CN1365710A - Nano inflammation-relieving and antitussive medicine and its preparing process - Google Patents
Nano inflammation-relieving and antitussive medicine and its preparing process Download PDFInfo
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- CN1365710A CN1365710A CN 01100653 CN01100653A CN1365710A CN 1365710 A CN1365710 A CN 1365710A CN 01100653 CN01100653 CN 01100653 CN 01100653 A CN01100653 A CN 01100653A CN 1365710 A CN1365710 A CN 1365710A
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Abstract
A nanometre medicine "Xiaoyan Zhike" is prepared from the nanometre powders of 9 Chinese medicinal materials including platycodon root, pseudostellaria root, stemona root, ephedra, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of antiinflammatory, town's shell, reduce phlegm, the nano inflammation-relieving and antitussive medicine of Dingchuan, the invention still further relates to the method for this medication preparation.
The inflammation-diminishing and cough-controlling sheet is a kind of classical Chinese patent medicine, mainly contains antiinflammatory, town's shell, reduces phlegm, effect such as Dingchuan, is used for diseases such as cough with copious phlegm, fullness in the chest QI rising in reverse order, tracheitis.But traditional inflammation-diminishing and cough-controlling sheet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano inflammation-relieving and antitussive medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano inflammation-relieving and antitussive medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Folium Elaeagni 100-300 part nanometer Radix Platycodonis 100-200 part nanometer Radix Pseudostellariae 100-300 part
Nanometer Radix Stemonae 60-150 part nanometer opium poppy shell 10-20 part nanometer Herba Ephedrae 15-40 part
Nanometer Fructus Viticis Negundo 80-200 part nanometer Radix Adenophorae 20-55 part nanometer Herba Andrographis 80-200 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Folium Elaeagni 150-250 part nanometer Radix Platycodonis 120-180 part nanometer Radix Pseudostellariae 150-250 part
Nanometer Radix Stemonae 80-120 part nanometer opium poppy shell 10-15 part nanometer Herba Ephedrae 20-30 part
Nanometer Fructus Viticis Negundo 100-150 part nanometer Radix Adenophorae 30-50 part nanometer Herba Andrographis 100-150 part
The optimum weight proportioning of medicine of the present invention is:
200 parts of 150 parts of nanometer Radix Pseudostellariaes of 200 parts of nanometer Radix Platycodoniss of nanometer Folium Elaeagni
25 parts in 12.5 parts of nanometer Herba Ephedraes of 100 parts of nanometer opium poppies of nanometer Radix Stemonae shell
125 parts of 37.5 parts of nanometer Herba Andrographis of 125 parts of nanometer Radix Adenophoraes of nanometer Fructus Viticis Negundo
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MP inflammation-diminishing and cough-controlling pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MP inflammation-diminishing and cough-controlling pressure,, get the inflammation-relieving and antitussive nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano inflammation-relieving and antitussive medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common inflammation-diminishing and cough-controlling tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano inflammation-relieving and antitussive medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as cough with copious phlegm, fullness in the chest QI rising in reverse order, tracheitis, and clinical efficacy significantly is better than traditional inflammation-diminishing and cough-controlling sheet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
200 parts of 150 parts of nanometer Radix Pseudostellariaes of 200 parts of nanometer Radix Platycodoniss of nanometer Folium Elaeagni
25 parts in 12.5 parts of nanometer Herba Ephedraes of 100 parts of nanometer opium poppies of nanometer Radix Stemonae shell
125 parts of 37.5 parts of nanometer Herba Andrographis of 125 parts of nanometer Radix Adenophoraes of nanometer Fructus Viticis Negundo
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
200 parts of 150 parts of nanometer Radix Pseudostellariaes of 200 parts of nanometer Radix Platycodoniss of nanometer Folium Elaeagni
25 parts in 12.5 parts of nanometer Herba Ephedraes of 100 parts of nanometer opium poppies of nanometer Radix Stemonae shell
125 parts of 37.5 parts of nanometer Herba Andrographis of 125 parts of nanometer Radix Adenophoraes of nanometer Fructus Viticis Negundo
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano inflammation cough-relieving powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
200 parts of 150 parts of nanometer Radix Pseudostellariaes of 200 parts of nanometer Radix Platycodoniss of nanometer Folium Elaeagni
25 parts in 12.5 parts of nanometer Herba Ephedraes of 100 parts of nanometer opium poppies of nanometer Radix Stemonae shell
125 parts of 37.5 parts of nanometer Herba Andrographis of 125 parts of nanometer Radix Adenophoraes of nanometer Fructus Viticis Negundo
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano inflammation cough-relieving membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: chest.
Claims (6)
1, a kind of nano inflammation-relieving and antitussive medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Folium Elaeagni 100-300 part nanometer Radix Platycodonis 100-200 part nanometer Radix Pseudostellariae 100-300 part
Nanometer Radix Stemonae 60-150 part nanometer opium poppy shell 10-20 part nanometer Herba Ephedrae 15-40 part
Nanometer Fructus Viticis Negundo 80-200 part nanometer Radix Adenophorae 20-55 part nanometer Herba Andrographis 80-200 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MP inflammation-diminishing and cough-controlling pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano inflammation-relieving and antitussive medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Folium Elaeagni 150-250 part nanometer Radix Platycodonis 120-180 part nanometer Radix Pseudostellariae 150-250 part
Nanometer Radix Stemonae 80-120 part nanometer opium poppy shell 10-15 part nanometer Herba Ephedrae 20-30 part
Nanometer Fructus Viticis Negundo 100-150 part nanometer Radix Adenophorae 30-50 part nanometer Herba Andrographis 100-150 part
3, nano inflammation-relieving and antitussive medicine according to claim 1, wherein the weight proportion of each nano raw material is:
200 parts of 150 parts of nanometer Radix Pseudostellariaes of 200 parts of nanometer Radix Platycodoniss of nanometer Folium Elaeagni
25 parts in 12.5 parts of nanometer Herba Ephedraes of 100 parts of nanometer opium poppies of nanometer Radix Stemonae shell
125 parts of 37.5 parts of nanometer Herba Andrographis of 125 parts of nanometer Radix Adenophoraes of nanometer Fructus Viticis Negundo
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano inflammation-relieving and antitussive medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano inflammation-relieving and antitussive medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MP inflammation-diminishing and cough-controlling pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100653 CN1365710A (en) | 2001-01-15 | 2001-01-15 | Nano inflammation-relieving and antitussive medicine and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100653 CN1365710A (en) | 2001-01-15 | 2001-01-15 | Nano inflammation-relieving and antitussive medicine and its preparing process |
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| CN1365710A true CN1365710A (en) | 2002-08-28 |
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| CN 01100653 Pending CN1365710A (en) | 2001-01-15 | 2001-01-15 | Nano inflammation-relieving and antitussive medicine and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316999C (en) * | 2003-08-11 | 2007-05-23 | 陈明元 | Medicine for treating wind warmth and lung heat pathocondition and its preparation method |
| CN104906059A (en) * | 2015-06-22 | 2015-09-16 | 南京华宽信息咨询中心 | Preparation method and application of anti-inflammatory and antasthmatic tablet |
-
2001
- 2001-01-15 CN CN 01100653 patent/CN1365710A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316999C (en) * | 2003-08-11 | 2007-05-23 | 陈明元 | Medicine for treating wind warmth and lung heat pathocondition and its preparation method |
| CN104906059A (en) * | 2015-06-22 | 2015-09-16 | 南京华宽信息咨询中心 | Preparation method and application of anti-inflammatory and antasthmatic tablet |
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