CN1621083A - Improvement of method for preparing healthy qi strengthening, astragalus root and glossy privet fruit containing medicine - Google Patents
Improvement of method for preparing healthy qi strengthening, astragalus root and glossy privet fruit containing medicine Download PDFInfo
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- CN1621083A CN1621083A CN 200310118934 CN200310118934A CN1621083A CN 1621083 A CN1621083 A CN 1621083A CN 200310118934 CN200310118934 CN 200310118934 CN 200310118934 A CN200310118934 A CN 200310118934A CN 1621083 A CN1621083 A CN 1621083A
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Abstract
The present invention relates to the improved preparation process of preparing available medicine Zhenqi medicine for strengthening body's resistance. The technological process of preparing available medicine Zhenqi medicine includes the steps of: alcohol reflux extraction of coarse powder of astragalus root and privet fruit, decompression distillation of the extracted liquid to obtain alcohol extracted extractum, decocting the medicine dregs, filtering to obtain filtrate, concentration and drying, mixing with the alcohol extracted extractum, further decompression drying, and spray drying to obtain dry extractum powder. The improved technological process can obtain the effective component oleanolic acid and higher content of astrasgaloside A.
Description
Technical field
The present invention relates to improvement to existing medicine " body resistance-strengthening Zhenqi " medicament preparation.
Background technology
Zhenqi Fuzheng medicine is to be used to improve immunity with the plant amedica Radix Astragali and Fructus Ligustri Lucidi with what the ratio of nearly 2: 1 (weight ratio) carried out that assembly produces, and treatment causes the medicine of leukopenia because of chemotherapy.The production technology of Zhenqi Fuzheng medicine is that the Radix Astragali and Fructus Ligustri Lucidi pulverizing are coarse powder in the prior art, and water decocts again, will obtain medicated powder after the aqueous extract drying again.Medicated powder incapsulated promptly make the commodity medicine.Show that after deliberation the active ingredient of Zhenqi Fuzheng medicine is organic acid, glycosides, Tie, Liu class and aminoacid and the trace element etc. in astragaloside, polysaccharide, the Fructus Ligustri Lucidi.Study in the organic acid of also finding Fructus Ligustri Lucidi in the Zhenqi Fuzheng medicine and be its active ingredient with oleanolic acid.But adopt prior art to extract in the gained medicine and can't obtain the oleanolic acid composition.And after repeatedly being improved, extraction process by water of the prior art still oleanolic acid can't be proposed from Fructus Ligustri Lucidi.
Summary of the invention
The present invention is to the improvement of existing Zhenqi Fuzheng medicine production technology, can overcome the deficiencies in the prior art through improved technology, can extract oleanolic acid from crude drug, improves the quality and the therapeutic effect of medicine.
Process modification of the present invention is first with the crude drug alcohol extraction, and then medicinal residues are carried out water extraction.Its concrete way is: earlier with the Radix Astragali and Fructus Ligustri Lucidi coarse powder alcohol reflux, the distilling under reduced pressure of gained liquid obtains alcohol-extracted extract, again the medicinal residues water behind ethanol extraction is decocted, carry out concentrate drying behind the filtrate extract again, add alcohol-extracted extract more therein, continue drying under reduced pressure, the reuse spray drying obtains dry extract.
Optimised process of the present invention be earlier with the Radix Astragali and Fructus Ligustri Lucidi coarse powder with 50～90% alcohol reflux of 3～8 times of amounts 1～4 hour, 50～90% alcohol reflux of 3～8 times of amounts of reuse 1～4 hour, merge filtrate twice, decompression recycling ethanol is no ethanol flavor to the medicine, and it is standby to obtain alcohol-extracted extract.The decocting that again will the medicinal residues after alcohol extraction adds 3～8 times boiled 1～4 hour, leached the laggard capable concentrating under reduced pressure of liquid and handled, and added alcohol-extracted extract more therein, continued concentrating under reduced pressure, and then carried out spray drying.
Through gained medicine of the present invention, its active ingredient is significantly higher than prior art, and can from crude drug, extract prior art the oleanolic acid that can't obtain.
The specific embodiment
Below provide embodiments of the invention and coherent detection data:
Take by weighing the Radix Astragali 1300～2000 gram, Fructus Ligustri Lucidi 600～1000 grams, with each medicated powder broken be less than 4 purpose coarse powder.The medicine coarse powder is mixed the back with the alcohol reflux of 3～8 times of amounts 50～90% 1～4 hour, and then measured 50～90% alcohol reflux 1～4 hour with 3～8 times.The filtrate that merges extracted twice, decompression recycling ethanol no ethanol to the medicine is distinguished the flavor of, and it is standby to obtain alcohol-extracted extract.
Again will the medicinal residues after alcohol extraction adding 3～8 times of decoctings boiled 1～4 hour, leaching the laggard row of liquid is evaporated to relative density and is 1.10 (60 ℃ of heat are surveyed), add alcohol-extracted extract, continuing to be evaporated to relative density is 1.15～1.20 (60 ℃ of heat are surveyed), carry out spray drying again, obtain about 440～600 grams of dry extract.
Show by analysis, behind employing the present invention, from every gram crude drug, can obtain astragaloside 0.180mg～0.540mg, oleanolic acid 2.160mg.And the water boiling and extraction technology of employing prior art, to identical crude drug, every gram only can obtain astragaloside 0.096mg～0.288mg, and oleanolic acid then can't obtain fully.By analyzing as seen, adopt technology of the present invention not only can from crude drug, propose to set upright the active ingredient oleanolic acid of medicine, but also the content of another active ingredient astragaloside is significantly improved.
Claims (2)
1, the method for body resistance-strengthening Zhenqi medicine preparation, the plant amedica Radix Astragali and Fructus Ligustri Lucidi pulverizing are coarse powder, ratio proportioning and the mixing that provides in pharmacopeia again, water carries out solid-liquid separation after decocting, with gained liquid concentrating under reduced pressure, spray drying, it is characterized in that the coarse powder alcohol reflux of elder generation with the Radix Astragali and Fructus Ligustri Lucidi, gained liquid obtains alcohol-extracted extract with distilling under reduced pressure, again the medicinal residues water behind ethanol extraction is decocted, carry out concentrate drying behind the filtrate extract, add alcohol-extracted extract more therein, continue drying under reduced pressure, spray drying obtains dry extract again.
2, the preparation method of body resistance-strengthening Zhenqi medicine according to claim 1, it is characterized in that earlier the Radix Astragali and Fructus Ligustri Lucidi coarse powder with 50～90% alcohol reflux of 3～8 times of amounts 1～4 hour, 50～90% alcohol reflux of 3～8 times of amounts of reuse 1～4 hour, merge filtrate twice, decompression recycling ethanol is to there not being the ethanol flavor, it is standby to obtain alcohol-extracted extract, again will the medicinal residues after alcohol extraction adding 3～8 times of decoctings boiled 1～4 hour, leaching the laggard capable concentrating under reduced pressure of liquid handles, add alcohol-extracted extract more therein, continue concentrating under reduced pressure, and then carry out spray drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310118934 CN1621083A (en) | 2003-11-28 | 2003-11-28 | Improvement of method for preparing healthy qi strengthening, astragalus root and glossy privet fruit containing medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310118934 CN1621083A (en) | 2003-11-28 | 2003-11-28 | Improvement of method for preparing healthy qi strengthening, astragalus root and glossy privet fruit containing medicine |
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| Publication Number | Publication Date |
|---|---|
| CN1621083A true CN1621083A (en) | 2005-06-01 |
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| CN 200310118934 Pending CN1621083A (en) | 2003-11-28 | 2003-11-28 | Improvement of method for preparing healthy qi strengthening, astragalus root and glossy privet fruit containing medicine |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169773A (en) * | 2011-12-20 | 2013-06-26 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method |
| CN103599189A (en) * | 2013-11-21 | 2014-02-26 | 贵州信邦制药股份有限公司 | Zhenqi Fuzheng (Chinese character) injection preparation and preparation method thereof |
| CN104013680A (en) * | 2014-05-28 | 2014-09-03 | 王庚禹 | Extractive for preparing astragalus membranaceus-ligustrum healthy-qi-reinforcing preparation |
| CN104771595A (en) * | 2015-03-23 | 2015-07-15 | 广西龙凤山生物科技有限责任公司 | Chinese medicinal composition for enhancing immunity and preparation method thereof |
| CN106138227A (en) * | 2015-03-31 | 2016-11-23 | 北京海吉星医疗科技有限公司 | A kind of Chinese medicine composition treating eczema |
| CN106176973A (en) * | 2015-05-08 | 2016-12-07 | 北京海吉星医疗科技有限公司 | A kind of ultrasonic extracting method of Chinese medicine composition |
-
2003
- 2003-11-28 CN CN 200310118934 patent/CN1621083A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169773A (en) * | 2011-12-20 | 2013-06-26 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method |
| CN103169773B (en) * | 2011-12-20 | 2015-07-15 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine compound preparation for enhancing livestock immunity and preparation method |
| CN103599189A (en) * | 2013-11-21 | 2014-02-26 | 贵州信邦制药股份有限公司 | Zhenqi Fuzheng (Chinese character) injection preparation and preparation method thereof |
| CN104013680A (en) * | 2014-05-28 | 2014-09-03 | 王庚禹 | Extractive for preparing astragalus membranaceus-ligustrum healthy-qi-reinforcing preparation |
| CN104771595A (en) * | 2015-03-23 | 2015-07-15 | 广西龙凤山生物科技有限责任公司 | Chinese medicinal composition for enhancing immunity and preparation method thereof |
| CN104771595B (en) * | 2015-03-23 | 2018-11-16 | 广西龙凤山生物科技有限责任公司 | A kind of Chinese medicine composition of strengthen immunity and preparation method thereof |
| CN106138227A (en) * | 2015-03-31 | 2016-11-23 | 北京海吉星医疗科技有限公司 | A kind of Chinese medicine composition treating eczema |
| CN106176973A (en) * | 2015-05-08 | 2016-12-07 | 北京海吉星医疗科技有限公司 | A kind of ultrasonic extracting method of Chinese medicine composition |
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