CN1602915A - Stomach motility promoting medicine for treating stomach and intestine function failure and its preparation - Google Patents
Stomach motility promoting medicine for treating stomach and intestine function failure and its preparation Download PDFInfo
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Abstract
The invention relates to a stomach power medicine for curing function failure of stomach intestine and its preparing method, prepared of the following raw materials in weight proportion: fried radix bupleuri 5-20, radix paeoniae alba 5-20, Asarum sieboldii 3-8, fuling 10-25, fried Radix scutellariae 10-25, Rhizoma Pinellinae Praeparata 5-20, areca-nut 10-20, raw rheum officinale 5-15, the membrane of a chicken's gizzard 5-20 and fruit of citron or trifoliate orange 5-20. It is used mainly to cure abdominal distension, bellyache, constipation, etc, and achieves better clinic effect in wide application to internal medicine, surgical department and department of orthopedics. It gives full play to the curative advantages of multiple uses and multiple target points of compound traditional Chinese medicine, convenient to take, low-price, having no obvious toxicity and side effect, and it is a pure Chinese medicinal preparation with a good prospect in applying and developing.
Description
Technical field
The present invention relates to treat the medicine for stomach dynamic of gastrointestinal functional failure, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
One, modern medicine understanding that stomach and intestine dynamics is changed:
(1) severe crisis changes gastrointestinal function
Gastrointestinal not only has digestion, absorption function under the physiological conditions, and also has endocrine, immunity, functions such as mucosal barrier.But under some pathological factor effect, for example infect, shock etc., gastrointestinal is rotten to the corn, hemorrhage because of strong stress.Continue to exist as the cause of disease, then can develop into toxical paralytic ileus, promptly so-called gastrointestinal functional failure is involved the various functions of gastrointestinal thereupon, especially the existence of enteroparalysis, both influence the gastrointestinal digestive and absorptive functions, can impel bacterial overgrowth breeding in the intestinal again, caused dysbacteriosis, cause that bacterial translocation and toxin absorb, activate the liver Kupffer Cell, cause a large amount of inflammatory cytokine to discharge, impel systemic inflammatory response syndrome and MOFE syndrome (MODS) to take place and development.
(2) gastrointestinal function changes behind the surgical operation
Surgical operation, especially abdominal postoperative, because wound and anesthesia are suppressed gastrointestinal function to the retardance of nerve, digestive tract power weakens, and causes postoperative to occur enteroparalysis in early days.The abdominal post-operation intestinal function recovery is slow, can cause that organismic internal environment is disorderly and bring out various complication, and operation wound is one of reason of intestinal endotoxemia generation simultaneously, and this weakens relevant with postoperative intestine paralysis, intestinal barrier function.
(3) gastrointestinal function changes in the bone disease
Lumbar vertebra compression fracture is early stage, because fracture back forms huge hematoma behind the peritoneum, compressing stimulating plant nerve causes digestive tract power unusual, causes that even enterokinesia is slowed down abdominal distention, stomachache vomiting and nausea are indigestion and loss of appetite, constipation.
Two, tcm theory and modern medicine:
Gastrointestinal dysfunction is the common disease of digestive system, is again severe complications in the clinical various severe crisis, even the person causes the displacement of intestinal bacteria and toxin, and then causes multiple organ dysfunction syndrome owing to gastrointestinal functional failure.The recovery of stomach and intestine dynamics is an approach of alleviating the initial and most critical of gastrointestinal functional failure, and doctor trained in Western medicine does not have any special measures treatment gastrointestinal and benumbs at present.Though do not have this name of disease of gastrointestinal functional failure in the Chinese medicine,, can belong to the traditional Chinese medical science " stomach is slow " " abdominal distention " sick categories such as " stomachache " according to its Clinical symptoms.Chinese medicine thinks that gastrointestinal belongs to six internal organs, the physiological function of six internal organs is " excreting foodstuff instead of storing essence " " FU-organ being filled with foodstuff but inability to be full of essence-QI " " moving and not quiet " " walk and do not keep ", its physiological characteristics " is usefulness to lead to ", six internal organs are valued for unblocked, the logical row of falling, otherwise then disease can take place, itself and become living serious symptom, danger disease, incruable disease.
Summary of the invention
The purpose of this invention is to provide the medicine for stomach dynamic for the treatment of gastrointestinal functional failure, it is to the gastrointestinal dysfunction person, but both broken stagnant, releasing enteroparalysis of circulation of qi promoting, recover gastrointestinal power, but the toxin expelling purging FU-organs solves bacterial translocation or toxin and absorbs problem again, also can turn round and look at simultaneously and protect healthy energy, repair gastrointestinal immunologic barrier function, current six internal organs function.
Another object of the present invention also is to provide manufacturing method for above mentioned medicine.
The present invention be the inventor in the more than two decades clinical position, through repeatedly practising exploration, developed through proved recipe.Prescription conception is with Basic Theories of Chinese Medicine " the six hollow viscera must keep its unobstructed " foundation, is intended to circulation of qi promoting intestinal stasis relieving, heat-clearing and toxic substances removing, purging FU-organs and lets out turbid.Can recover normal gastrointestinal power, remove enteroparalysis, blocking-up intestinal bacteria and endotoxin translocation.Clinically be mainly used in gastrointestinal functional failure in the internal medicine severe crisis; The enteroparalysis of surgery abdominal postoperative; The bloated vomiting of intestinal due to abdominal distention stomachache and the caused gastric hypokinesia of a variety of causes behind the lumbar vertebra compression fracture, inappetence, constipation etc.This side's clinical application is comparatively extensive, that tests repeatedly is clinical, determined curative effect, development is for one dashing and can take behind the granule, administration is very convenient, for the anxious critical illness of clinical treatment provides a measure safely and effectively, improved treatment rate and the treatment level of Chinese medicine greatly to severe crisis, can obtain good social benefit and economic benefit.
Medicine of the present invention is to be prepared from by following materials of weight proportions:
Radix Bupleuri Chinensis (parched) 5～20, the Radix Paeoniae Alba 5～20, Herba Asari 3～8, Poria 10～25, Radix Scutellariae (parched) 10～25, Rhizoma Pinelliae Preparatum 5～20, Semen Arecae 10～25, Radix Et Rhizoma Rhei 5～15, Endothelium Corneum Gigeriae Galli 5～20, Fructus Aurantii Immaturus 5～20.
The preparation method of the raw material of said ratio being made granule is:
1) Endothelium Corneum Gigeriae Galli is reserved, and is standby;
2) Herba Asari is used hydrodistillation separately, extract Aromatic water, Aromatic water and beta-schardinger dextrin-adopt the enclose condition of the preferred Oleum Asari-β of orthogonal design method-CYD clathrate molding, make the Herba Asari volatile oil enclose become Oleum Asari-β-CYD clathrate in clathrate, and be standby;
3) all the other medical materials that will be except that Radix Et Rhizoma Rhei and above-mentioned Herba Asari medicinal residues are in normal pressure, under the vacuum water extraction once, the time is 1～2 hour, filters filtrate for later use.
4) 3) in the decocting in water second time of raw material carry and add Radix Et Rhizoma Rhei in the process, common water extraction 1～2 hour filters filtrate for later use;
5) merge twice filtrate, in reduced vacuum, 75～85 ℃ are concentrated into thick paste, admix the Endothelium Corneum Gigeriae Galli powder mixing, in vacuum decompression, and 70～80 ℃ of dryings.
6) dried extractum was pulverized 80 mesh sieves, with Oleum Asari-β-CYD clathrate mixing.
7) with said mixture with 95% ethanol powder process, 60～70 ℃ of dryings;
8) after the drying, granulate, packing gets final product, every bag of 10g, every bag is equivalent to crude drug in whole 104g.
Medicine of the present invention also can be made other dosage form.
Medicine of the present invention recovers ascending or descending movement of vital Qi, Semen Arecae, the broken knot of Fructus Aurantii Immaturus circulation of qi promoting intestinal stasis relieving in the side, and 5 walk to scurry the current twelve regular channels with the hot perfume (or spice) of Herba Asari, and the special recovery gastrointestinal peristalsis of power is aided with Radix Et Rhizoma Rhei, Radix Scutellariae heat clearing away purging FU-organs toxin expelling.Radix Bupleuri, Radix Paeoniae Alba depressed liver-energy dispersing and QI regulating, harmonizing the functional activities of vital QI is assistant; Just protect gastric qi with Poria, Rhizoma Pinelliae Preparatum, Endothelium Corneum Gigeriae Galli spleen invigorating sending down the abnormal ascending QI with Gu.All medicines share plays altogether that circulation of qi promoting is broken to stagnate, and heat-clearing and toxic substances removing, purging FU-organs are let out the turbid merit of taking into account healthy energy.To the gastrointestinal dysfunction person, stagnate, remove enteroparalysis but both circulation of qi promoting is broken, recover gastrointestinal power, but toxin expelling purging FU-organs again solves bacterial translocation or toxin and absorbs problem; Also can turn round and look at simultaneously and protect healthy energy, repair gastrointestinal immunologic barrier function, give full play to the Chinese traditional compound medicine multipath, the treatment advantage of many target spots, and taking convenience, cheap, no obvious toxic-side effects is a pure Chinese medicinal preparation with good utilization DEVELOPMENT PROSPECT.
It below is the clinical observation result of medicine of the present invention.
1, physical data
87 routine body temperature are all more than 38 ℃, and have in excess syndrome of YANG MING FU-organ characteristics of syndrome and the following 1-5 item any 3 and the 6th, 7.1. heating, dry pharynx, dryness of the tongue are thought cold drink yearningly, and the thin ear of face is red; 2. fidgety, delirium or stupor; 3. rapid breathing, fullness in the chest and hypochondrium is vexed, the asthma abundant expectoration; 4. oliguria with reddish urine burns pain, constipation; 5. abdominal distention, stomachache, tenderness; Red or the red drop of red tongue plays prickle, and yellow fur is thick or thick in vain; 7. wiry forceful pulse or sliding number sink and lie prostrate strong or heavy number effectively.
87 examples are divided into treatment group and matched group at random, and 57 examples are organized in treatment, male 32 examples, women 25 examples; Age 13-78 year, average 44.2 years old; Pneumonia 19 examples wherein, acute cerebrovascular disease 15 examples, acute gallstone pancreatitis 12 examples, acute pyelonephritis 11 examples.Matched group 30 examples, male 17 examples, women 13 examples; Age 14-76 year, average 43.1 years old; Pneumonia 10 examples wherein, acute cerebrovascular disease 8 examples, acute gallstone pancreatitis 7 examples, acute pyelonephritis 5 examples.Two groups of sexes, age and primary disease no significant differences (p＞0.05) have comparability.
2, Therapeutic Method
Two groups all disorderly reach the Supporting Therapy of suiting the medicine to the illness according to environment rate in disease kind different application antibiotic, the correction.The treatment group adds uses medicine of the present invention, each 30ml that takes after mixing it with water, and day 2 times, adjust medication according to times of defecation the 3-5 days course of treatment, defecate every day and be advisable for 3-4 time, if the times of defecation showed increased, drug withdrawal when dehydration sign is arranged.
3, criterion of therapeutical effect
Produce effects: temperature recovery is normal in 3 days, and it is normal that hemogram checking recovers, and clinical symptoms is obviously alleviated, and it is normal that picture of the tongue recovers.Effectively: temperature recovery is normal in 4-7 day, and it is normal that hemogram recovers, and clinical symptoms SPR, picture of the tongue recover normal.Invalid: hemogram and symptom are not all improved after 7 days.
4, therapeutic outcome
Two groups of curative effects relatively see Table 1
Group n produce effects enabledisable total effective rate
Treatment organizes 57 38 (66.7) 16 (28.1) 3 (5.3) (94.7)
Matched group 30 12 (40.0) 16 (53.3) 2 (6.7) (93.3)
Two groups of total effective rates are close, no significant difference, and obvious effective rate treatment group is learned by statistics and is handled apparently higher than matched group, and significant difference (p＜0.05) is arranged.
5, discuss:
(1) in urgency, danger, seriously disease, use:
When various infectious calentura, acute pancreatitis, acute cerebrovascular disease, shock etc., gastrointestinal tract abdominal distention, stomachache, weight person occur and paralytic ileus, this moment occur and easily cause bacterial reproduction and undue growth in the intestinal because of being subjected to serious emergency reaction the lighter, cause transposition and the endotoxic release of intestinal bacteria, more than these patients when the gastrointestinal function obstacle occurring, often do not have special treatment way, and use medicine of the present invention can alleviate abdominal distention, stomachache significantly, enterokinesia is speeded, avoided the generation of paralytic ileus.By removing heat by catharsis expells the pathogenic heat, antibacterial and toxin are excreted simultaneously, can reduce the little ecological disorderly of intestinal bacteria, the transposition of control intestinal bacteria.At present, the intervention of eliminate the inflammation medium and protection gastrointestinal function Chinese medicine is a treatment means preferably in the treatment of critical illness.
(2) patient recovers gastrointestinal function as early as possible behind the help surgical operation:
Surgical operation, especially abdominal operation, because wound and anesthesia are to the retardance of nerve, cause digestive tract power to weaken, even paralytic ileus appears, clinical practice finds to use behind the surgical operation medicine of the present invention can recover the gastrointestinal function of patient behind the surgical operation as soon as possible, and the patient can be rehabilitated very soon.In addition, for some critical patients, especially the patient who needs the row enteral nutrition to support, if there is not good gastric motility, be impossible go the very smooth enteral nutrition Supporting Therapy that carries out, at this moment, we are in clinical position, the application of the invention medicine keeps the good gastric motility function of patient, makes that clinical nutrition Supporting Therapy is smooth.
(3) application of bone disease gastrointestinal dysfunction: lumbar vertebra compression fracture is early stage, owing to stroke the back hematoma, compressing stimulating plant nerve, cause digestive tract power unusual, enterokinesia is slowed down and is caused abdominal distention, stomachache, constipation, influence the healing of fracture site, use medicine of the present invention and can improve above-mentioned symptom rapidly, relieving constipation is rushed down turbid.The patient is rehabilitated as early as possible.
Drug main of the present invention will be used for the treatment of adjuvant therapy medicaments of abdominal distention that above disease causes, stomachache, constipation, various infectious disease, clinical nutrition Supporting Therapy etc., has obtained clinical effectiveness preferably in internal medicine, surgery and orthopaedics extensive use.
The specific embodiment
Embodiment 1:(weight portion unit: kilogram)
Choose following Chinese crude drug: Radix Bupleuri Chinensis (parched) 10, the Radix Paeoniae Alba 10, Herba Asari 6, Poria 15, Radix Scutellariae (parched) 15, Rhizoma Pinelliae Preparatum 10, Semen Arecae 15, Radix Et Rhizoma Rhei 10, Endothelium Corneum Gigeriae Galli 10, Fructus Aurantii Immaturus 10.
Preparation method:
1) Endothelium Corneum Gigeriae Galli is reserved, and is standby;
2) Herba Asari is used hydrodistillation separately, extract Aromatic water, Aromatic water and beta-schardinger dextrin-adopt the enclose condition of the preferred Oleum Asari-β of orthogonal design method-CYD clathrate molding, make the Herba Asari volatile oil enclose become Oleum Asari-β-CYD clathrate in clathrate, and be standby;
3) will all the other medical materials and above-mentioned Herba Asari medicinal residues time of water extraction under normal pressure, vacuum except that Radix Et Rhizoma Rhei be 1～2 hour, filter filtrate for later use.
4) 3) in the decocting in water second time of raw material carry and add Radix Et Rhizoma Rhei in the process, common water extraction 1～2 hour filters filtrate for later use;
5) merge twice filtrate, in reduced vacuum, 75～85 ℃ are concentrated into thick paste, admix the Endothelium Corneum Gigeriae Galli powder mixing, in vacuum decompression, and 70～80 ℃ of dryings.
6) dried extractum was pulverized 80 mesh sieves, with Oleum Asari-β-CYD clathrate mixing.
7) with said mixture with 95% ethanol powder process, 60～70 ℃ of dryings;
8) after the drying, granulate, packing gets final product, every bag of 10g, every bag is equivalent to crude drug in whole 104g.
Embodiment 2:(weight portion unit: kilogram)
Choose following Chinese crude drug: Radix Bupleuri Chinensis (parched) 5, the Radix Paeoniae Alba 5, Herba Asari 3, Poria 10, Radix Scutellariae (parched) 10, Rhizoma Pinelliae Preparatum 5, Semen Arecae 10, Radix Et Rhizoma Rhei 5, Endothelium Corneum Gigeriae Galli 5, Fructus Aurantii Immaturus 5.
Press the method preparation of embodiment 1.
Embodiment 3:(weight portion unit: kilogram)
Choose following Chinese crude drug: Radix Bupleuri Chinensis (parched) 15, the Radix Paeoniae Alba 15, Herba Asari 8, Poria 20, Radix Scutellariae (parched) 20, Rhizoma Pinelliae Preparatum 15, Semen Arecae 20, Radix Et Rhizoma Rhei 15, Endothelium Corneum Gigeriae Galli 15, Fructus Aurantii Immaturus 15.
Press the method preparation of embodiment 1.
Claims (2)
1. medicine for stomach dynamic for the treatment of gastrointestinal functional failure is characterized in that it being the medicament that is prepared from by following materials of weight proportions:
Radix Bupleuri Chinensis (parched) 5～20, the Radix Paeoniae Alba 5～20, Herba Asari 3～8, Poria 10～25, Radix Scutellariae (parched) 10～25, Rhizoma Pinelliae Preparatum 5～20, Semen Arecae 10～20, Radix Et Rhizoma Rhei 5～15, Endothelium Corneum Gigeriae Galli 5～20, Fructus Aurantii Immaturus 5～20.
2. the preparation method of the medicine for stomach dynamic of treatment gastrointestinal functional failure as claimed in claim is characterized in that making according to the following steps granule:
1) Endothelium Corneum Gigeriae Galli is reserved, and is standby;
2) Herba Asari is used hydrodistillation separately, extract Aromatic water, Aromatic water and beta-schardinger dextrin-adopt the enclose condition of the preferred Oleum Asari-β of orthogonal design method-CYD clathrate molding, make the Herba Asari volatile oil enclose become Oleum Asari-β-CYD clathrate in clathrate, and be standby;
3) all the other medical materials that will be except that Radix Et Rhizoma Rhei and above-mentioned Herba Asari medicinal residues are in normal pressure, under the vacuum water extraction once, the time is 1～2 hour, filters filtrate for later use;
4) 3) in the decocting in water second time of raw material carry and add Radix Et Rhizoma Rhei in the process, common water extraction 1～2 hour filters filtrate for later use;
5) merge twice filtrate, in reduced vacuum, 75～85 ℃ are concentrated into thick paste, admix the Endothelium Corneum Gigeriae Galli powder mixing, in vacuum decompression, and 70～80 ℃ of dryings;
6) dried extractum was pulverized 80 mesh sieves, with Oleum Asari-β-CYD clathrate mixing;
7) with said mixture with 95% ethanol powder process, 60～70 ℃ of dryings;
8) after the drying, granulate, packing gets final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100403371A CN100469380C (en) | 2004-07-28 | 2004-07-28 | Stomach motility promoting medicine for treating stomach and intestine function failure and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100403371A CN100469380C (en) | 2004-07-28 | 2004-07-28 | Stomach motility promoting medicine for treating stomach and intestine function failure and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1602915A true CN1602915A (en) | 2005-04-06 |
| CN100469380C CN100469380C (en) | 2009-03-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN1305499C (en) * | 2005-10-26 | 2007-03-21 | 柴伟利 | Medicine for treating chronic constipation |
| CN103083504A (en) * | 2013-03-07 | 2013-05-08 | 于晓红 | Traditional medical composition for treating constipation |
| CN103816262A (en) * | 2014-03-26 | 2014-05-28 | 杨巧芝 | Medicine for treating neonatal gastrointestinal dysfunction |
| CN104306610A (en) * | 2014-10-17 | 2015-01-28 | 王洪强 | Traditional Chinese medicine for treating hyperacidity and preparation method of traditional Chinese medicine |
| CN105456893A (en) * | 2015-12-25 | 2016-04-06 | 梁献彬 | Traditional Chinese medicine pill for treating dispelling gastrectasia and preparation method of traditional Chinese medicine pill |
| CN109172635A (en) * | 2018-05-16 | 2019-01-11 | 上海中医药大学 | A kind of preparation method of the Chinese medicine composition containing ramulus cinnamomi |
Family Cites Families (2)
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| CN1218685A (en) * | 1998-10-30 | 1999-06-09 | 阎作礼 | Capsule for enterogastric disease |
| CN1449773A (en) * | 2002-04-08 | 2003-10-22 | 胡仕华 | Chinese patent drug for treating gastric ulcer and its preparation method |
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- 2004-07-28 CN CNB2004100403371A patent/CN100469380C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305499C (en) * | 2005-10-26 | 2007-03-21 | 柴伟利 | Medicine for treating chronic constipation |
| CN103083504A (en) * | 2013-03-07 | 2013-05-08 | 于晓红 | Traditional medical composition for treating constipation |
| CN103816262A (en) * | 2014-03-26 | 2014-05-28 | 杨巧芝 | Medicine for treating neonatal gastrointestinal dysfunction |
| CN103816262B (en) * | 2014-03-26 | 2015-08-05 | 杨巧芝 | The medicine for the treatment of Neonatal gastrointestinal dysfunction |
| CN104306610A (en) * | 2014-10-17 | 2015-01-28 | 王洪强 | Traditional Chinese medicine for treating hyperacidity and preparation method of traditional Chinese medicine |
| CN105456893A (en) * | 2015-12-25 | 2016-04-06 | 梁献彬 | Traditional Chinese medicine pill for treating dispelling gastrectasia and preparation method of traditional Chinese medicine pill |
| CN109172635A (en) * | 2018-05-16 | 2019-01-11 | 上海中医药大学 | A kind of preparation method of the Chinese medicine composition containing ramulus cinnamomi |
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| Publication number | Publication date |
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| CN100469380C (en) | 2009-03-18 |
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