CN1308961A - Medicine for treating dermatopathy by photochemical therapy - Google Patents
Medicine for treating dermatopathy by photochemical therapy Download PDFInfo
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- CN1308961A CN1308961A CN 01103955 CN01103955A CN1308961A CN 1308961 A CN1308961 A CN 1308961A CN 01103955 CN01103955 CN 01103955 CN 01103955 A CN01103955 A CN 01103955A CN 1308961 A CN1308961 A CN 1308961A
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- psoralen
- medicine
- lanoline
- water
- cream preparation
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Abstract
A medicine for treating dermatopathy is disclosed. It is a 1-4% psoralen cream prepared from psorlen extracted from psoralea fruit, and features that it is applied in conjunction with the light source of photochemical therapeutic apparatus for dermatopathy. Its advantages are high curative effect, no by-effect and no irritation to skin. Its cure rate is 86% for psoriasis or 70% for leukoderma. Its effective rate is 95% for psoriasis or 97% for leukoderma.
Description
The present invention relates to the dermopathic medicine of a kind of treatment.
Dermatosis such as psoriasis, vitiligo etc. are some commonly encountered diseases, and the method for treatment is also a lot, for example treat psoriasis, but the external hormone preparation, also available oral or intravenous administration, they mostly are hormone or even chemotherapeutics greatly, though short-term is effective, but side effect is big; And for example the vitiligo patient adopts treatment by Chinese herbs mostly, and effect is very undesirable, " the Chinese skin magazine " statistical result showed in 1992～1997 years, and effective percentage is no more than 30%.Be to be that main medicine is treated psoriasis in motherland's traditional Chinese medical science ancient prescription with the Fructus Psoraleae bean, vitiligo, found in the treatment clinical course afterwards, after the patient takes the Fructus Psoraleae bean, through illumination, curative effect is improved, therefore people think and contain photoactive substance in the Fructus Psoraleae bean, so people wear into fine powder with the Fructus Psoraleae bean, taking out a kind of photosensitizing chemical material with alcoholic extract is psoralen, doctor trained in Western medicine is mixed with i.e. 2% the psoralen spirit solvent medicine for external use of tincture with it, some people also cooperates black light lamp to treat psoriasis and vitiligo this medicine, has curative effect preferably, but the tincture external has following shortcoming: (1) to the psoriatic, ethanol has local irritant effect, thereby influences therapeutic effect; (2) for the vitiligo patient, tincture and because tincture is liquid, easily flows on the normal skin around the affected part except that local excitation, makes normal skin stay pigment, presents the underworld road.
The objective of the invention is to overcome the shortcoming of prior art, propose a kind of external cream preparation that contains psoralen evident in efficacy.
Main technical schemes of the present invention: psoralen is joined in the water in oil substrate, through emulsifying make cream preparation and and the light source combination that provides of photochemistry instrument for curing skin diseases carry out photochemotherapy.
The present invention is by 2-4% psoralen ointment and provides emission wavelength to be constituted by the light source of 320～400nm.
The preparation method of cream preparation of the present invention may further comprise the steps:
(1) psoralen is added in the lanoline, stirred 50-60 minute down at 75 ℃, it is dissolved fully, the weight ratio of described psoralen and lanoline is 4～8: 92～96,
(2) the water-soluble phase of the ointment substrate of weight such as in the psoralen after step (1) dissolving, add,, make required cream preparation with mulser emulsifying 24 hours.
Step (2) water-soluble phase component of described ointment substrate and content (by weight percentage) thereof: lanoline 40%, potassium hydroxide 0.7%, dimethicone 10%, water 49.3%, said components gets final product through mixing emulsifying.
Psoralen of the present invention and other material all are commercial products.
Medicine of the present invention is applicable to the dermatosis that comprises psoriasis, vitiligo and chronic eczema, chronic dermatitis, alopecia areata, concrete using method: at first clean skin lesion position skin before the patient uses, outer then one deck ointment of the present invention that is coated with, consumption is 5g/100cm usually
2Carry out illumination with photochemistry instrument for curing skin diseases light source after 30～60 minutes, at distance light source 10-15cm place, treatment time is 4 minutes first, the next day once, after the rayed 5 times, increase by 30 second irradiation time, no longer than 10 minutes, general 20 times one courses of treatment, can reach promising result 2 courses of treatment.
Light source of the present invention is photochemistry instrument for curing skin diseases light source (seeing Fig. 1 and Fig. 2).By illustrated in figures 1 and 2, light source is made up of sphere sealing glass bulb 2, socket 1, polar filament 3, hydrargyrum 4 and body 5.Glass bulb 2 is provided with the polar filament 3 that connects electricity, and the two ends of body 5 are provided with socket 1, and socket 1 is installed on the lamp socket; Hydrargyrum 4 is housed in the glass bulb 2, behind power connection, vaporized mercury, the light (its peak value is 365nm) of 320～400nm wavelength that having produced cures the disease acts on.Because the middle part of glass bulb 2 is a spheroidal, its light source is a point source, and light is stable, and the characteristic of concentration of hot spot is good.
Major advantage of the present invention:
External cream preparation of the present invention is owing to contain the 2-4% psoralen, and combine with the light source of photochemistry instrument for curing skin diseases and to carry out photochemical therapy, therefore evident in efficacy, and to the body non-evident effect, as use the fluorescent lamp, its light contains long wave, medium wave and shortwave, and in, shortwave light do not have therapeutical effect, and can have side effects; Contain lanoline and alkali components in the ointment of the present invention, skin lesion place to the psoriatic has good protective action and emollescence, avoid the shortcoming of the chafe of tincture, vitiligo has equally also been had good protective action, therefore improved curative effect; Using method of the present invention is simple, convenient, is applicable to special outpatient clinic and patient treatment voluntarily at home.
External ointment of the present invention combines with the light source of photochemistry instrument for curing skin diseases and carries out photochemotherapy, treatment psoriatic effective percentage is 95%, cure rate is 86% (seeing table 1 for details), treatment vitiligo patient 68 examples, 48 examples of fully recovering, produce effects 8 examples, 10 examples that take a turn for the better, invalid 2 examples, promptly effective percentage is 97%, cure rate is 70%.
Further specify characteristics of the present invention below by instantiation.
Embodiment
This example is the cream preparation of preparation 4% psoralen, and concrete preparation process is as follows:
With the 1kg psoralen join the 11.5kg lanoline mutually in, stirred 45 minutes down at 75 ℃, it dissolved fully, the psoralen after will dissolving then join 12.5kg ointment substrate water-soluble mutually in, with mulser emulsifying 24 hours, promptly make required product.The color of product is creamy white.Table 1
* matched group is conventional for oral administration and external therapy.
| Project | Cure | Produce effects | Effectively | Invalid |
| The treatment group, people * matched group, people | ?34 ?19 | ?2 ?8 | ?1 ?1 | ????1 ????1 |
Claims (4)
1. the medicine of a treating dermatopathy by photochemical therapy is characterized in that it being that light source by the instrument for curing skin diseases of the cream preparation of 2-4% psoralen and emission wavelength 320～400nm is constituted.
2. according to the described medicine of claim 1, it is characterized in that the preparation process of described cream preparation may further comprise the steps:
(1) psoralen is added in the lanoline, stirred 50-60 minute down at 75 ℃, it is dissolved fully, the weight ratio of described psoralen and lanoline is 4～8: 92～96,
(2) the water-soluble phase of the ointment substrate of weight such as in the psoralen after step (1) dissolving, add,, make required cream preparation with mulser emulsifying 24 hours.
3. according to the described medicine of claim 2, it is characterized in that water-soluble phase component of the described ointment substrate of step (2) and percetage by weight thereof: lanoline 40%, potassium hydroxide 0.7%, dimethicone 10%, water 49.3%.
4. according to the described medicine of claim 1, it is characterized in that the light-source structure of described instrument for curing skin diseases: establish spherical sealing glass bulb at the body middle part, be provided with polar filament in the glass bulb and hydrargyrum is housed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103955 CN1308961A (en) | 2001-02-16 | 2001-02-16 | Medicine for treating dermatopathy by photochemical therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103955 CN1308961A (en) | 2001-02-16 | 2001-02-16 | Medicine for treating dermatopathy by photochemical therapy |
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| CN1308961A true CN1308961A (en) | 2001-08-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01103955 Pending CN1308961A (en) | 2001-02-16 | 2001-02-16 | Medicine for treating dermatopathy by photochemical therapy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711246A (en) * | 2007-04-08 | 2010-05-19 | 免疫之光有限责任公司 | Methods and systems for treating cell proliferation disorders |
-
2001
- 2001-02-16 CN CN 01103955 patent/CN1308961A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711246A (en) * | 2007-04-08 | 2010-05-19 | 免疫之光有限责任公司 | Methods and systems for treating cell proliferation disorders |
| CN104027809A (en) * | 2007-04-08 | 2014-09-10 | 免疫之光有限责任公司 | Methods and systems for treating cell proliferation disorders |
| US9352040B2 (en) | 2007-04-08 | 2016-05-31 | Immunolight, Llc. | Methods and systems for treating cell proliferation disorders |
| US9358292B2 (en) | 2007-04-08 | 2016-06-07 | Immunolight, Llc | Methods and systems for treating cell proliferation disorders |
| US9682146B2 (en) | 2007-04-08 | 2017-06-20 | Immunolight, Llc. | Methods and systems for treating cell proliferation related disorders |
| CN104027809B (en) * | 2007-04-08 | 2017-08-25 | 免疫之光有限责任公司 | Treat the method and system of cell proliferation disorders |
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