CN109078157A - A kind of anti-tumor drug and preparation method thereof - Google Patents
A kind of anti-tumor drug and preparation method thereof Download PDFInfo
- Publication number
- CN109078157A CN109078157A CN201811312664.6A CN201811312664A CN109078157A CN 109078157 A CN109078157 A CN 109078157A CN 201811312664 A CN201811312664 A CN 201811312664A CN 109078157 A CN109078157 A CN 109078157A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- tumor drug
- poria cocos
- ganoderma lucidum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of anti-tumor drug and preparation method thereof, which is made of the raw material components of following parts by weight: 13-21 parts of radix scutellariae, 10-20 parts of Herba Andrographitis, 11-18 parts of Prunella vulgaris, 7-15 parts of curcuma zedoary, 10-18 parts of white leaf rattan, 10-21 parts of dried orange peel, 9-15 parts of cortex cinnamomi, 11-19 parts of Poria cocos, 8-15 parts of ganoderma lucidum, 10-20 parts of Radix Astragali, 7-11 parts of Radix Glycyrrhizae.Drug effective percentage of the present invention is up to 98%, and quick, pharmacological property mitigates, and toxic side effect is small, no dependence；Full side's legislation is careful, medication is fastidious, compatibility is precise and appropriate；The present invention has fully demonstrated the theory of Traditional Chinese Medicine strengthening vital QI to eliminate pathogenic factors, giving consideration to both the incidental and fundamental.The present invention each bulk pharmaceutical chemicals synergistic effect is mended without stagnant, is rushed down without void, temperature of trembling with fear is suitable, the feeding taste of temperature, heat-clearing dissipating bind, and promoting blood circulation and stopping pain improves the antitumor ability of body, reduces the transfer of tumour, extend the service life of tumor patient.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, it is related to a kind of anti-tumor drug and preparation method thereof.
Background technique
Tumour is body under the effect of various carcinogenic factors, some cell of local organization loses pair at the genetic level
Its normal regulation grown leads to its clonal abnormality hyperplasia and the abnormality that is formed.Tumour is generally divided into benign by educational circles
With pernicious two major classes.Tumour has become the number one killer for 21 century threatening human survival, has more than 600 ten thousand people to die of respectively every year on average
Kind tumor disease.China is one of high-incidence country of world's cancer, and is presented a rapidly rising trend every year.
Clinically the drug for the treatment of tumour mainly has chemicals at present, but since chemotherapeutics toxicity is big, swollen killing
Also human autoimmunes' cell such as kill leucocyte, lymphocyte of non-selectivity while oncocyte, cause patient usually by
It being lowly complicated by infection in because of autoimmune ability, patient uses erious adverse reaction, and the course for the treatment of is long, and it is costly, in clinical use
There is biggish limitation.
Traditional Chinese medicine has unique advantage in terms for the treatment of tumour, has poison is secondary to make by the natural class drug of representative of Chinese medicine
With the features such as small, action target spot is various, tolerance is good, more and more it is taken seriously in terms for the treatment of tumour.But existing Chinese medicine
Medicine treats tumour, the unconspicuous defect of generally existing slow effect, effect.
Summary of the invention
The object of the present invention is to provide a kind of anti-tumor drugs and preparation method thereof, to solve to be mentioned in above-mentioned background technique
To the problem of.
The technical scheme adopted by the invention is that a kind of anti-tumor drug, is made of the raw material components of following parts by weight: yellow
13-21 parts of a kind of reed mentioned in ancient books, 10-20 parts of Herba Andrographitis, 11-18 parts of Prunella vulgaris, 7-15 parts of curcuma zedoary, 10-18 parts of white leaf rattan, 10-21 parts of dried orange peel, meat
Osmanthus 9-15 parts, 11-19 parts of Poria cocos, 8-15 parts of ganoderma lucidum, 10-20 parts of Radix Astragali, 7-11 parts of Radix Glycyrrhizae.
Further, a kind of anti-tumor drug is made of the raw material components of following parts by weight: 15-19 parts of radix scutellariae, Herba Andrographitis
13-17 parts, 12-16 parts of Prunella vulgaris, 10-14 parts of curcuma zedoary, 12-16 parts of white leaf rattan, 14-18 parts of dried orange peel, 11-15 parts of cortex cinnamomi, Poria cocos
13-17 parts, 11-15 parts of ganoderma lucidum, 14-18 parts of Radix Astragali, 7-11 parts of Radix Glycyrrhizae.
Further, a kind of anti-tumor drug is made of the raw material components of following parts by weight: 17 parts of radix scutellariae, Herba Andrographitis 15
Part, 14 parts of Prunella vulgaris, 12 parts of curcuma zedoary, 14 parts of white leaf rattan, 16 parts of dried orange peel, 13 parts of cortex cinnamomi, 15 parts of Poria cocos, 13 parts of ganoderma lucidum, Radix Astragali 16
Part, 9 parts of Radix Glycyrrhizae.
A kind of preparation method of anti-tumor drug, prepares as follows:
(1) 13-21 parts of radix scutellariae, 10-20 parts of Herba Andrographitis, 11-18 parts of Prunella vulgaris, curcuma zedoary 7-15 are weighed respectively by weight
It is part, 10-18 parts of white leaf rattan, 10-21 parts of dried orange peel, 9-15 parts of cortex cinnamomi, 11-19 parts of Poria cocos, 8-15 parts of ganoderma lucidum, 10-20 parts of Radix Astragali, sweet
It is 7-11 parts careless；
(2) radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng, dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae are added into water
Slightly boiled decoction three times, for the first time plus is equivalent to 11-13 times of above-mentioned raw materials gross mass and measures water, decoct 80-95min, second plus phase
When measuring water in 9-11 times of above-mentioned raw materials gross mass, 45-60min is decocted, third time plus be equivalent to 6-8 times of above-mentioned raw materials gross mass and measure
Water decocts 30-45min, merges decocting liquid three times, cools filtering, be concentrated under reduced pressure into 1-2g/mL, spare；
(3) concentrate obtained in step (2) is added into auxiliary material, the finished dosage forms of clinical needs is made.
Capsule, tablet, pill, granule or oral solution can be made in anti-tumor drug.
The effect of forming each raw material of the invention activity is as follows:
Radix scutellariae: heat-clearing and damp-drying drug, purging fire for removing toxin, miscarriage prevention, cooling blood and hemostasis.It can be used for being depressured, be calmness, anti-microbial effect, right
Blood lipid and blood glucose effect, are relievingd asthma at diuresis.
Herba Andrographitis: taste bitter and cold, return heart, lung, large intestine, bladder meridian, the effect of Herba Andrographitis are clearing heat and detoxicating, cool blood detumescences,
Herba Andrographitis is often used for cold, fever, abscess of throat, aphthae, pertussis overstrain cough, dysentery, puckery pain of heat gonorrhea, carbuncle swells sore
Ulcer, snakebite and bugbite etc..
Prunella vulgaris: for the wounded in the battle fruit ear of Labiatae herbaceos perennial Prunella vulgaris.Also known as iron color grass, wooden club grass etc..
With clearing away the liver-fire, the effect of Disperse hepatic depression.It is its bitter, pungent, it is cold in nature.Main product is in Soviet Union, Zhejiang, Anhui, Henan and other places.Zoopery confirms decoction
Have decompression, diuresis, shrink uterus, enhancing enterocinesia the effects of, clinic be usually used in headache caused by controlling hypertension, irascibility, dizziness,
The illnesss such as red eye, swell pain, photophobia shed tears, goiter, scrofula.
Curcuma zedoary: pungent, bitter, temperature returns liver, the spleen channel, promoting the circulation of qi blood-breaking, clearing stagnation and killing pain, Yong Yu abdominal mass and lump, tired menostasis, the thoracic obstruction heart
Bitterly, dyspepsia distending pain.Modern studies have found that curcuma zedoary has antitumor action.
White leaf rattan: nature and flavor are sweet, light, cool.It is slightly poisonous.Major function: clearing heat and detoxicating, removing blood stasis and acesodyne, hemostasis.For pulmonary tuberculosis
Hemoptysis, lung heat hemoptysis, gastrorrhagia, venomous snake bite, sore ulcer, scabies, bruise knife wound.
Dried orange peel: bitter, pungent, warm-natured, return lung, the spleen channel, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm, is used for abdominal fullness and distention, and deficiency of food is vomited and diarrhoea,
Coughing with a lot of sputum.
Cortex cinnamomi: supplementing Yuanyang, warming spleen and stomach, removing internal cold, promoting blood circulation.The Yang-function insufficiency of kidneyzang, cold weak pulse of limb are controlled, yang depletion is collapsed, and abdominal pain is let out
It rushes down, cold hernia renal mass, waist and knee crymodynia, menostasis abdominal mass, negative subcutaneous ulcer, streamer, and empty sun is floating more, heat in the upper and cold in the lower.
Poria cocos: Poria cocos " long term usage, peace soul are reposed, not hungry macrobiosis " is said in Shennong's Herbal.Poria cocos has antitoxic heart-soothing and sedative, loses
The effect of malicious anticancer.Medicinal peace, dampness removing is without hurting healthy tendency.The maintenance good merchantable brand that can be used as spring and summer wet season is taken in right amount, it can
Control difficult urination, edema swelling, sip and cough, the diseases such as inverse, vomiting during early pregnancy, diarrhea, spermatorrhea, stranguria with turbid discharge, palpitation with fear, amnesia of vomitting.Contained Poria cocos
Acid has the function of strengthen immunity, antitumor and calm, hypoglycemic etc., and can relax gastrointestinal smooth muscle, gastric acid inhibitory point
It secretes, prevents necrosis of liver cells, antibacterial and other effects.
Ganoderma lucidum: containing substances such as ganoderma lucidum polysaccharide, triterpene, organic germaniums, can promote the phagocytosis of macrophage, improve T leaching
Bar cell and the activity of cell and the conversion ratio of lymphocyte are killed, promotes the formation of immunoglobulin, enhance body constitution.Spirit
The substances such as polysaccharide, triterpene, the organic germanium of sesame can penetrate into cancer cell with telomere covalent bond, so that enzyme molecule is elongated denaturation, break
The telomerase activation of bad cancer cell, makes cancer cell-apoptosis.Ganoderma lucidum polysaccharide stimulates human body non-specific antibody to generate, and can promote macrophage
The phagocytosis of cell improves the activity of T cell and NK cell, improves the conversion ratio of lymphocyte, increasing leukocyte, so clever
Sesame, which has, promotes immunoglobulin to be formed, and improves the effect of body independently presses down cancer ability.
Radix Astragali: for perennial herb.Chinese medicine thinks " the spleen being the foundation of acquired constitution ".Taste send representative figure Li Gao to think Radix Astragali
" beneficial vigour and mend three coke ", it is referred to as " all medicines of tonifying Qi most " that Radix Astragali is embroidered in the yellow palace of the Qing Dynasty.Warm-natured sweet in flavor, return lung, the spleen channel are main to use
In invigorating qi, consolidating exterior, promoting urination and detoxification, apocenosis, expelling pus and promoting granulation.For deficiency of vital energy and acking in strength, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, just
Metrorrhagia leakage, exterior deficiency spontaneous perspiration, deficiency of vital energy and edema, ulcer is difficult to burst, burst for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；Chronic rephrilis protinuria,
Diabetes.Radix Astragali is sweet in flavor, and gas tepor, gas is thin and taste is dense, and can rise can drop, and the yang aspect of yang is nontoxic.Special tonifying Qi.Start with lunar, sufficient
Lunar, hand lacks the warp of yin.Its function is a lot of, and its only effect person, is enriching blood especially.
Radix Glycyrrhizae: it is sweet in flavor, it is mild-natured；It invigorates the spleen and benefits qi, is clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription；For taste
Weakness, shortness of breath and palpitation, coughing with a lot of sputum, wrist abdomen, four limbs contraction, too fat to move sore, alleviates drug toxicity, is strong fatigue and weakness.
The beneficial effects of the present invention are: a variety of medicinal materials are used cooperatively by the present invention, a kind of antitumor Chinese medicine is had developed
Composition, drug effective percentage are up to 98%, and quick, pharmacological property mitigates, and toxic side effect is small, no dependence；Full side's legislation is careful, uses
Medicine is fastidious, compatibility is precise and appropriate；The present invention has fully demonstrated the theory of Traditional Chinese Medicine strengthening vital QI to eliminate pathogenic factors, giving consideration to both the incidental and fundamental, radix scutellariae, Herba Andrographitis,
Prunella vulgaris is clearing heat and detoxicating, antitumor；Curcuma zedoary promoting qi circulation and relieving pain, white leaf rattan removing blood stasis and acesodyne, the two share inrigorating qi and promoting blood circulation, blood-activating analgetic；
Dried orange peel regulating qi-flowing for strengthening spleen promotes the absorption of above-mentioned each bulk pharmaceutical chemicals；Cold dispelling in cortex cinnamomi temperature；Poria cocos, ganoderma lucidum clearing away the heart fire and tranquillizing, it is antitumor；It is yellow
Stilbene is that help class is antitumor；Radix Glycyrrhizae coordinating the drug actions of a prescription alleviates drug toxicity, strong.The present invention each bulk pharmaceutical chemicals synergistic effect, mend without
It is stagnant, it rushes down without void, temperature of trembling with fear is suitable, the feeding taste of temperature, heat-clearing dissipating bind, and promoting blood circulation and stopping pain improves the antitumor ability of body, reduces tumour
Transfer, extend the service life of tumor patient.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
Embodiment 1
A kind of anti-tumor drug of the present embodiment, is made of the raw material components of following parts by weight: 17 parts of radix scutellariae, Herba Andrographitis 15
Part, 14 parts of Prunella vulgaris, 12 parts of curcuma zedoary, 14 parts of white leaf rattan, 16 parts of dried orange peel, 13 parts of cortex cinnamomi, 15 parts of Poria cocos, 13 parts of ganoderma lucidum, Radix Astragali 16
Part, 9 parts of Radix Glycyrrhizae.
Preparation method: (1) by above-mentioned raw materials group be grouped as weigh respectively radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng,
Dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae；
(2) radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng, dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae are added into water
Slightly boiled decoction three times, for the first time plus is equivalent to 12 times of amount water of above-mentioned raw materials gross mass, decocts 90min, for the second time plus be equivalent to
10 times of amount water of total mass of raw material to be stated, 55min is decocted, third time, which adds, is equivalent to 7 times of amount water of above-mentioned raw materials gross mass, 35min is decocted,
Collecting decoction cools filtering, is concentrated under reduced pressure into 1-2g/mL, spare；
(3) concentrate obtained in step (2) is added into auxiliary material, is made using modern general traditional chinese medicine preparation technology oral
Liquid.
Embodiment 2
A kind of anti-tumor drug of the present embodiment, is made of the raw material components of following parts by weight: 15 parts of radix scutellariae, Herba Andrographitis 13
Part, 12 parts of Prunella vulgaris, 10 parts of curcuma zedoary, 12 parts of white leaf rattan, 14 parts of dried orange peel, 11 parts of cortex cinnamomi, 13 parts of Poria cocos, 11 parts of ganoderma lucidum, Radix Astragali 14
Part, 7 parts of Radix Glycyrrhizae.
Preparation method: (1) by above-mentioned raw materials group be grouped as weigh respectively radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng,
Dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae；
(2) radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng, dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae are added into water
Slightly boiled decoction three times, for the first time plus is equivalent to 12 times of amount water of above-mentioned raw materials gross mass, decocts 90min, for the second time plus be equivalent to
10 times of amount water of total mass of raw material to be stated, 55min is decocted, third time, which adds, is equivalent to 7 times of amount water of above-mentioned raw materials gross mass, 35min is decocted,
Collecting decoction cools filtering, is concentrated under reduced pressure into 1-2g/mL, spare；
(3) concentrate obtained in step (2) is added into auxiliary material, ball is made using modern general traditional chinese medicine preparation technology
Agent.
Embodiment 3
A kind of anti-tumor drug of the present embodiment, is made of the raw material components of following parts by weight: 19 parts of radix scutellariae, Herba Andrographitis 17
Part, 16 parts of Prunella vulgaris, 14 parts of curcuma zedoary, 16 parts of white leaf rattan, 18 parts of dried orange peel, 15 parts of cortex cinnamomi, 17 parts of Poria cocos, 15 parts of ganoderma lucidum, Radix Astragali 18
Part, 11 parts of Radix Glycyrrhizae.
Preparation method: (1) by above-mentioned raw materials group be grouped as weigh respectively radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng,
Dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae；
(2) radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng, dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae are added into water
Slightly boiled decoction three times, for the first time plus is equivalent to 12 times of amount water of above-mentioned raw materials gross mass, decocts 90min, for the second time plus be equivalent to
10 times of amount water of total mass of raw material to be stated, 55min is decocted, third time, which adds, is equivalent to 7 times of amount water of above-mentioned raw materials gross mass, 35min is decocted,
Collecting decoction cools filtering, is concentrated under reduced pressure into 1-2g/mL, spare；
(3) concentrate obtained in step (2) is added into auxiliary material, particle is made using modern general traditional chinese medicine preparation technology
Agent.
Embodiment 1-3 is the significant anti-tumor drug of therapeutic effect, wherein 1 gained anti-tumor drug of embodiment faces
Bed application is as follows: 3 hospital's screening ages, 200 between 35-60 years old are diagnosed as the patient of tumour, wherein women 100
Example, male 100.
The crowd is observed continuously in the last week of experiment, records symptom and variation, is randomly divided into two groups, experimental group
And control group, experimental group use the made anti-tumor drug of the embodiment of the present invention 1, control group is anti-swollen using common treatment in the market
The drug of tumor.
Curative effect situation criterion: effective: to take a course for the treatment of (course for the treatment of is six months) tumour and reduce, immunity mentions
Height, it is energetic, it is painless；It is effective: to take a course for the treatment of (course for the treatment of is six months) tumour and be substantially achieved inhibition, be immunized
Power increases, spiritual not good enough, pain relief；It is invalid: to take a course for the treatment of (course for the treatment of is six months) tumour and do not reduce, very
To continued growth, mental status is poor, still there is pain, and symptom is obvious.
Instructions of taking: taking the oral solution that the embodiment of the present invention 1 is prepared during treatment, a 10mL is sooner or later each daily
It takes once, continuously takes a course for the treatment of, the results are shown in Table 1.
Table 1 takes the verifying of 1 products obtained therefrom therapeutic effect of embodiment
| Experimental group | Control group | |
| Number of cases | 100 | 100 |
| Male's number of cases | 50 | 50 |
| Women number of cases | 50 | 50 |
| Effective number of cases | 33 | 10 |
| Effective number of cases | 65 | 81 |
| Invalid number of cases | 2 | 9 |
| It is efficient | 98% | 91% |
Therapeutic effect: from table 1, it is apparent that taking the experimental group of 1 gained anti-tumor drug of the embodiment of the present invention
Effective and effective totally 98 (98%) is invalid 2 (2%).And the effective percentage of control group only reaches 91%, takes obtained by the present invention
The experimental group of anti-tumor drug is substantially better than the control group for taking other drugs.
Disclosed above is only specific embodiments of the present invention, and still, the embodiment of the present invention is not limited to this, Ren Heben
What the technical staff in field can think variation should all fall into protection scope of the present invention.
Claims (5)
1. a kind of anti-tumor drug, which is characterized in that be made of the raw material components of following parts by weight:
13-21 parts of radix scutellariae, 10-20 parts of Herba Andrographitis, 11-18 parts of Prunella vulgaris, 7-15 parts of curcuma zedoary, 10-18 parts of white leaf rattan, dried orange peel 10-
21 parts, 9-15 parts of cortex cinnamomi, 11-19 parts of Poria cocos, 8-15 parts of ganoderma lucidum, 10-20 parts of Radix Astragali, 7-11 parts of Radix Glycyrrhizae.
2. anti-tumor drug as described in claim 1, which is characterized in that be made of the raw material components of following parts by weight:
15-19 parts of radix scutellariae, 13-17 parts of Herba Andrographitis, 12-16 parts of Prunella vulgaris, 10-14 parts of curcuma zedoary, 12-16 parts of white leaf rattan, dried orange peel 14-
18 parts, 11-15 parts of cortex cinnamomi, 13-17 parts of Poria cocos, 11-15 parts of ganoderma lucidum, 14-18 parts of Radix Astragali, 7-11 parts of Radix Glycyrrhizae.
3. anti-tumor drug as claimed in claim 2, which is characterized in that be made of the raw material components of following parts by weight:
17 parts of radix scutellariae, 15 parts of Herba Andrographitis, 14 parts of Prunella vulgaris, 12 parts of curcuma zedoary, 14 parts of white leaf rattan, 16 parts of dried orange peel, 13 parts of cortex cinnamomi, Poria cocos
15 parts, 13 parts of ganoderma lucidum, 16 parts of Radix Astragali, 9 parts of Radix Glycyrrhizae.
4. the preparation method of anti-tumor drug a method according to any one of claims 1-3, which is characterized in that prepare as follows:
(1) 13-21 parts of radix scutellariae, 10-20 parts of Herba Andrographitis, 11-18 parts of Prunella vulgaris, 7-15 parts of curcuma zedoary, white is weighed respectively by weight
10-18 parts of leaf rattan, 10-21 parts of dried orange peel, 9-15 parts of cortex cinnamomi, 11-19 parts of Poria cocos, 8-15 parts of ganoderma lucidum, 10-20 parts of Radix Astragali, Radix Glycyrrhizae 7-
11 parts；
(2) add water slightly boiled radix scutellariae, Herba Andrographitis, Prunella vulgaris, curcuma zedoary, Bai Yeteng, dried orange peel, cortex cinnamomi, Poria cocos, ganoderma lucidum, Radix Astragali, Radix Glycyrrhizae
It decocts three times, for the first time plus is equivalent to 11-13 times of above-mentioned raw materials gross mass and measures water, decoct 80-95min, second plus be equivalent to
9-11 times of above-mentioned raw materials gross mass measures water, decocts 45-60min, third time plus is equivalent to 6-8 times of above-mentioned raw materials gross mass and measures water,
30-45min is decocted, merges decocting liquid three times, cools filtering, be concentrated under reduced pressure into 1-2g/mL, it is spare；
(3) concentrate obtained in step (2) is added into auxiliary material, the finished dosage forms of clinical needs is made.
5. the preparation method of anti-tumor drug as claimed in claim 4, which is characterized in that the anti-tumor drug can be made
Capsule, tablet, pill, granule or oral solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811312664.6A CN109078157A (en) | 2018-11-06 | 2018-11-06 | A kind of anti-tumor drug and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811312664.6A CN109078157A (en) | 2018-11-06 | 2018-11-06 | A kind of anti-tumor drug and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109078157A true CN109078157A (en) | 2018-12-25 |
Family
ID=64844767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811312664.6A Pending CN109078157A (en) | 2018-11-06 | 2018-11-06 | A kind of anti-tumor drug and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109078157A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111249423A (en) * | 2020-03-19 | 2020-06-09 | 杭州憶盛医疗科技有限公司 | Antitumor drug and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156892A (en) * | 2007-09-19 | 2008-04-09 | 江苏省江大绿康生物工程技术研究有限公司 | A preparation method of active component composition of antineoplastic improving phylactic power |
-
2018
- 2018-11-06 CN CN201811312664.6A patent/CN109078157A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156892A (en) * | 2007-09-19 | 2008-04-09 | 江苏省江大绿康生物工程技术研究有限公司 | A preparation method of active component composition of antineoplastic improving phylactic power |
Non-Patent Citations (1)
| Title |
|---|
| 李秋荐等: "扶正抗癌方治疗晚期胰腺癌51例", 《中国医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111249423A (en) * | 2020-03-19 | 2020-06-09 | 杭州憶盛医疗科技有限公司 | Antitumor drug and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101711848B (en) | Chinese medicinal composition capable of adjunctively treating tumour | |
| CN101564464B (en) | Chinese medicament for adjusting organism immunity of tumor patients | |
| CN105381424A (en) | Traditional Chinese medicine for detoxifying human viscera and preparation method of traditional Chinese medicine | |
| CN109078157A (en) | A kind of anti-tumor drug and preparation method thereof | |
| CN105106919B (en) | A kind of healthy medicated wine and its preparation method and application | |
| CN103860773A (en) | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof | |
| CN107890521A (en) | A kind of Chinese medicine composition of liver protection and eyesight and its preparation method of pill | |
| CN105213758A (en) | A kind of Chinese medicine composition for the treatment of chronic pneumonia and preparation method thereof | |
| CN107362301B (en) | Xiangling appetizing granules | |
| CN105250758A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN104825817A (en) | Traditional Chinese medicine preparation with antitumor effect | |
| CN103948852A (en) | Traditional Chinese medicinal preparation for treating gastric ulcer and preparation method thereof | |
| CN105641222A (en) | Traditional Chinese medicine for treating gastric cancer | |
| CN105833228A (en) | Drug preparation for reversing gastric cancer drug resistance and application thereof | |
| CN105214001B (en) | A kind of Chinese medicine composition for treating hypertensive patients coronary heart disease | |
| CN104940777A (en) | Electuary capable of treating liver-yang hyperactivity and spleen weakness type diarrhea during menstruation and preparation method thereof | |
| CN104491316A (en) | Traditional Chinese medicine preparation for treating middle-warmer energy insufficiency type prostate hyperplasia | |
| CN104587297A (en) | Traditional Chinese medicine capsule for treating scleroderma and preparation method thereof | |
| CN112076241A (en) | Traditional Chinese medicine preparation for preventing yin deficiency and internal heat | |
| CN101979043B (en) | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases | |
| CN111388638A (en) | Traditional Chinese medicine for losing weight and conditioning suitable for autumn use | |
| CN107812087A (en) | It is a kind of to treat Chinese medicine composition increased under band and preparation method thereof | |
| CN101085277A (en) | Traditional Chinese medicine composition for curing chronic renal failure | |
| CN109200113A (en) | Chinese medicine composition and preparation method thereof for weight-reducing | |
| CN101095775A (en) | Chinese traditional medicine for treating diabetes deafness |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181225 |
|
| RJ01 | Rejection of invention patent application after publication |