CN1653125A - 白内障和其它眼病发展的改善 - Google Patents
白内障和其它眼病发展的改善 Download PDFInfo
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- CN1653125A CN1653125A CNA038112213A CN03811221A CN1653125A CN 1653125 A CN1653125 A CN 1653125A CN A038112213 A CNA038112213 A CN A038112213A CN 03811221 A CN03811221 A CN 03811221A CN 1653125 A CN1653125 A CN 1653125A
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- alkyl
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- methyl
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
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- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
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- PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 description 1
- XEBWQGVWTUSTLN-UHFFFAOYSA-M phenylmercury acetate Chemical compound CC(=O)O[Hg]C1=CC=CC=C1 XEBWQGVWTUSTLN-UHFFFAOYSA-M 0.000 description 1
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- 210000002381 plasma Anatomy 0.000 description 1
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- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
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- 210000003491 skin Anatomy 0.000 description 1
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- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
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Abstract
Description
Tempol-H的浓度 μM | |||
30分钟 | 60分钟 | 120分钟 | |
化合物1 | 51.0 | 20.0 | 1.5 |
30.0 | 30.0 | 1.2 | |
18.0 | 6.0 | 7.0 | |
30.0 | 3.0 | 8.0 | |
平均值 | 32.3 | 14.8 | 4.4 |
μg/ml | (5.5) | (2.5 ) | (0.75) |
Tempol-H的浓度 μM | |||
30分钟 | 90分钟 | 血液 | |
化合物3 | 31.4 | 11.6 | 2.3 |
22.2 | 9.0 | 2.5 | |
平均值 | 26.8 | 10.8 | 2.4 |
μg/ml | (4.6) | (1.9) | (0.4) |
化合物2 | 52.4 | 6.0 | 3.6 |
35.2 | 5.7 | 0.6 | |
平均值 | 43.8 | 5.9 | 2.1 |
μg/ml | (7.5) | (1.0) | (0.4) |
条件 | 溶解性mg/ml | 溶解性%w/v |
水 | 74.9 | 7.5 |
0.9%氯化钠 | 40.5 | 4.1 |
pH值为4.8的0.01M乙酸盐缓冲液 | 68.6 | 6.9 |
pH值为4.8的0.01M柠檬酸盐缓冲液 | 71.1 | 7.1 |
水+1%w/v的甘油 | 62.2 | 6.2 |
水+1%w/v的丙二醇 | 63.8 | 6.4 |
实施例 | IR CKBr)cm-1羰基 | 1H-NMR(270MHz,DMSO-d6)ppm:酯部分 |
57 | 1716 | 3.75(S,9H);6.95(s,2H) |
61 | 17381687 | 2.79(t,2H);3.31(t,2H);7.45(m,2H);7.55(m,1H);7.93(d,2H) |
53 | 1682 | 6.87(d,2H);7.83(d,2H),10.3(br,s,1H) |
51 | 17181755 | 3.9(s,3H),7.18(d,2H),8.07(d,2H0 |
59 | 1723 | 6.54,7.85(dd,J=16.0Hz);6.84(m,1H);7.24(m,1H);7.54(d,1H);7.86(d,1H);10/2(br,s,1H) |
61 | 1718 | 1.96(m,2H);2.30(m,4H);2.78(m,2H) |
49 | 1688 | 2.88(S,6H);6.65(d,2H);7.73(d,2H) |
53 | 1682 | 3.70(s,3H);7.20(d,2H);7.72(d,2H) |
起始物质(结构) | 化学名称 |
Claims (60)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US38128702P | 2002-05-17 | 2002-05-17 | |
US60/381,287 | 2002-05-17 |
Publications (2)
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CN1653125A true CN1653125A (zh) | 2005-08-10 |
CN100469776C CN100469776C (zh) | 2009-03-18 |
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CNB038112213A Expired - Fee Related CN100469776C (zh) | 2002-05-17 | 2003-05-19 | 白内障和其它眼病发展的改善 |
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US (3) | US7442711B2 (zh) |
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CN102746218A (zh) * | 2011-04-21 | 2012-10-24 | 默克专利股份有限公司 | 化合物和液晶介质 |
US8999460B2 (en) | 2011-04-21 | 2015-04-07 | Merck Patent Gmbh | Compounds and liquid-crystalline medium |
CN102746218B (zh) * | 2011-04-21 | 2017-04-26 | 默克专利股份有限公司 | 化合物和液晶介质 |
US9920248B2 (en) | 2011-04-21 | 2018-03-20 | Merck Patent Gmbh | Compounds and liquid-crystalline medium |
CN102584683A (zh) * | 2012-02-29 | 2012-07-18 | 中国人民解放军第四军医大学 | Tempol类衍生物的合成及辐射防护作用 |
CN102584683B (zh) * | 2012-02-29 | 2014-12-24 | 中国人民解放军第四军医大学 | Tempol类衍生物的合成及辐射防护作用 |
Also Published As
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JP2005527605A (ja) | 2005-09-15 |
IL164639A0 (en) | 2005-12-18 |
US20080274983A1 (en) | 2008-11-06 |
US20040002461A1 (en) | 2004-01-01 |
US7442711B2 (en) | 2008-10-28 |
AU2003243282A1 (en) | 2003-12-02 |
KR20060013632A (ko) | 2006-02-13 |
AU2003243282B2 (en) | 2008-05-01 |
JP4615309B2 (ja) | 2011-01-19 |
NO20045483L (no) | 2004-12-16 |
IL164639A (en) | 2012-02-29 |
CA2484512C (en) | 2013-04-16 |
WO2003096991A3 (en) | 2004-02-26 |
CA2484512A1 (en) | 2003-11-27 |
ZA200408449B (en) | 2007-09-26 |
MXPA04011416A (es) | 2005-09-30 |
EP1507826A2 (en) | 2005-02-23 |
WO2003096991A2 (en) | 2003-11-27 |
US8383648B2 (en) | 2013-02-26 |
CN100469776C (zh) | 2009-03-18 |
EP1507826A4 (en) | 2007-11-07 |
US20130131052A1 (en) | 2013-05-23 |
BR0310057A (pt) | 2007-04-10 |
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