CN1424084A - Honeysuckle flower and coptis root powder injection and its preparing method - Google Patents
Honeysuckle flower and coptis root powder injection and its preparing method Download PDFInfo
- Publication number
- CN1424084A CN1424084A CN 02155199 CN02155199A CN1424084A CN 1424084 A CN1424084 A CN 1424084A CN 02155199 CN02155199 CN 02155199 CN 02155199 A CN02155199 A CN 02155199A CN 1424084 A CN1424084 A CN 1424084A
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- CN
- China
- Prior art keywords
- injection
- injectable powder
- baicalin
- pharmaceutic adjuvant
- silver yellow
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Abstract
A powder injection for treating upper respiratory tract infection, acute tonsillitis, and pharyngitis is prepared from the honeysuckle flower's extract whose main component is chlorogenic acid, baicalein and water-soluble additive for injection. Its advantages are high curative effect and stability, and long storage time.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of injection silver yellow injectable powder that is used for the treatment of diseases such as upper respiratory tract infection, acute tonsillitis, pharyngitis and preparation method thereof.
Background technology
Silver yellow has the effect of heat clearing away, detoxifcation, sore-throat relieving, is used for acute tonsillitis, upper respiratory tract infection and wind-heat invading the lung and causes diseases such as heating, cough, pharyngalgia.Silver yellow pin, sheet, granule, capsule and the oral liquid etc. made with Flos Lonicerae and Radix Scutellariae extract all come out.But, main component chlorogenic acid and baicalin are put meeting oxidative degradation for a long time in the YINHUANG ZHUSHEYE under solution condition, and this process has more been quickened in the temperature rising, through the invention test determination, chlorogenic acid and baicalin content before and after the heat sterilization descends 20%, and is positioned over 30 ℃ following 30 days of temperature, content descends 40%, and placed for a long time, solution produces precipitation, makes the use of liquid drugs injection dangerous.Moreover aqueous injection freezes in the north winter, and inconvenience is used, and heating for dissolving has been quickened the degraded of composition again.As seen the quality of YINHUANG ZHUSHEYE is very unstable, thereby has influenced curative effect.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of good stability is provided, transportation and all more convenient injection silver yellow injectable powder of use.
Injection silver yellow injectable powder of the present invention is by Flos Lonicerae extract (main component chlorogenic acid＞18%), and baicalin (purity＞92%) and water for injection dissolubility pharmaceutic adjuvant are formed.The content of Flos Lonicerae extract is (weight proportion) 5%-30% in the injectable powder, and baicalin is 10%-90%, and all the other are pharmaceutic adjuvant, and total amount satisfies 100%.
Among the present invention, described pharmaceutic adjuvant is a lot, for example, can adopt one or more of common amino acids, glucose, lactose, mannitol, polyvinylpyrrolidone, low molecular dextran, sodium chloride, calcium gluconate or calcium phosphate.
The preparation method of above-mentioned injection silver yellow injectable powder is as follows: above-mentioned Flos Lonicerae extract, baicalin, pharmaceutic adjuvant are made sterile solution by component proportioning and water for injection under 20-30 ℃ of condition, the control pH value is 5.5-8.5.Spray-dried or lyophilization, the airtight injection silver yellow injectable powder that gets product.
During use, available water for injection is mixed with injection with injectable powder.Through check, every index all meets the requirements.
The silver yellow injectable powder that the present invention proposes, good stability, storage period is long, transports and easy to use, and can guarantee the curative effect of medicine, has avoided the deficiency of aqueous injection.
The specific embodiment
Embodiment 1,100 grades with in going to the workshop, extracting honeysuckle extract (containing chlorogenic acid composition＞18%) 125g, baicalin (purity＞92%) 200g, add the water for injection of 1000ml～5000ml, under 20 ℃ condition, add the low molecular dextran of above-mentioned two kinds of composition weight 5%, regulating pH is 6.5, solution aseptic filtration, the aseptic spray drying of filtrate is packed as 1000, roll lid, packing gets product.
Embodiment 2,100 grades with in going to the workshop, extracting honeysuckle extract (containing chlorogenic acid composition＞18%) 125g, baicalin (purity＞92%) 200g, the water for injection that adds 1000ml～5000ml under 30 ℃ condition, adds the mannitol of 200g～300g, regulating pH is 8.5, solution aseptic filtration, filtrate are sub-packed in 1000 5ml cillin bottles, lyophilization, roll lid, promptly get injection silver yellow injectable powder.
Claims (3)
1, a kind of injection silver yellow injectable powder is characterized in that by Flos Lonicerae extract, and baicalin and water for injection dissolubility pharmaceutic adjuvant are formed, the content of Flos Lonicerae extract is (weight proportion) 5%-30% in the injectable powder, baicalin is 10%-90%, is pharmaceutic adjuvant in addition, and total amount is 100%.
2, silver yellow injectable powder according to claim 1 is characterized in that pharmaceutic adjuvant is one or more of aminoacid, glucose, lactose, mannitol, polyvinylpyrrolidone, low molecular dextran, sodium chloride, calcium gluconate or calcium phosphate.
3, a kind of preparation method of injection silver yellow injectable powder as claimed in claim 1 or 2, it is characterized in that concrete steps are as follows: Flos Lonicerae extract, baicalin, pharmaceutic adjuvant and water for injection are made sterile solution under 20-30 ℃ of condition by the component part by weight, the control pH value is 5.5-8.5, spray-dried or lyophilization, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02155199 CN1424084A (en) | 2002-12-19 | 2002-12-19 | Honeysuckle flower and coptis root powder injection and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02155199 CN1424084A (en) | 2002-12-19 | 2002-12-19 | Honeysuckle flower and coptis root powder injection and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1424084A true CN1424084A (en) | 2003-06-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02155199 Pending CN1424084A (en) | 2002-12-19 | 2002-12-19 | Honeysuckle flower and coptis root powder injection and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1424084A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292779C (en) * | 2005-09-22 | 2007-01-03 | 太阳石（唐山）药业有限公司 | Chinese traditional medicine preparation for treating paediatric acute tonsillitis |
| CN100438888C (en) * | 2005-03-15 | 2008-12-03 | 天津市轩宏医药技术有限公司 | Freeze-dried preparation containing honeysuckle flower and astragalus root and its preparing method |
| CN106619592A (en) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | Medicine for treating acute pharyngitis |
-
2002
- 2002-12-19 CN CN 02155199 patent/CN1424084A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100438888C (en) * | 2005-03-15 | 2008-12-03 | 天津市轩宏医药技术有限公司 | Freeze-dried preparation containing honeysuckle flower and astragalus root and its preparing method |
| CN1292779C (en) * | 2005-09-22 | 2007-01-03 | 太阳石（唐山）药业有限公司 | Chinese traditional medicine preparation for treating paediatric acute tonsillitis |
| CN106619592A (en) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | Medicine for treating acute pharyngitis |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |