CN1371267A - Cosmetic composition - Google Patents

Abstract

According to the present invention there is provided a cosmetic composition comprising: (a) at least one quaternary ammonium agent; (b) emollient; and (c) polar solvent; wherein the composition comprises vesicles, said vesicles comprising quaternary ammonium agent and emollient. The compositions of the present invention give good skin care benefits, such as good skin feel, good skin softness and/or good skin smoothness, with low levels of negatives such as greasiness, stickiness or tack.

Description

Cosmetic composition

Technical field

The present invention relates to cosmetic composition.The cosmetic composition of skin sense, skin softness and/or the skin smoothness effect that can provide is provided particularly.

Background of invention

Skin is by the several layers cellularity, and these cells cover and protect the keratin and the collagen fiber albumen of the skeleton that constitutes skin texture.The outermost layer of these cellular layers is called horny layer, and the known 25nm albumen bundle that is centered on by the thick layer of 8nm constitutes.The general penetrable cutin tunic of anion surfactant and organic solvent, and destroy the integrity of skin through degreasing (promptly removing the lipid material in the horny layer).Thisly will bring harsh feeling, thereby finally can make surfactant and solvent and keratin interact, produce stimulation skin surface topology structural damage effect.

Recognizing at present along horny layer keeps the moisture gradient that suits extremely important to cuticular function from inside to outside.These moisture are considered to cuticular plasticizer (plasticizer) sometimes, its most ex vivos.If humidity is low excessively, under at cold climate, during the moisture deficit of outer layer of stratum corneum, can not carry out suitably plasticising to tissue, skin can be peeled and be produced scratchiness.If moisture deficit in the horny layer, percutaneous permeability also can reduce to a certain extent.On the other hand, the outside excess moisture of skin will make horny layer finally absorb the bound water of 3 to 5 times of its deadweights.This can make skin turgor and wrinkling, and makes skin that the permeability of water and other polar molecule is approximately increased 2-3 doubly.

Therefore, need a kind of compositions, this compositions can be ignored the deleterious interaction that skin may run in washing, work and amusement process, helps horny layer to keep the isolation and the water retaining function of its best.

Past has made such compositions, claims that they can help horny layer to keep its barrier and water retaining function.Such compositions is attempted by using one or more " skin protection beneficiating ingredient (skinbenefit agent) " to keep these functions.It is for example, a kind of that to bring the method for required benefit to skin be to introduce the emollient material in skin care compositions.But moisture is lost in these emollient material delaying skins, and has protective effect.But their important disadvantages is dermal sensation poor (being that they often make us feeling greasy) on skin, and has and be difficult to friction and be coated with into (rub-in), be difficult to absorb and residual characteristic.An example of emollient material is a polyol polyester oil.These materials are known to be can be used in the cosmetic composition.Referring to for example US-A-6,013,271, a kind of skin care compositions of O/w emulsion form that is is wherein disclosed, said composition comprises the amphiphilic emulsifying agent material of the oil phase, water and the organic liquid Cheng Jing that contain polyol carboxylate's liquid.And, US-A-5,916,575 also disclose a kind of non-emulsive personal cleaning compositions, wherein comprise bubble with surfactant, water and insoluble can be the skin condition component of solid polyalcohol carboxylate and insoluble skin condition oil.

Seem the consumption of skin protection beneficiating ingredient and provide to skin between the effect of compositions of beneficial effect to exist direct relation.But in fact the content of skin beneficiating ingredient is high more, and the danger that can produce associated unfavorable effect is also just high more.Therefore, up to the present, need balance to comprise the benefit and the detrimental effect relevant of the compositions of high-load skin beneficiating ingredient with this high-load.Therefore, the content of the skin beneficiating ingredient that need comprise is high and therefore provide height to moisten effect and hydration and outstanding dermal sensation, skin softness and skin smoothness benefits is provided, but shows relevant detrimental effect such as greasy, cohesiveness or the low compositions of sticky property.

The quaternary ammonium composition also is the principal component that can be used in the cosmetic composition.Referring to for example WO-A-99/27904, WO-A-96/32089 and EP-A-789,076.And US-A-5 discloses in 804,205 and it is said the skin care compositions that highly moistens effect and can not stay " adhesion " or " sticky " residue can be provided.Contain the nonirritating hydrophobic microsphere that 2 quaternary ammonium compound, wetting agent and mean diameters with alkyl of 16-22 carbon atom are lower than 50 μ m in these compositionss.It is said that hydrophobic polymerizing microballoons can obviously reduce and wetting agent content high relevant " cohesiveness ".US-A-5, the compositions in 804,205 can also comprise emollient such as the vaseline or the mineral oil of low consumption.

Now be surprised to find that comprise at least a quaternary ammonium composition, emollient and polar solvent and wherein compositions comprise that the compositions that comprises quaternary ammonium composition and emollient in vesicle (vesicles) and the described vesicle provides associated benefits such as dermal sensation, skin softness and the skin smoothness of high level, but show that detrimental effect such as greasy, cohesiveness or sticky property are little.

Although do not wish to be subjected to the restriction of any theory, believe that the quaternary ammonium composition among the present invention has formed vesicle, wherein include the emollient material.Form these vesicles for impelling, need polar solvent.The emollient that in vesicle, comprises, believe that remaining emollient is emulsive by the quaternary ammonium composition.In addition, also believe vesicle guaranteed emollient can be equably, be applied on the skin and cohesiveness/sticky property minimum smoothly.Even when compositions comprises the emollient of high percentage ratio, for example 20% o'clock, its common unfavorable effect was also very low.And, believe that the quaternary ammonium composition help to reduce the loss from the skin that emollient brings because of environmental factors such as water or friction.And, believe that the quaternary ammonium composition itself has brought skin care benefits such as good moist effect, good dermal sensation, good skin softness.

Summary of the invention

The invention provides a kind of cosmetic composition, comprising:

(a) at least a quaternary ammonium composition;

(b) emollient; With

(c) polar solvent;

Wherein compositions comprises vesicle, comprises quaternary ammonium composition and emollient in the described vesicle.

Compositions of the present invention provides good skin care benefits such as good moist effect (moisturisation), good skin hydration effect, good dermal sensation, good skin softness and/or good skin flatness, and detrimental effect such as greasy feeling, sticky sense or cohesiveness are low simultaneously.

Detailed Description Of The Invention

Compositions of the present invention comprises at least a quaternary ammonium composition, emollient and polar solvent, wherein comprises vesicle in the said composition, comprises quaternary ammonium composition and emollient in the described vesicle.These compositions will describe in detail hereinafter.

Compositions of the present invention can be used in the purpose of any appropriate.Especially, compositions of the present invention is suitable for being applied topically on the skin.Particularly, these skin care compositions and methods can be the forms of cream frost, emulsion (lotion), gel etc.Preferred cosmetic composition of the present invention is the form at the oil-in-water emulsion of one or more oil phases of continuous aqueous phase, each oil phase contains single oily components or is the mixture of the oily components of miscible or homogenizing form, but described different oil phase contains material or each mixtures of material that differs from one another.

Preferably, compositions of the present invention contains and is less than 10%, preferably is less than 5%, more preferably less than 3%, and the anion surfactant of 0% (weight) more preferably also.

Compositions of the present invention preferably is mixed with viscosity and is at least about 1, and 000mPa.s preferably is about 1,000 to about 300,000mPa.s, be more preferably 2,500 to about 250,000mPa.s, particularly be about 5,000 to about 200, (26.8 ℃ of 000mPa.s, net phase, Brookfield DV-II+ spindle CP52/CP41) product.The quaternary ammonium composition

The present composition must contain at least a quaternary ammonium composition (quaternary ammoniumagent).Be applicable to that the various quaternary ammonium compositions in the cosmetic composition all can be used in the compositions of the present invention.Term used herein " quaternary ammonium composition " is meant the chemical compound with quaternary nitrogen atoms or the mixture of chemical compound, and wherein quaternary nitrogen atoms is replaced by one or more, preferred two parts that contain 6 or 6 above carbon atoms.Be preferred for quaternary ammonium composition of the present invention and be selected from those quaternary ammonium compositions that have by the quaternary nitrogen that two wherein every parts contain more than 10 or 10, the part of preferred 12 or 12 above carbon atoms replaces.

Preferably, contain at least 0.01% in the compositions of the present invention, more preferably at least 0.1%, also more preferably at least 1.5%, the further more preferably quaternary ammonium composition of at least 3% (weight).

Being preferred for quaternary ammonium composition of the present invention is selected from:

(a) quaternary ammonium compound shown in the general formula (I):

R wherein ₁And R ₂Be C independently ₁-C ₄Alkyl or C ₁-C ₄Hydroxyalkyl or hydrogen.R ₃And R ₄Be to have about 8 alkyl or alkenyls independently to about 22 carbon atoms.X ^-Be the become salt anionic compatible with other adjuvant composition with quaternary ammonium compound.

The preferred quaternary ammonium compound of this apoplexy due to endogenous wind is the wherein R with general formula (I) ₁And R ₂Be methyl or ethoxy, and R ₃And R ₄Be to comprise at least 11 carbon atoms, the straight or branched alkyl of preferred at least 15 carbon atoms or the season amine of alkenyl.

(b) general formula (II) or (III) shown in quaternary ammonium compound:

Each R wherein ₅The unit is independently from each other H, side chain or straight chain C ₁-C ₆Alkyl, side chain or straight chain C ₁-C ₆Hydroxyalkyl and their mixture, preferable methyl and ethoxy; Each R ₆The unit is straight or branched C independently of one another ₁₁-C ₂₂Alkyl, straight or branched C ₁₁-C ₂₂Alkenyl and their mixture; X ^-Be can be compatible with the adjuvant composition with the skin care active composition anion; M is 1-4, is preferably 2; N is 1-4, is preferably 2, and Q is selected from following carbonyl unit:

With

R wherein ₇Be H, C ₁-C ₄Alkyl, C ₁-C ₄Hydroxyalkyl, and their mixture.

In the example of above-mentioned quaternary ammonium compound, unit-QR ₆Containing generally is the fatty acyl group unit of being derived and being obtained by the triglyceride source.The triglyceride source is preferably derived from Adeps Bovis seu Bubali, partially hydrogenated Adeps Bovis seu Bubali, Adeps Sus domestica, partially hydrogenated Adeps Sus domestica, vegetable oil and/or partially hydrogenated vegetable oil, as low erucic acid rapeseed oil, safflower oil, Oleum Arachidis hypogaeae semen, rapeseed oil, sunflower oil, Semen Maydis oil, soybean oil, tall oil, Testa oryzae wet goods, and these oily mixture.

Counter ion counterionsl gegenions X in the above-claimed cpd ^-Can be various compatible aniones, the anion of strong acid preferably, for example chloride ion, bromide ion, methylsulfate, ethyl sulphate, sulfate radical, nitrate anion etc. are more preferably chloride ion and methylsulfate.Anion also can but preferably do not have double charge, X in this case ^-Represent group half.

Preferred quaternary ammonium compound is diester and/or diamides quaternary ammonium (DEQA) chemical compound among the present invention, and diester and diamides are shown in general formula (II), and wherein carbonyl Q is selected from:

With

Adeps Bovis seu Bubali, low erucic acid rapeseed oil and Petiolus Trachycarpi oil are convenient and the economic unitary source of fatty acyl group, are suitable in the present invention as R ₆The unit.

Counter ion counterionsl gegenions X ^-Can be chloride ion, bromide ion, methylsulfate, formate, sulfate radical, nitrate anion, and composition thereof.In fact anion X ^-Only the counter ion counterionsl gegenions as positively charged quaternary ammonium compound exist.Do not consider within the scope of the invention it is defined as any specific anion.

In the present invention, when regulation adopts diester, wherein will comprise monoesters and three esters by the common existence that brings in the preparation process.

(c) general formula (IV) or (V) shown in quaternary ammonium compound:

R wherein ₉Be no cyclic aliphatic C ₁₅-C ₂₁Alkyl, and R ₁₀Be C ₁-C ₆Alkyl or alkenyl (alkylene).

It is about 4 that the pKa value of these ammonium compoundss is no more than, and can produce positive charge on the spot when disperseing in aqueous solution, and condition is that the pH of final composition is no more than about 6.

(d) general formula (VI) or (VII) shown in quaternary ammonium compound:

R wherein ₉And R ₁₀As hereinbefore defined, R ₁₁Be selected from C ₁-C ₄Alkyl and hydroxyalkyl.

Counter ion counterionsl gegenions X ^-Can be chloride ion, bromide ion, methylsulfate, formate, sulfate radical, nitrate anion, and composition thereof.In fact anion X ^-Only the counter ion counterionsl gegenions as positively charged quaternary ammonium compound exist.Do not consider in the scope of the invention it is defined as any specific anion.

(e) general formula (VIII) or (IX) shown in quaternary ammonium compound:

Wherein n is 1-6, R ₉Be selected from no cyclic aliphatic C ₁₅-C ₂₁Alkyl, R ₁₂Be C ₁-C ₄Alkyl and hydroxyalkyl.

It is about 4 that the pKa value of these ammonium compoundss (VIII) is no more than, and can produce cationic charge on the spot when disperseing in aqueous solution, and condition is that the pH of final composition is no more than about 6.

Counter ion counterionsl gegenions X ^-(IX) can be chloride ion, bromide ion, methylsulfate, formate, sulfate radical, nitrate anion, and composition thereof.In fact anion X only exists as the counter ion counterionsl gegenions of positively charged quaternary ammonium compound.Do not plan in the scope of the invention it is defined as any specific anion.

(f) general formula (X), (XI), (XIII) or (XII) shown in quaternary ammonium compound:

R wherein ₅, R ₆, Q, n be identical with the definition (III) with above-mentioned general formula (II) with X-, R ₁₃Be selected from C ₁-C ₆Alkylidene, preferably ethylidene, and z are 0-4.

(g) mixture of above-mentioned quaternary ammonium compound.

Be preferred for quaternary ammonium composition among the present invention and be described in above-mentioned (b) part those.Particularly, preferably diester shown in above-mentioned general formula (II) and/or diamides quaternary ammonium (DEQA) chemical compound.The diester that is preferred among the present invention is the wherein R shown in the general formula (II) ₅, R ₆And X ^-As indicated above, and Q is as follows those:

The diamides that is preferred among the present invention is general formula (the wherein R shown in the ID ₅, R ₆And X ^-As indicated above, and Q is as follows those:

The preferred examples that is applicable to the quaternary ammonium compound of the present composition is: N; N-two (canola acyl group-oxygen-ethyl)-N; N-alkyl dimethyl ammonium chloride, N; N-two (canola acyl group-oxygen-ethyl)-N-methyl; N-(2-ethoxy) methylsulfuric acid ammonium, N; N-two (canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) ammonium chloride and their mixture.Be particularly preferred for the N of being of the present invention, N-two (canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) methylsulfuric acid ammonium.

Although preferred quaternary ammonium compound is derived from ＂ canola acyl group (canolyl) ＂ fatty acyl group; but the example of the quaternary ammonium compound that other is suitable for can be by following displaced fatty acyl group derived from wherein above-mentioned ＂ canola acyl group ＂: ＂ Adeps Bovis seu Bubali acyl group, cocoyl, palmityl (palmyl), lauroyl, oleoyl, Oleum Ricini acyl group, stearyl, palmityl (palmityl) ＂ substitute, and these are corresponding to the unitary triglyceride of these fatty acyl groups source of deriving.These alternative fatty acyl group sources can comprise saturated entirely, perhaps preferably to the undersaturated carbochain of small part.Emollient

Second kind of solvent in the present composition is emollient (emollient).Slickness and flexibility that emollient is used for lubricated skin, promotes skin, prevention or alleviate xerosis cutis, and/or protection skin.Knownly there are various suitable emollient, and all can be with in the present invention.The Cosmetics that Sagarin showed has comprised numerous examples that are suitable for use as the material of emollient among the Science and Technology (the 2nd edition, the 1st volume, 32-43 page or leaf (1972)).Preferably, compositions of the present invention comprises greater than 1%, more preferably is at least 5%, also more preferably is at least 10%, further preferably is at least the emollient of 20% (weight).

The emollient that is preferred among the present invention is selected from:

I) have and contain 7 straight or branched hydrocarbon approximately, as dodecane, squalane, vaseline, cholesterol and their derivant, Parleam, 2-Methylpentadecane and C to about 40 carbon atoms ₇-C ₄₀Isoparaffin (is C ₇-C ₄₀Branched-chain hydrocarbons).

Ii) C ₁-C ₃₀Carboxylic acid and C ₂-C ₃₀The C of dicarboxylic acids ₁-C ₃₀Alcohol ester, for example isononyl isononanoate, isopropyl myristate, propanoic acid myristin, isopropyl stearate, behenic acid docosane alcohol ester, maleic acid dioctyl ester, diisopropyl adipate and dilinoleic acid diisopropyl ester.

Iii) C ₁-C ₃₀The monoglyceride of carboxylic acid, two glyceride and triglyceride and ethoxylated derivative thereof.The polyethyleneglycol derivative of the glyceride that is suitable for comprises: PEG-20 Semen Armeniacae Amarum glyceride, PEG-60 Semen Armeniacae Amarum glyceride, PEG-11 American Avocado Tree glyceride, PEG-6 suffering/caprin, PEG-8 suffering/caprin, PEG-20 corn glyceride, PEG-60 corn glyceride, PEG-60 Radix Oenotherae erythrosepalae oil glyceride, PEG-7 glyceryl cocos nucifera oil ester, PEG-30 glyceryl cocos nucifera oil ester, PEG-40 glyceryl cocos nucifera oil ester, PEG-78 glyceryl cocos nucifera oil ester oil ester, PEG-80 glyceryl cocos nucifera oil ester, PEG-12 glyceryl dioleate, PEG-15 glyceryl isostearate, PEG-20 glyceryl isostearate, PEG-30 glyceryl isostearate, PEG-75 cocoa butter glyceride, PEG-20 hydrogenated palm oil glyceride, PEG-70 Fructus Mangifera Indicae glyceride, PEG-13 ermine YOUGAN grease, PEG-75 sal tree YOUGAN grease, PEG10 olive oil glyceride, PEG-12 palm-kernel oil glyceride, PEG-45 palm-kernel oil glyceride, PEG-8 glyceryl laurate and PEG-30 glyceryl laurate.The mixture of the polyethyleneglycol derivative of glyceride also can be used for the present invention.

Iv) C ₁-C ₃₀The alkylidene diol ester of carboxylic acid, for example C ₁-C ₃₀The ethylene glycol ester of carboxylic acid and diester, and propylene glycol monoester and diester, for example diglycol stearate.

V) organopolysiloxane oil.Organopolysiloxane oil can be mixture volatile, nonvolatile or volatility and non-volatile polysiloxanes.Term used herein " nonvolatile " is meant and is liquid under environmental condition, and flash-point (under 1 atmospheric pressure) is more than or equal to those about 100 ℃ polysiloxanes.Term used herein " volatile " is meant all other polysiloxane oil.The organopolysiloxane oil that is suitable for can be selected from the various polysiloxanes of volatility and viscosity leap relative broad range.Preferred non-volatile polysiloxanes.The polysiloxanes that is suitable for is disclosed in United States Patent (USP) 5,069,897 (December was authorized on the 3rd in 1991).Be preferred for organopolysiloxane of the present invention and be selected from polydimethylsiloxane that poly-alkylsiloxane, alkyl replace, dimethiconol, poly-alkaryl siloxanes and composition thereof.More preferably being used for of the present invention is poly-alkylsiloxane and ring-type polymethyl siloxane (cyclomethicone).Polydimethylsiloxane preferably in the poly-alkylsiloxane.

Vi) vegetable oil and hydrogenated vegetable oil.The example of vegetable oil and hydrogenated vegetable oil comprises: the partial hydrogenation of the oil in safflower oil, Oleum Ricini, Oleum Cocois, Oleum Gossypii semen, pilchardine, palm-kernel oil, Petiolus Trachycarpi oil, Oleum Arachidis hypogaeae semen, soybean oil, rapeseed oil, Semen Lini oil, Testa oryzae oil, Oleum Pini, Oleum sesami, sunflower oil, above-mentioned source and perhydrogenate form, and their mixture.

Vii) animal oil, for example cod liver oil, lanoline and derivant thereof are as acetylated lanolin and lanolin fatty acid isopropyl ester.Preferred lanolin oil.

The viii) operable C that also has polypropylene glycol ₄-C ₂₀The C of alkyl ether, polypropylene glycol ₁-C ₂₀Carboxylate and two-C ₈-C ₃₀Alkyl ether, example comprise PPG-14 butyl ether, PPG-15 stearyl ether, dicaprylyl ether, dodecyl Octyl Ether and composition thereof.

Ix) polyol carboxylic acid ester.

X) mixture of mentioned component.

The emollient that is preferred in the present composition is selected from: dodecane, squalane, cholesterol and derivant thereof, 2-Methylpentadecane, isononyl isononanoate, vaseline, lanoline and derivant thereof, safflower oil, Oleum Ricini, Oleum Cocois, Oleum Gossypii semen, palm-kernel oil, Petiolus Trachycarpi oil, Oleum Arachidis hypogaeae semen, soybean oil, polyol carboxylic acid ester and their mixture.More preferably be used for emollient of the present invention and be selected from polyol carboxylic acid ester, vaseline and their mixture.

These esters are derived from sugar or polyol moiety and one or more carboxylic moiety.Depend on the sour and sugared of formation, these esters can be the liquid or solid form at ambient temperature.The example of liquid ester comprises: four oleic acid glucose esters, glucose four esters of soya fatty acid (unsaturated), mannose four esters of mixed soya fatty acid, oleic galactose four esters, linoleic arabinose four esters, xylose four linoleates, five oleic acid gala sugar esters, four oleic acid sorbitol esters, unsaturated soya fatty acid sorbitol six esters, the five oleic acid esters of xylitol, four oleic acid sucrose ester, five oleic acid sucrose ester, six oleic acid sucrose ester, seven oleic acid sucrose ester, eight oleic acid sucrose ester and composition thereof.The example of solid ester comprises: sorbitol six esters, carboxylate moiety wherein are that mol ratio is 1: 2 palm acid ester and an Arachidate; Raffinose octaester, carboxylate moiety wherein are that mol ratio is 1: 3 linoleate and a docosane acid esters; Maltose seven esters, wherein esterification carboxylic moiety are that mol ratio is 3: 4 sunflower oil fatty acid and a lignocerane acid esters; The octaester of sucrose, wherein esterification carboxylic moiety are that mol ratio is 2: 6 oleate and a docosane acid esters; And the octaester of sucrose, wherein esterification carboxylic moiety is that mol ratio is 1: 3: 4 laurate, linoleate and a docosane acid esters.Preferred solid material is an Olestra, and wherein esterification degree is 7-8, and fatty acid part wherein is C ₁₈Single-and/or two-unsaturated acids and behenic acid, wherein the mol ratio of unsaturated acids and behenic acid is 1: 7-3: 5.Particularly preferred sugar cube polyester is the octaester of sucrose, wherein contains 7 22 carbon fatty acid parts and about 1 oleic acid part in the molecule approximately.Other material comprises Oleum Gossypii semen or soya fatty acid sucrose ester.These Esters also are disclosed in United States Patent (USP) 2,831,854; United States Patent (USP) 4,005,196 (Jandacek, on January 25th, 1977 authorized); United States Patent (USP) 4,005,195 (Jandacek, on January 25th, 1977 authorized), United States Patent (USP) 5,306,516 people such as (, on April 26th, 1994 authorized) Letton; United States Patent (USP) 5,306,515 (people such as Letton, on April 26th, 1994 authorized); United States Patent (USP) 5,305,514 (people such as Letton, on April 26th, 1994 authorized); United States Patent (USP) 4,797,300 (people such as Jandacek, on January 10th, 1989 authorized); United States Patent (USP) 3,963,699 (people such as Rizzi, on June 15th, 1976 authorized); United States Patent (USP) 4,518,772 (Volpenhein, on May 21st, 1985 authorized); And United States Patent (USP) 4,517,360 (Volpenhein, on May 21st, 1985 authorized).

Be applicable to that the polynary ester of polyol fatty acid of the present invention can be prepared by the whole bag of tricks known in the art.These methods comprise that the various catalyst of employing carry out ester exchange by polyhydric alcohol and methyl, ethyl or glycerin fatty acid ester; Adopt fat acyl chloride that polyhydric alcohol is carried out acylation; Adopt fatty acid anhydride that polyhydric alcohol is carried out acylation; And known employing fatty acid carries out acylation to polyhydric alcohol.Can be referring to for example United States Patent (USP) 2,831,854; United States Patent (USP) 4,005, the content described in 196 (Jandacek, on January 25th, 1977 authorized).

Particularly preferred material is the material of the poly-oleic acid sucrose ester of INCI called after.Polar solvent

Also must comprise polar solvent in the compositions of the present invention.Any polar solvent that is suitable for being used in the cosmetic composition all can be with in the present invention.But this polar solvent should have enough polarity, to impel the vesicle that forms among the present invention.The polar solvent that is preferred in the present composition is a water.

Preferably contain 10% to 90% in the compositions of the present invention, more preferably 20% to 80%, the polar solvent of 30% to 60% (weight) more preferably also.Vesicle

Combination species of the present invention must comprise vesicle (vesicle), and described vesicle comprises quaternary ammonium composition and emollient.Plant used term " vesicle " in the present invention and be meant one or more bilayers of being arranged to seal, be generally spherical geometries, described bilayer comprises quaternary ammonium composition mentioned above.In compositions of the present invention, vesicle is preferred to be spherical substantially.The vesicle that exists in the present composition can detect by microscopic analysis (polarized light microscopy that adopts Nikon Eclipse E800 microscope to amplify 60 times detects).

The number average size of vesicle is 0.01 μ m-30 μ m among preferred the present invention, more preferably 0.02 μ m-15 μ m.Optional member

Can contain various optional components in the present composition, these optional members are suitable for making the present composition to have more pleasant beauty treatment or beautify characteristic, and additional result of use perhaps is provided.This optional member commonly used is that those of ordinary skills are known.Comprising various used for cosmetic compositions, as at " international cosmetics dictionary of CTFA and handbook (CTFA International Cosmetic IngredientDictionary and Handbook, the 7th edition, Wenninger and McEwen compile, (cosmetics, toilet articles and fragrance association company, Washington, D.C., 1997)) in can find those.Some non-limiting examples in these optional members have below been listed.Wetting agent

The particularly preferred optional member that is used in the present composition is a wetting agent.The term " wetting agent " that the present invention uses is meant the material that can bring the water conservation benefit to skin.Comprise at least 1% (weight) in the preferred present composition, more preferably at least 5% (weight), more preferably at least 10% (weight) also, the further preferred wetting agent of at least 20% (weight).

Any wetting agent of cosmetic composition that is applicable to all can be used for the present invention.The non-limiting example that can be used for wetting agent of the present invention is disclosed among WO98/22085, WO98/18444 and the WO97/01326.Be preferred for wetting agent of the present invention and be selected from, but be not limited to: aminoacid and derivant thereof, as proline and arginine aspartate; 1,3 butylene glycol, propylene glycol and water; and Korean pine platymiscium (codiumtomentosum) extract, collagen amino acid or peptide, creatinine; diglycerol, biological polyoses glue-1 (biosaccharide gum-1), glucosamine salt; glucuronate; glutamate, Glu, the polyglycol ether of glycerol (for example glycerin polyoxyethylene ether 20), glycerol; glycerol list propoxylate; glycogen, hexanediol, Mel and extract thereof or derivant; hydrogenated starch hydrolysates; the hydrolysis mucopolysaccharide, inositol, keratin aminoacid; urea; LAREX A-200 (available from Larex), glycosaminoglycans, methoxyl group PEG-10; methyl gluceth-10 and-20 (all can be available from Amerchol; be positioned at Edison, NJ), methyl glucoside; the 3-methyl isophthalic acid; the 3-butanediol, N-acetyl glucosamine salt, Polyethylene Glycol and derivant thereof are (as the PEG15 butanediol; PEG4; the PEG5 tetramethylolmethane, PEG6, PEG8; PEG9); tetramethylolmethane, 1, the 2-pentanediol; the PPG-1 glycerin ether; PPG-9,2-Pyrrolidone-5-carboxylic acid and salt thereof such as glyceryl pca, sugared isomerate; SEACARE (available from Secma); sericin, Silk Amino Acids, acetyl group hyaluronate sodium; hyaluronate sodium; poly (sodium aspartate), polyglutamic acid sodium, sorbitol polyoxyethylene ether (sorbeth) 20; sorbitol polyoxyethylene ether 6; sugar and sugar alcohol and derivant such as glucose; mannose and polyglycereol sorbitol, trehalose, triglycerin; trimethylolpropane; three (methylol) aminomethane salt, yeast extract, and their mixture.

More preferably, be used for wetting agent of the present invention and be selected from: glycerol, urea, butanediol, Polyethylene Glycol and derivant thereof, and their mixture.Also more preferably, being used for wetting agent of the present invention is selected from: glycerol, urea and their mixture, particularly glycerol.Other skin beneficiating ingredient

Can use other skin beneficiating ingredient in the compositions of the present invention.The example that can be used for other skin beneficiating ingredient of the present composition comprises:

(a) element-vitamine compound

Can contain element-vitamine compound, its precursor and derivant thereof in the present composition.These element-vitamine compounds can be native forms, also can be synthesized forms.The element-vitamine compound that is suitable for comprises: vitamin A (for example, beta-carotene, tretinoin, retinol, retinoid (retinoids), retinyl palmitate, propanoic acid retinol ester etc.), vitamin B (for example, nicotinic acid, nicotiamide, riboflavin, pantothenic acid etc.), vitamin C (for example, ascorbic acid etc.), vitamin D (for example, ergosterol, ergocalciferol, cholecalciferol etc.), vitamin E (for example, tocopherol acetate etc.) and vitamin K (for example, phytonadione, menadione, phthiocol etc.) chemical compound.The element-vitamine compound that is preferred in the present composition is a vitamin B ₃Chemical compound.Vitamin B ₃Chemical compound is specially adapted to regulate skin, and related content is disclosed among the WO-A-97/39733.If use element-vitamine compound, then preferably comprise about 0.01% (weight) in the present composition to about 50% (weight), be more preferably 0.1% (weight) to about 10% (weight), also be more preferably the vitamin B of 0.5% (weight) to about 5% (weight) ₃Chemical compound.

Be used for term ＂ vitamin B of the present invention ₃Chemical compound ＂ is meant the chemical compound with following formula:

Wherein R is-CONH ₂(being nicotiamide) ,-COOH (being nicotinic acid) or-CH ₂OH (being cigarette base alcohol (nicotinyl alcohol)); Its derivant; And the salt of above-claimed cpd.

Said vitamin B ₃The example of the derivant of chemical compound comprises: nicotinate comprises the non-distensibility of blood vessel ester of nicotinic acid; Cigarette base alcohol ester, nicotinic acid N-oxide and the nicotinoyl amine n-oxide of cigarette base aminoacid, carboxylic acid.

Suitable vitamins B ₃Examples for compounds is well known in the art, and can buy from a plurality of sources, for example the Sigma chemical company (St.Louis, MO); ICN Biomedicines, Inc. (Irvin, CA) and the Aldrich chemical company (Milwaukee, WI).

Element-vitamine compound can be substantially adds with the form of pure product, or adds to separate the form that obtains extract by natural origin (for example plant) through suitable physics and/or chemical method.

(b) crease-resistant and anti-atrophoderma active component

The example that can be used for crease-resistant and anti-atrophoderma (anti-skin atrophy) active component in the present composition comprises: lactic acid and derivant thereof; Tretinoin and derivant thereof (for example cis with trans); Retinol; Retinyl ester; Nicotiamide; Salicylic acid and derivant thereof; The D of sulfur-bearing and L-aminoacid and derivant and salt, particularly N-acetyl derivative, wherein preferred examples is N-acetyl group-L-cysteine; Thio-alcohol, for example, ethyl mercaptan; Hydroxy acid; Phytic acid; Thioctic acid; Lysophosphatidic acid, and decorticating agent (skin peel agent) (for example, phenols etc.), but be not limited only to these.

(c) antimicrobial and antifungal activity composition

Can be used for the antimicrobial of the present composition and the example of antifungal activity composition comprises: Beta-lactam medicine, quinolones, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4 '-three chloro-2 '-hydroxy diphenyl ether, 3,4,4 '-three chloro-carbanilides, phenyl phenol, phenoxypropanol, the phenoxy group isopropyl alcohol, doxycycline, capreomycin, chlohexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, esomedina, metronidazole, penta oxygen benzene carbon amidine, gentamycin, kanamycin, lincomycin (lineomycin), methacycline, hexamethylenamine, minocycline (minocycline), neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole, quadracycline, erythromycin, erythromycin zinc, erythromycin propionate lauryl sulfate, erythromycin stearate, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate Capastat sulfate, chlorhexidine gluconate, chlorhexidine dihydrochloride, chlortetracycline hydrochloride, tetramycin hydrochloride, clindamycin hydrochloride, ebutol, the hydrochloric acid metronidazole, hydrochloric acid penta oxygen benzene carbon amidine, gentamycin sulfate, kanamycin sulfate, lincomycin hydrochloride (lineomycin), methacycline hydrochloride, methenamine hippu, mandelamine, minocycline hydrochloride, polygynax, netilmicin sulfate, paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, the hydrochloric acid miconazole, amantadine hydrochloride (amanfadine hydrochloride), PK-Merz (Merz) (amanfadine sulfate), Octopirox, chlorxylone, nystatin, tolnaftate (tolnaftate), pyrithione zinc and clotrimazole.

(d) sunscreen actives composition

Can comprise the sunscreen actives composition in the compositions of the present invention.Various sunscreen actives compositions are all in the present invention available.These sunscreen include organic compounds and salt and inorganic particulate material.Although without wishing to be bound by theory, believe that sunscreen can prevent to be subjected to ultraviolet radiation by one or more following mechanism protection skins, comprising: absorption, scattering and reflect UV radiation.The non-limiting example of these sunscreen is disclosed in: United States Patent (USP) 5,087,445 (people such as Haffey, on February 11st, 1992 authorized); United States Patent (USP) 5,073,372 (people such as Turner, December was authorized on the 17th in 1991); United States Patent (USP) 5,073,371 (people such as Turner, December was authorized on the 17th in 1991); United States Patent (USP) 5,160,731 (people such as Sabatelli, on November 3rd, 1992 authorized); United States Patent (USP) 5,138,089 (Sabatelli, on August 11st, 1992 authorized); United States Patent (USP) 5,041,282 (Sabatelli, on August 20th, 1991 authorized); United States Patent (USP) 4,999,186 (people such as Sabatelli, on March 12nd, 1991 authorized); United States Patent (USP) 4,937,370 (Sabatelli, authorize June 26 nineteen ninety); And people such as Segarin is in the described content of " cosmetic science and technology " (Cosmetics Science and Technology, the VIII chapter is below 189 pages).Wherein, preferred sunscreen is selected from: p-methoxycinnamic acid 2-Octyl Nitrite; ethylhexyl salicylate; PARSOL 340; the hydroxyl methoxy benzophenone; N; N-dimethylaminobenzoic acid 2-Octyl Nitrite; para-amino benzoic acid; 2-phenyl-benzimidazole-5-sulfonic acid; salicylic acid ester in the high Meng; the p-methoxycinnamic acid diethanolamine; 4; 4 '-methoxyl group-tert-butyl group dibenzoyl methane; 4-isopropyl diphenyl formyl methane; 3-(4-methyl benzal) Camphora; the 3-benzylidene camphor; 4-N; N-dimethylaminobenzoic acid and 2; the ester of 4-dihydroxy benzophenone; 4-N; the ester of N-dimethylaminobenzoic acid and 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; 4-N; the ester of N-dimethylaminobenzoic acid and 4-hydroxy benzophenone acyl group methane; 4-N; the ester of N-dimethylaminobenzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; 4-N; N-two (2-ethylhexyl)-amino benzoic Acid and 2; the ester of 4-dihydroxy benzophenone; 4-N; the ester of N-two (2-ethylhexyl) amino benzoic Acid and 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; 4-N; the ester of N-two (2-ethylhexyl) amino benzoic Acid and 4-hydroxy benzophenone acyl group methane; 4-N; the ester of N-two (2-ethylhexyl) amino benzoic Acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; 4-N; N-(2-ethylhexyl) methylamino benzoic acid and 2; the ester of 4-dihydroxy benzophenone; 4-N; the ester of N-(2-ethylhexyl) methylamino benzoic acid and 2-hydroxyl-4-(2-hydroxyl-oxethyl) benzophenone; 4-N; the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-hydroxy benzophenone acyl group methane; 4-N, the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; titanium dioxide; zinc oxide; ferrum oxide and composition thereof.

The sunscreen that more preferably is used for the present composition is selected from: N; N-dimethyl-para-amino benzoic acid 2-Octyl Nitrite; p-methoxycinnamic acid 2-Octyl Nitrite; octocrylene; ethylhexyl salicylate; salicylic acid ester in the high Meng; para-amino benzoic acid; the hydroxyl methoxy benzophenone; 2-Phenylbenzimidazole-5-sulfonic acid; the p-methoxycinnamic acid diethanolamine; 4; 4 '-methoxyl group-tert-butyl group dibenzoyl methane; 4-isopropyl diphenyl formoxyl methane; 3-(4-methyl benzal) Camphora; the 3-benzylidene camphor; 4-N, the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; titanium dioxide; zinc oxide; ferrum oxide and composition thereof.

The definite consumption of the sunscreen that can use depends on selected sunscreen and the sun protection factor that will reach, and (Sun Protection Factor SPF) is worth and different.SPF often is used to weigh the photoprotection that sunscreen prevents to produce skin erythema.Referring to Federal Register, 43 volumes, No. 166,38206-38269 page or leaf, on August 25th, 1978.Thickening agent

The present composition preferably contains thickening agent.Any thickening agent of cosmetic composition that is applicable to all can be used for the present invention.Preferred thickening is selected from non-ionic water-soluble polymer, aliphatic alcohol and composition thereof.The non-ionic polymers that is suitable for comprises such water-soluble polymer, as cellulose ether (for example hydroxy butyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, ethylhydroxyethylcellulose, hydrophobically modified hydroxyethyl-cellulose and hydroxyethyl-cellulose), poly-(oxygen ethylene), polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, amylose (amulose), ethoxy amylose (amylose), starch and starch derivatives.The aliphatic alcohol that is suitable for is high-molecular weight, the nonvolatile primary alconol with following general formula:

RCH ₂OH

Wherein R is C _8-20Alkyl.They can be made by natural oil or fat, by with fatty acid-the COOH carboxyl reduction becomes the hydroxyl-functional base to obtain.The aliphatic alcohol that perhaps, can prepare identical or similar structures by conventional method known in the art.Suitable aliphatic alcohol comprises: tadenan, C ₉-C ₁₁Alcohol, C ₁₂-C ₁₃Alcohol, C ₁₂-C ₁₅Alcohol, C ₁₂-C ₁₆Alcohol, C ₁₄-C ₁₅Alcohol, capryl alcohol, spermaceti/stearyl alcohol, cocoanut oil alcohol, decanol, different spermol, isooctadecanol, lauryl alcohol, oleyl alcohol, palm kernel alcohol, stearyl alcohol, spermol, tallow alcohol, tridecyl alcohol or myristyl alcohol, but be not to be only limited to these.Other optional member

Can contain various other optional components in the present composition.These annexing ingredients should be pharmaceutically useful.By functional classification, be applicable to that the non-limiting example of the composition in the present composition comprises: grinding agent, absorbent, anti-acne active ingredient, anticaking agent, dandruff removing agent, antiperspirant, antioxidant, the antiviral activity composition, artificial suntan and promoter, bio-additive, bleach, bleach-activating, brightening agent, synergist, buffer agent, chelating agen, chemical addition agent, coloring agent, the beauty treatment composition, cleaning agent, the used for cosmetic astringent, the used for cosmetic antibacterial, modifier, deodorizer, the decortication active component, depilatory, medicinal astringent, dyestuff, transfection agents, enzyme, the external application analgesic agent, foaming agent, correctives, film former, perfume composition, anthelmintic, antifungus agent, on-steroidal anti-inflammatory activity composition, opacifier, oxidation dye, oxidant, the deinsectization composition, pH regulator agent such as citric acid, the pH buffer agent, active constituents of medicine, plasticizer, antiseptic, free radical scavenger, skin or hair or fingernail bleach, skin or hair or fingernail conditioner, skin or hair or fingernail penetration enhancer, stabilizing agent, surfactant, surface amendment, Reducing agent, the temperature inhibitor, viscosity modifier and heating agent are as the heating zeolite.What be applicable to this beautifies component (aesthetic component) as coloring agent, essential oil, skin healing agent.Other optional material that is applicable to this comprises: pigment.The pigment that is applicable to the present composition can be organic and/or inorganic constituents.In term pigment scope, also have less colored or the low gloss material, as the delustring finishing agent, and light scattering agent.The example of the pigment that is suitable for has ferrum oxide, acyl glutamic acid ferrum oxide, titanium dioxide, ultramarine, D﹠amp; C dyestuff, alkermes and their mixture.Compound method

Compositions of the present invention prepares in the mode that quaternary ammonium compound can form vesicle.Also contain emollient in the described vesicle.Preferably, also comprise wetting agent in the described vesicle.For guaranteeing the optimum performance feature, preferred compositions of the present invention is prepared as follows:

(i) under the temperature that is higher than the quaternary ammonium congruent melting point with all or part of quaternary ammonium composition and wetting agent, water solublity skin care activity composition (if comprising), preferably also have polar solvent mixed mutually;

(ii) randomly, this mixture of vigorous stirring;

(iii) in another independent container, prepare Emulsion as follows: be higher than under the temperature of quaternary ammonium compound fusing point and mix with containing the oil phase of emollient, relevant thickening agent (is under the oil-soluble situation at described thickening agent) and remaining quaternary ammonium composition.Prepare water separately.Water, relevant thickening agent (is under the water miscible situation at described thickening agent) are heated to the temperature identical with oil phase with other water soluble ingredient.

(iv) the temperature of the oil phase of balance Emulsion and water roughly merges water and oil phase under stirring condition then.

(v) when preparation Emulsion, the mixture of making in the step (i) is under agitation added in the above-mentioned Emulsion.

Using method

Cosmetic composition of the present invention can conventional mode use, and is used for nursing skin.With the compositions of effective dose, be generally extremely about 50 grams of about 0.1 gram, preferred about 1 gram to about 20 compositionss that restrain are applied to wet or do, on the preferred wet skin.The application of compositions generally includes compositions rubbed on skin and smears, and normally carries out with hands and finger.Then compositions is stayed on the skin, perhaps, preferably rinsed from skin.

Therefore, the preferable methods of nursing skin comprises the following steps:

(a) cosmetic composition with effective dose is applied on the skin,

(b) rinsing skin.

Preferred aspect of the present invention relates to said method, be included in be applied to compositions on the wet hair before, compositions is applied on the dry skin.Therefore, preferable methods comprises

(i) cosmetic composition with effective dose is applied on the dry skin;

(ii) at the following rinsing skin of shower (shower);

(iii) use described compositions once more; And

(iv) rinsing once more.

Most damages to human body skin be by skin in cleaning process repeat repeatedly to be exposed to the compositions that contains surfactant in and produce.Have now found that and to alleviate this damage by method of the present invention.Therefore another method for optimizing comprises:

(i) adopt the compositions that contains surfactant to clean skin;

(ii) rinsing skin;

(iii) compositions of the present invention is used for moist skin;

(iv) rinsing skin.

Now also find compositions of the present invention when introducing, particularly suitable as the part in the conventional cleaning procedure.Therefore another method for optimizing comprises:

(i) application comprises following compositions on skin:

(a) at least a quaternary ammonium compound;

(b) wetting agent; With

(ii) rinsing skin;

(iii) repeating step (i) and (ii) in 48 hours.

Compositions of the present invention can also be used for alleviating because of skin be exposed to damage that ultraviolet radiation causes, in swimming or similarly contact the damage that causes in the water exercise with water or contact the skin injury that causes during in bathing with water.

Embodiment

Following examples are used to further specify the embodiment preferred in the scope of the invention.Listed embodiment only is used for illustrative purposes, is not to be used for limiting the present invention, and under the situation that does not deviate from the spirit or scope of the present invention, there is multiple variation pattern in the present invention.Unless otherwise indicated, all the components is all with the weight percent meter of active component.

Embodiment	??1	??2	??3	??4	??5	??6	??7	??8	??9	??10	??11	??12	??13
																% (weight)
Quaternary ammonium composition (seeing note)	??3	??3	??3	??3	??3	??3	??3	??3	??3	??3	???3	???3	??3	??A
															Glycerol	??32	??32	??32	??32	??32	??32	??32	??-	??-	??-	???-	???-	??-	??A
Urea	??-	??-	??-	??-	??-	??-	??-	??22	??22	??22	???22	???22	??22	??A
															Vaseline	??-	??-	??10	??-	??12	??15	??-	??-	??-	??10	???-	???12	??15	??B
Lanoline 1	??-	??-	??-	??7.5	??5	??-	??15	??-	??-	??-	???10	???10	??-	??B
															The Coronet lanoline 1	??-	??-	??-	??-	??-	??-	??5	??-	??-	??-	???-	???-	??-	??B
Super sterol ester 1	??-	??-	??-	??-	??-	??-	??5	??-	??-	??-	???-	???-	??-	??B
															Sefa cotton oil acid esters	??21	??21	??12	??12	??-	??-	??-	??21	??21	??12	???12	???-	??-	??B
Polydimethylsiloxane 10 centistokes	??-	??0.5	??0.5	??0.5	??-	??0.5	??0.5	??0.5	??-	??-	???-	??0.5	??0.5	??B
															Polydimethylsiloxane 1000 centistokes	??-	??1.0	??1.0	??1.0	??-	??1.0	??1.0	??1.0	??-	??-	???-	??1.0	??1.0	??B
The ring-type polymethyl siloxane	??-	??2.5	??2.5	??2.5	??-	??2.5	??2.5	??2.5	??-	??-	???-	??2.5	??2.5	??B
															Florasun?PEG-10 2	??-	??2	??-	??2	??-	??3	??-	??1	??-	??-	???3	???-	??-	??B
Methyl parahydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	???0.5	??0.5	??0.5	??A
															Propyl p-hydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	???0.5	??0.5	??0.5	??B
The EDTA disodium	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	???0.1	??0.1	??0.1	??A

Sodium benzoate	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	?0.3	??0.3	??0.3	??0.3	??0.3	??B
															Nicotiamide	????5	????5	????3		????5	????5	????5	????3	???5			????5	????5	??A
Pantothenylol	????3	????3	????1		????3	????3	????3	????1	???3			????3	????3	??A
															Tocopherol acetate	????2	????2	??0.5		????2	????2	????2	??0.5	???2			????2	????2	??B
Retinyl palmitate	??0.1	????-	????-	????-	????-	????-	?0.05	????-	???-	??0.1	????-	????-	????-	??B
															Parsol?1789 3	????-	????1	????-	????1	??0.5	????-	??0.1	????-	???1	????-	????1	????-	????1	??B
Parsol?MCX 3	????-	????5	????-	????5	??2.5	????-	??0.5	????-	???5	????-	????5	????-	????5	??B
															Citric acid	????1	??0.5	????1	??0.5	??0.5	????1	??0.5	????1	?0.3	?0.75	????1	????1	????1	??A
Salicylic acid	????-	??0.5	????-	??0.5	??0.5	????-	??0.5	????-	?0.7	????-	????-	????-	????-	??A
															Triethanolamine	??0.1	????-	????-	??0.1	??0.1	????-	????-	????-	?0.1	????-	????-	??0.9	??0.5	??C
Sodium hydroxide	????-	????-	??0.1	??0.1	??0.1	????-	????-	??0.1	???-	??0.1	????-	????-	????-	??C
															Polyquaternary ammonium salt-10	????-		????-	??1.0		????-	??0.5	???-	?0.6	????-	????-	????-	??0.5	??B
Polymer KG 30 4	????-	??0.7	????-		??0.7	????-		???-	???-	??0.8	????-	????-	????-	??B
															Spice	??0.5	??0.5	??0.5	??0.5	??0.5	????-	??0.5	??0.5	?0.5	??0.5	??0.5	??0.5	??0.5	??E
Spermol	????3	????-	????-	??-	??2.6	????-	????-	??2.2	???-	??2.2	????-	??2.5	????-	??C
															Stearyl alcohol	????2	????-	????-	??-	??1.5	????-	????-	??3.2	???-	??1.1	????-	??1.6	????-	??C
Spermaceti/stearyl alcohol	????-	????-	????4	??-	??0.4	????-	????-	????-	?3.4	????-	????-	????-	??3.4	??C
															Tadenan	????2	????-	????2	??-	????-	????-	????-	??0.6	???-	??0.7	????-	????-	????-	??C
Natrosol?330?Plus	????1	????-	????-	??-	??0.4	????-	????-	??0.7	?0.6		????-	??0.5	?0.25	??C
															Natrosol?250?HHR	????-	????-	????1	??-	??0.3	????-	????-	????-	???-	??1.2	????-	????-	??0.3	??C
Jaguar?HP?105 5	????-	??1.2	????-	??-	????-	????-	????-	????-	???-	????-	??0.8	????-	????-	??D
															Jaguar?C14S 5	????-	????-	????-	??1	????-	????-	????-	????-	???-	????-	????-	????-	????-	??D
Jaguar?C13S 5	????-	????-	????-	??-	????-	??1.2	????-	????-	???-	????-	????-	????-	????-	??D
															Xanthan gum	????-	????-	????-	??-	????-	????-	??2.0	????-	???-	????-	????-	????-	????-	??D
Sodium chloride	????-	????-	??0.1	??-	????-	????-	??0.5	??0.2	???-	??0.3	????-	????-	????-	??A
															Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

Embodiment	??14	??15	??16	??17	??18	??19	??20	??21	??22	??23	??24	??25	??26
																% (weight)
Quaternary ammonium composition (seeing note)	???8	???8	????8	???8	???8	???8	???8	???8	???8	???8	???8	???8	???8	??A
															Glycerol	??32	??32	??32	??32	??32	??32	??32	???-	???-	???-	???-	???-	???-	??A
Urea	???-	???-	??-	???-	???-	???-	???-	??22	??22	??22	??22	??22	??22	??A
															Vaseline	???-	???-	??10	???-	??12	??15	???-	???-	???-	??10	???-	??12	??15	??B
Lanoline 1	???-	???-	??-	??7.5	???5	???-	??15	???-	???-	???-	??10	??10	???-	??B
															The Coronet lanoline 1	???-	???-	??-	???-	???-	???-	???5	???-	???-	???-	???-	???-	???-	??B
Super sterol ester 1	???-	???-	??-	???-	???-	???-	???5	???-	???-	???-	???-	???-	???-	??B
															Sefa cotton oil acid esters	??21	??21	??12	??12	???-	???-	???-	??21	??21	??12	??12	???-	???-	??B
Polydimethylsiloxane 10 centistokes	???-	??0.5	??0.5	??0.5	???-	??0.5	??0.5	??0.5	???-	???-	???-	??0.5	??0.5	??B
															Polydimethylsiloxane 1000 centistokes	???-	??1.0	??1.0	??1.0	???-	??1.0	??1.0	??1.0	???-	???-	???-	??1.0	??1.0	??B
The ring-type polymethyl siloxane	???-	??2.5	??2.5	??2.5	???-	??2.5	??2.5	??2.5	???-	???-	???-	??2.5	??2.5	??B
															Florasun?PEG-10 2	???-	???2	??-	???2	???-	???3	???-	???1	???-	???-	???3	???-	???-	??B
Methyl parahydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??A
															Propyl p-hydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??B
The EDTA disodium	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??A
															Sodium benzoate	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??B
Nicotiamide	???5	???5	????3		???5	???5	???5	???3	???5			???5	???5	??A
															Pantothenylol	???3	???3	????1		???3	???3	???3	???1	???3			???3	???3	??A
Tocopherol acetate	???2	???2	??0.5		???2	???2	???2	??0.5	???2			???2	???2	??B
															Retinyl palmitate	??0.1	???-	???-	???-	???-	???-	?0.05	???-	???-	???-	???-	???-	??0.15	??B
Parsol?1789 3	???-	???1	???-	???1	??0.5	???-	??0.1	???-	???1	???-	???1	???-	???1	??B
															Parsol?MCX 3	???-	???5	???-	???5	??2.5	???-	??0.5	???-	???5	???-	???5	???-	???5	??B
Citric acid	???1	??0.5	??1	??0.5	??0.5	???1	??0.5	???1	??0.3	?0.75	???1	???1	???1	??A
															Salicylic acid	???-	??0.5	???-	??0.5	??0.5	???-	??0.5	???-	??0.7	???-	???-	???-	???-	??A
Triethanolamine	??0.1	???-	???-	??0.1	??0.1	???-	???-	???-	??0.1	???-	???-	??0.9	??0.5	??C
															Sodium hydroxide	???-	???-	??0.1	??0.1	??0.1	???-	???-	??0.1	???-	??0.1	???-	???-	???-	??C
Polyquaternary ammonium salt-10	???-		???-	??1.0		???-	??0.5	???-	??0.6	???-	???-	???-	??0.5	??B
															Polymer KG 30 4	???-	??0.7	???-		??0.7	???-		???-	???-	??0.8	???-	???-	???-	??B

Spice	??0.5	??0.5	??0.5	???0.5	??0.5	???-	???0.5	???0.5	???0.5	??0.5	???0.5	???0.5	???0.5	??E
															Spermol	??3	??-	??-	???-	??2.6	???-	???-	???2.2	???-	??2.2	???-	???2.5	???-	??C
Stearyl alcohol	??2	??-	??-	???-	??1.5	???-	???-	???3.2	???-	??1.1	???-	???1.6	???-	??C
															Spermaceti/stearyl alcohol	??-	??-	??4	???-	??0.4	???-	???-	???-	???3.4	??-	???-	???-	???3.4	??C
Tadenan	??2	??-	??2	???-	??-	???-	???-	???0.6	???-	??0.7	???-	???-	???-	??C
															Natrosol?330?Plus	??1	??-	??-	???-	??0.4	???-	???-	???0.7	???0.6	??-	???-	???0.5	???0.25	??C
Natrosol?250?HHR	??-	??-	??1	???-	??0.3	???-	???-	???-	???-	??1.2	???-	???-	???0.3	??C
															Jaguar?HP?105 5	??-	??1.2	??-	???-	??-	???-	???-	???-	???-	??-	???0.8	???-	???-	??D
Jaguar?C14S 5	??-	??-	??-	???1	??-	???-	???-	???-	???-	??-	???-	???-	???-	??D
															Jaguar?C13S 5	??-	??-	??-	???-	??-	???1.2	???-	???-	???-	??-	???-	???-	???-	??D
Xanthan gum	??-	??-	??-	???-	??-	???-	???2.0	???-	???-	??-	???-	???-	???-	??D
															Sodium chloride	??-	??-	??0.1	???-	??-	???-	???0.5	???0.2	???-	??0.3	???-	???-	???-	??A
Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

Embodiment	??27	??28	???29	???30	??31	???32	???33	???34	??35	??36	???37	??38	??39	??40	??41
																		% (weight)
Quaternary ammonium composition (seeing note)	??3	??3	???3	???3	??3	???3	???3	???3	??3	??3	???3	??3	??3	??3	??3	??A
																	Glycerol	??15	??16	???22	???9	??8	???9	???-	???32	??32	??32	???32	??32	??32	??32	??32	??A
Propylene glycol	??-	??16	???-	???-	??-	???5	???12	???-	??-	??-	???-	??-	??-	??-	??-	??A
																	Butanediol	??-	??-	???8	???8	??-	???8	???12	???-	??-	??-	???-	??-	??-	??-	??-	??A
Urea	??-	??-	???-	???12	??-	???2	???9	???-	??-	??-	???-	??-	??-	??-	??-	??B
																	Vaseline	??-	??-	???10	???-	??12	???15	???-	???-	??4	??7.5	???-	??12	??5	??-	??6	??B
Lanoline 1	??-	??-	???-	???7.5	??7.5	???-	???15	???-	??3.5	??-	???3	??-	??-	??-	??-	??B
																	The Coronet lanoline 1	??-	??-	???-	???-	??-	???-	???-	???-	??7	??-	???6.7	??-	??-	??6	??-	??B
Super sterol ester 1	??-	??-	???-	???-	??-	???-	???-	???-	??3.5	??-	???6.5	??-	??3	??6	??3	??B
																	2-Methylpentadecane	??-	??-	???-	???-	??-	???-	???-	???-	??-	??5	???-	??3	??-	??-	??3	??B
Isononyl isononanoate	??-	??-	???-	???-	??-	???-	???-	???-	??-	??3	???-	??5	??-	??-	??-	??B
																	Sefa cotton oil acid esters	??21	??21	???12	???12	??-	???-	???-	???13	??-	??8	???-	??-	??8	??12	??10	??B
Sefa docosane acid esters	??-	??-	???-	???-	??-	???-	???-	???9	??-	??-	???3	??-	??5	??-	??-	??B
																	Polydimethylsiloxane	??-	??0.5	???0.5	???0.5	??-	???0.5	???0.5	???0.5	??-	??-	???-	??0.5	??0.5	??-	??-	??B

10 centistokes
																	Polydimethylsiloxane 1000 centistokes	??-	??1.0	??1.0	??1.0	??-	???1.0	??1.0	??1.0	???-	????-	???-	???1.0	???1.0	??-	??-	??B
The ring-type polymethyl siloxane	??-	??2.5	??2.5	??2.5	??-	???2.5	??2.5	??2.5	???-	????-	???-	???2.5	???2.5	??-	??-	??B
																	Florasun?PEG-10 2	??-	??2	??-	??2	??-	???3	??-	??1	???-	????-	???3	???-	???-	??2.5	??-	??B
Methyl parahydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	???0.5	??0.5	??0.5	???0.5	????0.5	???0.5	???0.5	???0.5	??0.5	??0.5	??A
																	Propyl p-hydroxybenzoate	??0.5	??0.5	??0.5	??0.5	??0.5	???0.5	??0.5	??0.5	???0.5	????0.5	???0.5	???0.5	???0.5	??0.5	??0.5	??B
The EDTA disodium	??0.1	??0.1	??0.1	??0.1	??0.1	???0.1	??0.1	??0.1	???0.1	????0.1	???0.1	???0.1	???0.1	??0.1	??0.1	??A
																	Sodium benzoate	??0.3	??0.3	??0.3	??0.3	??0.3	???0.3	??0.3	??0.3	???0.3	????0.3	???0.3	???0.3	???0.3	??0.3	??0.3	??B
Nicotiamide	??3	??5	??5			???5	??5	??5	???3	????3		???5	???5	??5	??3	??A
																	Pantothenylol	??1	??3	??3			???3	??3	??3	???1	????1		???3	???3	??3	??1	??A
Tocopherol acetate	??0.5	??2	??2			???2	??2	??2	???0.5	????0.5		???2	???2	??2	??0.5	??B
																	Retinyl palmitate	??-	??-	??-	??0.1	??-	???0.05	??-	??-	???0.1	????-	???-	???-	???-	??-	??-	??B
Parsol?1789 3	??-	??1	??-	??1	??0.5	???-	??1	??-	???1	????-	???1	???-	???0.1	??1	??-	??B
																	Parsol?MCX 3	??-	??5	??-	??5	??2.5	???-	??5	??-	???5	????-	???5	???-	???0.5	??5	??-	??B
Citric acid	??1	??0.5	??1	??0.5	??0.5	???1	??0.5	??1	???0.3	????0.75	???1	???1	???1	??1	??-	??A
																	Salicylic acid	??-	??0.5	??-	??0.5	??0.5	???-	??0.5	??-	???0.7	????-	???-	???-	???-	??-	??0.5	??A
Triethanolamine	??0.1	??-	??-	??0.1	??0.1	???-	??-	??-	???0.1	????-	???-	???0.9	???0.5	??-	??-	??C
																	Sodium hydroxide	??-	??-	??0.1	??0.1	??0.1	???-	??-	??0.1	???-	????0.1	???-	???-	???-	??-	??0.6	??C
Polyquaternary ammonium salt-10	??-	??-	??-	??1.0	??-	???-	??0.5	??-	???0.6	????-	???-	???-	???0.5	??1.0	??-	??B
																	Polymer KG 30 4	??-	??0.7	??-	??-	??0.7	???-		??-	???-	????0.8	???-	???-	???-	??-	??0.8	??B
Spice	??0.5	??0.5	??0.5	??0.5	??0.5	???-	??0.5	??0.5	???0.5	????0.5	???0.5	???0.5	???0.5	??0.5	??0.5	??E
																	Spermol	??3	??-	??-	??-	??2.6	???-	??-	??2.2	???-	????2.2	???-	???2.5	???-	??-	??3.2	??C
Stearyl alcohol	??2	??-	??-	??-	??1.5	???-	??-	??3.2	???-	????1.1	???-	???1.6	???-	??-	??2.6	??C
																	Spermaceti/stearyl alcohol	??-	??-	??4	??-	??0.4	???-	??-	??-	???3.4	????-	???-	???-	???3.4	??-	??-	??C
Tadenan	??2	??-	??2	??-	??-	???-	??-	??0.6	???-	????0.7	???-	???-	???-	??-	??0.2	??C
																	Natrosol?330?Plus	??1	??-		??-	??0.4	???-	??-	??0.7	???0.6	????-	???-	???0.5	???0.25	??-	??0.6	??C
Natrosol?250?HHR	??-	??-	??1	??-	??0.3	???-	??-	??-	???-	????1.2	???-	???-	???0.3	??-	??-	??C
																	Jaguar?HP?105 5	??-	??1.2	??-	??-	??-	???-	??-	??-	???-	????-	???0.8	???-	???-	??-	??-	??D
Jaguar?C14S 5	??-	??-	??-	??1	??-	???-	??-	??-	???-	????-	???-	???-	???-	??-	??-	??D

Jaguar?C13S 5	????-	???-	????-	???-	??-	??1.2	???-	???-	???-	???-	???-	???-	???-	??0.8	??-	??D
																	Xanthan gum	????-	???-	????-	???-	??-	???-	??3.0	???-	???-	???-	???-	???-	???-	??-	??-	??D
Sodium chloride	????-	???-	??0.1	???-	??-	???-	??0.5	??0.2	???-	??0.3	???-	???-	???-	??0.2	??0.1	??A
																	Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

Embodiment	??42	???43	???44	??45	??46	??47	??48	?49	??50	???51	???52	???53	??54	???55	??56
																		% (weight)
Quaternary ammonium composition (seeing note)	???8	????8	????8	???8	???8	???8	???8	??8	???8	????8	????8	????8	???8	????8	???8	??A
																	Glycerol	??15	???16	???22	???9	???8	???9	???-	?32	??32	???32	???32	???32	??32	???32	??32	??A
Propylene glycol	???-	???16	????-	???-	???-	???5	??12	??-	???-	????-	????-	????-	???-	????-	???-	??A
																	Butanediol	???-	????-	????8	???8	???-	???8	??12	??-	???-	????-	????-	????-	???-	????-	???-	??A
Urea	???-	????-	????-	??12	???-	???2	???9	??-	???-	????-	????-	????-	???-	????-	???-	??B
																	Vaseline	???-	????-	???10	???-	??12	??15	???-	??-	???4	??7.5	????-	???12	????5	????-	???6	??B
Lanoline 1	???-	????-	????-	?7.5	?7.5	???-	??15	??-	?3.5	????-	????3	????-	????-	????-	???-	??B
																	The Coronet lanoline 1	???-	????-	????-	???-	???-	???-	???-	??-	???7	????-	??6.7	????-	????-	????6	???-	??B
Super sterol ester 1	???-	????-	????-	???-	???-	???-	???-	??-	?3.5	????-	??6.5	????-	????3	????6	???3	??B
																	2-Methylpentadecane	???-	????-	????-	???-	???-	???-	???-	??-	???-	????5	????-	????3	????-	????-	???3	??B
Isononyl isononanoate	???-	????-	????-	???-	???-	???-	???-	??-	???-	????3	????-	????5	????-	????-	???-	??B
																	Sefa cotton oil acid esters	??21	???21	???12	??12	???-	???-	???-	?13	???-	????8	????-	????-	????8	???12	??10	??B
Sefa docosane acid esters	???-	????-	????-	???-	???-	???-	???-	??9	???-	????-	????3	????-	????5	????-	???-	??B
																	Polydimethylsiloxane 10 centistokes	???-	??0.5	??0.5	??0.5	???-	?0.5	?0.5	0.5	???-	????-	????-	??0.5	??0.5	????-	???-	??B
Polydimethylsiloxane 1000 centistokes	???-	??1.0	??1.0	??1.0	???-	?1.0	?1.0	1.0	???-	????-	????-	??1.0	??1.0	????-	???-	??B
																	The ring-type polymethyl siloxane	???-	??2.5	??2.5	??2.5	???-	?2.5	?2.5	2.5	???-	????-	????-	??2.5	??2.5	????-	???-	??B
Florasun?PEG-10 2	???-	????2	????-	????2	???-	???3	???-	??1	???-	????-	????3	????-	????-	??2.5	????-	??B
																	Methyl parahydroxybenzoate	?0.5	??0.5	??0.5	??0.5	?0.5	?0.5	?0.5	0.5	?0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??A
Propyl p-hydroxybenzoate	?0.5	??0.5	??0.5	??0.5	?0.5	?0.5	?0.5	0.5	?0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??B
																	The EDTA disodium	?0.1	??0.1	??0.1	??0.1	?0.1	?0.1	?0.1	0.1	?0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??0.1	??A
Sodium benzoate	?0.3	??0.3	??0.3	??0.3	?0.3	?0.3	?0.3	0.3	?0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??0.3	??B

Nicotiamide	??3	??5	??5			??5	??5	??5	??3	??3		??5	??5	??5	??3	??A
																	Pantothenylol	??1	??3	??3			??3	??3	??3	??1	??1		??3	??3	??3	??1	??A
Tocopherol acetate	??0.5	??2	??2			??2	??2	??2	??0.5	??0.5		??2	??2	??2	??0.5	??B
																	Retinyl palmitate	??-	??-	??-	??-	??-	??-	??-	??-	??0.05	??-	??-	??0.1	??-	??-	??-	??B
Parsol?1789 3	??-	??1	??-	??1	??0.5	??-	??1	??-	??1	??-	??1	??-	??0.1	??1	??-	??B
																	Parsol?MCX 3	??-	??5	??-	??5	??2.5	??-	??5	??-	??5	??-	??5	??-	??0.5	??5	??-	??B
Citric acid	??1	??0.5	??1	??0.5	??0.5	??1	??0.5	??1	??0.3	??0.75	??1	??1	??1	??1	??-	??A
																	Salicylic acid	??-	??0.5	??-	??0.5	??0.5	??-	??0.5	??-	??0.7	??-	??-	??-	??-	??-	??0.5	??A
Triethanolamine	??0.1	??-	??-	??0.1	??0.1	??-	??-	??-	??0.1	??-	??-	??0.9	??0.5	??-	??-	??C
																	Sodium hydroxide	??-	??-	??0.1	??0.1	??0.1	??-	??-	??0.1	??-	??0.1	??-	??-	??-	??-	??0.6	??C
Polyquaternary ammonium salt-10	??-	??-	??-	??1.0	??-	??-	??0.5	??-	??0.6	??-	??-	??-	??0.5	??1.0	??-	??B
																	Polymer KG 30 4	??-	??0.7	??-	??-	??0.7	??-	??-	??-	??-	??0.8	??-	??-	??-	??-	??0.8	??B
Spice	??0.5	??0.5	??0.5	??0.5	??0.5	??-	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??0.5	??E
																	Spermol	??3	??-	??-	??-	??2.6	??-	??-	??2.2	??-	??2.2	??-	??2.5	??-	??-	??3.2	??C
Stearyl alcohol	??2	??-	??-	??-	??1.5	??-	??-	??3.2	??-	??1.1	??-	??1.6	??-	??-	??2.6	??C
																	Spermaceti/stearyl alcohol	??-	??-	??4	??-	??0.4	??-	??-	??-	??3.4	??-	??-	??-	??3.4	??-	??-	??C
Tadenan	??2	??-	??2	??-	??-	??-	??-	??0.6	??-	??0.7	??-	??-	??-	??-	??0.2	??C
																	Natrosol?330?Plus	??1	??-	??-	??-	??0.4	??-	??-	??0.7	??0.6	??-	??-	??0.5	??0.2	??-	??0.6	??C
Natrosol?250?HHR	??-	??-	??1	??-	??0.3	??-	??-	??-	??-	??1.2	??-	??-	??0.3	??-	??-	??C
																	Jaguar?HP?105 5	??-	??1.2	??-	??-	??-	??-	??-	??-	??-	??-	??0.8	??-	??-	??-	??-	??D
Jaguar?C14S 5	??-	??-	??-	??1	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??-	??D
																	Jaguar?C13S 5	??-	??-	??-	??-	??-	??1.2	??-	??-	??-	??-	??-	??-	??-	??0.8	??-	??D
Xanthan gum	??-	??-	??-	??-	??-	??-	??3.0	??-	??-	??-	??-	??-	??-	??-	??-	??D
																	Sodium chloride	??-	??-	??0.1	??-	??-	??-	??0.5	??0.2	??-	??0.3	??-	??-	??-	??0.2	??0.1	??A
Water	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	In right amount	??A

1: available from Croda

2: available from Floratech, AZ, USA

3: available from Hoffman La Roche, NJ, USA

4: available from Amerchol, NJ, USA

5: available from Rhodia, NJ, USA note embodiment 1,4,7,9,17,20,22,24, and in 28,36,38,47,49,53,56, what quaternary ammonium compound adopted is VARISOFT TA100, and by the Goldschmidt supply, commodity are called Varisoft TA100.Embodiment 2,3, and 5,6,8,10; 15,16,18,19,21,23; 26,27,31,33,34,35; 37,41,45,46,48; in 50,51,52,54,55; that quaternary ammonium compound adopts is N, N-two (canola acyl group-oxygen-ethyl)-N-methyl, and N-(2-ethoxy) methylsulfuric acid ammonium, by the Goldschmidt supply, commodity are called Rewoquat V3620.Among the embodiment 11; that quaternary ammonium compound adopts is N; N-two (canola acyl group-oxygen-ethyl)-N-methyl; N-(2-ethoxy) methylsulfuric acid ammonium; supply by Goldschmidt; among the commodity RewoquatWE18 embodiment 12 by name; that quaternary ammonium compound adopts is N; N-two-(canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) ammonium chloride is supplied by Goldschmidt; among exploitation material (WE25) embodiment 13; what quaternary ammonium compound adopted is two (h-tallow acylamino-ethyl) (2-ethoxy) the methylsulfuric acid ammoniums of methyl, and by the Goldschmidt supply, commodity are called Varisoft 110.Among the embodiment 14, what quaternary ammonium compound adopted is two (Adeps Bovis seu Bubali acylamino-ethyl) (2-ethoxy) the methylsulfuric acid ammoniums of methyl, and by the Goldschmidt supply, commodity are called Varisoft 222.Among the embodiment 25; what quaternary ammonium compound adopted is methyl isophthalic acid-Adeps Bovis seu Bubali acyl ethyl-2-Adeps Bovis seu Bubali imidazoline; supply by Goldschmidt; among the exploitation material embodiment 29; what quaternary ammonium compound adopted is methyl isophthalic acid-Adeps Bovis seu Bubali acylamino-ethyl-2-Adeps Bovis seu Bubali imidazoline; supply by Goldschmidt; among the exploitation material embodiment 30; what quaternary ammonium compound adopted is methyl isophthalic acid-Adeps Bovis seu Bubali acyl ethyl-2-Adeps Bovis seu Bubali imidazoline Methylsulfate; by the Goldschmidt supply, among the embodiment 32, what quaternary ammonium compound adopted is methyl isophthalic acid-Adeps Bovis seu Bubali acylamino-ethyl-2-Adeps Bovis seu Bubali imidazoline Methylsulfate; supply by Goldschmidt; commodity are called Varisoft 475, and among Varisoft 445 embodiment 39, that quaternary ammonium compound adopts is N; N-dimethyl-N-(canola acyl group-oxygen-ethyl)-N-(canola acylamino-ethyl) amine is supplied by Kao.Among the embodiment 40; that quaternary ammonium compound adopts is N; N-dimethyl-N (canola acyl group-oxygen-ethyl)-N-(canola acylamino-ethyl) methylsulfuric acid ammonium; in Kao supply embodiment 42; that quaternary ammonium compound adopts is N; N '-two (2-Adeps Bovis seu Bubali acyl group oxygen ethyl)-N; N; N '; N '-tetramethylene dichloro diammonium is disclosed in United States Patent (USP) 4728337; United States Patent (USP) 4721512; in the United States Patent (USP) 4906413, in the embodiment of Ciba-Geigy company 43; that quaternary ammonium compound adopts is N; N '-two (2-canola acyl group oxygen ethyl)-N, N '-dimethyl-N, N '-(2-ethoxy)-1; 6-hexane methylsulfuric acid diammonium is disclosed among the patent EP0503155A1 and EP0803498 of Goldschmidt-Witco.Among the embodiment 44, what quaternary ammonium compound adopted is by fatty acid, two functional groups (or multi-functional base) acid and triethanolamine reaction, then through quaternized dimerization that obtains and oligomeric esters quaternary ammonium compound, be disclosed in WO 98/49132 (Kao) and the United States Patent (USP) 5,880,289 (Henkel).Method is used to comprise the embodiment of component C:

1. pre-composition 1: each component under the condition that is higher than selected quaternary ammonium compound conversion temperature in the mixed A group, the quaternary ammonium compound and the water that keep scheduled volume do not add.Violent mixed this pre-composition.

2. pre-composition 2: remaining quaternary ammonium compound and water in each component in B and the C group and the above pre-composition 1 is mixed.Be heated to more than the fusing point of quaternary ammonium compound and oils.

3. pre-composition 1 and 2 is mixed, and be cooled to 40 ℃, stir adding essence.Be used to comprise the embodiment of component D:

1. pre-composition 1: each component under the condition that is higher than selected quaternary ammonium compound conversion temperature in the mixed A group, the water that keeps scheduled volume does not add.Violent mixed this pre-composition.

2. pre-composition 2: stir down, and remaining water in each component in the D group and the above pre-composition 1 is mixed.

With pre-composition 1 and 2 and B and E group in each component mixed.Vigorous stirring.

The compositions of the foregoing description provides good skin care benefits, as good moist effect, good hydration, good skin usability, good skin softness and/or good skin flatness, detrimental effect such as greasy, cohesiveness or sticky property are low simultaneously.

Claims (10)

1. cosmetic composition, said composition comprises:

(a) at least a quaternary ammonium composition;

(b) emollient; With

(c) polar solvent;

Wherein compositions comprises vesicle, comprises quaternary ammonium composition and emollient in the described vesicle.

2. according to the compositions of claim 1, wherein said compositions comprises the quaternary ammonium composition of 0.01%, more preferably at least 1% weight.

3. according to the compositions of claim 1 or 2, wherein said compositions comprises the emollient of at least 1%, more preferably at least 5% weight.

4. according to the compositions of aforementioned each claim, wherein said emollient is selected from dodecane, squalane, cholesterol and derivant thereof, 2-Methylpentadecane, isononyl isononanoate, vaseline, lanoline and derivant thereof, safflower oil, Oleum Ricini, Oleum Cocois, Oleum Gossypii semen, palm-kernel oil, Petiolus Trachycarpi oil, Oleum Arachidis hypogaeae semen, soybean oil, polyol carboxylic acid ester and their mixture.

5. according to the compositions of aforementioned each claim, the number average size of wherein said vesicle is 0.01 μ m to 30 μ m, preferred 0.02 μ m to 15 μ m.

6. according to the compositions of aforementioned each claim, wherein the quaternary ammonium composition is selected from general formula (II) or (III) those:

Each R wherein ₅The unit is independently from each other hydrogen, side chain or straight chain C ₁-C ₆Alkyl, side chain or straight chain C ₁-C ₆Hydroxyalkyl and their mixture, preferable methyl and ethoxy; Each R ₆The unit is straight or branched C independently of one another ₁₁-C ₂₂Alkyl, straight or branched C ₁₁-C ₂₂Alkenyl and their mixture; X ^-Be can be compatible with the adjuvant composition with the skin care active composition anion; M is 1-4, is preferably 2; N is 1-4, is preferably 2, and Q is selected from following carbonyl unit:

With

R wherein ₇Be H, C ₁-C ₄Alkyl, C ₁-C ₄Hydroxyalkyl, and their mixture.

7. according to the compositions of aforementioned each claim; wherein the quaternary ammonium composition is selected from N; N-two (canola acyl group-oxygen-ethyl)-N; N-alkyl dimethyl ammonium chloride, N; N-two (canola acyl group-oxygen-ethyl)-N-methyl; N-(2-ethoxy) methylsulfuric acid ammonium, N, N-two (canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) ammonium chloride and their mixture.

8. according to the compositions of aforementioned each claim, wherein said polar solvent is a water.

9. according to the compositions of aforementioned each claim, wherein said compositions also comprises wetting agent.

10. the application of the described compositions of aforementioned each claim in nursing skin.