CN1572283A - 头发处理组合物和头发再处理组合物 - Google Patents
头发处理组合物和头发再处理组合物 Download PDFInfo
- Publication number
- CN1572283A CN1572283A CN200410049566.XA CN200410049566A CN1572283A CN 1572283 A CN1572283 A CN 1572283A CN 200410049566 A CN200410049566 A CN 200410049566A CN 1572283 A CN1572283 A CN 1572283A
- Authority
- CN
- China
- Prior art keywords
- acid
- hair
- atom
- weight
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 230000006378 damage Effects 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 14
- 230000008439 repair process Effects 0.000 claims abstract description 5
- 239000013543 active substance Substances 0.000 claims abstract description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 50
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 239000002537 cosmetic Substances 0.000 claims description 15
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 235000011054 acetic acid Nutrition 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 239000004310 lactic acid Substances 0.000 claims description 9
- 235000014655 lactic acid Nutrition 0.000 claims description 9
- 239000002453 shampoo Substances 0.000 claims description 9
- 125000001118 alkylidene group Chemical group 0.000 claims description 8
- 125000004429 atom Chemical group 0.000 claims description 8
- 229960003624 creatine Drugs 0.000 claims description 8
- 239000006046 creatine Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 102000011782 Keratins Human genes 0.000 claims description 5
- 108010076876 Keratins Proteins 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- 235000011167 hydrochloric acid Nutrition 0.000 claims description 5
- YWWVWXASSLXJHU-AATRIKPKSA-N (9E)-tetradecenoic acid Chemical compound CCCC\C=C\CCCCCCCC(O)=O YWWVWXASSLXJHU-AATRIKPKSA-N 0.000 claims description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
- 208000001840 Dandruff Diseases 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 4
- YZGQDNOIGFBYKF-UHFFFAOYSA-N Ethoxyacetic acid Chemical compound CCOCC(O)=O YZGQDNOIGFBYKF-UHFFFAOYSA-N 0.000 claims description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 4
- 241001597008 Nomeidae Species 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 125000002723 alicyclic group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- JBDSSBMEKXHSJF-UHFFFAOYSA-N cyclopentanecarboxylic acid Chemical compound OC(=O)C1CCCC1 JBDSSBMEKXHSJF-UHFFFAOYSA-N 0.000 claims description 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 4
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- IJFXRHURBJZNAO-UHFFFAOYSA-N meta--hydroxybenzoic acid Natural products OC(=O)C1=CC=CC(O)=C1 IJFXRHURBJZNAO-UHFFFAOYSA-N 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 4
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 4
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 4
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 230000008719 thickening Effects 0.000 claims description 4
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 108010014258 Elastin Proteins 0.000 claims description 3
- 102000016942 Elastin Human genes 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- 108010009736 Protein Hydrolysates Proteins 0.000 claims description 3
- 240000008042 Zea mays Species 0.000 claims description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 229960003344 climbazole Drugs 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 229920002549 elastin Polymers 0.000 claims description 3
- 229960004275 glycolic acid Drugs 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 235000011007 phosphoric acid Nutrition 0.000 claims description 3
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims description 3
- 239000003531 protein hydrolysate Substances 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 2
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 claims description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims description 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N 5-oxoproline Chemical compound OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- FKLSONDBCYHMOQ-UHFFFAOYSA-N 9E-dodecenoic acid Natural products CCC=CCCCCCCCC(O)=O FKLSONDBCYHMOQ-UHFFFAOYSA-N 0.000 claims description 2
- YWWVWXASSLXJHU-UHFFFAOYSA-N 9E-tetradecenoic acid Natural products CCCCC=CCCCCCCCC(O)=O YWWVWXASSLXJHU-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 2
- 229920000305 Nylon 6,10 Polymers 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- 235000021319 Palmitoleic acid Nutrition 0.000 claims description 2
- 229940122511 Sebum inhibitor Drugs 0.000 claims description 2
- 239000004902 Softening Agent Substances 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 2
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 229940036350 bisabolol Drugs 0.000 claims description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 2
- PVEOYINWKBTPIZ-UHFFFAOYSA-N but-3-enoic acid Chemical compound OC(=O)CC=C PVEOYINWKBTPIZ-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 2
- XZJZNZATFHOMSJ-KTKRTIGZSA-N cis-3-dodecenoic acid Chemical compound CCCCCCCC\C=C/CC(O)=O XZJZNZATFHOMSJ-KTKRTIGZSA-N 0.000 claims description 2
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 claims description 2
- IFDVQVHZEKPUSC-UHFFFAOYSA-N cyclohex-3-ene-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCC=CC1C(O)=O IFDVQVHZEKPUSC-UHFFFAOYSA-N 0.000 claims description 2
- XUDOZULIAWNMIU-UHFFFAOYSA-N delta-hexenoic acid Chemical compound OC(=O)CCCC=C XUDOZULIAWNMIU-UHFFFAOYSA-N 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 2
- KAHRQPGKVRVNQV-UHFFFAOYSA-N docosanoic acid;icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCCCCCC(O)=O KAHRQPGKVRVNQV-UHFFFAOYSA-N 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- FPIQZBQZKBKLEI-UHFFFAOYSA-N ethyl 1-[[2-chloroethyl(nitroso)carbamoyl]amino]cyclohexane-1-carboxylate Chemical compound ClCCN(N=O)C(=O)NC1(C(=O)OCC)CCCCC1 FPIQZBQZKBKLEI-UHFFFAOYSA-N 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- LQJBNNIYVWPHFW-QXMHVHEDSA-N gadoleic acid Chemical compound CCCCCCCCCC\C=C/CCCCCCCC(O)=O LQJBNNIYVWPHFW-QXMHVHEDSA-N 0.000 claims description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- LDHQCZJRKDOVOX-IHWYPQMZSA-N isocrotonic acid Chemical compound C\C=C/C(O)=O LDHQCZJRKDOVOX-IHWYPQMZSA-N 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- 229960004488 linolenic acid Drugs 0.000 claims description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims description 2
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- 235000006408 oxalic acid Nutrition 0.000 claims description 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims description 2
- 229950001046 piroctone Drugs 0.000 claims description 2
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 235000019260 propionic acid Nutrition 0.000 claims description 2
- 229960004889 salicylic acid Drugs 0.000 claims description 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000001117 sulphuric acid Substances 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 2
- UFDHBDMSHIXOKF-UHFFFAOYSA-N tetrahydrophthalic acid Natural products OC(=O)C1=C(C(O)=O)CCCC1 UFDHBDMSHIXOKF-UHFFFAOYSA-N 0.000 claims description 2
- NIDHFQDUBOVBKZ-NSCUHMNNSA-N trans-hex-4-enoic acid Chemical compound C\C=C\CCC(O)=O NIDHFQDUBOVBKZ-NSCUHMNNSA-N 0.000 claims description 2
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims description 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 150000003751 zinc Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 abstract 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 49
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 38
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 38
- -1 creatine compound Chemical class 0.000 description 36
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 17
- 238000012360 testing method Methods 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 6
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000003093 cationic surfactant Substances 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 125000001453 quaternary ammonium group Chemical group 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- 230000001771 impaired effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- 229920003169 water-soluble polymer Polymers 0.000 description 4
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004040 coloring Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 150000002357 guanidines Chemical class 0.000 description 3
- 230000003806 hair structure Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 2
- 229920006317 cationic polymer Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 2
- 229960003067 cystine Drugs 0.000 description 2
- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- YLYBTZIQSIBWLI-UHFFFAOYSA-N octyl acetate Chemical group CCCCCCCCOC(C)=O YLYBTZIQSIBWLI-UHFFFAOYSA-N 0.000 description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- ZWVMLYRJXORSEP-LURJTMIESA-N (2s)-hexane-1,2,6-triol Chemical compound OCCCC[C@H](O)CO ZWVMLYRJXORSEP-LURJTMIESA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- YBRJTUFWBLSLHY-UHFFFAOYSA-N 2-[2-(2-octadecanoyloxyethoxy)ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOC(=O)CCCCCCCCCCCCCCCCC YBRJTUFWBLSLHY-UHFFFAOYSA-N 0.000 description 1
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 description 1
- XWNSFEAWWGGSKJ-UHFFFAOYSA-N 4-acetyl-4-methylheptanedinitrile Chemical compound N#CCCC(C)(C(=O)C)CCC#N XWNSFEAWWGGSKJ-UHFFFAOYSA-N 0.000 description 1
- 241001044369 Amphion Species 0.000 description 1
- 239000007848 Bronsted acid Substances 0.000 description 1
- KVPMCFRZLDLEJW-UHFFFAOYSA-N C(C(=O)O)(=O)O.NCCC(=O)O Chemical compound C(C(=O)O)(=O)O.NCCC(=O)O KVPMCFRZLDLEJW-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical class CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical class NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004153 Potassium bromate Substances 0.000 description 1
- 229920003081 Povidone K 30 Polymers 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241001080929 Zeugopterus punctatus Species 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- MSZJEPVVQWJCIF-UHFFFAOYSA-N butylazanide Chemical compound CCCC[NH-] MSZJEPVVQWJCIF-UHFFFAOYSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003251 chemically resistant material Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- YIOJGTBNHQAVBO-UHFFFAOYSA-N dimethyl-bis(prop-2-enyl)azanium Chemical class C=CC[N+](C)(C)CC=C YIOJGTBNHQAVBO-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- LFQSCWFLJHTTHZ-LIDOUZCJSA-N ethanol-d6 Chemical compound [2H]OC([2H])([2H])C([2H])([2H])[2H] LFQSCWFLJHTTHZ-LIDOUZCJSA-N 0.000 description 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- DXTIKTAIYCJTII-UHFFFAOYSA-N guanidine acetate Chemical compound CC([O-])=O.NC([NH3+])=N DXTIKTAIYCJTII-UHFFFAOYSA-N 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 239000008266 hair spray Substances 0.000 description 1
- 230000003699 hair surface Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940056582 human hair preparation Drugs 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000008832 photodamage Effects 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 150000007519 polyprotic acids Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 235000019396 potassium bromate Nutrition 0.000 description 1
- 229940094037 potassium bromate Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- YARNEMCKJLFQHG-UHFFFAOYSA-N prop-1-ene;styrene Chemical compound CC=C.C=CC1=CC=CC=C1 YARNEMCKJLFQHG-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- PFSKLZABYDOTKP-UHFFFAOYSA-N pyridine;zinc Chemical compound [Zn].C1=CC=NC=C1 PFSKLZABYDOTKP-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- XUXNAKZDHHEHPC-UHFFFAOYSA-M sodium bromate Chemical compound [Na+].[O-]Br(=O)=O XUXNAKZDHHEHPC-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical class [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/04—Preparations for permanent waving or straightening the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
- A61Q5/065—Preparations for temporary colouring the hair, e.g. direct dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/10—Preparations for permanently dyeing the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及头发处理组合物或头发再处理组合物,所述组合物用于防止化学处理组合物所致的损伤,并用于修复已受损头发,其中还使用至少一种通式(I)和/或(II)的化合物作为活性物质。
Description
技术领域
本发明涉及头发处理组合物或头发再处理组合物,所述组合物用于防止化学处理组合物所致的损伤,并用于修复已受损头发。
背景技术
人们的头发每天暴露于各种各样的作用下。除了由于刷、梳理、扎起或系在后面造成的机械压力外,头发还受到例如强UV辐射、冷、风和水的环境作用的侵袭。个人的生理状况(如年龄、健康)也影响对角蛋白纤维的损伤。
但是,尤其用化学试剂进行处理还改变头发的结构和表面性质。例如长效卷发、漂洗、染色、着色(tinting)、烫平等的方法以及用侵蚀性的表面活性剂频繁清洗都或多或少地导致对头发结构的严重损伤。因此,例如,在长效卷发过程中,头发的皮层和角质层都受到侵害。在还原步骤中胱氨酸的二硫桥键断开,在随后的氧化步骤中被部分氧化为磺基丙氨酸。
漂洗时,不仅黑色素受到破坏,而且约15-25重量%的胱氨酸二硫键在温和漂洗时被氧化。在过度漂洗时该氧化甚至可达45重量%(K.F.de Polo,A Short Textbook of Cosmetology,2000,Verlag fürchemische Industrie,H.Ziolkowsky GmbH)。
因此,化学处理、频繁清洗或UV辐射导致头发的不利的力学性质。其变脆、干燥、没有光泽、疏松和难于梳理。而且,它丧失水分、弹性,和尤其是耐力学性和拉伸强度。这从湿发的延展的拉伸力和断裂力的显著下降看出。此外,相对于健康的头发,它更不耐化学物质、表面活性剂和环境影响所致的进一步损伤。
有特殊的制剂用于修复受到这种损伤的头发,例如,润丝(hairrinses)、生发油(hair tonics)、洗发香波、留在头发上的护发剂(leave-inconditioners)等,但其特别地改善受损头发的梳理性、手感和光泽。这种类型的商品护发组合物主要含有基于烷基铵的阳离子表面活性剂、聚合物、蜡或油。这些化合物的功效可归功于阳离子季铵基团的静电相互作用或头发表面的疏水作用。但头发的(生物)化学修复并未因而实现。
长期以来就已经很关注这样一个问题,即头发受到损伤就会使耐力学性大大降低。
例如使用肌酸在该领域中是已知的。DE-A-101 14 561和DE-A-101 196 08中描述了在组合物中使用肌酸化合物,所述组合物用于角质纤维尤其是人发的硬化、加强、重构(restructuring)或增加光泽、量或梳理性。
使用肌酸的缺点在于肌酸只能通过水相进行配制而其在水溶液中又总是与肌酸酐处于平衡,因此就不再能作为头发的活性物质。
相对于这些背景技术,进一步鉴定具有类似于肌酸的结构和/或具有类似的生理作用或者帮助和提高肌酸作用的新物质非常重要。
因此,还需要用于头发处理组合物和头发再处理组合物的活性组分,其可以以多种方式使用,其改善头发的耐力学性,保护头发以免头发结构的进一步受损,并且使环境影响和成型、上色处理已经对头发造成、产生的结构损伤减少到最小。
本发明的目的是利用这样的活性组分,其能改善受损头发的耐力学性,并能保护头发免受化学处理或外界因素,如烟、雾、活性氧类、自由基和尤其是与光有关的损伤所造成的损伤。
现已令人惊奇地发现,在处理和再处理头发的制剂中,简单的烷基胍化合物和其酸结合物(acid conjugates)达到了所有这些希望的标准。
因此本发明的一个主题是烷基胍化合物和/或其盐结合物在头发处理组合物和头发再处理组合物中的用途,所述组合物用以防止化学处理组合物所致的损伤并用以修复已经受损的头发,其中,至少存在一种通式(I)和/或(II)的化合物
和/或其盐或水合物作为活性物质,其中R1、R2 a)各自独立为H、具有2-30个C原子,优选4-22个C原子,特别是8-12个C原子的任选含有双键、羟烷基、烷氧基、羧基烷基的任选支化的烃基,或
b)其中该基团还可具有脂环族或杂环族组分,其为饱和、不饱和或芳香族,具有3-10个原子,优选4-6个原子的环大小,其可进一步带有具有1-30个C原子,优选4-22个C原子的饱和或不饱和烃取代基,或
c)烷基酰胺亚烷基或烷基酯亚烷基,其可进一步含有a)和
b)中所提到的结构元素,而且结构元素a)、b)、c)可在各个元素内组合,也可互相组合,
R3 为亚烷基,具有1-30个C原子,优选4-22个C原子的任选支化的烃基,该烃基任选含有双键或脂环族或杂环族组分,其为饱和、不饱和或芳香族,具有3-10个原子,优选具有4-6个原子的环大小,或其中元素-N(R1)-R3-(R2)N-中的R1和R2可形成5至8元环。
本发明的又一个主题是根据式(I)的烷基胍和/或其盐,其中基团R1、R2中的至少一个不为氢。
此外,本发明的又一个主题是根据式(II)的烷基胍和/或其盐,其中R3为烃基,优选为具有4-18个C原子,优选6-12个C原子的亚烷基,且R1和R2具有上面所指含义并且优选为氢。
本发明的进一步主题由权利要求描述。
根据本发明使用或附加使用的烷基胍,尤其是直链烷基胍,既有良好的稳定性又有良好的配方性,甚至在低使用浓度下也产生显著的作用,其没有毒性,来自天然或天然等同物,头发和头皮对其具有非常好的耐受,与其它组分具有高相容性,且能毫无问题地掺入头发处理组合物中。而且,它们还可具有轻度杀菌作用。
DE-C-506 282中对烷基胍的制备进行了描述。在该方法中,在质子酸的存在下,在醇溶液中使用氨腈使烷基胺胍基化。产物以结晶盐形式得到。
DE-A-195 27 313中对胍衍生物的制备方法及其作为皮肤化妆品的用途进行了描述。这包括(多)烷基胍和烷氧基胍,其在使用时产生良好的皮肤感觉并具有保湿和软化角蛋白的作用。
JP-A-2000247866中也对皮肤化妆品进行了描述,其具有优异的护理效果并含有肌酸和/或肌酸酐,以及其他药物活性组分和/或生物活性物质。
JP-A-5-194150中描述了C6-24-烷基胍与脂肪醇组合作为护发剂的用途。
因此根据已知的现有技术,烷基胍衍生物的用途限于用在对头发进行表面处理的护发剂中,或用作对头发进行表面处理的护发剂,以及用在皮肤化妆品配方中。迄今没有发现任何有关这类化合物的用于加强和保护受损头发及其修复的惊人的性质。
已证明通式(I)的烷基胍和/或其盐和/或其水合物特别适合本发明的意图,且因此是优选的。
原则上,所有用于化妆品的无害的无机或有机的一元或多元酸均适于成盐,例如,甲酸、乙酸、丙酸、庚酸、辛酸、壬酸、癸酸、十一烷酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、花生酸、山萮酸、环戊烷甲酸、环己烷羧酸、丙烯酸、甲基丙烯酸、乙烯基乙酸、巴豆酸、2-/3-/4-戊烯酸、2-/3-/4-/5-己烯酸、月桂烯酸、肉豆蔻脑酸、棕榈油酸、油酸、顺-9-二十碳烯酸、山梨酸、亚油酸、亚麻酸、新戊酸、乙氧基乙酸、苯乙酸、乳酸、2-乙基己酸、草酸、羟基乙酸、苹果酸、丙二酸、琥珀酸、酒石酸、戊二酸、柠檬酸、己二酸、庚二酸、辛二酸、壬二酸、癸二酸、安息香酸、邻-/间-/对-甲苯酸、水杨酸、3-/4-羟基苯甲酸、邻苯二甲酸、或其完全或部分氢化的衍生物如六氢化-或四氢化邻苯二甲酸、碳酸、磷酸、盐酸、硫酸和其混合物,尤其是乳酸、酒石酸、乙酸和盐酸。此处,在本发明的意图内,既可使用适合的胍衍生物的彼此混合物也可使用混和盐。
根据本发明,用于头发再处理、成型和护理的化妆品制剂特别理解为意指那些在头发的化学处理后使用的头发处理组合物(头发再处理组合物),和化学头发处理组合物,使用该组合物使头发结构受损,而通过向其中加入烷基胍化合物可以使该损伤降低到最小(头发处理组合物)。
此处,烷基胍通常可以以0.01-10.0重量%的浓度存在,优选以0.1-5.0重量%的浓度存在,尤其是以0.1-2.0重量%的浓度存在。
头发再处理组合物为例如润丝、生发油、再生组合物、留在头发上的护发剂、洗发香波、二合一洗发香波、定型配方如泡沫定型剂、喷发胶或头发干燥洗液(hair drier lotions)、发露(hair lotions)、发梢流体(hair tip fluids)。它们可以制为凝胶、乳液、溶液、气溶胶喷雾或泡沫、非气溶胶喷雾或泡沫。
本发明的用于化学处理后的头发处理的化妆品制剂的pH为3-7,因此优选含有水溶性酸或适合于此的缓冲混合物,其稳定该pH值。
本发明的用于化学处理后的头发处理的化妆品制剂,除了含有烷基胍化合物外还可含有对于特定的应用目的来说有利和/或常用的其他组分。
因此,洗发香波可含有,例如,3-30重量%的发泡的阴离子、两性离子、两性和非离子表面活性剂。润丝和生发油含有0-10重量%,优选0.5-5重量%的乳化剂,0-10重量%,优选0.5-5重量%的增稠度剂(consistency-imparting),和0-20重量%的来源于植物和合成的化妆油、软化剂(emollients)、维生素制剂和蛋白质。而且洗发香波、润丝、生发油和再生剂优选含有0-8重量%,优选0.1-5重量%的阳离子表面活性剂和水溶性聚合物,其具有季铵基团,用来降低静电和改善梳理性、手感和光泽。
通常,阳离子表面活性剂为
-季铵化合物,例如,烷基三甲基铵盐、二烷基二甲基铵盐、三烷基甲基铵盐和咪唑啉鎓盐化合物。长烷基链由含10-22个C原子的碳链组成,季氮的反离子,例如,是卤离子、硫酸根、乙酸根、乳酸根、羟基乙酸根、硝酸根或磷酸根。市场上可找到该类产品,名称为Varisoft300、432 CG、442-100 P、BT 85,由Goldschmidt Rewo生产,DehyquartA,由Henkel生产;
-酯季铵盐(esterquats),如市售的,名称为DehyquartF75,由Henkel生产,或ArmocareVGH-70,由Akzo生产;
-烷基酰胺基季铵盐(alkylamidoquats),如商业上可得到的,例如,名称为VarisoftPATC和RTM 50,由Goldschmidt Rewo生产。
具有季铵基团的水溶性聚合物为,例如
-阳离子纤维素衍生物,如商业上可得到的,名称为CelquatH100和L 200,由National Starch生产,或Polymer JR,由Amerchol生产,
-聚合的二甲基二烯丙基铵盐,及其与丙烯酸和甲基丙烯酸酯和酰胺的共聚物。从商业上得到的,由Calgon生产的名称为Merquat100,或Merquat550的产品是这种阳离子聚合物的例子,
-乙烯基吡咯烷酮与二烷基氨基丙烯酸酯和甲基丙烯酸酯的季铵化衍生物的共聚物。这种化合物可商业上得到,名称为Gafquat735,和Gafquat744,由ISP生产,
-乙烯基吡咯烷酮/乙烯基咪唑鎓甲氯化物共聚物,如所提供的,名称为LuviquatFC 370、FC 550、FC 905和HM-552,由BASF生产,
-季铵化的聚乙烯醇,
-季铵化的动物或植物来源的蛋白质水解产物,其基于角蛋白、胶原蛋白、弹性蛋白、小麦、稻谷、大豆、牛奶、丝、玉米。这种产物在市场上销售,例如,名称为CroquatWheat和Silk,由Croda生产,PromoisW-32CAQ、Silk CAQ、WG CAQ,由Seiwa Kasei生产,或Quat-CollCDMA,由Brooks生产,
-瓜尔胶羟基丙基三甲基氯化铵,
-氨基官能化的聚二甲基硅氧烷或羟氨改性的聚硅氧烷,如商品ABlLQuat 3272和ABlLQuat 3474,由Goldschmidt生产,DowCorning929乳液、Dow Corning939,由Dow Corning生产。
定型剂配方和其它头发成型制剂通常含有0.1-5重量%的可溶于水或水-醇介质的成膜聚合物,任选与阳离子表面活性剂或阳离子聚合物一起使用。成膜剂的例子为乙烯基吡咯烷酮的均聚物、N-乙烯基甲酰胺的均聚物、乙烯基吡咯烷酮和乙酸乙烯酯的共聚物、乙烯基吡咯烷酮、乙酸乙烯酯和丙酸乙烯基酯的三元共聚物、聚丙烯酰胺、聚乙烯醇、高分子量聚乙二醇或乙二醇与丙二醇的高分子量共聚物、脱乙酰壳多糖。这些产品可在市场上找到,名称为LuviskolK30、K60、K80、VA37E,由BASF生产,或PVP/VA E335和PVP K30,由ISP生产。
现有技术中已知进行各种应用的典型基本配方,其包含在,例如,各种原材料和活性组分的生产小册子中。这些存在的配方通常可以不加变化地采用。即使需要改变和优化,所希望的修改也不复杂,通过简单的试验就能进行。
典型的润丝/生发油配方含有,例如:
a)0.1-2重量%的至少一种通式(I)和/或(II)的化合物,
b)0.1-5重量%的乳化剂,
c)0.1-5重量%的增稠度剂,
d)0.1-5重量%的具有季铵基团的阳离子表面活性剂和/或水溶性聚合物,
e)0-10重量%的其它化妆品活性组分,防腐剂,及常用添加剂和赋形剂,
f)水,补充到100重量%。
典型的洗发香波配方含有,例如:
a)0.1-2重量%的至少一种通式(I)和/或(II)的化合物,
b)3-30重量%的发泡的阴离子、两性(amphoteric)、两性(ampholytic)或非离子表面活性剂,
c)0.1-5重量%的具有季铵基团的阳离子表面活性剂和/或水溶性聚合物,
d)0.1-6.0重量%的增稠剂,
e)0-10重量%的其它化妆品活性组分,乳浊剂,溶剂及常用添加剂和赋形剂,
f)水,补充到100重量%。
由于其温和的杀菌作用,因此,通式(I)和/或(II)的化合物还可用作或附加用作温和去屑配方中的活性化合物。
本发明的用于化学头发处理的制剂是,用于头发持久成型,如长效卷发的组合物,和定型组合物或头发滑顺组合物,改变颜色的试剂,如漂洗剂、氧化染色剂和着色剂以及基于直接上色染料(direct-drawing dyes)的洗发香波。
本发明的用于对头发进行化学处理的制剂除了含有烷基胍化合物及其衍生物外,还进一步含有各种应用中常用的组分。
对于长效卷发溶液,有例如1-10重量%的巯基乙酸、巯基乙酸盐或酯。长效卷发定型剂或漂洗剂优选含有2-10重量%的氧化剂,例如溴酸钾、溴酸钠或过氧化氢。头发平滑剂则基于强碱,或还原剂,例如疏基乙酸盐的使用。头发染色剂含有直接上色的头发染色剂或氧化染料前体。
最后,本发明的制剂还可含有常用于这类制剂中的化妆品赋形剂和添加剂。这种赋形剂为,例如诸如乙醇、异丙醇、乙二醇、丙二醇、甘油和二甘醇的增溶剂,诸如EDTA、NTA、β-丙氨酸二乙酸和磷酸的配合剂,防腐剂,抗氧化剂,香料,给化妆品制剂着色的着色剂,诸如胶乳、苯乙烯/PVP和苯乙烯-丙烯酰胺共聚物的乳化剂,诸如乙二醇一和二硬脂酸酯以及PEG-3二硬脂酸酯的珠光剂,颜料,防晒剂,增稠剂或推进剂。
本发明的化妆品制剂中烷基胍化合物还可与其他头发化妆活性组分组合,例如,神经酰胺,假神经酰胺(pseudoceramide),基于角蛋白、胶原蛋白、弹性蛋白、小麦、稻谷、大豆、牛奶、丝、玉米的植物或动物来源的蛋白质水解产物,去屑活性组分,如吡啶酮乙醇胺盐(piroctone olamine)、奥玛啶锌盐(zinc omadine)和甘宝素(climbazole)、皮脂抑制剂(sebostatics)、维生素、泛醇、吡咯烷酮羧酸、红没药醇、植物提取物。
本发明的头发处理组合物以常用方式进行制备,烷基胍化合物既溶解于水相也溶解于油相。优选最后通过加入酸和/或缓冲混合物将pH调至所要值。
下文给出一些制备实施例和配方。这些内容对发明主题进行说明但不对其进行限制。
制备实施例:
乙酸辛基胍鎓和乙酸C16-22-烷基胍鎓的制备:
在升温及搅拌下,将30.7g辛胺或70.8g C16-22-烷基胺(0.2375mol)溶解在30ml正丁醇中。在升温过程中加入14.2g乙酸(0.2365mol)。达到反应温度90℃后,在3小时的时间内逐滴加入10.0g氨腈(0.2379mol)的丁醇(约60ml)溶液,再将料液在90℃下搅拌3小时。冷却后,用旋转蒸发仪在减压下抽提溶剂。产物使用丙酮进行悬浮,过滤并以***洗涤。终产物为无色结晶粉末。
乙酸辛基胍鎓:13C-NMR,100MHz,CD3OD,25℃:δ=181.0(1C,COOHAcOH),159.3(1C,C胍鎓gr.),42.9(1C,CH2),33.4(1C,CH2),30.8(1C,CH2),30.4(1C,CH2),28.2(1C,CH2),24.8(1C,CH2),24.1(1C,CH3,AcOH),14.9(1C,CH3);MALDI-TOF[m/z]:172.2(M+H+)。
乙酸C16-22-烷基胍鎓:13C-NMR,100MHz,CD30D,50℃:δ=178.5(1C,COOHAcOH),157.1(1C,C胍gr.),40.6(1C,CH2),31.2(1C,CH2),28.9(1C,CH2),28.5(1C,CH2),28.5(1C,CH2),28.1(1C,CH2),25.9(1C,CH2),22.5(1C,CH2),21.8(1C,CH3,AcOH),12.6(1C,CH3);MALDI-TOF[m/z]:284.2(C16-胍+H+),312.2(C18-胍+H+),340.2(C20-胍+H+),368.3(C22-胍+H+)。
氯化辛基胍鎓的制备:
首先引入15.4g辛胺(0.1194mol)和20ml正丁醇并在搅拌下升温至90℃。在升温过程中加入11.0g盐酸(37%;0.1137mol)。达到反应温度90℃后,在3小时的时间内逐滴加入5.0g氨腈(0.1308mol)的丁醇(约60ml)溶液,再将料液在90℃下搅拌4小时。冷却后,用旋转蒸发仪在减压下抽提溶剂。将产物溶于水并用NaCl溶液分离。通过加入乙醇对产物进行干燥,随后进行蒸馏。终产物为高粘性无色液体。
13C-NMR,100MHz,CD3OD,25℃:δ=158.6(1C,C胍鎓gr.),42.9(1C,CH2),42.8(1C,CH2),33.0(1C,CH2),30.4(1C,CH2),29.9(1C,CH2),27.8(1C,CH2),23.8(1C,CH2),14.8(1C,CH3);MALDI,TOF[m/z]:172.2(M+H+),192.9(M+Na+)。
乳酸辛基胍鎓的制备:
将15.4g辛胺(0.1194mol)和20ml正丁醇引入多颈圆底烧瓶中,并在搅拌下升温至90℃。在升温过程中加入10.2g乳酸(0.1137mol)。达到反应温度90℃后,在3小时的时间内逐滴加入5.0g氨腈(0.1194mol)的丁醇(约60ml)溶液,再将料液在90℃下搅拌3小时。冷却后,用旋转蒸发仪在减压下抽提溶剂。产物使用丙酮进行悬浮,过滤并以***洗涤。终产物为无色结晶粉末。
13C-NMR,100MHz,CD30D,20℃:δ=182.4(1C,COOH乳酸),158.7(1C,C胍鎓gr.),69.6(1C,COH乳酸),42.5(1C,CH2),33.0(1C,CH2),30.34(1C,CH2),30.0(1C,CH2),27.8(1C,CH2),23.7(1C,CH2),21.7(1C,CH3,乳酸),14.5(CH3);MALDI-TOF[m/z]:172.1(M+H+)。
乙酸己烷-1,6-二胍鎓的制备:
引入36.27g(0.312mol)1,6-二氨基己烷、37.49g(0.624mol)乙酸和180ml正丁醇,并升温至90℃。将氨腈溶解在80ml 1-丁醇中并且在90℃下在3小时内逐滴连续加入。加完后,让混合物接着在90℃下再反应4小时。将溶剂在旋转蒸发仪上抽提除去。然后将残渣从水中重结晶,洗涤两次,每次用50ml丙酮,产物在60℃下真空干燥。所得终产物为淡米色(pale beige)结晶粉末。
13C-NMR,100MHz,D2O,20℃:δ=181.1(2C,COOHAcOH),156.6(2C,C胍鎓gr.),40.9(2C,CH2),27.6(2C,CH2),25.3(2C,CH2),23.2(2C,CH3,AcOH);MALDI-TOF[m/z]:201.2(M+H+)。
乙酸N,N-二丁基胍鎓的制备:
引入55.86g(0.432mol)二丁胺、25.96g(0.432mol)乙酸和100ml1-丁醇,并升温至90℃。将氨腈溶解在60ml正丁醇中,并且在90℃下在3小时内逐滴连续加入。加完后,让混合物接着在90℃下反应4小时。在76℃下,将沉淀的盐过滤出来,并洗涤两次,每次用50ml丙酮。将产物在60℃的旋转蒸发仪上真空干燥,所得终产物为无色结晶物质。
13C-NMR,100MHz,乙醇-d6,20℃:δ=178.8(1C,COOHAcOH),155.9(1C,胍基C胍鎓gr.),48.1(2C,CH2),29.0(2C,CH2),23.3(TC,CH3,AcOH),19.2(2C,CH2),12.9(2C,CH2);MALDI-TOF[m/z]:172.2(M+H+)。
配方:
应用试验:
所用头发:
欧洲头发(欧洲人的头发),自然脱落。
头发预先受到的损伤:
使用市售的产品进行每次持久波浪烫和漂洗。
对受损头发的处理:
以示例配方对受损头发进行处理。
表1:
润丝A | 润丝B(非本发明的) | |
烷基胍鎓化合物[重量%] | 2.0 | - |
Ceteareth-25[重量%] | 0.5 | 0.5 |
Cetearyl醇[重量%] | 2.0 | 2.0 |
HCl | 至pH=5 | 至pH=5 |
水[重量%] | 至100 | 至100 |
通过用试验配方处理之前和之后的个体头发的成对比较来确定烷基胍化合物对受损头发的耐力学性的改善。
对于每个试验配方,测定30种潮湿的个体头发。试验步骤如下:
1.用水湿润预受损头发并使用DiaStron生产的全自动装置Mtt670测得拉伸15%所需的力。
2.将头发在水浴中浸泡至少2小时以进行恢复。
3.然后将头发在试验配方中浸泡30分钟之后将每种头发在流水下漂洗约7秒钟。
4.将头发放置过夜(=12小时)从而在空气中干燥。
5.按照如上所述再次测量头发以水湿润后将经处理的头发拉伸15%所需的力。
6.计算以试验配方处理之前和之后的15%拉伸力的差,并用作烷基胍化合物对受损头发的耐力学性的改善的量度。
为了对测量进行统计学评价,使用t-检验以成对比较处理之前和之后的测量值,并将经处理的头发的测量值与空白处理结果进行比较。这样可作出有关测量的统计可靠性结论(为此参见:R.E.Kaiser,J.A.Mühlbauer,“Elementare Tests zur Beurteilung von Meβdaten”[Elementary Tests for the Assessment of Measurements],B.I.Wissenschaftsverlag,Mannheim 1983)。统计可靠性>95%则认为存在显著性差异,>99%则表示测量差异高度显著性,>99.9%则其差异极其高度显著性。
表2a:
测定处理之前和之后将个体头发拉伸15%所需的力(至少30个独立测量):
根据表1的试验配方,使用式(I)的新化合物,其中R1=H,以乙酸盐存在 | 力15%之后力15%之前[mN] | σ | 成对t-检验[%] | t-检验:与空白平均值比较[%] |
HSP B | 0.49 | 2.41 | 72.9 | |
HSP A其中R2=C4 | 1.36 | 1.62 | 100.0 | 89.0 |
HSP A其中R2=C6 | 1.72 | 1.61 | 100.0 | 97.8 |
HSP A其中R2=C8 | 3.51 | 1.64 | 100.0 | 100.0 |
HSP A其中R2=C10 | 3.00 | 1.83 | 100.0 | 100.0 |
HSP A其中R2=C12 | 3.30 | 1.64 | 100.0 | 100.0 |
HSP A其中R2=C16 | 1.89 | 1.33 | 100.0 | 99.3 |
HSP A某中R2=C18 | 1.80 | 1.45 | 100.0 | 98.7 |
HSP A其中R2=C22 | 0.94 | 2.21 | 97.3 | 54.0 |
HSP:润丝
力15%之后:以试验配方处理之后的15%拉伸力。
力15%之前:以试验配方处理之前的15%拉伸力。
σ:标准偏差
因此,烷基胍化合物能够高显著性地提高受损头发的15%拉伸力,即,其能含人惊讶地显著改善受损头发的耐力学性。
表2b:
确定以具有不同基团R1、R2和R3的式(I)和(II)的新化合物处理之前和之后,将个体头发拉伸15%的力(至少30个独立测量)
根据表1的含有新化合物的试验配方 | 力15%之后力15%之前[mN] | σ | 成对的t-检验[%] | t-检验与空白平均值比较[%] |
HSP B | 0.49 | 2.41 | 72.9 | |
含有式(I)化合物的HSP | ||||
HSP A,其中R1=H;R2=C6;乳酸盐 | 1.36 | 1.96 | 99.9 | 97.8 |
HSP A,其中R1=H;R2=C8;乳酸盐 | 3.65 | 2.27 | 100 | 95.1 |
HSP A,其中R1=H;R2=C10;乳酸盐 | 3.44 | 2.07 | 100 | 90.8 |
HSP A,其中R1=H;R2=C12;乳酸盐 | 4.38 | 2.26 | 100 | 99.9 |
HSP A,其中R1=H;R2=油基;乙酸盐 | 6.33 | 3.63 | 100 | 100 |
HSP A,其中R1=H;R2=椰子油基(coco);乙酸盐 | 4.79 | 2.78 | 100 | 99.9 |
HSP A,其中R1=H;R2=苯基;碳酸盐 | 0.66 | 2.94 | 77.2 | 99.8 |
HSP A,其中R1=H;R2=苄基;乙酸盐 | 1.58 | 2.29 | 99.9 | 15 |
HSP A,其中R1=C4;R2=C4;乙酸盐 | 2.16 | 3.12 | 99.9 | 50 |
HSP A,其中R1=C8;R2=C8;乙酸盐 | 4.54 | 2.58 | 100 | 100 |
HSP A,其中R1=H;R2=H(OCH2CH2)14;乙酸盐 | 3.59 | 3.06 | 100 | 62 |
HSP A,其中R1=CH2CH2OH;R2=棕榈酰基乙胺(palmoylethylamide);乙酸盐 | 3.64 | 2.69 | 100 | 71 |
HSP A,其中R1=H;R2=6-己酸丁胺(6-caproic acid butylamide);磷酸盐 | 2.06 | 1.69 | 100 | 83 |
HSP A,其中R1=H;R2=烷基聚二甲基硅氧烷;乙酸盐 | 2.85 | 1.85 | 100 | 47 |
HSP A,其中R1+R2+N=(-(CH2)2-O-(CH2)2-);乙酸盐 | 0.56 | 2.57 | 75 | 99.95 |
HSP A,含精氨酸 | 0.358 | 2.65 | 49.3 | 99.6 |
HSP含式(II)化合物: | ||||
HSP A,其中R1、R2=H;R3=C6;乙酸盐 | 3.45 | 2.4 | 100 | 99.5 |
HSP A,其中R1、R2=H;R3=C12;乙酸盐 | 3.6 | 2.84 | 100 | 90 |
HSP:润丝
力15%之后:以试验配方处理之后的15%拉伸力。
力15%之前:以试验配方处理之前的15%拉伸力。
σ:标准偏差
如表2b所示,类型非常不同的胍化合物都能高显著性地提高受损头发的15%拉伸力,即其能含人惊讶地显著改善受损头发的耐力学性。与新化合物相比,精氨酸只能不显著地改善受损头发的拉伸力。
通过化学试剂来保护头发免受损伤:
头发受损越严重,如由于持久波浪烫或漂洗,头发中可被水或表面活性剂萃取出来的水溶性蛋白质碎片/肽的浓度越高。用表面活性剂萃取促进洗发香波对头发的洗涤。在头发的洗涤过程中,受损头发还比健康头发损失更多的肽。
为了说明,将头发预先进行损伤。为此,对头发进行持久的波浪烫和漂洗各一次。
表3:
含有2%活性组分的润丝的试验配方:
TEGINACIDC(乳化剂) | 0.5% |
TEGO链烷醇1618(增稠度剂) | 2.0% |
烷基胍化合物 | 2.0%AS |
防腐剂(CA24) | q.s. |
HCl | pH=5.0 |
水 | 至100.0% |
将预先损伤的发束(重:约4g)浸入试验配方中(作用时间:30分钟),然后在自来水下漂洗1分钟(T=35℃)。之后将其放置在空气中干燥12小时。
蛋白质损失的测定:
室温下,将约0.5g头发+约15ml月桂基醚硫酸钠(8%)振荡3小时。随后将溶液倾析出并进行离心。然后通过测量295nm处的UV吸收以光度法来测定溶液的蛋白质浓度。使用角蛋白水解产物为标准品(M=1000,Promois WK-H,Seiwa Kasei)。
表4:
测定基于1g头发的蛋白质损失(至少三个独立测量):
根据表3的含有式(I)的新化合物的配方,其中R1=H,以乙酸盐形式存在 | 蛋白质损失[mg/g头发] | σ |
自然的 | 13.7 | 0.39 |
受损的 | 35.0 | 0.87 |
空白 | 28.8 | 0.62 |
R2=C4 | 20.3 | 0.12 |
R2=C6 | 26.0 | 1.25 |
R2=C8 | 26.8 | 0.43 |
R2=C10 | 26.4 | 0.79 |
R2=C12 | 23.5 | 0.67 |
R2=C16 | 25.9 | 0.79 |
R2=C18 | 29.8 | 0.54 |
R2=C22 | 28.9 | 0.84 |
σ=标准偏差
认识到烷基胍鎓化合物降低受损头发的蛋白质损失;尤其是短链化合物此处显示非常好的保护作用。
Claims (9)
1.一种头发处理组合物或头发再处理组合物,所述组合物用于防止化学处理组合物或外界因素所致的损伤,用于修复已受损头发并用于加强头发,其中,存在至少一种通式(I)和/或(II)的化合物
和/或其盐或水合物作为活性物质,其中
R1、R2 a)各自独立为H、具有2-30个C原子,优选4-22个C原子,特别是8-12个C原子的任选含有双键、羟烷基、烷氧基、羧基烷基的任选支化的烃基,或
b)其中该基团还可具有脂环族或杂环族组分,其为饱和、不饱和或芳香族,具有3-10个原子,优选4-6个原子的环大小,其可进一步带有具有1-30个C原子,优选4-22个C原子的饱和或不饱和烃取代基,或
c)烷基酰胺亚烷基或烷基酯亚烷基,其可进一步含有a)和
b)中所提到的结构元素,而且结构元素a)、b)、c)可在各个元素内组合,也可互相组合,
R3 为亚烷基,具有1-30个C原子,优选4-22个C原子的任选支化的烃基,该烃基任选含有双键或脂环族或杂环族组分,其为饱和、不饱和或芳香族,具有3-10个原子,优选具有4-6个原子的环大小,或其中元素-N(R1)-R3-(R2)N-中的R1和R2可形成5至8元环。
2.如权利要求1的头发处理组合物或头发再处理组合物,式(I)和/或其盐,其中基团R1、R2中的至少一个不为氢。
3.如权利要求1的头发处理组合物或头发再处理组合物,式(II)和/或其盐,其中R3为烃基,优选为具有4-18个C原子的亚烷基,且R1和R2具有上面所指含义。
4.如权利要求1-3任一项的头发处理组合物或头发再处理组合物,其中,另外应用盐形式的至少一种选自下列物质的酸:甲酸、乙酸、丙酸、庚酸、辛酸、壬酸、癸酸、十一烷酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、花生酸、山萮酸、环戊烷甲酸、环己烷羧酸、丙烯酸、甲基丙烯酸、乙烯基乙酸、巴豆酸、2-/3-/4-戊烯酸、2-/3-/4-/5-己烯酸、月桂烯酸、肉豆蔻脑酸、棕榈油酸、油酸、顺-9-二十碳烯酸、山梨酸、亚油酸、亚麻酸、新戊酸、乙氧基乙酸、苯乙酸、乳酸、2-乙基己酸、草酸、羟基乙酸、苹果酸、丙二酸、琥珀酸、酒石酸、戊二酸、柠檬酸、己二酸、庚二酸、辛二酸、壬二酸、癸二酸、安息香酸、邻-/间-/对-甲苯酸、水杨酸、3-/4-羟基苯甲酸、邻苯二甲酸、或其完全或部分氢化的衍生物如六氢化-或四氢化邻苯二甲酸、碳酸、磷酸、盐酸、硫酸和其混合物,尤其是乳酸、酒石酸、乙酸和盐酸。
5.如权利要求1的头发处理组合物或头发再处理组合物,其含有0.05-10.0重量%的通式(I)和/或(II)的化合物和/或其盐和/或其水合物。
6.如权利要求1-5任一项的头发处理组合物或头发再处理组合物,所述组合物包含0-10重量%的一或多种乳化剂、0-10%重量的一或多种增稠度剂、0-10重量%的一或多种,优选阳离子的表面活性剂、0-20重量%的一或多种化妆油或软化剂,和常用浓度的常用赋形剂和添加剂,其含有0.05-10.0重量%的如权利要求1-4任一项所述的通式(I)和/或(II)的化合物和/或其盐和/或其水合物。
7.如权利要求6的头发处理组合物或头发再处理组合物,还包含选自以下的一或多种头发化妆活性组分:基于角蛋白、胶原蛋白、弹性蛋白、小麦、稻谷、大豆、牛奶、丝、玉米的动物或植物来源的蛋白质水解产物;去屑活性组分,如吡啶酮乙醇胺盐、奥玛定锌盐和甘宝素、皮脂抑制剂;维生素、泛醇、吡咯烷酮羧酸、红没药醇、植物提取物、肌酸、神经酰胺。
8.如权利要求7所述的头发处理组合物和头发再处理组合物在生产洗发香波、保留在头发上的配方中的用途。
9.如权利要求1-8任一项所述的头发处理组合物作为具有去屑作用的化妆品配方中活性组分的用途。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03013799.6 | 2003-06-18 | ||
EP03013799A EP1493423B1 (de) | 2003-06-18 | 2003-06-18 | Haarbehandlungsmittel und Haarnachbehandlungsmittel zum Schutz vor Schäden durch chemische Behandlung und zur Reparatur bereits geschädigter Haare enthaltend als Wirksubstanz Alkylguanidin-Verbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1572283A true CN1572283A (zh) | 2005-02-02 |
Family
ID=33427062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200410049566.XA Pending CN1572283A (zh) | 2003-06-18 | 2004-06-18 | 头发处理组合物和头发再处理组合物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20040258652A1 (zh) |
EP (1) | EP1493423B1 (zh) |
JP (1) | JP2005008632A (zh) |
CN (1) | CN1572283A (zh) |
AT (1) | ATE329565T1 (zh) |
AU (1) | AU2004201873A1 (zh) |
BR (1) | BRPI0402394A (zh) |
CA (1) | CA2467190A1 (zh) |
DE (1) | DE50303835D1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113194919A (zh) * | 2018-12-20 | 2021-07-30 | 莱雅公司 | 使用包含含有脂肪族二羧酸阴离子的肉碱盐或肉碱衍生物盐的组合物处理角蛋白纤维的方法 |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134056A1 (en) * | 2004-12-20 | 2006-06-22 | Goldschmidt Ag | Use of alkylguanidines as cationic emulsifiers |
DE102005004704A1 (de) | 2005-02-02 | 2006-08-10 | Goldschmidt Gmbh | Guanidinogruppen-haltige Siloxane und deren Verwendung für kosmetische Formulierungen |
US20060269498A1 (en) * | 2005-05-17 | 2006-11-30 | Gerard Malle | Hair shaping composition comprising at least one polyguanidine other than hydroxide |
US7820147B2 (en) * | 2005-11-18 | 2010-10-26 | Mata Michael T | Hair restorative compositions and methods for treating damaged hair and safely chemically treating hair |
EP2965625A1 (en) | 2007-08-16 | 2016-01-13 | The University of Chicago | Plant pathogen resistance |
US20110009446A1 (en) * | 2008-01-11 | 2011-01-13 | Nektar Therapeutics | Oligomer-guanidine class conjugates |
JP5498667B2 (ja) * | 2008-04-15 | 2014-05-21 | 花王株式会社 | 毛髪化粧料 |
DE102008002707A1 (de) | 2008-06-27 | 2009-12-31 | Evonik Goldschmidt Gmbh | Haarbehandlungsmittel und Haarnachbehandlungsmittel zum Schutz vor Schäden durch chemische Behandlung und zur Reparatur bereits geschädigter Haare enthaltend als Wirksubstanzen Etherguanidine |
DE102009001788A1 (de) * | 2009-03-24 | 2010-09-30 | Henkel Ag & Co. Kgaa | Schonendes Bleichmittel |
RU2746990C2 (ru) | 2015-05-01 | 2021-04-23 | Л'Ореаль | Применение активных агентов при химической обработке |
US10441518B2 (en) | 2015-11-24 | 2019-10-15 | L'oreal | Compositions for treating the hair |
JP6873994B2 (ja) | 2015-11-24 | 2021-05-19 | ロレアル | 毛髪を処置するための組成物 |
WO2017091797A1 (en) | 2015-11-24 | 2017-06-01 | L'oreal | Compositions for treating the hair |
CA3026108A1 (en) | 2016-06-10 | 2017-12-14 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
WO2017217660A1 (ko) * | 2016-06-13 | 2017-12-21 | 연세대학교 산학협력단 | 수베르산 또는 이의 염을 유효성분으로 함유하는 피부보습 개선, 피부각질 제거, 피부탄력 증진, 홍반 억제, 피부주름 개선 또는 피부광노화 개선 효과를 갖는 조성물 |
US11135150B2 (en) | 2016-11-21 | 2021-10-05 | L'oreal | Compositions and methods for improving the quality of chemically treated hair |
EP3554494A4 (en) | 2016-12-19 | 2021-02-17 | Cellixbio Private Limited | COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION |
MX2019009527A (es) * | 2017-02-13 | 2019-09-23 | Unilever Nv | Metodo para fortalecer el cabello. |
EA038216B1 (ru) * | 2017-02-13 | 2021-07-26 | ЮНИЛЕВЕР АйПи ХОЛДИНГС Б.В. | Способ укрепления волос, подвергнутых окислительной обработке |
US11433011B2 (en) | 2017-05-24 | 2022-09-06 | L'oreal | Methods for treating chemically relaxed hair |
WO2019083288A1 (ko) * | 2017-10-25 | 2019-05-02 | 연세대학교 산학협력단 | 수베르산을 유효성분으로 포함하는 탈모 방지 또는 발모 촉진용 조성물 |
US11596588B2 (en) | 2017-12-29 | 2023-03-07 | L'oreal | Compositions for altering the color of hair |
US11090249B2 (en) | 2018-10-31 | 2021-08-17 | L'oreal | Hair treatment compositions, methods, and kits for treating hair |
JP7282335B2 (ja) * | 2018-11-14 | 2023-05-29 | コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー | グアニジン誘導体を含む発毛促進用組成物 |
US11419809B2 (en) | 2019-06-27 | 2022-08-23 | L'oreal | Hair treatment compositions and methods for treating hair |
WO2022115645A1 (en) | 2020-11-25 | 2022-06-02 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2814703B2 (ja) * | 1990-06-19 | 1998-10-27 | ライオン株式会社 | 毛髪化粧料 |
JP3453021B2 (ja) * | 1996-01-22 | 2003-10-06 | 花王株式会社 | 毛髪化粧料 |
JPH1135424A (ja) * | 1997-07-22 | 1999-02-09 | Kao Corp | 毛髪化粧料 |
JP3776211B2 (ja) * | 1997-07-22 | 2006-05-17 | 花王株式会社 | 毛髪化粧料 |
JP4011678B2 (ja) * | 1997-07-22 | 2007-11-21 | 花王株式会社 | グアニジン誘導体及びこれを含有する毛髪化粧料 |
JP2002029936A (ja) * | 2000-07-21 | 2002-01-29 | Lion Corp | 毛髪化粧料 |
US20020172655A1 (en) * | 2001-03-01 | 2002-11-21 | Mitsubishi Chemical Corporation | Cosmetic-use polymer, cosmetic employing same, and method of preparing same |
US20030108508A1 (en) * | 2001-08-21 | 2003-06-12 | Ajinomoto Co., Inc | Hair cosmetic |
-
2003
- 2003-06-18 AT AT03013799T patent/ATE329565T1/de not_active IP Right Cessation
- 2003-06-18 EP EP03013799A patent/EP1493423B1/de not_active Expired - Lifetime
- 2003-06-18 DE DE50303835T patent/DE50303835D1/de not_active Expired - Lifetime
-
2004
- 2004-05-04 AU AU2004201873A patent/AU2004201873A1/en not_active Abandoned
- 2004-05-13 CA CA002467190A patent/CA2467190A1/en not_active Abandoned
- 2004-06-02 US US10/858,945 patent/US20040258652A1/en not_active Abandoned
- 2004-06-10 JP JP2004172219A patent/JP2005008632A/ja active Pending
- 2004-06-17 BR BR0402394-3A patent/BRPI0402394A/pt not_active Application Discontinuation
- 2004-06-18 CN CN200410049566.XA patent/CN1572283A/zh active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113194919A (zh) * | 2018-12-20 | 2021-07-30 | 莱雅公司 | 使用包含含有脂肪族二羧酸阴离子的肉碱盐或肉碱衍生物盐的组合物处理角蛋白纤维的方法 |
CN113194919B (zh) * | 2018-12-20 | 2023-10-20 | 莱雅公司 | 使用包含含有脂肪族二羧酸阴离子的肉碱盐或肉碱衍生物盐的组合物处理角蛋白纤维的方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1493423B1 (de) | 2006-06-14 |
US20040258652A1 (en) | 2004-12-23 |
CA2467190A1 (en) | 2004-12-18 |
AU2004201873A1 (en) | 2005-01-13 |
JP2005008632A (ja) | 2005-01-13 |
EP1493423A1 (de) | 2005-01-05 |
ATE329565T1 (de) | 2006-07-15 |
DE50303835D1 (de) | 2006-07-27 |
BRPI0402394A (pt) | 2005-05-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1572283A (zh) | 头发处理组合物和头发再处理组合物 | |
CA1117695A (fr) | Composition de conditionnement de la chevelure | |
CA1123550A (fr) | Compositions cosmetiques a base de polymeres polyammonium quaternaires | |
US20040258651A1 (en) | Use of alkylguanidine compounds for the treatment and after-treatment of hair | |
EP2895141B1 (en) | Hair care polymer | |
US10456341B2 (en) | Compositions and methods for simultaneous reshaping and direct coloring of hair | |
CA2092990C (fr) | Dispersions cationiques a base de ceramides et/ou de glycoceramides | |
JP5947340B2 (ja) | 毛髪処理剤 | |
US6620410B1 (en) | Hair care compositions and protection from ultraviolet radiation | |
FR3030240A1 (fr) | Procede de traitement des fibres keratiniques avec une composition comprenant un acide amine | |
JP2004002261A (ja) | コンディショニング剤 | |
GB2128195A (en) | Protein derivative containing grafted ultraviolet-absorbing radicals the process for its preparation and compositions in which it is present | |
JP2022168056A (ja) | 毛髪強化剤 | |
JP2017535558A (ja) | カチオン性ポリマーを含有するパーソナルケア組成物 | |
CN107921295A (zh) | 含莲花油的头发清洁组合物及其应用 | |
JP6940076B2 (ja) | 毛髪処理方法 | |
US10765617B2 (en) | Personal care compositions comprising copolymers of cationic monomers and acryloyl lactam based monomers, process for the same and method of use | |
JPH0848766A (ja) | 重合体及びその製造方法 | |
CA1158984A (fr) | Agents cosmetiques a base de polymeres cationiques, compositions cosmetiques les contenant et leur application | |
TWI804529B (zh) | 毛髮處理方法 | |
CN1362057A (zh) | 头发化妆品组合物 | |
JP3202135B2 (ja) | 頭髪化粧料 | |
JP7281172B2 (ja) | 化粧料 | |
US20150297488A1 (en) | Composition comprising a dicarbonyl compound and method for smoothing the hair using this composition | |
US11753484B2 (en) | Cellulose ether-lactam hybrid polymers, compositions, and methods for preparing and using the hybrid polymers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |