CN1528209A - Health-care food with immune modulation and cltiradiation function and preparing method thereof - Google Patents
Health-care food with immune modulation and cltiradiation function and preparing method thereof Download PDFInfo
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- CN1528209A CN1528209A CNA031350526A CN03135052A CN1528209A CN 1528209 A CN1528209 A CN 1528209A CN A031350526 A CNA031350526 A CN A031350526A CN 03135052 A CN03135052 A CN 03135052A CN 1528209 A CN1528209 A CN 1528209A
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Abstract
The present invention relates to a health-care food with functions of regulating immunity and resisting radiation and its preparation process. It is made up by using Chinese medicinal materials of rhodiola, polygonatum root, astragalus root, lycium berry, hippophae rhmnoides and green tea as raw material through the processes of water-extraction, cold storage, centrifugalization, filtration and adding auxiliary material. Said food can be easily absorbed by human body, and its biological utilization rate is high.
Description
Technical field
The present invention relates to a kind of health food, is a kind of health food with immunomodulating, radiation-resisting functional and preparation method thereof specifically.
Background technology
Along with the progress of society, the popularizing of computer, radiation has become a kind of hidden danger of serious harm human health, but really has immunomodulating and radiation-resisting functional is actually rare for health food all over the body.
Summary of the invention
The purpose of this invention is to provide a kind of health food and preparation method thereof with immunomodulating, radiation-resisting functional.
To be raw material with Radix Rhodiolae, Rhizoma Polygonati, the Radix Astragali, Fructus Lycii, Fructus Hippophae, green tea form through scientific composition is refining with reference to the modern pharmacological research achievement health food of the present invention.
Radix Rhodiolae is Tibetan medicine commonly used, and its main effective ingredient has multiple compositions such as rhodioside, polysaccharide, protein, flavone compound, alkaloid.Modern pharmacological research shows, Radix Rhodiolae have immunomodulating, resisting fatigue, anti-hypoxia, radioprotective, antibiotic, suppress effects such as blood sugar increasing, preventing tumor.Zoopery proves that Radix Rhodiolae can obviously promote the increase of mouse thymus and spleen weight.To the phagocytic function test of mice reticuloendothelial system, prove that Radix Rhodiolae can strengthen the speed of cleaning up of mouse vein colloid carbon granules, the phagocytic function of reticuloendothelial system there is obvious potentiation.In addition, the experiment proved that the contained polysaccharide of Radix Rhodiolae can significantly improve survival rate to being subjected to according to mice, and hemopoietic system is also had obvious protective effect, its significant degree can be compared with the positive drug Benzalkonium, and this seldom sees in Chinese medicine and natural drug.
Rhizoma Polygonati has the medicine-food two-purpose function.The Rhizoma Polygonati beginning is stated from " Mingyi Bielu ", motherland's medical science thinks that Rhizoma Polygonati has good enriching yin and nourishing kidney, invigorating the spleen and replenishing QI effect, thereby be usually used in nourishing and fit keeping function and treatment is suffered from a deficiency of the kidney and the disease of weakness of the spleen and stomach, and think that the nourishing effect of Rhizoma Polygonati is main relevant with the promotion functions of immune system.Modern pharmacology studies have shown that Rhizoma Polygonati has multiple beneficial such as slow down aging, adjusting immunity in the effect of health.Rhizoma Polygonati contains sibiricoside, polysaccharide, quinones and various trace elements, and wherein polygonatum polysaccharide (PSP) is one of important component of Rhizoma Polygonati bioactive substance.
Experiment in vitro shows that polygonatum polysaccharide has the moderate excitation to normal person's lymphocyte transformation, and immunologic hypofunction patient's lymphocyte transformation is then had the height excitation.Zoopery shows, giving the immunology that coarse solomon's seal polysaccharide carries out with the filling stomach studies confirm that, coarse solomon's seal polysaccharide can make mouse thymus, spleen weight increase, can obviously strengthen mice carbon clearance speed, to mice reticuloendothelial system phagocytic function, tangible activation and potentiation are arranged, improve the humoral immunity level of animal spleen T total cellular score and external source thymus-dependent antigen, Rhizoma Polygonati extract can promote mouse spleen lymphocyte to transform.Result of study shows that Rhizoma Polygonati has immunoloregulation function.
Zoopery shows, to whole body
60Co radiation gamma mice, polygonatum polysaccharide can obviously resist
60The minimizing of the blood cell count that the Co gamma-rays causes, and can make erythrocyte C
3The b receptor is spent askew rate and immune complex rosette rate to shine more merely obviously to increase, and the hemopoietic function of radiation damage mice is had significant protective effect.
The chemical constituent of the Radix Astragali mainly contains multiple compositions such as saponin, polysaccharide.Motherland's medical science record Radix Astragali has multiple effects such as nourishing, dampness removing, pain relieving, calmness.Modern pharmacological research shows that the Radix Astragali has diuresis, blood pressure lowering, antibiotic, radioprotective, raise immunity and makes effects such as cAMP in plasma increases.Zoopery shows, astragalus polysaccharides is to having favorable protection and therapeutical effect by the renal function injury due to the microwave, and the chromosome damage that can repair by INDUCED BY MICROWAVE IRRADIATION promptly has antimutagenic effect.
The chemical constituent of Fructus Lycii mainly contains lycium barbarum polysaccharide, betanin, carotenoid and various trace elements.Wherein lycium barbarum polysaccharide has the promotion immunization, is one of main active of Fructus Lycii.In addition, the experiment proved that lycium barbarum polysaccharide can be alleviated the leukopenia that radiotherapy causes, increase the periphery blood T lymphocyte number, adjust patient's immunocyte ratio, significant radiation resistance is arranged.
Mainly contain materials such as flavone, linoleic acid, vitamin E, plant sterol in the Fructus Hippophae, show through zoopery, what Fructus Hippophae extract can significantly improve mouse macrophage engulfs percent and phagocytic index, strengthen macrophage lysosomal acid phosphatase nonspecific esterase activity, the effect of the macrophage function of enhancing is arranged.In addition, Fructus Hippophae can significantly improve GY
60The survival rate of Co roentgenization mice can improve spleen hemopoietic focus number, and bone marrow nucleated cell digital display work is increased.Can significantly reduce bone marrow smear and incarnadine the cell micronucleus rate, strengthen protective action chmice acute radiation sickness.
Mainly contain tea polyphenols class, alkaloids, the anthropoid required various trace elements of multivitamin in the green tea.Experimental results show that green tea has tangible radiation resistance, its main mechanism of action is that tea polyphenols class, lipopolysaccharide and vitamin E and C contained in the green tea can poison the generation Detoxication to the peroxidating that the caused free radical of radiation is caused, especially tea polyphenolic compounds can antioxidation and is removed free radical, play the effect that prevents the radiation infringement, thereby reach the radioprotective effect.In addition, the contained tea polyphenols class of green tea can play the antioxidative effect in the present invention, thereby has increased the stability of product.
The reasonable combination coordinated of above-mentioned each raw material can make health food of the present invention have significant immunomodulating and radiation-resisting functional.
Health food of the present invention mainly is to be made by the raw material of following weight parts:
Radix Rhodiolae 0.1-5 part
Rhizoma Polygonati 0.1-5 part
Radix Astragali 0.1-10 part
Fructus Lycii 0.1-5 part
Fructus Hippophae 0.1-5 part
Green tea 0.1-5 part
Health food of the present invention can adopt the conventional method of Chinese medicine preparation to make any conventional oral preparations.
Used adjuvant is the raw material of following weight portion during the preparation oral liquid:
Xylitol 0.1-5 part
Potassium sorbate 0.01-2 part
The preparation method that above-mentioned each raw material components is made health food effective ingredient of the present invention is:
(1) chooses Radix Rhodiolae, Rhizoma Polygonati, the Radix Astragali, Fructus Lycii, Fructus Hippophae, the green tea that conforms to quality requirements, clean standby;
(2) above-mentioned raw materials is put into extraction pot, the decocting that adds 6 times of weight boils 2-3 time, and each 1-2 hour, merge extractive liquid, cold preservation after 300 eye mesh screens filter was handled;
(3) get supernatant after the extracting solution centrifugal treating with cold preservation, supernatant liquid filtering is got health food effective ingredient of the present invention.
Required adjuvant commonly used adopted common process to can be made into any peroral dosage form commonly used when health food active ingredient of the present invention added the preparation different dosage form, as oral liquid, soft capsule, hard capsule, granule, tablet etc.
Health food of the present invention shows through effect experiment, toxicological experiment and stability experiment, remarkable, nontoxic, the good stability of its effect, and take confirmation through majority and have immunomodulating, radiation-resisting functional really, building body, and the health food that can eat for a long time.Have reasonable recipe, craft science easily is absorbed by the body, the bioavailability height; The complete maturation of preparation method; Characteristics such as prescription is unique, and immunomodulating, radiation-resisting functional are remarkable, and taking dose is little.
Concrete experiment method
Below in conjunction with embodiments of the invention the present invention is further described, but the present invention is not limited to embodiment, those of ordinary skills do some modification, still in protection domain of the present invention.
Embodiment 1-5: prepare health-care food oral liquid of the present invention, the weight proportion of each raw material components sees the following form.
| Embodiment number | Radix Rhodiolae (kg) | Rhizoma Polygonati (kg) | The Radix Astragali (kg) | Fructus Lycii (kg) | Fructus Hippophae (kg) | Green tea (kg) | Xylitol (kg) | Potassium sorbate (kg) |
| ????1 | ????0.1 | ????0.1 | ????0.1 | ????0.1 | ????0.1 | ????0.1 | ????0.1 | ????0.01 |
| ????2 | ????0.3 | ????0.5 | ????0.9 | ????0.4 | ????0.2 | ????0.2 | ????0.4 | ????0.02 |
| ????3 | ????1.0 | ????2.0 | ????5.0 | ????2.0 | ????0.5 | ????2.0 | ????2.0 | ????0.08 |
| ????4 | ????3.0 | ????3.0 | ????8.0 | ????4.0 | ????1.0 | ????3.0 | ????3.0 | ????1.50 |
| ????5 | ????5.0 | ????5.0 | ????10.0 | ????5.0 | ????5.0 | ????5.0 | ????5.0 | ????2.00 |
Preparation method following (with embodiment 2 is the example explanation, and other is substantially the same manner as Example 2 except that raw material consumption difference):
(1) chooses raw material
Choose satisfactory Radix Rhodiolae 0.3kg, Rhizoma Polygonati 0.5kg, Radix Astragali 0.9kg, Fructus Lycii 0.4kg, Fructus Hippophae 0.2kg, green tea 0.2kg, clean standby.
(2) extract raw material
Above-mentioned each raw material is put into extraction pot, and the decocting that adds 6 times of weight boils 2 times, be respectively 2 hours, 1.5 hours at every turn, and merge extractive liquid,, 4-0 ℃ of cold preservation is handled after 300 eye mesh screens filter.
(3) preparation feed liquid
Extracting solution after the cold preservation is added in the centrifuge, and 2000 rev/mins of centrifugal treating of rotating speed 10 minutes are got supernatant then and are filtered with plate frame filter, filter the back and add sorbitol 0.4kg, potassium sorbate 0.02kg, add distilled water again to ormal weight, stir evenly, place.
(4) embedding
With the feed liquid embedding for preparing in 100 bottles of 100ml oral liquid bottles.
(5) sterilization
The oral liquid that embedding is good adopted 100 ℃ of water vapour flowing steam sterilizations 30 minutes.
(6) quality inspection
Test by company standard to semi-finished product in the sterilization back.
(7) packing
After the assay was approved, in the carton of packing into, seal seal, be finished product.
Used each crude drug of present embodiment should meet " 2000 editions requirements of Chinese pharmacopoeia.Green tea can be selected the commercially available Xihu Longjing Tea that meets national standard, HUANGSHANMAOFENG, dongting biluchun (tea) etc.
Every bottle of net content 100ml of health-care food oral liquid of the present invention, every bottle contains crude polysaccharides and is no less than 100mg.
Using method is oral, every day 3 times, 1 bottle of every day.
Claims (3)
1, a kind of health food with immunomodulating, radiation-resisting functional is characterized in that it is to be made by the raw material of following weight portion:
Radix Rhodiolae 0.1-5 part
Rhizoma Polygonati 0.1-5 part
Radix Astragali 0.1-10 part
Fructus Lycii 0.1-5 part
Fructus Hippophae 0.1-5 part
Green tea 0.1-5 part.
2, health food according to claim 1, used adjuvant is the raw material of following weight portion when it is characterized in that preparing oral liquid:
Xylitol 0.1-5 part
Potassium sorbate 0.01-2 part.
3, the preparation method of claim 1,2 health food active ingredient is characterized in that comprising the following steps:
(1) chooses Radix Rhodiolae, Rhizoma Polygonati, the Radix Astragali, Fructus Lycii, Fructus Hippophae, the green tea that conforms to quality requirements, clean standby;
(2) above-mentioned raw materials is put into extraction pot, the decocting that adds 6 times of weight boils 2-3 time, and each 1-2 hour, merge extractive liquid, cold preservation after 300 eye mesh screens filter was handled;
(3) get supernatant after the extracting solution centrifugal treating with cold preservation, supernatant liquid filtering is got health food effective ingredient of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN03135052.6A CN1286403C (en) | 2003-09-29 | 2003-09-29 | Health-care food with immune modulation and cltiradiation function and preparing method thereof |
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| CN03135052.6A CN1286403C (en) | 2003-09-29 | 2003-09-29 | Health-care food with immune modulation and cltiradiation function and preparing method thereof |
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| CN1528209A true CN1528209A (en) | 2004-09-15 |
| CN1286403C CN1286403C (en) | 2006-11-29 |
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100355368C (en) * | 2005-01-11 | 2007-12-19 | 贵阳中医学院 | Health-care products with improving immunity and preventing radiative harm and production thereof |
| CN100370914C (en) * | 2005-12-09 | 2008-02-27 | 郭志忠 | Health-care tea containing antifatigue anti senility Chinese herbal medicine |
| CN100387146C (en) * | 2005-07-30 | 2008-05-14 | 吴煌发 | Radiation resistant tea |
| CN101850027A (en) * | 2009-03-31 | 2010-10-06 | 北京因科瑞斯医药科技有限公司 | Pharmaceutical composition with functions of radiation resistance and immunity enhancement and preparation method thereof |
| CN101485716B (en) * | 2009-03-03 | 2010-12-29 | 中国人民解放军第四军医大学 | Medicament for treating radiation injury and preparation method thereof |
| CN101129441B (en) * | 2007-09-20 | 2011-05-18 | 尹治华 | Rhodiola rosea capsule and its preparing method |
| CN102388999A (en) * | 2011-11-11 | 2012-03-28 | 中国科学院西北高原生物研究所 | Preparation method of rhodiola root tea bag |
| CN101474309B (en) * | 2009-01-22 | 2013-04-17 | 中国人民解放军海军医学研究所 | Preparation method of composition with anti-fatigue and anti-anoxia functions |
| CN103054034A (en) * | 2013-02-04 | 2013-04-24 | 李玉兰 | Food adding fluid and preparation method thereof |
| CN103653108A (en) * | 2012-09-10 | 2014-03-26 | 李水平 | Radiation-proof oxidation resistant functional beverage and production process thereof |
| CN103859377A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Formula and preparation method of life cultivation and health preservation food helpful for reducing radiation injury |
| CN104256820A (en) * | 2014-10-10 | 2015-01-07 | 青岛嘉瑞生物技术有限公司 | Chinese herbal medicine health oral solution with radiation resistance function |
| CN104905237A (en) * | 2014-03-12 | 2015-09-16 | 李涛 | Inonotus obliquus composite electuary and production method thereof |
| CN105028792A (en) * | 2015-08-29 | 2015-11-11 | 渤海大学 | Barbary wolfberry fruit and sea-buckthorn sugar-free health tea beverage and preparing method thereof |
| CN105381214A (en) * | 2015-10-29 | 2016-03-09 | 甘肃中医药大学 | Application of traditional Chinese medicine composition in preparing medicine for treating altitude sickness |
| CN105724988A (en) * | 2016-02-22 | 2016-07-06 | 叶芳 | Composite fruit and vegetable beverage capable of reducing computer radiation hazard |
| CN106387562A (en) * | 2016-09-18 | 2017-02-15 | 天津北洋百川生物技术有限公司 | Turnip root and herba rhodiolae composite beverage and preparation technology thereof |
| CN107853570A (en) * | 2017-12-09 | 2018-03-30 | 党亮才 | A kind of anti-aging medicine congee of radioresistance and preparation method thereof |
| CN109528925A (en) * | 2017-09-21 | 2019-03-29 | 范文昆 | One kind refreshes the mind tea |
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Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100355368C (en) * | 2005-01-11 | 2007-12-19 | 贵阳中医学院 | Health-care products with improving immunity and preventing radiative harm and production thereof |
| CN100387146C (en) * | 2005-07-30 | 2008-05-14 | 吴煌发 | Radiation resistant tea |
| CN100370914C (en) * | 2005-12-09 | 2008-02-27 | 郭志忠 | Health-care tea containing antifatigue anti senility Chinese herbal medicine |
| CN101129441B (en) * | 2007-09-20 | 2011-05-18 | 尹治华 | Rhodiola rosea capsule and its preparing method |
| CN101474309B (en) * | 2009-01-22 | 2013-04-17 | 中国人民解放军海军医学研究所 | Preparation method of composition with anti-fatigue and anti-anoxia functions |
| CN101485716B (en) * | 2009-03-03 | 2010-12-29 | 中国人民解放军第四军医大学 | Medicament for treating radiation injury and preparation method thereof |
| CN101850027B (en) * | 2009-03-31 | 2013-08-28 | 北京因科瑞斯医药科技有限公司 | Pharmaceutical composition with functions of radiation resistance and immunity enhancement and preparation method thereof |
| CN101850027A (en) * | 2009-03-31 | 2010-10-06 | 北京因科瑞斯医药科技有限公司 | Pharmaceutical composition with functions of radiation resistance and immunity enhancement and preparation method thereof |
| CN102388999A (en) * | 2011-11-11 | 2012-03-28 | 中国科学院西北高原生物研究所 | Preparation method of rhodiola root tea bag |
| CN103653108A (en) * | 2012-09-10 | 2014-03-26 | 李水平 | Radiation-proof oxidation resistant functional beverage and production process thereof |
| CN103653108B (en) * | 2012-09-10 | 2014-12-10 | 李水平 | Radiation-proof oxidation resistant functional beverage and production process thereof |
| CN103859377A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Formula and preparation method of life cultivation and health preservation food helpful for reducing radiation injury |
| CN103054034A (en) * | 2013-02-04 | 2013-04-24 | 李玉兰 | Food adding fluid and preparation method thereof |
| CN104905237A (en) * | 2014-03-12 | 2015-09-16 | 李涛 | Inonotus obliquus composite electuary and production method thereof |
| CN104256820A (en) * | 2014-10-10 | 2015-01-07 | 青岛嘉瑞生物技术有限公司 | Chinese herbal medicine health oral solution with radiation resistance function |
| CN105028792B (en) * | 2015-08-29 | 2019-04-05 | 渤海大学 | A kind of fructus lycii sea-buckthorn sugar-free health-care tea beverage and preparation method thereof |
| CN105028792A (en) * | 2015-08-29 | 2015-11-11 | 渤海大学 | Barbary wolfberry fruit and sea-buckthorn sugar-free health tea beverage and preparing method thereof |
| CN105381214A (en) * | 2015-10-29 | 2016-03-09 | 甘肃中医药大学 | Application of traditional Chinese medicine composition in preparing medicine for treating altitude sickness |
| CN105381214B (en) * | 2015-10-29 | 2020-01-07 | 甘肃中医药大学 | Application of traditional Chinese medicine composition in preparation of medicine for treating altitude disease |
| CN105724988A (en) * | 2016-02-22 | 2016-07-06 | 叶芳 | Composite fruit and vegetable beverage capable of reducing computer radiation hazard |
| CN106387562A (en) * | 2016-09-18 | 2017-02-15 | 天津北洋百川生物技术有限公司 | Turnip root and herba rhodiolae composite beverage and preparation technology thereof |
| CN109528925A (en) * | 2017-09-21 | 2019-03-29 | 范文昆 | One kind refreshes the mind tea |
| CN107853570A (en) * | 2017-12-09 | 2018-03-30 | 党亮才 | A kind of anti-aging medicine congee of radioresistance and preparation method thereof |
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Address after: 132000 Jilin high tech Zone, Jilin Province Road No. three, No. 4 Patentee after: Jilin cloud Health Food Co., Ltd. Address before: 132012 No. two, No. 3, hi tech Zone, Jilin, Jilin Patentee before: Jilin Xinkeqi Health-care Food Co., Ltd. |
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Granted publication date: 20061129 Termination date: 20200929 |