tonifying speen and tonifying kidney, warming YANGization is turbid. Conventional JISHENG SHENQI WAN closes Bao Yuan Tang plus-minus.
5. type of deficiency of YIN leading to hyper activity of YANG: body is the most fertile the thinnest, dizziness and tinnitus, night xerostomia, soreness of the waist and knees, or limbs Numbness, little sleep disturbed by dreams, hypomnesis, the few tongue of red tongue, pulse condition stringy and thready pulse.Primary disease often merges Atherosclerosis Change.Treatment: nourishing YIN for suppressing the hyperactive YANG, turbid raising clearly of dispelling.Conventional ZHIBAI DIHUANG WAN plus-minus.
Summary of the invention:
The purpose of the present invention is aiming at TL amount or part in blood plasma and exceedes the origin cause of formation of normal high limit, it is provided that A kind of to regulate the inherent physiological function of human body, harmless, body fat metabolism can be promoted, extensive The Chinese medicine composition of TL amount normal level in multiple blood plasma.
The technical solution of the present invention is: one treats lipid metabolism disease technical field, be specifically related to Seven kinds of Chinese herbal medicine are the Chinese medicine composition that raw material makes for treating hyperlipemia, it is characterised in that it be by under The Chinese herbal medicine stating weight is made:
Rhizoma Alismatis 30, Fructus Crataegi 15, Semen Cassiae 15, Radix Salviae Miltiorrhizae 15, Radix Polygoni Multiflori 15, the Radix Astragali 15, Fructus Lycii 10 Take above-mentioned Chinese medicine composition, be decocted in water for oral dose.
The important feature of the present invention is the Clinical pharmacological efficiency of each component in medicament and the function of each component cures mainly As follows:
Rhizoma Alismatis: another name marshy land, car Herba Sonchi Oleracei etc., these flavour of a drug are sweet, cold in nature.Enter kidney, bladder warp.Modern medicine study Showing, Rhizoma Alismatis has notable diuresis, has and well reduces blood cholesterol, anti-liver cirrhosis and lipotropism fat Liver effect.Tcm clinical practice is summed up, and Rhizoma Alismatis is the good medicine of eliminating dampness and diuresis, has a promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria, Feelings cardiopulmonary, rush down effect of kidney fire.It is usually used in hyperlipemia, fatty liver etc..
Fructus Crataegi: calling red melon wood, Rhododendron simsii Planch. fruit etc., these flavour of a drug are sour, sweet, slightly warm in nature, enter spleen, stomach, liver Warp.Modern medicine study shows, Fructus Crataegi has increases the secretion of enzyme, facilitating digestion in gastric juice, it is also possible to expand Open blood vessel, reduce serum cholesterol, blood pressure lowering, increase the effects such as coronary flow.Tcm clinical practice is summed up, Fructus Crataegi is the good medicine of promoting digestion, has long-pending, the dissipating blood stasis circulation of qi promoting of helping digestion, effect of benefiting stomach and stopping pain, is usually used in stomach Gastral cavity distension, dyspepsia, hyperlipidemia, the disease such as meat stagnation.
Semen Cassiae: another name Horse hoof, false Semen phaseoli radiati etc., these flavour of a drug are sweet, bitter, salty, cold nature, enter liver, kidney, Large intestine channel.Modern medicine study shows, Semen Cassiae has vasoconstrictive, reduces blood pressure and can make aorta medicated porridge Sample plaque reduces and cholesterol level reduces, and reduces the pharmacological action of total blood fat in blood plasma.TCM Bed is summed up, and Semen Cassiae is the good medicine of liver heat removing and eyesight improving, has clearing away heat to improve acuity of vision.Effect of loosening bowel to relieve constipation, can be used for The ancillary drug of hyperlipidemia.
Radix Salviae Miltiorrhizae: call blood red wood, Arisaema balansae Engl. etc., this medical herbs bitter in the mouth, cold nature.Enter the heart, Liver Channel.Modern medicine Research shows, this medicine energy coronary artery dilator and peripheral vessels, increases the blood flow of arteria coronaria, improves cardiac function, Decreased heart rate, improves myocardial contraction, reduces myocardial infarct size, has the medicine such as anticoagulation, blood fat reducing simultaneously Reason effect.Tcm clinical practice is summed up, and Radix Salviae Miltiorrhizae is the good medicine of blood circulation promoting and blood stasis dispelling, has a blood circulation promoting and blood stasis dispelling, removing heat from blood detumescence, Calm the nerves hemostasis, the effect of the relieving restlessness that clears away heart-fire, be usually used in the coronary heart disease etc. that hyperlipidemia causes.
Radix Polygoni Multiflori: the another name Radix Polygoni Multiflori, Caulis Polygoni Multiflori root etc., this medical herbs sweet in the mouth, puckery, warm in nature, enter liver, the heart, kidney Warp.Modern medicine study shows, this medicine has heart tonifying, enhances metabolism, defying age, anti-hemostatic tube medicated porridge sample Hardening, decreased heart rate, increase coronary flow, reduce the clinical medicine such as generation of aged coronary heart disease, arteriosclerosis Reason effect.Tcm clinical practice is summed up, and Radix Polygoni Multiflori is the good medicine of building body, has removing toxicity for eliminating carbuncles, loosening bowel to relieve constipation Effect, be usually used in hepatic and renal YIN deficiency, blood deficiency and yellow complexion, early whitening of beard and hair, soreness of the waist and knees, controlling of hyperlipidemia etc. Treat.
The Radix Astragali: the continuous Radix Astragali of another name, this medical herbs sweet in the mouth, warm in nature.Enter lung, spleen channel.Modern medicine study shows, The Clinical pharmacological efficiencies such as the Radix Astragali has heart tonifying, excited respiratory center, protects the liver, reducing blood sugar and blood fat.TCM Bed is summed up, and the Radix Astragali is the good medicine of invigorating QI to consolidate the body surface resistance.It is solid that the present invention has used this effect of the Radix Astragali to carry out patient and his family Table.
Fructus Lycii: another name lycium barbarum, blood Fructus Lycii etc., this Chinese medicine sweet in the mouth, property are flat, enter liver, kidney channel.Existing Showing for medical research, Fructus Lycii has the sweet cell regeneration effect of promotion, and fat can be suppressed to deposit in liver, Reduce blood middle cholesterol content and alleviate the pharmacological action of arteriosclerosis.Tcm clinical practice is summed up, and Fructus Lycii is to mend The good medicine of kidney improving eyesight, has the effects such as nourishing the liver and kidney, replenishing YIN and blood, replenishing vital essence to improve eyesight.For asthenia damage of essence, Soreness of waist and knee joint, have a dizzy spell, tinnitus of passing out semen, unconsciously sweat and tire, sexual impotence sterile, interior-heat is quenched one's thirst, blood deficiency and yellow complexion Deng disease.
Example:
Former patient Tang, female, 57 years old, great Hua town, Dahua Yao Nationality Autonomous County Da Wu people from village, Dahuayaozu was autonomous Find during county people's hospital's Physical Check-Ups that in blood plasma, TL amount exceedes normal high limit, be diagnosed as hyperlipidemia, The medical institutions part-time to inventor go to a doctor.Private prosecution addiction delicious food usually, sitting drowsiness, often sense is dizzy not well, Breast gastral cavity painful abdominal mass is vexed, indolent and listless weak.A corpse or other object for laboratory examination and chemical testing is shown in: facial edema, obesity, coldness of the body with chills, and limbs are heavy, White and greasy fur, pulse condition stringy and rolling pulse.Take Chinese crude drug: Rhizoma Alismatis 30 grams, Fructus Crataegi 15 grams, Semen Cassiae 15 grams, Radix Salviae Miltiorrhizae 15 grams, Radix Polygoni Multiflori 15 grams, the Radix Astragali 15 grams, Fructus Lycii 10 grams.Totally 15 doses.Doctor's advice patient is low after going back After fat diet one week, taking above-mentioned Chinese medicine composition and be decocted in water for oral dose, every day, potion, drew blood further consultation to hospital after 15 days, In result display blood plasma, TL amount has declined, and then opens above-mentioned Chinese medicine composition 30 doses and continues to take, during further consultation Not dizzy, can fall asleep, uncomfortable in chest alleviate, in blood plasma, TL amount declines 25%.

Claims (1)

1. the invention belongs to treat lipid metabolism disease technical field, be specifically related to seven kinds of Chinese herbal medicine as raw material Make the Chinese medicine composition for treating hyperlipemia, it is characterised in that it is by the medium-height grass of following weight parts proportioning Medicine is made: Rhizoma Alismatis 30, Fructus Crataegi 15, Semen Cassiae 15, Radix Salviae Miltiorrhizae 15, Radix Polygoni Multiflori 15, the Radix Astragali 15, Fructus Lycii 10。
CN201610321399.2A 2016-05-17 2016-05-17 Traditional Chinese medicine composition for treating hyperlipidaemia Pending CN105832925A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110765A (en) * 2020-01-10 2020-05-08 冉兆勇 Soup for promoting blood circulation, removing blood stasis and reducing fat

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686498A (en) * 2005-04-15 2005-10-26 吴金珠 Jiangzhitongmai Chinese medicine for treating high blood fat disease
CN101496872A (en) * 2008-01-28 2009-08-05 天科仁祥技术(北京)有限责任公司 Chinese medicinal composition for reducing blood fat and preparation method thereof
CN102188560A (en) * 2010-03-08 2011-09-21 *** Traditional Chinese medicine for treating hyperlipidemia
CN103768297A (en) * 2014-01-15 2014-05-07 解程 Traditional Chinese medicine for treating hyperlipoidemia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686498A (en) * 2005-04-15 2005-10-26 吴金珠 Jiangzhitongmai Chinese medicine for treating high blood fat disease
CN101496872A (en) * 2008-01-28 2009-08-05 天科仁祥技术(北京)有限责任公司 Chinese medicinal composition for reducing blood fat and preparation method thereof
CN102188560A (en) * 2010-03-08 2011-09-21 *** Traditional Chinese medicine for treating hyperlipidemia
CN103768297A (en) * 2014-01-15 2014-05-07 解程 Traditional Chinese medicine for treating hyperlipoidemia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110765A (en) * 2020-01-10 2020-05-08 冉兆勇 Soup for promoting blood circulation, removing blood stasis and reducing fat

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Application publication date: 20160810