CN104147465A - Traditional Chinese medicine cough suppressing preparation - Google Patents

Traditional Chinese medicine cough suppressing preparation Download PDF

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CN104147465A
CN104147465A CN201310176128.9A CN201310176128A CN104147465A CN 104147465 A CN104147465 A CN 104147465A CN 201310176128 A CN201310176128 A CN 201310176128A CN 104147465 A CN104147465 A CN 104147465A
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parts
chinese medicine
radix
preparation
cough
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CN104147465B (en
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何宗仁
李成义
师玉琦
孙百贞
李竹兰
宋敏平
宋月红
宋小兰
陈双明
陈耀武
王邦荣
祝可锦
刘杰
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Gansu Pu pharmaceutical Limited by Share Ltd
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GANSU PUAN PHARMACEUTICALS CO Ltd
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Abstract

The invention relates to the traditional Chinese medicine synthesis pharmaceutical technology field, and concretely relates to a traditional Chinese medicine cough suppressing preparation. The traditional Chinese medicine cough suppressing preparation is characterized in that the preparation is prepared from the following traditional Chinese medicines, by weight, 40-80 parts of catnip, 40-80 parts of radix peucedani, 40-80 parts of balloonflower roots, 40-80 parts of radix stemonae, 40-80 parts of tatarian aster roots, 35-70 parts of dried orange peels, 60-120 parts of cordate houttuynia, 35-70 parts of mint, 40-80 parts of opium poppy shells, 35-70 parts of licorice, 0.5-5 parts of stevioside, 0.5-5 parts of honey and 0.1-0.2 part of sodium benzoate. The preparation employs honey and perfume oil as medicines, the medicine properties are mild, the therapeutic effects are definite, and the preparation is suitable for taking of the aged and children. The preparation has no obvious toxic and side effects or adverse reactions. Clinic usage results show that the preparation takes effects on the medicine application day for the vast majority of patients, cough is relieved, and pharynx tickle is remitted.

Description

A kind of Chinese medicine cough arresting
Technical field
The present invention relates to Chinese medicine synthesis pharmaceutical technical field, be specifically related to a kind of Chinese medicine cough arresting.
Background technology
Cough is the common sympton of respiratory tract disease, especially more and more colder at weather, when the chance of having a cold increases, more easily causes cough.In population of China, have every year the patient of cough symptom to reach 6% left and right, reach as high as 9%, and due to the deterioration of the ecological environment, the factors such as air pollution stimulate, crowd's ratio of suffering from cough symptom has the trend of rising.In the medicine of common cough-relieving, Western medicine and Chinese patent medicine have his own strong points: Western medicine mainly causes the reason of cough according to respiratory tract, directly suit the medicine to the illness, instant effect, but need to combine other drug Comprehensive Treatment more, as respiratory tract infection need be used antibiotics simultaneously, flu needs to share anti-cold medicine.And Chinese patent medicine is as suit the medicine to the illness used, determined curative effect, though take effect not as Western medicine rapid, take stopgap measures and effect a permanent cure, therefore welcome by patient.And existing Chinese medicine majority only eliminating the phlegm, cough-relieving, relieving asthma, one or several treatments of antiinflammatory, and for above symptom comprehensively treatment Chinese patent medicine seldom, its curative effect is also not obvious.
Theory of Chinese medical science thinks that wind is first of six climate exopathogens, and ailment said due to cold or exposure is violated lung, wind being YANG-pathogen, and benefaction and number becomes, injures lung, and lung is declared respectful mistake department, loses irrigating that mist reveals, therefore paroxysm of cough, assassination swashs and increases the weight of, itching throat, less expectorant; As for thin fur, floating pulse or floating number etc. all ailment said due to cold or exposure injure the card of lung.We institute controls and belongs to traditional Chinese medical science exogenous cough, and it be its pathogenesis essence that ailment said due to cold or exposure is violated lung, and it is controlled mainly at lung, employing dispelling wind and ventilating the lung, relieving cough and resolving phlegm be for method.
Summary of the invention
The object of the invention is to by providing a kind of Chinese medicine cough arresting treatment ailment said due to cold or exposure to violate the caused paroxysm of cough of lung, assassination is sharp to be increased the weight of, itching throat, the symptoms such as few expectorant, dispelling wind and ventilating the lung, relieving cough and resolving phlegm.
Object of the present invention is achieved through the following technical solutions:
A Chinese medicine cough arresting, is characterized in that being made by the Chinese medicine of following weight portion: Herba Schizonepetae: 40~80 parts, Radix Peucedani: 40~80 parts, Radix Platycodonis: 40~80 parts, the Radix Stemonae: 40~80 parts, Radix Asteris: 40~80 parts, Pericarpium Citri Reticulatae: 35~70 parts, Herba Houttuyniae: 60~120 parts, Herba Menthae: 35~70 parts, Pericarpium Papaveris: 40~80 parts, Radix Glycyrrhizae: 35~70 parts, stevioside: 0.5~5 part, 0.5~5 part of Mel, 0.1~0.2 part of sodium benzoate.
A Chinese medicine cough arresting, is characterized in that: preferably the Chinese medicine of following weight portion is made: Herba Schizonepetae: 50 parts, Radix Peucedani: 50 parts, Radix Platycodonis: 50 parts, the Radix Stemonae: 50 parts, Radix Asteris: 50 parts, Pericarpium Citri Reticulatae: 42 parts, Herba Houttuyniae: 75 parts, Herba Menthae: 42 parts, Pericarpium Papaveris: 50 parts, Radix Glycyrrhizae: 42 parts, stevioside: 5 parts, Mel: 0.2 part of 5 part, sodium benzoate.
The described Radix Stemonae, Radix Asteris, Pericarpium Papaveris, Radix Glycyrrhizae are processed with honey.
This Chinese medicine cough arresting formula Herba Schizonepetae dispelling wind and ventilating the lung, Radix Peucedani lowering the adverse-rising QI to resolve phlegm, declaring smooth lung qi is monarch drug.Pericarpium Citri Reticulatae dispersing and lowering lung-QI, relieving cough and resolving phlegm; Radix Asteris master enters lung meridian, and nourishing the lung to keep the adverse QI downward is opened lung strongly fragrant, the turbid and cough-relieving of reducing phlegm; Radix Stemonae lung moistening, reduces phlegm, and newly coughs, chronic cough is all suitable; Radix Platycodonis is opened lung qi dispersing gas and sharp chest and diaphragm throat, and four assist monarch drug, and existing sweet and pungent flavors inducing perspiration and pertaining to yang has again that sweetness and bitterness is respectful reduces to cloudy effect, is ministerial drug altogether.Herba Houttuyniae removing summer-heat lung-heat; Herba Menthae dispelling wind sore-throat relieving, declares smooth mechanism of qi; Pericarpium Papaveris convergence lung qi, astringing lung-QI and relieving cough, prevents that all wind medicines from dispersing too, three medicines are assistant altogether.Radix Glycyrrhizae expelling phlegm for arresting cough, QI invigorating lung moistening, inducting the medicines into affected channel is for making medicine.All medicines share, and play dispelling wind and ventilating the lung, the effect of relieving cough and resolving phlegm.
The preparation technology of Chinese medicine cough arresting
1, Herba Schizonepetae, Radix Peucedani, Radix Asteris, Pericarpium Citri Reticulatae, Herba Menthae Chinese medicine of the five flavours raw material are adopted to steam distillation, with the water soaking of 10 times of amounts 1 hour, distill 5 hours, collection volatile oil is standby; Divide water intaking decocting liquid, medicinal residues decoct with water 1 hour, filter, and merge decocting liquid, standby;
2, Radix Platycodonis, the Radix Stemonae, Radix Glycyrrhizae, Herba Houttuyniae, Pericarpium Papaveris Chinese medicine of the five flavours raw material are decocted with water to twice, 2 hours for the first time, 1 hour for the second time, filter, filtrate and above-mentioned decocting liquid merge, and are condensed into the clear paste that relative density is about 1.17~1.22 (50 ℃);
3, gained clear paste in step 2 is added to ethanol and make to reach 60% containing alcohol amount, stir, place 12 hours, get supernatant, remaining liquid divides and gets liquid and supernatant merging through high speed centrifugation, decompression recycling ethanol, and liquid concentration is that relative density is the clear paste of 1.17~1.22 (50 ℃);
4, in step 3 gained clear paste, add standby volatile oil in step 1, add stevioside and Mel, add water and stir evenly, add sodium benzoate and stir evenly, fill warehouse-in obtains this product.
Beneficial effect of the present invention is extraction by steam distillation volatile oil mode after Herba Schizonepetae, Radix Peucedani, Radix Asteris, Pericarpium Citri Reticulatae, Herba Menthae Chinese medicine of the five flavours raw material blister to be used as medicine, and its active ingredient extraction ratio is 97%, brings into play to greatest extent itself effect.The Radix Stemonae, Radix Asteris, Pericarpium Papaveris, Radix Glycyrrhizae are extracted its effective ingredient after adopting processed with honey, not only can strengthen lung moistening function, play medicine half merit effect doubly.Pericarpium Papaveris, through after processed with honey, also can suppress the untoward reaction of Pericarpium Papaveris.Herba Schizonepetae, Herba Houttuyniae, Radix Glycyrrhizae are share the effect that not only strengthens we's treatment allergic cough, and our antibacterial action is also strengthened greatly.
Medicine of the present invention adopts processed with honey and aromatic oil to be used as medicine, and makes the property of medicine gentle, determined curative effect, suitable old man, child's taste.Medicine adopts processed with honey and Herba Menthae to be used as medicine, and feels silk silk immediately refrigerant, very salubrious after taking.With stevioside, replace sucrose as flavoring agent, its sugariness is high, good stability and be more suitable for diabetic to take.This medicine belongs to Chinese medicine preparation, without obvious toxic-side effects and untoward reaction, by result in clinical application, shows, most patients can take effect in medication the same day, and cough alleviates, and itching throat is alleviated.
The specific embodiment
Embodiment 1
Choose the Chinese medicine of following weight portion: Herba Schizonepetae: 50 parts, Radix Peucedani: 50 parts, Radix Platycodonis: 50 parts, the Radix Stemonae: 50 parts, Radix Asteris: 50 parts, Pericarpium Citri Reticulatae: 42 parts, Herba Houttuyniae: 75 parts, Herba Menthae: 42 parts, Pericarpium Papaveris: 50 parts, Radix Glycyrrhizae: 42 parts, stevioside: 5 parts, Mel: 0.2 part of 5 part, sodium benzoate.
The described Radix Stemonae, Radix Asteris, Pericarpium Papaveris, Radix Glycyrrhizae are processed with honey.
Processing cost product as follows:
(1), Herba Schizonepetae, Radix Peucedani, Radix Asteris, Pericarpium Citri Reticulatae, Herba Menthae Chinese medicine of the five flavours raw material are adopted to steam distillation, with the water soaking of 10 times of amounts 1 hour, distill 5 hours, collection volatile oil is standby; Divide water intaking decocting liquid, medicinal residues decoct with water 1 hour, filter, and merge decocting liquid, standby.
(2) Radix Platycodonis, the Radix Stemonae, Radix Glycyrrhizae, Herba Houttuyniae, the Pericarpium Papaveris five tastes are decocted with water twice, adding for the first time 10 times of amounts of water decocts 2 hours, adding for the second time 10 times of amounts of water decocts 1 hour, filter, filtrate and above-mentioned steps (1) gained decocting liquid merges, and it is 1.17~1.22 clear paste that concentrating under reduced pressure becomes relative density;
(3) gained clear paste in step (2) is added to ethanol and make to reach 60% containing alcohol amount, stir, place 12 hours, get supernatant, remaining liquid divides and gets liquid and supernatant merging through high speed centrifugation, decompression recycling ethanol, and liquid concentration is that relative density is the clear paste of 1.17~1.22 (50 ℃);
(4) in step (3) gained clear paste, add standby volatile oil in step (1), add stevioside and Mel, stir evenly, add sodium benzoate and stir evenly, fill warehouse-in obtains this product.
A kind of Chinese medicine cough arresting Clinical efficacy and safety experiment
1, mice Chinese medicine cough arresting gavage experiment
Maximum dosage-feeding is 80ml/kg, and (containing crude drug 40g/kg) is 106.67 times of 0.75ml/kg of clinical dosage, therefore think that this medicine acute toxicity is less, clinical use is safer.
2, Chinese medicine cough arresting clinical trial
The II phase is clinical: by Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine, Guang-amen Hospital, China Traditional Chinese Medicine Instl, Henan Prov. Inst. of Chinese Medicine & Pharmacology, Hospital No.1 Attached to Tianjin Traditional Chinese Medicine College, 5 units of Second Hospital Attached To Tianjin Chinese Medicine College, jointly completed, altogether selected 239 examples; Wherein test group is selected in 119 examples, ITT crowd's 117 examples, and PP crowd's 117 examples, matched group is selected in 119 examples; Result is that the clinical use of Chinese medicine cough arresting is safe and effective, blood, urine, just conventional before and after test group treatment, and the heart, liver, renal function have no abnormal changes, and safety detects and has no toxic and side effects, has no adverse reaction, and carries out III clinical trial phase.
The III phase is clinical: by Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine, Guang-amen Hospital, China Traditional Chinese Medicine Instl, Henan Prov. Inst. of Chinese Medicine & Pharmacology, Hospital No.1 Attached to Tianjin Traditional Chinese Medicine College, 5 units of Second Hospital Attached To Tianjin Chinese Medicine College, jointly completed, altogether selected 480 examples; Wherein test group is selected in 360 examples, ITT crowd's 356 examples, PP crowd's 355 examples; Matched group is selected in 120 examples; Result of the test is that the clinical use of Chinese medicine cough arresting is safe and effective, blood, urine, just conventional before and after test group treatment, the heart, liver, renal function have no abnormal changes, safety detects and has no toxic and side effects, have no adverse reaction, III clinical trial phase results suggest: Chinese medicine cough arresting treatment cough ailment said due to cold or exposure is violated lung card determined curative effect.
Clinical trial conclusion: the Chinese medicine cough arresting obvious effective rate of healing is 67.05%, and total effective rate is 87.61%(PP); Contrast medicine (JIZHI TANGJIANG) more obvious effective rate is 49.57%, and total effective rate is 75.21%(PP), between group, relatively there is remarkable significant difference (P=0.0004).Individual event symptom therapeutic evaluation: relatively have significant significant difference (P<0.05) between cough, itching throat, expectoration, nasal obstruction watery nasal discharge, fever with aversion to cold primary symptom group, prompting Chinese medicine cough arresting is violated the lung card primary symptom curative effect that has superiority to ailment said due to cold or exposure.By provincial institute for drug control cough arresting, detect, indices all meets quality standard requirement.Be that character, morphine content, minimum fill are all up to specification; Relative density 1.20, pH value 6.1, Hesperidin (C 28h 34o 15) content 0.67mg/ml, arsenic salt does not surpass 3/1000000ths.
Blood, urine, just conventional before and after the treatment of Chinese medicine cough arresting test group, the heart, liver, renal function have no abnormal changes, and safety detects and has no toxic and side effects, has no adverse reaction, and clinical test results prompting treatment cough ailment said due to cold or exposure is violated the determined curative effect of lung.

Claims (4)

1. a Chinese medicine cough arresting, is characterized in that being made by the Chinese medicine of following weight portion: Herba Schizonepetae: 40~80 parts, Radix Peucedani: 40~80 parts, Radix Platycodonis: 40~80 parts, the Radix Stemonae: 40~80 parts, Radix Asteris: 40~80 parts, Pericarpium Citri Reticulatae: 35~70 parts, Herba Houttuyniae: 60~120 parts, Herba Menthae: 35~70 parts, Pericarpium Papaveris: 40~80 parts, Radix Glycyrrhizae: 35~70 parts, stevioside: 0.5~5 part, 0.5~5 part of Mel, 0.1~0.2 part of sodium benzoate.
2. Chinese medicine cough arresting as claimed in claim 1, is characterized in that being made by the Chinese medicine of following weight portion: Herba Schizonepetae: 50 parts, Radix Peucedani: 50 parts, Radix Platycodonis: 50 parts, the Radix Stemonae: 50 parts, Radix Asteris: 50 parts, Pericarpium Citri Reticulatae: 42 parts, Herba Houttuyniae: 75 parts, Herba Menthae: 42 parts, Pericarpium Papaveris: 50 parts, Radix Glycyrrhizae: 42 parts, stevioside: 5 parts, Mel: 0.2 part of 5 part, sodium benzoate.
3. Chinese medicine cough arresting as claimed in claim 1 or 2, is characterized in that: the described Radix Stemonae, Radix Asteris, Pericarpium Papaveris, Radix Glycyrrhizae are processed with honey.
4. Chinese medicine cough arresting as claimed in claim 1 or 2, is characterized in that: described Herba Schizonepetae, Radix Peucedani, Radix Asteris, Pericarpium Citri Reticulatae, Herba Menthae Chinese medicine of the five flavours raw material are used as medicine in extraction by steam distillation volatile oil mode, and its active ingredient extraction ratio is 97%.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105194320A (en) * 2015-11-10 2015-12-30 周红梅 Traditional Chinese medicine composition for treating infantile chronic cough
CN115814032A (en) * 2022-08-23 2023-03-21 甘肃普安制药股份有限公司 Lung-ventilating cough-relieving mixture and application thereof as lung cancer-resisting medicine
CN116036206A (en) * 2022-08-29 2023-05-02 甘肃普安制药股份有限公司 Mixture for ventilating and stopping cough and application of mixture as medicine for resisting chronic obstructive pulmonary disease

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105194320A (en) * 2015-11-10 2015-12-30 周红梅 Traditional Chinese medicine composition for treating infantile chronic cough
CN115814032A (en) * 2022-08-23 2023-03-21 甘肃普安制药股份有限公司 Lung-ventilating cough-relieving mixture and application thereof as lung cancer-resisting medicine
CN116036206A (en) * 2022-08-29 2023-05-02 甘肃普安制药股份有限公司 Mixture for ventilating and stopping cough and application of mixture as medicine for resisting chronic obstructive pulmonary disease

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