CN1368273A - Nano medicine 'Zhenzhu Niuhuang' and its preparing process - Google Patents
Nano medicine 'Zhenzhu Niuhuang' and its preparing process Download PDFInfo
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- CN1368273A CN1368273A CN 01102627 CN01102627A CN1368273A CN 1368273 A CN1368273 A CN 1368273A CN 01102627 CN01102627 CN 01102627 CN 01102627 A CN01102627 A CN 01102627A CN 1368273 A CN1368273 A CN 1368273A
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Abstract
A nanometre (0.1-200 nm) medicine "Zhenzhu Niuhuang" is prepared from the nanometre powders of 11 Chinese medicinal amterials including pearl, bezoar, borax, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Zhenzhu Niuhuang ' of a kind of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the invention still further relates to the method for this medication preparation.
It is a kind of classical Chinese patent medicine that 'Zhenzhu Niuhuang looses, and mainly contains effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is used for diphtheria, laryngopharynx swelling and pain, sore throat aphtha that hyperactivity of toxic heat causes.But traditional 'Zhenzhu Niuhuang looses and absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Zhenzhu Niuhuang ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Zhenzhu Niuhuang '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano-pearl 6-18 part nano bezoar 6-18 part nanometer Borax 70-150 part
Nanometer catechu 60-150 part nanometer Herba Menthae 100-200 part nano phellodendron bark 60-150 part
The female 60-150 part of nano natural indigo 120-300 part nano Sichuan fritillary bulb nanometer Cinnabaris 120-300 part
Nanometer Medulla Junci 12-30 part nanometer Borneolum Syntheticum 12-30 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano-pearl 8-15 part nano bezoar 8-15 part nanometer Borax 80-120 part
Nanometer catechu 80-120 part nanometer Herba Menthae 120-180 part nano phellodendron bark 80-120 part
The female 80-120 part of nano natural indigo 150-250 part nano Sichuan fritillary bulb nanometer Cinnabaris 150-250 part
Nanometer Medulla Junci 15-25 part nanometer Borneolum Syntheticum 15-25 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 10 parts of nanometer Boraxs of 10 parts of nano bezoars of nano-pearl
100 parts of 150 parts of nano phellodendron barks of 100 parts of nanometer Herba Menthaes of nanometer catechu
200 parts in the female 100 parts of nanometer Cinnabaris of 200 parts of nano Sichuan fritillary bulbs of nano natural indigo
20 parts of 20 parts of nanometer Borneolum Syntheticums of nanometer Medulla Junci
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get 'Zhenzhu Niuhuang preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Zhenzhu Niuhuang ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale; common 'Zhenzhu Niuhuang powder preparation material is micron or the above particle diameter of millimeter; can only cross the 80-120 mesh sieve; the drug material that the present invention is made; particle diameter is at 0.1--200nm; the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Zhenzhu Niuhuang ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as diphtheria that hyperactivity of toxic heat causes, laryngopharynx swelling and pain, sore throat aphtha, and clinical efficacy significantly is better than traditional 'Zhenzhu Niuhuang and looses.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 10 parts of nanometer Boraxs of 10 parts of nano bezoars of nano-pearl
100 parts of 150 parts of nano phellodendron barks of 100 parts of nanometer Herba Menthaes of nanometer catechu
200 parts in the female 100 parts of nanometer Cinnabaris of 200 parts of nano Sichuan fritillary bulbs of nano natural indigo
20 parts of 20 parts of nanometer Borneolum Syntheticums of nanometer Medulla Junci
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 10 parts of nanometer Boraxs of 10 parts of nano bezoars of nano-pearl
100 parts of 150 parts of nano phellodendron barks of 100 parts of nanometer Herba Menthaes of nanometer catechu
200 parts in the female 100 parts of nanometer Cinnabaris of 200 parts of nano Sichuan fritillary bulbs of nano natural indigo
20 parts of 20 parts of nanometer Borneolum Syntheticums of nanometer Medulla Junci
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard; do not add any adjuvant; make nano-pearl bovine calculus powder needle injection, every injection content is the 5-20 milligram; each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 10 parts of nanometer Boraxs of 10 parts of nano bezoars of nano-pearl
100 parts of 150 parts of nano phellodendron barks of 100 parts of nanometer Herba Menthaes of nanometer catechu
200 parts in the female 100 parts of nanometer Cinnabaris of 200 parts of nano Sichuan fritillary bulbs of nano natural indigo
20 parts of 20 parts of nanometer Borneolum Syntheticums of nanometer Medulla Junci
Production method is as follows:
In the GMP cleaning shop; with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after; according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard; filmogen adopts polyvinyl alcohol; make nano-pearl Calculus Bovis membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram; every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano medicine ' Zhenzhu Niuhuang ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano-pearl 6-18 part nano bezoar 6-18 part nanometer Borax 70-150 part
Nanometer catechu 60-150 part nanometer Herba Menthae 100-200 part nano phellodendron bark 60-150 part
The female 60-150 part of nano natural indigo 120-300 part nano Sichuan fritillary bulb nanometer Cinnabaris 120-300 part
Nanometer Medulla Junci 12-30 part nanometer Borneolum Syntheticum 12-30 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Zhenzhu Niuhuang ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano-pearl 8-15 part nano bezoar 8-15 part nanometer Borax 80-120 part
Nanometer catechu 80-120 part nanometer Herba Menthae 120-180 part nano phellodendron bark 80-120 part
The female 80-120 part of nano natural indigo 150-250 part nano Sichuan fritillary bulb nanometer Cinnabaris 150-250 part
Nanometer Medulla Junci 15-25 part nanometer Borneolum Syntheticum 15-25 part
3, nano medicine ' Zhenzhu Niuhuang ' according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 10 parts of nanometer Boraxs of 10 parts of nano bezoars of nano-pearl
100 parts of 150 parts of nano phellodendron barks of 100 parts of nanometer Herba Menthaes of nanometer catechu
200 parts in the female 100 parts of nanometer Cinnabaris of 200 parts of nano Sichuan fritillary bulbs of nano natural indigo
20 parts of 20 parts of nanometer Borneolum Syntheticums of nanometer Medulla Junci
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Zhenzhu Niuhuang 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Zhenzhu Niuhuang 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102627 CN1368273A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Zhenzhu Niuhuang' and its preparing process |
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| CN 01102627 CN1368273A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Zhenzhu Niuhuang' and its preparing process |
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| CN1368273A true CN1368273A (en) | 2002-09-11 |
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| CN 01102627 Pending CN1368273A (en) | 2001-02-06 | 2001-02-06 | Nano medicine 'Zhenzhu Niuhuang' and its preparing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879653B (en) * | 2006-05-17 | 2011-12-21 | 苟仕金 | Bezoar nano-powder preparation process and pharmaceutical preparation thereof |
| CN104825779A (en) * | 2015-04-23 | 2015-08-12 | 刘德臻 | Traditional Chinese medicine oral aerosol |
| CN104906348A (en) * | 2015-06-11 | 2015-09-16 | 王淑霞 | Traditional Chinese medicine oral aerosol |
| CN105106096A (en) * | 2015-09-18 | 2015-12-02 | 赵梅 | Oral care solution |
-
2001
- 2001-02-06 CN CN 01102627 patent/CN1368273A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879653B (en) * | 2006-05-17 | 2011-12-21 | 苟仕金 | Bezoar nano-powder preparation process and pharmaceutical preparation thereof |
| CN104825779A (en) * | 2015-04-23 | 2015-08-12 | 刘德臻 | Traditional Chinese medicine oral aerosol |
| CN104906348A (en) * | 2015-06-11 | 2015-09-16 | 王淑霞 | Traditional Chinese medicine oral aerosol |
| CN105106096A (en) * | 2015-09-18 | 2015-12-02 | 赵梅 | Oral care solution |
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| WD01 | Invention patent application deemed withdrawn after publication |