CN1433762A - New use of fluoroquinolone group medicine and berberine - Google Patents
New use of fluoroquinolone group medicine and berberine Download PDFInfo
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- CN1433762A CN1433762A CN 02102753 CN02102753A CN1433762A CN 1433762 A CN1433762 A CN 1433762A CN 02102753 CN02102753 CN 02102753 CN 02102753 A CN02102753 A CN 02102753A CN 1433762 A CN1433762 A CN 1433762A
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- berberine
- norfloxacin
- ofloxacin
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Abstract
The present invention relates to a new application of ordinary use antibiotic drug, and is characterized by that it utilizes the fluoroquinolone medicines, for example norfloxacin or oxyfloxacin and berberine, and makes them into double-component medicine preparation for relieving acute alcoholism alleviating symptoms produced after drinking.
Description
Technical field of the present invention belongs to the new purposes of medicine, particularly antibiotics fluoroquinolones and berberine is used to remove crapulent new purposes.
Background technology of the present invention is as follows: Chinese liquor is made up of ethanol and water two large divisions basically, except that three kinds of main component ethanol, esters, methanol, also has some as noxious substances such as acids, aldehydes, Alcohols,fusel, lead.Drinks is not fatty, can detect micro-amino acid in Chinese liquor, contains more protein, peptide class, aminoacid, saccharide and organic acid in wine and the medicated beer.But which kind of wine no matter, the total content of these materials generally can not surpass 1%.Though some study prompting, some composition in the drinks is good for one's health, and comparing with its danger to health is insignificant really.The fatal influence that some ethanol cause all can take place under very low drinking amount, as driving, operate machines or all the more so when participating in should be noted that power high concentration movable.
Alcoholism is to contain the not normal state that ethanol (ethanol) beverage causes that the excited earlier back of nervus centralis suppresses because of Excessive Intake.But general spontaneous recovery, the only a few severe patient can be dead because of respiratory and circulatory failure.Excitation period: breathing has vinosity, and general speech increases, and is rough sometimes unreasonable, and grief and joy is staggered.The ataxia phase: clumsy in one's movement and inharmonious, fall.Slurred speech, and do not have coherence, vomiting sometimes.Lethargic stage: go to sleep gradually, pale complexion, skin is clammy, body temperature is low, the sound of snoring is arranged, rapid pulse slow, stupor etc., and severe patient can be dead because of respiratory failure.
Excessive drinking, drunkly cause uncomfortablely, the traditional Chinese medical science claims " alcoholism " since time immemorial.In order to tackle alcoholism, alleviate the symptom that insobriety occurs, from ancient times to the present all there is the people constantly exploring the antialcoholic method, various Chinese medicine prescriptions are many, and the product of making that has is sold in the market, as " the extra large Wang Jin cup " in Shenzhen.Though relieving the effect of alcohol perhaps with Chinese medicine can " second day more comfortable ", people still wish to have a kind of relieving the effect of alcohol fast and product that price is not high.
Main contents of the present invention adopt existing antibiotics fluoroquinolones medicine commonly used such as norfloxacin or ofloxacin etc. to form the bi-component antialcoholic drug with berberine exactly, be the treatment gastroenteropathy from original purposes, anti-inflammation develops into dryout, alleviating the various symptoms that the back of drinking occurs, mainly is the symptom in excitation period and ataxia phase.Symptoms such as fidgety, lethargy, dehydration, tic, shock, shallow breathing can appear in serious acute alcoholism, should rush to the hospital rapidly.
Main medicine and characteristic are as follows:
Fluoroquinolones is used more in recent years, and choosing is wherein used two kinds more widely:
1. norfloxacin Norfloxacin
Another name: norfloxacin, power alcohol sieve Eoroxin, Lexinor, Norxin, Uroxacin
Classification: classes of anti-infective medicine; Antimicrobial drug; Synthetic antibacterial drug.
Preparation and specification: capsule: 100mg/ grain.
Pharmacology and application: this product untwists DNA by suppressing antibacterial and DNA helicase, loses normal morphology and function, reaches antibacterial action.This product antimicrobial spectrum is wider, and Gram-positives such as golden Portugal bacterium, streptococcus, escherichia coli, bacillus pyocyaneus and Serratieae and negative bacterium are all had very strong antibacterial activity, and is stronger to the negative bacterium effect.The clinical various infection that are used for due to the sensitive organism more are to be used for urinary tract infection, also are used for typhoid fever, otitis media, tonsillitis and penicillin-fast gonorrhea etc.
Dosage form usage and consumption: oral: each 0.1～0.2g, every day 3 times, be 1～2 week the course of treatment.Be used for typhoid fever or gonorrhea is answered escalated dose, the each oral 0.2～0.3g of typhoid fever, every day 4 times, gonorrhea 0.8g, decoction being taken at a draught.
Points for attention: lighter gastrointestinal reaction can be arranged, headache, dizzy, insomnia, cardiopalmus, erythra also can occur, idol has hematuria, transaminase and blood urea nitrogen to increase.The careful usefulness of anemia of pregnant woman, nursing women, children's and decreased renal function person.
2. ofloxacin Ofloxacin Capsules
Another name: ofloxacin, Oflocet, fertile Flucloxacillin Tarivid
Classification: classes of anti-infective medicine; Antimicrobial drug; Synthetic antibacterial drug.
Preparation and specification: capsule: 100mg/ grain.
Pharmacology and application: this product has a broad antifungal spectrum, active strong not only comprises aerobism Gram-positive and negative bacterium, and comprises that a part of anaerobe, mycoplasma all have good action.Clinical can be used for due to the sensitive organism respiratory tract, urinary tract, intestinal, skin and soft tissue, gallbladder and biliary tract, middle ear, nasal sinuses, prevent acute and chronic infection such as capsule, also can be used for immunodeficiency person and infect.
Dosage form usage and consumption: oral: each 0.2～0.3g, every day 2 times, tuberculosis consumption 0.3g every day, decoction being taken at a draught.Control typhoid fever repeated infection .05g every day serve on for 3～6 weeks.
Points for attention: have gastrointestinal reaction, as feel sick, vomiting, anorexia and erythra, insomnia, dizzy, headache etc., accidental liver, renal function injury and leukopenia.Anemia of pregnant woman, the careful usefulness of child, the renal insufficiency person answers decrement to take.
3. berberine
Medicine name: little Pi's alkali Berberine, the little Pi's alkali of hydrochloric acid.
Another name: berberine Umbellatine
Classification: classes of anti-infective medicine; Antimicrobial drug; Synthetic antibacterial drug;
Preparation and specification: tablet: 100mg/ sheet.
Pharmacology and application: a kind of alkaloid of this product for from plants such as Rhizoma Coptidis, Cortex Phellodendri or Radix Berberidis, extracting, now use synthetic more, be an effective antibacterial, dysentery bacterium, Bacillus typhi, golden Portugal bacterium there are inhibitory action.
Dosage form usage and consumption: oral: each 0.1～0.4g, every day 2～3 times.
Points for attention: oral untoward reaction is less, and idol has nauseating, vomiting, erythra and medicine heat, can disappear after the drug withdrawal.
Embodiment 1: general degree is drunk, and self-induction does not have drunk possibility, and just some heating is blushed a little, and stomach has discomfort slightly.
Prescription: the little Pi's alkali of hydrochloric acid 100mg * 3
Norfloxacin 100mg * 1
Instructions about how to take medicine: the end back of drinking is sent down with warm water, and having a short interval gets final product.
Embodiment 2: duration of alcohol consumption is long, and the self-induction insobriety has drunk possibility, and heating is blushed, and speech increases, dance for joy, and stomach discomfort, sensation feels sick.
Prescription: the little Pi's alkali of hydrochloric acid 100mg * 4～6
Norfloxacin 100mg * 2～3
Instructions about how to take medicine: the end back of drinking is sent down with warm water, and having a short interval gets final product.
Embodiment 3: general degree is drunk, and self-induction does not have drunk possibility, and just some heating is blushed a little, and stomach has discomfort slightly.
Prescription: the little Pi's alkali of hydrochloric acid 100mg * 3
Ofloxacin 100mg * 1
Instructions about how to take medicine: the end back of drinking is sent down with warm water, and having a short interval gets final product.
Embodiment 4: duration of alcohol consumption is long, and the self-induction insobriety has drunk possibility, and heating is blushed, and speech increases, dance for joy, and stomach discomfort, sensation feels sick.
Prescription: the little Pi's alkali of hydrochloric acid 100mg * 4～6
Ofloxacin 100mg * 2～3
Instructions about how to take medicine: the end back of drinking is sent down with warm water, and having a short interval gets final product.
Points for attention: 1, to above-mentioned antibiotics allergy sufferers Ying Shenyong.2, we forbid taking before wine.3, exceed with clothes at every turn, do not eliminate fully, can after 4 hours, obey for the second time as sensory symptoms.
Claims (7)
1. one kind is used to eliminate the drug regimen of various malaise symptoms afterwards of drinking, and it is characterized in that being combined by antibiotics fluoroquinolones and berberine.
2. according to the described drug regimen of claim 1, it is characterized in that being made up of two kinds of medicines such as antibiotics norfloxacin commonly used and berberines, its prescription composition is:
Each 1～3 of norfloxacin 100mg/ grain
Each 3～6 of berberine 100mg/ sheet.
3. according to claim 1 or 2 described drug regimens, it is characterized in that being made up of two kinds of medicines such as antibiotics norfloxacin commonly used and berberines, its prescription composition is:
Each 1～2 of norfloxacin 100mg/ grain
Each 3～4 of berberine 100mg/ sheet.
4. according to claim 1 or 2 described drug regimens, it is characterized in that being made up of two kinds of medicines such as antibiotics norfloxacin commonly used and berberines, its prescription composition is:
Each 2～3 of norfloxacin 100mg/ grain
Each 4～6 of berberine 100mg/ sheet.
5. according to the described drug regimen of claim 1, it is characterized in that being made up of two kinds of medicines such as antibiotics ofloxacin commonly used and berberines, its prescription composition is:
Each 1～3 of ofloxacin 100mg/ grain
Each 3～6 of berberine 100mg/ sheet.
6. according to claim 1 or 5 described drug regimens, it is characterized in that being made up of two kinds of medicines such as antibiotics ofloxacin commonly used and berberines, its prescription composition is:
Each 1～2 of ofloxacin 100mg/ grain
Each 3～4 of berberine 100mg/ sheet.
7. according to claim 1 or 5 described drug regimens, it is characterized in that being made up of two kinds of medicines such as antibiotics ofloxacin commonly used and berberines, its prescription composition is:
Each 2～3 of ofloxacin 100mg/ grain
Each 4～6 of berberine 100mg/ sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02102753 CN1433762A (en) | 2002-01-23 | 2002-01-23 | New use of fluoroquinolone group medicine and berberine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02102753 CN1433762A (en) | 2002-01-23 | 2002-01-23 | New use of fluoroquinolone group medicine and berberine |
Publications (1)
| Publication Number | Publication Date |
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| CN1433762A true CN1433762A (en) | 2003-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02102753 Pending CN1433762A (en) | 2002-01-23 | 2002-01-23 | New use of fluoroquinolone group medicine and berberine |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423957C (en) * | 2004-01-27 | 2008-10-08 | 坎培诺洛有限公司 | Attachment system for the spokes of a bicycle wheel |
| CN103316100A (en) * | 2013-07-12 | 2013-09-25 | 镇江天和生物技术有限公司 | Chinese-western compound preparation for treating chicken colibaciuosis |
| CN104434921A (en) * | 2014-11-05 | 2015-03-25 | 辽宁宏泰药业有限公司 | Oral preparation for treating bacterial intestinal diseases of livestock and preparation method thereof |
-
2002
- 2002-01-23 CN CN 02102753 patent/CN1433762A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423957C (en) * | 2004-01-27 | 2008-10-08 | 坎培诺洛有限公司 | Attachment system for the spokes of a bicycle wheel |
| CN103316100A (en) * | 2013-07-12 | 2013-09-25 | 镇江天和生物技术有限公司 | Chinese-western compound preparation for treating chicken colibaciuosis |
| CN104434921A (en) * | 2014-11-05 | 2015-03-25 | 辽宁宏泰药业有限公司 | Oral preparation for treating bacterial intestinal diseases of livestock and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |