CN104587175A - Formula of traditional Chinese medicine for treating diabetes mellitus - Google Patents
Formula of traditional Chinese medicine for treating diabetes mellitus Download PDFInfo
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Abstract
The invention provides a drug for treating diabetes mellitus. The drug is prepared from raw materials including 4-9 parts of ginseng, 6-9 parts of tea polyphenols, 4-9 parts of konjac, 4-9 parts of chaenomeles speciosa, 2-5 parts of radix ophiopogonis, 3-7 parts of herba ecliptae, 2-6 parts of peach kernels, 5-9 parts of Chinese yams, 3-6 parts of radix cyathulae, 5-10 parts of moutan barks, 3-5 parts of schisandra chinensis, 5-9 parts of berberine, 3-6 parts of radix scrophulariae, 2-8 parts of mulberry leaves, 2-8 parts of cortex lycii, 3-6 parts of radix rehmanniae and 3-6 parts of radix trichosanthis. The drug is simple and unique in formula and preparation method.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, be specifically Chinese patent medicine prepared by crude drug with Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Diabetes are commonly encountered diseases, frequently-occurring disease, many, ferritic deficiency of YIN not enough by natural endowment, multiple because of eating and drinking without temperance, feelings will are unsuccessful or labor for caused by excessively, take chronic hyperglycemia as the metabolism disorder disease of feature, the traditional Chinese medical science claims diabetes, because the deficiency of YIN is scorching, the five internal organs are weak, cause the three-many-one-little classical symptom of polyphagia, polydipsia, polyuria and emaciated physique, its General Symptoms lumbago, extremities aching pain, the sense of brothers ant, numbness, skin pruritus, hyposexuality, severe patient can concurrent heart, kidney and retinopathy, and can produce ketoacidosis and cause stupor, dead.
Theory of Chinese medical science is thought: the basic pathogenesis of diabetes is that the deficiency of YIN is scorching, take the deficiency of YIN as this, and scorching is mark, YIN fluid deficiency then scorching inclined Sheng, both reciprocal causations again, and more void is then scorching more contains for the moon, scorchingly more contains then that the moon is more empty.The main diseases position of quenching one's thirst is lung, spleen, stomach, kidney, and its middle kidney is the most key.Lung governing diffusion, be source waterborne, cloudy impairing the lung is dry, and body fluid loses in compress, then taste lose it and moisten foster, and kidney yin is lost it and moistened.Stomach is reservoir of food and drink, and The spleen has the function to transport and transform nutrients, is stomach its body fluid capable, and stomach-Yin side consumes, deficiency of spleen-YIN, then rapid digestion of food and do not fill muscle, body fluid being unable to be produced and scorching interior vehement, the upper lung liquid that burns again, lower consumption kidney yin.The main water store essential substances of kidney, be the congenital foundation, deficiency of the kidney yin is deficiency-fire produced in the interior then, also can go up consumption lung spleen, therefore stomach-heat due to lung-dryness is suffered from a deficiency of the kidney and often existed simultaneously, affects each other, polydipsia, polyphagia, polyuria and become thin normal mutual and see, deficiency of both QI and YIN, and negative and positive all decline.Interdependence between yin and yang is use mutually, protracted inflammation of quenching one's thirst, the disease of the common deficiency of both QI and YIN of deficient YIN affecting YANG, and the disease of deficiency in both YIN and YANG, asthenia of both the spleen and kidney, appears in the passing of time then deficiency of YIN affecting YANG.Positive QI-insufficiency, raw in blood stasis, yin asthenia generating intrinsic heat, damages cloudy consumption liquid, then blood vessels are empty for it puckeryly forms blood stasis, deficiency of both QI and YIN or deficiency of both YIN and YANG.The weary source of blood biochemical, runs unable, also the hemopoietic stasis of blood, makes again blood vessels obstructed, and internal organs lose supports, and therefore quench one's thirst normal relevant with blood stasis, with YIN nourishing and the production of body fluid promoting in treatment, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling is basic principle.
Doctor trained in Western medicine mainly uses metformin, glimepiride, gliclazide, rosiglitazone etc. to the treatment of diabetes, although these medicines have and reasonablely fall hypoglycemic effect, but toxic and side effects is obvious, take in process and want periodic monitoring blood glucose, life-time service can cause the infringement of hepatic and renal function and produce toleration, if dosage is excessive, blood glucose can be made to be reduced to below normal value, cause hypoglycemia, even can cause hypoglycemic shock, stupor, severe patient can lethally be died.
The Chinese-western medicine preparation diabetes pill of the treatment diabetes used clinically at present, falls hypoglycemic Western medicine glimepiride although add to have, has certain effect, fall hypoglycemic DeGrain, and have certain side effect to the symptom alleviating three-many-one-little.
Summary of the invention
The object of the present invention is to provide a kind of pure Chinese medicine formula utilizing treatment diabetes, effectively can reduce blood glucose, eliminate because the deficiency of YIN is scorching, the five internal organs weakness causes polyphagia, polydipsia, the generation of the three-many-one-little classical symptom of polyuria and emaciated physique.
The present invention realizes above-mentioned purpose like this: a kind of Chinese medicine formula for the treatment of diabetes, and belong to and reduce blood sugar type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 2-6 part, Radix Ophiopogonis 2-6 part, Rhizoma Dioscoreae 5-10 part, Rhizoma Anemarrhenae 5-10 part, Fructus Ligustri Lucidi 5-10 part, Herba Ecliptae 3-8 part, Rhizoma Atractylodis Macrocephalae (parched) 5-10 part, Radix Astragali 3-8 part, Semen Persicae 2-7 part, Radix Paeoniae Rubra 5-10 part, Cortex Moutan 5-11 part, Radix Cyathulae 3-8 part, Fructus Arctii 3-8 part, Radix Rehmanniae 5-11 part, Cortex Lycii 3-8 part, Radix Trichosanthis 3-8 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 4-6 part, Radix Ophiopogonis 4-6 part, Rhizoma Dioscoreae 8-10 part, Rhizoma Anemarrhenae 8-10 part, Fructus Ligustri Lucidi 8-10 part, Herba Ecliptae 5-8 part, Rhizoma Atractylodis Macrocephalae (parched) 8-10 part, Radix Astragali 6-8 part, Semen Persicae 4-7 part, Radix Paeoniae Rubra 8-10 part, Cortex Moutan 8-11 part, Radix Cyathulae 6-8 part, Fructus Arctii 5-8 part, Radix Rehmanniae 8-11 part, Cortex Lycii 6-8 part, Radix Trichosanthis 6-8 part.
Preferred Chinese medicine ingredients and weight portion are further: Radix Ginseng 5.7 parts, Radix Ophiopogonis 5.7 parts, Rhizoma Dioscoreae 9.5 parts, the Rhizoma Anemarrhenae 9.5 parts, Fructus Ligustri Lucidi 9.5 parts, Herba Ecliptae 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 9.5 parts, the Radix Astragali 6.8 parts, 5 parts, Semen Persicae, Radix Paeoniae Rubra 9.5 parts, Cortex Moutan 9.5 parts, Radix Cyathulae 6.8 parts, Fructus Arctii 6 parts, 9.5 parts, the Radix Rehmanniae, Cortex Lycii 6.8 parts, Radix Trichosanthis 6 parts.
Adopt one kettle way to obtain by the production method that above-mentioned each component makes medicine of the present invention, that is, by after all medicament mixing, add water to 1 ~ 2 times of medicine gross weight, soak 30min, at 110 ~ 120 DEG C, heat 20min, then reduce temperature to 100 ~ 105 DEG C, continue heating 20min, then raised temperature to 110 ~ 120 DEG C, continue heating 10min, be again cooled to 80 ~ 90 DEG C, heating 10min, cooling, filters, removes slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into paste extractum, dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, after sterilizing, make tablet or pill.
Or by above-mentioned gained extractum, dry and pulverize, add after adjuvant is mixed and granulate, pack after dry sterilization, make granule.
Its pharmacological action of the formula that foregoing invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Rhizoma Dioscoreae tonifying spleen-yin and consolidating semen is micro-, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Ecliptae nourishing YIN to lower pathogenic fire, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and regulating the stomach, Radix Astragali QI invigorating, with the effect of ginseng of helping others, Semen Persicae, Radix Paeoniae Rubra, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Fructus Arctii, the Radix Rehmanniae, Cortex Lycii clearing away heat and cooling blood, fall asthenic fire clearly, Radix Trichosanthis promoting the production of body fluid to quench thirst.By the reasonable formula of ten a few herbs, reach nourshing Yin and drynsessmoistening prescription, YIN nourishing and the production of body fluid promoting, fall hypoglycemic effect, through Clinical practice successful.
The Chinese medicine that the formula of foregoing invention is obtained has the following advantages:
1. this formula is with natural edible-plant medicine for raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 9 Zhou Houneng make blood glucose be reduced to normal level, within 67 weeks, can fully recover, and this medicine, without sweet taste, cures tracing study in latter 6 months, is normally, to human non-toxic's side effect, without toleration through hepatic and renal function inspection.
2. the Chinese medicine for treating diabetes obtained by formula of foregoing invention is without bitterness sense, can long-term taking, and sick the lighter, dose reduces by half, sick severe one, according to aggravation dose, will blood glucose can be caused because dosage is excessive to be reduced to below normal value, cause hypoglycemia.
3. the formula of foregoing invention can use with other antidiabetic drugs and insulin combination, but can greatly reduce the dosage of antidiabetic drug and insulin, and therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. the formula YIN nourishing and the production of body fluid promoting of foregoing invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can take foot bath further, takes formula with the use for the treatment of diabetes with this.
For showing the therapeutic effect of medicine of the present invention to diabetes, the present invention selects medical history, the state of an illness, age, sex and former Therapeutic Method suitable patient 150 example to observe for system temporarily, is divided into 2 groups at random.Treatment group 80 example, man 48 example, female 32 example; 44.5 ~ 76.8 years old age, average (60.65 ± 16.15) year; Diabetic duration 3 ~ 15.2 years, average (6.22 ± 2.51) year; Diabetic duration 0.55 ~ 6.5 year, average (3.85 ± 0.72) year.Matched group 70 example, man 36 example, female 34 example; 42.4 ~ 71.5 years old age, average (56.95 ± 14.55) year; Diabetic duration 2.5 ~ 14.2 years, average (4.88 ± 2.16) year; Diabetic duration 0.3 ~ 5.8 year, average (3.46 ± 1.15) year.The aspects such as 2 groups of patient ages, sex, the course of disease, state of an illness compare, and difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 3 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the matched group antidiabetic drug of the application adopts diabetes pill.
Detection method is periodic detection fasting glucose (FPG), after the meal 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situations.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 1 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 2 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
To have diversity remarkable in the reduction of Chinese medicine formula to blood sugar content of foregoing invention as can be seen from Table 1, fasting glucose content is reduced to 4.9 ± 0.28 from 16.3 ± 0.95,2 hours after the meal, blood sugar content is reduced to 3.95 ± 1.85 from 21.85 ± 0.73, this difference tool is very significant (P < 0.01), but the formula of foregoing invention basic there was no significant difference (P >=0.05) compared with diabetes pill.Take formula of the present invention after 3 months, glucose in urine content significance reduces, and this content is reduced to normal urine sugar value, described in patient, the phenomenon of polyphagia, polydipsia, polyuria without, through the treatment of nearly 3 months, body weight reached normal level substantially.As can be seen from Table 2, take Chinese medicine formula of the present invention, before and after cholesterol and triglyceride, content obviously reduces, after the treatment of 3 months, substantially normal level is reached, this difference tool is very significant (P < 0.01), and insulin content before the treatment after, within 2 hours after the meal, slightly increase, but difference is little, also difference is little compared with diabetes pill for above-mentioned formula of the present invention, its no significant difference (P > 0.05).After 67 weeks take, diabetes are effected a radical cure substantially, and the cure rate through adding up diabetics reaches 95%, after again through the tracing study of 6 months, hepatic and renal function is all normal, does not find toxic and side effects.
Another object of the present invention is to provide a kind of Chinese medicine formula for the treatment of diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 4-8 part, Herba Ephedrae alkaloid 2-7 part, Pollen Typhae ketone 2-5 part, Radix Angelicae Pubescentis 2-5 part, β-eucalyptus leaves oleyl alcohol 4-8 part, Radix Pternopetali vulgaris 3-9 part, Radix Puerariae 3-9 part, Rhizoma Anemarrhenae 4-8 part, Fructus Ligustri Lucidi 4-8 part, Herba Ecliptae 5-10 part, Rhizoma Atractylodis Macrocephalae (parched) 5-9 part, Semen Persicae 2-5 part, Cortex Moutan 5-9 part, Radix Cyathulae 3-6 part, Fructus Arctii 3-6 part, Radix Scrophulariae 4-8 part, Cortex Lycii 3-6 part, Herba Leonuri 2-7 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 6-8 part, Herba Ephedrae alkaloid 5-7 part, Pollen Typhae ketone 3.5-5 part, Radix Angelicae Pubescentis 2-3.5 part, β-eucalyptus leaves oleyl alcohol 6-8 part, Radix Pternopetali vulgaris 6.5-8 part, Radix Puerariae 5-7 part, Rhizoma Anemarrhenae 5-6.5 part, Fructus Ligustri Lucidi 5-7 part, Herba Ecliptae 5-7 part, Rhizoma Atractylodis Macrocephalae (parched) 6.5-7.8 part, Semen Persicae 2.5-4.2 part, Cortex Moutan 6.8-8.5 part, Radix Cyathulae 4-5.5 part, Fructus Arctii 4-6 part, Radix Scrophulariae 4-6 part, Cortex Lycii 3-5 part, Herba Leonuri 5-7 part.
Preferred Chinese medicine ingredients and weight portion are further: Radix Ginseng 6.5 parts, Herba Ephedrae alkaloid 5.5 parts, Pollen Typhae ketone 4 parts, Radix Angelicae Pubescentis 3 parts, β-eucalyptus leaves oleyl alcohol 6.5 parts, Radix Pternopetali vulgaris 7 parts, Radix Puerariae 5.8 parts, the Rhizoma Anemarrhenae 6 parts, Fructus Ligustri Lucidi 6 parts, Herba Ecliptae 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 7 parts, 3.8 parts, Semen Persicae, Cortex Moutan 7.5 parts, Radix Cyathulae 4.5 parts, Fructus Arctii 4.5 parts, Radix Scrophulariae 5.5 parts, Cortex Lycii 4.5 parts, Herba Leonuri 5 parts.
Adopt one kettle way to obtain by the production method that above-mentioned each component makes medicine of the present invention, that is, by after all medicament mixing, 1 ~ 2 times of medicine gross weight is added water to, soak 30min, at 110 ~ 120 DEG C, heat 20min, then reduce temperature to 100 ~ 105 DEG C, cooling, filter, remove slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into paste extractum, dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, after sterilizing, make tablet or pill.
Or by above-mentioned gained extractum, dry and pulverize, add after adjuvant is mixed and granulate, pack after dry sterilization, make granule.
Its pharmacological action of the formula that the present invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Herba Ephedrae alkaloid can increase insulin sensitivity, reduce serum free fatty acid, improve Insulin Resistance, and then repair B cell, Pollen Typhae ketone hemostasis with astringents, promoting the circulation of blood blood stasis dispelling, blood sugar lowering, blood fat reducing.Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain, controls lumbocrural pain, and β-eucalyptus leaves oleyl alcohol can drying damp and strengthening spleen, expelling wind and cold, and then increase glycogen synthase activity, Radix Pternopetali vulgaris cold expelling regulating QI to relieve pain, strengthening spleen, tonifying kidney, Radix Puerariae improves liver function, enhance metabolism, blood falls in toxin expelling, adjusting blood lipid blood glucose, promotion hemopoietic
Suppress aldose reductase activity, affect islet beta cell function.Rhizoma Dioscoreae tonifying spleen-yin and consolidating semen is micro-, the Rhizoma Anemarrhenae, Fructus Ligustri Lucidi, Herba Ecliptae nourishing YIN to lower pathogenic fire, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and regulating the stomach, Radix Astragali QI invigorating, with the effect of ginseng of helping others, Semen Persicae, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Radix Scrophulariae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, entering nutrient blood with controlling heat, Fructus Arctii, Cortex Lycii clearing away heat and cooling blood, falling asthenic fire clearly.By the reasonable formula of ten a few herbs, reach nourshing Yin and drynsessmoistening prescription, YIN nourishing and the production of body fluid promoting, fall hypoglycemic effect, through Clinical practice successful.
The Chinese medicine that the formula of foregoing invention is obtained has the following advantages:
1. this formula is with natural edible-plant medicine for raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 8 Zhou Houneng make blood glucose be reduced to normal level, within 65 weeks, can fully recover, and this medicine, without sweet taste, cures tracing study in latter 6 months, is normally, to human non-toxic's side effect, without toleration through hepatic and renal function inspection.
2. the Chinese medicine for treating diabetes obtained by formula of the present invention, can long-term taking without bitterness sense, and sick the lighter, dose reduces by half, sick severe one, according to aggravation dose, will blood glucose can be caused because dosage is excessive to be reduced to below normal value, cause hypoglycemia.
3. formula of the present invention promotes insulin secretion type, AMP activated protein kinase can be stimulated active, increase insulin sensitivity, reduce serum free fatty acid (FFA) level, improve cell membrane Insulin receptor density, improve insulin resistant, can with other antidiabetic drug conbined usage (medicine of insulin can not be increased), but can greatly reduce the dosage of antidiabetic drug, therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. formula YIN nourishing and the production of body fluid promoting of the present invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can take foot bath further, takes formula with the use for the treatment of diabetes with this.
For showing the therapeutic effect of medicine of the present invention to diabetes, the present invention selects medical history, the state of an illness, age, sex and former Therapeutic Method suitable patient 100 example to observe for system temporarily, is divided into 2 groups at random.Treatment group 67 example, man 35 example, female 32 example; 46 ~ 73 years old age, average (59.5 ± 13.5) year; Diabetic duration 5 ~ 16.2 years, average (10.6 ± 5.6) year; Diabetic duration 0.55 ~ 7 year, average (3.78 ± 3.22) year.Matched group 33 example, man 19 example, female 14 example; 39.5 ~ 74.5 years old age, average (57 ± 17.5) year; Diabetic duration 4.3 ~ 16.2 years, average (4.25 ± 5.95) year; Diabetic duration 0.6 ~ 8.1 year, average (4.35 ± 3.75) year.The aspects such as 2 groups of patient ages, sex, the course of disease, state of an illness compare, and difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 2 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the matched group antidiabetic drug of the application adopts diabetes pill.
Detection method is periodic detection fasting glucose (FPG), after the meal 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situations.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 3 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 4 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
The diversity that reduces blood sugar content of above-mentioned Chinese medicine formula is remarkable as can be seen from Table 3, this difference tool is very significant (P < 0.01), but, after taking 3 months, fasting glucose content does not reach normal level substantially, eat latter two as a child, blood sugar content is near 11, explanation, after taking above-mentioned Chinese medicine, resistance to sugar amount shows slightly reduction, and single after 67 weeks, blood sugar content is within normal level; Above-mentioned Chinese medicine formula significant difference compared with diabetes pill little (p >=0.05), took Chinese medicine formula of the present invention after 3 months, and before and after cholesterol and triglyceride, content obviously reduces, and TG drops to 0.11 ± 0.15mmol/L from 3.7 ± 1.8mmol/L; TC drops to 4.28 ± 0.3mmol/L from 12.0 ± 2.8mmol/L, this difference tool is very significant (P < 0.01), as can be seen from Table 4, for insulin content, front and back significant difference, Fins is elevated to 45.9 ± 12.6pmol/L from 21.37 ± 5.9pmol/L, and 2hlns is elevated to 128.3 ± 13pmol/L from 35.8 ± 9.4pmol/L, reach normal level, its difference has significant (P < 0.01).Illustrate, this magistral medicines may have the effect of excreting insulin, promotes to have have the diabetes patient of hypercholesterolemia and triglyceride to reduce cholesterol level and fat content simultaneously simultaneously.Described in patient, the phenomenon of polyphagia, polydipsia, polyuria without, body weight also reaches normal level gradually, and after 65 weeks, the cure rate of diabetics reaches 98%, and through the tracing study of 6 months, hepatic and renal function was normally, does not find toxic and side effects.
Another object of the present invention is to provide a kind of Chinese medicine formula for the treatment of diabetes, belong to the Chinese medicine formula strengthening insulin sensitivity sexual type, Chinese medicine ingredients and weight portion are: Radix Ginseng 2-8 part, epi-nutgall base catechin and gallate 4-9 part, M. laxiflora 3-6 part, Radix Pternopetali vulgaris 5-10 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-6 part, Radix Paeoniae Alba 3-6 part, Semen Persicae 5-9 part, Cortex Moutan 3-6 part, Radix Cyathulae 3-6 part, Fructus Arctii 3-6 part, Radix Scrophulariae 4-6 part, Cortex Lycii 3-6 part, Radix Scutellariae 4-8 part, Fructus Momordicae 3-6 part, Folium Mori 4-8 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 6-8 part, epi-nutgall base catechin and gallate 8-9 part, M. laxiflora 4-6 part, Radix Pternopetali vulgaris 5-8 part, Radix Ophiopogonis 2-4 part, Herba Ecliptae 5-6 part, Radix Paeoniae Alba 5-6 part, Semen Persicae 7-9 part, Cortex Moutan 3-5 part, Radix Cyathulae 3-5 part, Fructus Arctii 4-6 part, Radix Scrophulariae 5-6 part, Cortex Lycii 3-5 part, Radix Scutellariae 5-7 part, Fructus Momordicae 3-5 part, Folium Mori 6-8 part.
Preferred Chinese medicine ingredients and weight portion are further: Radix Ginseng 7 parts, epi-nutgall base catechin and gallate 9 parts, M. laxiflora 6 parts, Radix Pternopetali vulgaris 6 parts, Radix Ophiopogonis 3 parts, Herba Ecliptae 5 parts, the Radix Paeoniae Alba 5 parts, 8.5 parts, Semen Persicae, Cortex Moutan 4.8 parts, Radix Cyathulae 4.8 parts, Fructus Arctii 4.8 parts, Radix Scrophulariae 5.5 parts, Cortex Lycii 4.5 parts, Radix Scutellariae 6 parts, Fructus Momordicae 4.5 parts, 6 parts, Folium Mori.
Adopt one kettle way to obtain by the production method that above-mentioned each component makes medicine of the present invention, that is, by after all medicament mixing, add water to 1 ~ 2 times of medicine gross weight, soak 30min, at 110 ~ 120 DEG C, heat 20min, then reduce temperature to 100 ~ 105 DEG C, continue heating 20min, then raised temperature to 110 ~ 120 DEG C, continue heating 10min, be again cooled to 80 ~ 90 DEG C, heating 10min, cooling, filters, removes slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into paste extractum, dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, after sterilizing, make tablet or pill.
Or by above-mentioned gained extractum, dry and pulverize, add after adjuvant is mixed and granulate, pack after dry sterilization, make granule.
Its pharmacological action of the formula that foregoing invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, the redox state of epi-nutgall base catechin and gallate scalable cell regulates and controls for the gene of glyconeogenesis enzyme and the phosphorylation of protein-tyrosine of encoding, affect the kinase activity of islet secretion, significantly hypoglycemic activity.Radix Pternopetali vulgaris cold expelling regulating QI to relieve pain, strengthening spleen, tonifying kidney, Radix Puerariae improves liver function, and enhance metabolism, blood falls in toxin expelling, and adjusting blood lipid blood glucose, promotion hemopoietic, suppress aldose reductase activity, affect pancreas B cell function.M. laxiflora dispelling wind to relieve the exterior syndrome, dispelling wind and removing obstruction in the collateral, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Herba Ecliptae, Radix Paeoniae Alba nourishing YIN to lower pathogenic fire, Semen Persicae, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Fructus Arctii, Cortex Lycii clearing away heat and cooling blood, fall asthenic fire clearly, Radix Scrophulariae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, enters nutrient blood with controlling heat.Radix Scutellariae, Fructus Momordicae, Folium Mori lung heat clearing rush down stomach, removing heat from blood dampness, clearing heat and moistening lung, heat clearing and damp drying, eliminating fire and detoxication, hemostasis, blood pressure lowering.
The Chinese medicine that the formula of foregoing invention is obtained has the following advantages:
1. this formula is with natural edible-plant medicine for raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 10 Zhou Houneng make blood glucose be reduced to normal level, within 70 weeks, can fully recover, and this medicine, without sweet taste, cures tracing study in latter 6 months, is normally, to human non-toxic's side effect, without toleration through hepatic and renal function inspection.
2. the Chinese medicine for treating diabetes obtained by formula of the present invention, can long-term taking without bitterness sense, and sick the lighter, dose reduces by half, sick severe one, according to aggravation dose, will blood glucose can be caused because dosage is excessive to be reduced to below normal value, cause hypoglycemia.
3. formula peroxide activator enzyme body proliferator activated receptor γ (PPAR γ) of the present invention, strengthen insulin sensitivity sexual type, improve the level of insulin receptor beta-subunit albumen, improve the level of Insulin receptor INSR, improve the sensitivity of target cell to insulin, improve insulin resistant further.Regulate the activity of desmoenzyme system to carry out regulation and control substance metabolism, promote the differentiation of adipose cell, increase glucose transporters content.This formula can use with other antidiabetic drugs and insulin combination, but can greatly reduce the dosage of antidiabetic drug and insulin, and therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. formula YIN nourishing and the production of body fluid promoting of the present invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can take foot bath further, takes formula with the use for the treatment of diabetes with this.
For showing the therapeutic effect of formula to diabetes of foregoing invention, the present invention selects medical history, the state of an illness, age, sex and former Therapeutic Method suitable patient 92 example to observe for system temporarily, is divided into 2 groups at random.Treatment group 58 example, man 33 example, female 25 example; 38.8 ~ 77.4 years old age, average (58.1 ± 19.3) year; Diabetic duration 3.9 ~ 16.4 years, average (10.15 ± 6.25) year; Diabetic duration 0.48 ~ 5.7 year, average (3.09 ± 2.61) year.Matched group 34 example, man 14 example, female 20 example; 43.3 ~ 74.6 years old age, average (58.95 ± 15.65) year; Diabetic duration 2.8 ~ 20.5 years, average (11.65 ± 8.85) year; Diabetic duration 0.6 ~ 10.4 year, average (5.5 ± 4.9) year.The aspects such as 2 groups of patient ages, sex, the course of disease, state of an illness compare, and difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 2 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the matched group antidiabetic drug of the application adopts diabetes pill.
Detection method is periodic detection fasting glucose (FPG), after the meal 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situations.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 5 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 6 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
The diversity that reduces blood sugar content of above-mentioned Chinese medicine formula is remarkable as can be seen from Table 5, this difference tool is very significant (P < 0.01), after taking 3 months, blood sugar content is reduced to normal level, but, this Chinese medicine Chinese medicine formula compared with diabetes pill substantially without significant differences (P >=0.05); As can be seen from Table 6, take Chinese medicine formula of the present invention, before and after cholesterol and triglyceride, content obviously reduces, this difference tool is very significant (P < 0.01), and the index of cholesterol and triglyceride reaches normal level, and insulin content, front and back significant difference, its difference has significant (P < 0.01), and after 3 months, insulin content reaches normal level.Take formula of the present invention after 70 weeks, glucose in urine content significance reduces, this content belongs to normal urine sugar value, described in patient, the phenomenon of polyphagia, polydipsia, polyuria without, body weight also reaches normal level gradually, the cure rate of diabetes reaches 99%, through the tracing study of 6 months, hepatic and renal function was normally, does not find toxic and side effects.Chinese medicine formula of the present invention is taken in explanation, may stimulate or promote insulin secretion, promotes that cholesterol and triglyceride decompose, reaches normal level gradually.
Another object of the present invention is to provide a kind of Chinese medicine formula for the treatment of diabetes, belongs to Inhibiting α-glucosidase active form Chinese medicine formula, and Chinese medicine ingredients and weight portion are: Radix Ginseng 4-9 part, tea polyphenols 6-9 part, Rhizoma amorphophalli 4-9 part, money Fructus Chaenomelis 4-9 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-7 part, Semen Persicae 2-6 part, Rhizoma Dioscoreae 5-9 part, Radix Cyathulae 3-6 part, Cortex Moutan 5-10 part skin, Fructus Schisandrae Chinensis 3-5 part, berberine 5-9 part, Radix Scrophulariae 3-6 part, Folium Mori 2-8 part, Cortex Lycii 2-8 part, Radix Rehmanniae 3-6 part, Radix Trichosanthis 3-6 part.
Preferred Chinese medicine ingredients and weight portion are: Radix Ginseng 6-9 part, tea polyphenols 6-8 part, Rhizoma amorphophalli 6-9 part, money Fructus Chaenomelis 6-9 part, Radix Ophiopogonis 3-5 part, Herba Ecliptae 3-5 part, Semen Persicae 4-6 part, Rhizoma Dioscoreae 6-8 part, Radix Cyathulae 3-5 part, Cortex Moutan 7-9 part skin, Fructus Schisandrae Chinensis 3-5 part, berberine 6-9 part, Radix Scrophulariae 4-6 part, Folium Mori 6-8 part, Cortex Lycii 6-8 part, Radix Rehmanniae 4-6 part, Radix Trichosanthis 4-6 part.
Further Chinese medicine ingredients and weight portion are: Radix Ginseng 6.8 parts, tea polyphenols 6.8 parts, Rhizoma amorphophalli 6 parts, money Fructus Chaenomelis 7 parts, Radix Ophiopogonis 3 parts, Herba Ecliptae 5 parts, 4 parts, Semen Persicae, Rhizoma Dioscoreae 7.5 parts, Radix Cyathulae 4.5 parts, Cortex Moutan 8 parts of skins, Fructus Schisandrae Chinensis 4 parts, berberine 6.8 parts, Radix Scrophulariae 4.5 parts, 6 parts, Folium Mori, Cortex Lycii 6 parts, 4.5 parts, the Radix Rehmanniae, Radix Trichosanthis 4.5 parts.
Adopt one kettle way to obtain by the production method that above-mentioned each component makes medicine of the present invention, that is, by after all medicament mixing, add water to 1 ~ 2 times of medicine gross weight, soak 30min, at 110 ~ 120 DEG C, heat 20min, then reduce temperature to 100 ~ 105 DEG C, continue heating 20min, then raised temperature to 110 ~ 120 DEG C, continue heating 10min, be again cooled to 80 ~ 90 DEG C, heating 10min, cooling, filters, removes slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into paste extractum, dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, after sterilizing, make tablet or pill.
Or by above-mentioned gained extractum, dry and pulverize, add after adjuvant is mixed and granulate, pack after dry sterilization, make granule.
Its pharmacological action of the formula that the present invention obtains is: Radix Ginseng strongly invigorating primordial QI, promoting the production of body fluid to quench thirst, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, tea polyphenols Inhibiting α-glucosidase is active, also certain inhibitory action is had to α-amylase, Glucose transport activity can be reduced simultaneously, delay or the sugared absorption and digestion that slows down, thus improve its carbohydrate tolerance.The absorption of Rhizoma amorphophalli delay glucose and fat, dietary fiber can promote that cholesterol is converted into cholic acid, reduces cholic acid circulation, reduces cholesterol.Money Fructus Chaenomelis suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness, Radix Ophiopogonis sour and sweet drugs can transforme into YIN, hold back liquid and promote the production of body fluid, Herba Ecliptae nourishing YIN to lower pathogenic fire, Rhizoma Dioscoreae tonifying spleen-yin and consolidating semen is micro-, Semen Persicae, Cortex Moutan, Radix Cyathulae blood circulation promoting and blood stasis dispelling, Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Radix Scrophulariae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, enters nutrient blood with controlling heat.Berberine, the Radix Rehmanniae, Folium Mori, Cortex Lycii lung heat clearing rush down stomach, removing heat from blood dampness, clearing heat and moistening lung, heat clearing and damp drying, clearing away heat and cooling blood, fall asthenic fire clearly, eliminating fire and detoxication, hemostasis, blood pressure lowering, Radix Trichosanthis promoting the production of body fluid to quench thirst.
The Chinese medicine that the formula of foregoing invention is obtained has the following advantages:
1. this formula is with natural edible-plant medicine for raw material, and each component all meets national politics and law regulation.Utilize the comprehensive function of every Chinese medicine, 9 Zhou Houneng make blood glucose be reduced to normal level, within 60 weeks, can fully recover, and this medicine, without sweet taste, cures tracing study in latter 6 months, is normally, to human non-toxic's side effect, without toleration through hepatic and renal function inspection.
2. the Chinese medicine for treating diabetes obtained by formula of the present invention, can long-term taking without bitterness sense, and sick the lighter, dose reduces by half, sick severe one, according to aggravation dose, will blood glucose can be caused because dosage is excessive to be reduced to below normal value, cause hypoglycemia.
3. formula Inhibiting α-glucosidase of the present invention is active, and delay glucose absorbs, and has antagonism to the fat increase that post-prandial glycemia and surfeit carbohydrate cause, and promotes that insulin recovers, and protection pancreas, this blood sugar reducing function can increase the sugar tolerance of human body.This formula can use with other antidiabetic drugs and insulin combination, but can greatly reduce the dosage of antidiabetic drug and insulin, and therapeutic effect significantly increases, the immunocompetence of enhancing body.
4. formula YIN nourishing and the production of body fluid promoting of the present invention, clearing heat and moistening dryness, blood circulation promoting and blood stasis dispelling, eliminates the situation that stomach-heat due to lung-dryness is suffered from a deficiency of the kidney, and eliminates polydipsia, polyphagia, polyuria and weak state of becoming thin.
5. after the formula of foregoing invention has been taken, its screenings can take foot bath further, takes formula with the use for the treatment of diabetes with this.
For showing the therapeutic effect of foregoing invention medicine to diabetes, the present invention selects medical history, the state of an illness, age, sex and former Therapeutic Method suitable patient 83 example to observe for system temporarily, is divided into 2 groups at random.Treatment group 48 example, man 38 example, female 21 example; 36.4 ~ 80 years old age, average (58.2 ± 21.8) year; Diabetic duration 4.8 ~ 20 years, average (12.4 ± 7.6) year; Diabetic duration 1.2 ~ 7.4 years, average (4.3 ± 3.1) year.Matched group 35 example, man 17 example, female 18 example; 42.5 ~ 75.3 years old age, average (58.9 ± 16.4) year; Diabetic duration 6.6 ~ 19.7 years, average (13.15 ± 6.55) year; Diabetic duration 0.8 ~ 8.2 year, average (5.75 ± 2.45) year.The aspects such as 2 groups of patient ages, sex, the course of disease, state of an illness compare, and difference there are no significant meaning (P > 0.05), has comparability.Wherein treatment group stops former medicine one week on former treatment basis, takes medicine of the present invention, and every day, potion, was decocted in water for oral dose, and observes 3 months, within 2 weeks, is a course for the treatment of; Matched group blood sugar lowering medication routinely, wherein hypoglycemic medicine and dosage and test group match, and the matched group antidiabetic drug of the application adopts diabetes pill.
Detection method is periodic detection fasting glucose (FPG), after the meal 2 hours blood glucoses (2hPG), glucose in urine, fasting insulin (Fins), 2 hours after the meal insulins (2hlns), cholesterol (TC), triglyceride (TG), three-many-one-little present situations.Can be divided into normal (-) according to the degree of its performance, mile abnormality (+), moderate abnormal (++), severe abnormal (+++).
Table 7 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes FPG, 2hPG, glucose in urine, three-many-one-little after 3 months
Table 8 is the difference comparsion of employing 2 groups of Chinese medicine formula treatment diabetes Fins, 2hlns, TG, TC after 3 months
The diversity that reduces blood sugar content of this Chinese medicine formula is remarkable as can be seen from Table 7, FPG drops to 3.6 ± 1.29mmol/L from 18.56 ± 2.85, 2hPG drops to 4.44 ± 2.02 from 24.8 ± 2.22, this difference tool is very significant (P < 0.01), and Chinese medicine formula also has significant difference (P < 0.01) compared with diabetes pill, take the Chinese medicine of above-mentioned formula, blood sugar content just can drop to normal level, described in patient, polyphagia, polydipsia, the phenomenon of polyuria without, body weight also reaches normal level gradually.As can be seen from Table 8, take Chinese medicine formula of the present invention, after 3 months, before and after cholesterol and triglyceride, content obviously reduces, this difference tool is very significant (P < 0.01), and insulin content, front and back significant difference, its difference has significant (P < 0.01).After 60 weeks, the cure rate of diabetes reaches 95.5%, and through the tracing study of 6 months, hepatic and renal function was normally, does not find toxic and side effects.
Detailed description of the invention
Embodiment 1
Treat a Chinese medicine formula for diabetes, belong to and reduce blood sugar type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 2.5g, Radix Ophiopogonis 2.5g, Rhizoma Dioscoreae 5.8g, Rhizoma Anemarrhenae 5.8g, Fructus Ligustri Lucidi 5.8g, Herba Ecliptae 3.6g, Rhizoma Atractylodis Macrocephalae (parched) 5.8g, Radix Astragali 3.6g, Semen Persicae 2.5g, Radix Paeoniae Rubra 5.8g, Cortex Moutan 5.8g, Radix Cyathulae 3.6g, Fructus Arctii 3.6g, Radix Rehmanniae 5.8g, Cortex Lycii 3.6g, Radix Trichosanthis 3.6g.
Embodiment 2
Treat a Chinese medicine formula for diabetes, belong to and reduce blood sugar type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 5.5g, Radix Ophiopogonis 5.5g, Rhizoma Dioscoreae 8.8g, Rhizoma Anemarrhenae 8.8g, Fructus Ligustri Lucidi 9.2g, Herba Ecliptae 7g, Rhizoma Atractylodis Macrocephalae (parched) 9.2g, Radix Astragali 7g, Semen Persicae 6.5g, Radix Paeoniae Rubra 9.2g, Cortex Moutan 9.2g, Radix Cyathulae 7g, Fructus Arctii 6.5g, Radix Rehmanniae 9.2g, Cortex Lycii 7g, Radix Trichosanthis 7g.
Embodiment 3
Treat a Chinese medicine formula for diabetes, belong to and reduce blood sugar type Chinese medicine formula, Chinese medicine ingredients and weight portion are: Radix Ginseng 5.7g, Radix Ophiopogonis 5.7g, Rhizoma Dioscoreae 9.5g, Rhizoma Anemarrhenae 9.5g, Fructus Ligustri Lucidi 9.5g, Herba Ecliptae 6g, Rhizoma Atractylodis Macrocephalae (parched) 9.5g, Radix Astragali 6.8g, Semen Persicae 5g, Radix Paeoniae Rubra 9.5g, Cortex Moutan 9.5g, Radix Cyathulae 6.8g, Fructus Arctii 6g, Radix Rehmanniae 9.5g, Cortex Lycii 6.8g, Radix Trichosanthis 6g.
Embodiment 4
Treat a Chinese medicine formula for diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 4.5g, Herba Ephedrae alkaloid 2.8g, Pollen Typhae ketone 2.5g, Radix Angelicae Pubescentis 2.5g, β-eucalyptus leaves oleyl alcohol 4.5g, Radix Pternopetali vulgaris 3.8g, Radix Puerariae 3.8g, Rhizoma Anemarrhenae 4.5g, Fructus Ligustri Lucidi 4.5g, Herba Ecliptae 5.8g, Rhizoma Atractylodis Macrocephalae (parched) 5.8g, Semen Persicae 2.8g, Cortex Moutan 5.5g, Radix Cyathulae 3.8g, Fructus Arctii 3.8g, Radix Scrophulariae 4.5g, Cortex Lycii 3.8g, Herba Leonuri 3g.
Embodiment 5
Treat a Chinese medicine formula for diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 7g, Herba Ephedrae alkaloid 6g, Pollen Typhae ketone 4g, Radix Angelicae Pubescentis 3g, β-eucalyptus leaves oleyl alcohol 7g, Radix Pternopetali vulgaris 7g, Radix Puerariae 6.5g, Rhizoma Anemarrhenae 6g, Fructus Ligustri Lucidi 6g, Herba Ecliptae 6g, Rhizoma Atractylodis Macrocephalae (parched) 7.5g, Semen Persicae 2.5g, Cortex Moutan 7g, Radix Cyathulae 5g, Fructus Arctii 4g, Radix Scrophulariae 4g, Cortex Lycii 5g, Herba Leonuri 7g.
Embodiment 6
Treat a Chinese medicine formula for diabetes, belong to and promote insulin secretion type Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 6.5g, Herba Ephedrae alkaloid 5.5g, Pollen Typhae ketone 4g, Radix Angelicae Pubescentis 3g, β-eucalyptus leaves oleyl alcohol 6.5g, Radix Pternopetali vulgaris 7g, Radix Puerariae 5.8g, Rhizoma Anemarrhenae 6g, Fructus Ligustri Lucidi 6g, Herba Ecliptae 6g, Rhizoma Atractylodis Macrocephalae (parched) 7g, Semen Persicae 3.8g, Cortex Moutan 7.5g, Radix Cyathulae 4.5g, Fructus Arctii 4.5g, Radix Scrophulariae 5.5g, Cortex Lycii 4.5g, Herba Leonuri 5g.
Embodiment 7
Treat a Chinese medicine formula for diabetes, belong to the Chinese medicine formula strengthening insulin sensitivity sexual type, Chinese medicine ingredients and weight are: Radix Ginseng 3.5g, epi-nutgall base catechin and gallate 4.8g, M. laxiflora 3.8g, Radix Pternopetali vulgaris 6.5g, Radix Ophiopogonis 3.5g, Herba Ecliptae 3.8g, Radix Paeoniae Alba 3.8g, Semen Persicae 6.0g, Cortex Moutan 3.8g, Radix Cyathulae 3.8g, Fructus Arctii 3.8g, Radix Scrophulariae 4.5g, Cortex Lycii 3.8g, Radix Scutellariae 4.5g, Fructus Momordicae 33.8g, Folium Mori 4.5g.
Embodiment 8
Treat a Chinese medicine formula for diabetes, belong to the Chinese medicine formula strengthening insulin sensitivity sexual type, Chinese medicine ingredients and weight are: Radix Ginseng 6.5g, epi-nutgall base catechin and gallate 8g, M. laxiflora 4.5g, Radix Pternopetali vulgaris 8g, Radix Ophiopogonis 4g, Herba Ecliptae 6g, Radix Paeoniae Alba 6g, Semen Persicae 7g, Cortex Moutan 3.5g, Radix Cyathulae 3.5g, Fructus Arctii 6g, Radix Scrophulariae 6g, Cortex Lycii 5g, Radix Scutellariae 7g, Fructus Momordicae 3g, Folium Mori 8g.
Embodiment 9
Treat a Chinese medicine formula for diabetes, belong to the Chinese medicine formula strengthening insulin sensitivity sexual type, Chinese medicine ingredients and weight are: Radix Ginseng 7g, epi-nutgall base catechin and gallate 9g, M. laxiflora 6g, Radix Pternopetali vulgaris 6g, Radix Ophiopogonis 3g, Herba Ecliptae 5g, Radix Paeoniae Alba 5g, Semen Persicae 8.5g, Cortex Moutan 4.8g, Radix Cyathulae 4.8g, Fructus Arctii 4.8g, Radix Scrophulariae 5.5g, Cortex Lycii 4.5g, Radix Scutellariae 6g, Fructus Momordicae 4.5g, Folium Mori 6g.
Embodiment 10
Treat a Chinese medicine formula for diabetes, belong to Inhibiting α-glucosidase active form Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 4g, tea polyphenols 6g, Rhizoma amorphophalli 4g, money Fructus Chaenomelis 4.5g, Radix Ophiopogonis 2.5g, Herba Ecliptae 3.5g, Semen Persicae 2.8g, Rhizoma Dioscoreae 5g, Radix Cyathulae 3g, Cortex Moutan 6g, Fructus Schisandrae Chinensis 3.8g, berberine 5g, Radix Scrophulariae 3.8g, Folium Mori 2.8g, Cortex Lycii 2.8g, Radix Rehmanniae 3.5g, Radix Trichosanthis 3.5g.
Embodiment 11
Treat a Chinese medicine formula for diabetes, belong to Inhibiting α-glucosidase active form Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 9 parts, tea polyphenols 8 parts, Rhizoma amorphophalli 9 parts, money Fructus Chaenomelis 9g, Radix Ophiopogonis 5g, Herba Ecliptae 5g, Semen Persicae 6g, Rhizoma Dioscoreae 6g, Radix Cyathulae 5g, Cortex Moutan 9g, Fructus Schisandrae Chinensis 5g, berberine 9g, Radix Scrophulariae 6g, Folium Mori 8g, Cortex Lycii 8g, Radix Rehmanniae 6g, Radix Trichosanthis 6g.
Embodiment 12
Treat a Chinese medicine formula for diabetes, belong to Inhibiting α-glucosidase active form Chinese medicine formula, Chinese medicine ingredients and weight are: Radix Ginseng 6.8g, tea polyphenols 6.8g, Rhizoma amorphophalli 6g, money Fructus Chaenomelis 7g, Radix Ophiopogonis 3g, Herba Ecliptae 5g, Semen Persicae 4g, Rhizoma Dioscoreae 7.5g, Radix Cyathulae 4.5g, Cortex Moutan 8g, Fructus Schisandrae Chinensis 4g, berberine 6.8g, Radix Scrophulariae 4.5g, Folium Mori 6g, Cortex Lycii 6g, Radix Rehmanniae 4.5g, Radix Trichosanthis 4.5g.
Embodiment 13
One kettle way is adopted to obtain Chinese medicine formula of the present invention every medicine, that is, by after all medicament mixing, add water to 1 ~ 2 times of medicine gross weight, soak 30min, at 110 ~ 120 DEG C, heat 20min, then reduce temperature to 100 ~ 105 DEG C, continue heating 20min, then raised temperature to 110 ~ 120 DEG C, continue heating 10min, be again cooled to 80 ~ 90 DEG C, heating 10min, cooling, filters, removes slag, add antiseptic, after bottle packaging, make oral liquid;
Or above-mentioned oral liquid heating evaporation is condensed into paste extractum, dry and pulverize, add auxiliary materials and mixing, pelletizing press sheet, after sterilizing, make tablet or pill.
Or by above-mentioned gained extractum, dry and pulverize, add after adjuvant is mixed and granulate, pack after dry sterilization, make granule.
Claims (3)
1. treat a Chinese medicine formula for diabetes, it is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 4-9 part, tea polyphenols 6-9 part, Rhizoma amorphophalli 4-9 part, money Fructus Chaenomelis 4-9 part, Radix Ophiopogonis 2-5 part, Herba Ecliptae 3-7 part, Semen Persicae 2-6 part, Rhizoma Dioscoreae 5-9 part, Radix Cyathulae 3-6 part, Cortex Moutan 5-10 part, Fructus Schisandrae Chinensis 3-5 part, berberine 5-9 part, Radix Scrophulariae 3-6 part, Folium Mori 2-8 part, Cortex Lycii 2-8 part, Radix Rehmanniae 3-6 part, Radix Trichosanthis 3-6 part.
2. the Chinese medicine formula for the treatment of diabetes according to claim 1, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 6-9 part, tea polyphenols 6-8 part, Rhizoma amorphophalli 6-9 part, money Fructus Chaenomelis 6-9 part, Radix Ophiopogonis 3-5 part, Herba Ecliptae 3-5 part, Semen Persicae 4-6 part, Rhizoma Dioscoreae 6-8 part, Radix Cyathulae 3-5 part, Cortex Moutan 7-9 part, Fructus Schisandrae Chinensis 3-5 part, berberine 6-9 part, Radix Scrophulariae 4-6 part, Folium Mori 6-8 part, Cortex Lycii 6-8 part, Radix Rehmanniae 4-6 part, Radix Trichosanthis 4-6 part.
3. the Chinese medicine formula for the treatment of diabetes according to claim 1, is characterized in that, Chinese medicine ingredients and weight portion are: Radix Ginseng 6.8 parts, tea polyphenols 6.8 parts, Rhizoma amorphophalli 6 parts, money Fructus Chaenomelis 7 parts, Radix Ophiopogonis 3 parts, Herba Ecliptae 5 parts, 4 parts, Semen Persicae, Rhizoma Dioscoreae 7.5 parts, Radix Cyathulae 4.5 parts, Cortex Moutan 8 parts, Fructus Schisandrae Chinensis 4 parts, berberine 6.8 parts, Radix Scrophulariae 4.5 parts, 6 parts, Folium Mori, Cortex Lycii 6 parts, 4.5 parts, the Radix Rehmanniae, Radix Trichosanthis 4.5 parts.
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| CN109700893A (en) * | 2019-02-20 | 2019-05-03 | 安徽农业大学 | Application of the tea in the drug that diabetes diuresis symptom is alleviated in preparation |
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| CN109700893A (en) * | 2019-02-20 | 2019-05-03 | 安徽农业大学 | Application of the tea in the drug that diabetes diuresis symptom is alleviated in preparation |
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