CN101181603A - Facial palsy correcting paste and preparation method thereof - Google Patents
Facial palsy correcting paste and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a facial palsy rectify patch and a treatment method. The rectify patch consists of medicines and the patches for bearing the medicines. The medicines are made of master medicines and auxiliary medicines. The master medicines comprise the medicines as follows: radix astragali, cassia twig, gambir plant, red peony, salvia miltiorrhiza, szechuan lovage rhizome, kudzuvine root, great burdock achene, earthworm, weeping forsythiae capsule, baical skullcap root, honeysuckle flower, medcinal evodia fruit, zedoary root, turmeric, divaricate saposhnikovia root, magnetite, Bungarus multicinctus, Chinese sage herb, simpleleaf shrub chastetree fruit and paris polyphylla; while the auxiliary medicines comprise one milliliter of laurocapam with a concentration of one percent. The invention can make full use of the Chinese medicine effect and has quick medical effect and obvious efficacy; the medicine is stuck at the joints, channels and collaterals on the surface corresponding to the human body viscera so as to exert a certain positive excitation, so that the nerves can change during the process of energy conversion and information coding; the invention also can activate, enhance, decrease or deactivate some enzymes inside the cell, thereby promoting the body own solution and the recovery ability through the nerves and the internal secretion so as to cure diseases and eliminate symptoms.
Description
Technical field
The present invention relates to a kind of Chinese medicine plaster, and preparation method thereof.
Background technology
Facial paralysis is a facial paralysis, is to be a kind of commonly encountered diseases of principal character with facial expression muscle group dyskinesia, and general symptom is a facial hemiparalysis.It is a kind of commonly encountered diseases, frequently-occurring disease, and it is not subjected to age limit.Actions such as patient's face is often the most basic lifts eyebrow, close one's eyes, drum mouth all can't be finished.
The traditional Chinese medical science thinks that primary disease is many by positive QI-insufficiency, collaterals being void and defenceless, weakened defensive QI, the ailment said due to cold or exposure apoplex involving the channels and collaterals of taking advantage of a weak point, the resistance of QI and blood numbness, facial foot sun is bright lose in moistening foster so that muscle vertical slow do not receive due to.Many employing acupuncture are main on the treatment facial paralysis, perhaps use oral medicinal herb, acupuncture often acts on the facial paralysis initial stage, and effect is not ideal enough, and oral medicinal herb, owing to be subjected to the administration kind, time, decompose excretory influence in dosage and the body, make the blood drug level instability, the diseased region drug level is low, thereby influences the defective of the curative effect of facial paralysis, therefore clinically, no matter these Therapeutic Method use separately or partner treatment, all can not accomplish the end in view, and often stay light or heavy sequela to the patient easily, even aggravate disease, cause facial edema or subcutaneous hemorrhage.
Summary of the invention
Problem at prior art exists the objective of the invention is to overcome above-mentioned shortcoming, and facial palsy correcting card a kind of easy to use, evident in efficacy and preparation method thereof is provided.
The present invention solves the technical scheme that its technical problem takes: a kind of facial palsy correcting paste, and it is made up of medicine and medicament-carried paster, and described medicine is made by principal agent and accessory drugs, and described principal agent is made up of the medicine of following weight: the Radix Astragali 15～20 grams; Ramulus Cinnamomi 8～12 grams; Ramulus Uncariae Cum Uncis 12～16 grams; Radix Paeoniae Rubra 12～16 grams; Radix Salviae Miltiorrhizae 10～15 grams; Rhizoma Chuanxiong 10～15 grams; Radix Puerariae 12～16 grams; Fructus Arctii 10～15 grams; Pheretima 8～12 grams; Fructus Forsythiae 10～16 grams; Radix Scutellariae 10～15 grams; Flos Lonicerae 10～16 grams; Fructus Evodiae 8～12 grams; Rhizoma Curcumae 8～12 grams; Rhizoma Curcumae Longae 10～16 grams; Radix Saposhnikoviae 10～16 grams; Magnetitum 25～50 grams; Agkistrodon 8～12 grams; Herba Salviae Chinensis 15～20 grams; Fructus Viticis 12～16 grams; Rhizoma Paridis 15～20 grams, described accessory drugs is: 150～200 milliliters of 1% laurocapram.
Described facial palsy correcting paste, described principal agent is made up of the medicine of following weight: the Radix Astragali 15 grams; Ramulus Cinnamomi 8 grams; Ramulus Uncariae Cum Uncis 12 grams; Radix Paeoniae Rubra 12 grams; Radix Salviae Miltiorrhizae 105 grams; Rhizoma Chuanxiong 10 grams; Radix Puerariae 12 grams; Fructus Arctii 10 grams; Pheretima 8 grams; Fructus Forsythiae 10 grams; Radix Scutellariae 10 grams; Flos Lonicerae 10 grams; Fructus Evodiae 8 grams; Rhizoma Curcumae 8 grams; Rhizoma Curcumae Longae 10 grams; Radix Saposhnikoviae 10 grams; Magnetitum 25 grams; Agkistrodon 8 grams; Herba Salviae Chinensis 15 grams; Fructus Viticis 12 grams; Rhizoma Paridis 15 grams, described accessory drugs is: 150 milliliters of 1% laurocapram.
Described facial palsy correcting paste, described principal agent is made up of the medicine of following weight: the Radix Astragali 20 grams; Ramulus Cinnamomi 12 grams; Ramulus Uncariae Cum Uncis 16 grams; Radix Paeoniae Rubra 16 grams; Radix Salviae Miltiorrhizae 15 grams; Rhizoma Chuanxiong 15 grams; Radix Puerariae 16 grams; Fructus Arctii 15 grams; Pheretima 12 grams; Fructus Forsythiae 16 grams; Radix Scutellariae 15 grams; Flos Lonicerae 16 grams; Fructus Evodiae 12 grams; Rhizoma Curcumae 12 grams; Rhizoma Curcumae Longae 16 grams; Radix Saposhnikoviae 16 grams; Magnetitum 50 grams; Agkistrodon 12 grams; Herba Salviae Chinensis 20 grams; Fructus Viticis 16 grams; Rhizoma Paridis 20 grams, described accessory drugs is: 200 milliliters of 1% laurocapram.
Described facial palsy correcting paste, described principal agent is made up of the medicine of following weight: the Radix Astragali 18 grams; Ramulus Cinnamomi 10 grams; Ramulus Uncariae Cum Uncis 14 grams; Radix Paeoniae Rubra 14 grams; Radix Salviae Miltiorrhizae 13 grams; Rhizoma Chuanxiong 13 grams; Radix Puerariae 14 grams; Fructus Arctii 13 grams; Pheretima 10 grams; Fructus Forsythiae 13 grams; Radix Scutellariae 13 grams; Flos Lonicerae 13 grams; Fructus Evodiae 10 grams; Rhizoma Curcumae 10 grams; Rhizoma Curcumae Longae 13 grams; Radix Saposhnikoviae 13 grams; Magnetitum 37 grams; Agkistrodon 10 grams; Herba Salviae Chinensis 18 grams; Fructus Viticis 14 grams; Rhizoma Paridis 18 grams, described accessory drugs is: 180 milliliters of 1% laurocapram.
The method for preparing described facial palsy correcting card, the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Radix Puerariae, Fructus Arctii, Pheretima, Agkistrodon, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Fructus Evodiae, Rhizoma Curcumae, Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Salviae Chinensis, Fructus Viticis, Magnetitum after the processing process of preparing Chinese medicine are taken by weighing by required weight, and pulverized sieve No. six, add 1% laurocapram mix homogeneously paste making agent then, it is standby to have carried out sponge ring on the non-woven fabrics paster in advance, then the unguentum made is put into sponge ring according to the weight of each plaster 5 gram.
Facial paralysis is many because of wind and cold invasion and attack, vasospasm, facial nerve tissue ischemia, edema and adhesion.The Radix Astragali is set upright consolidating superficial resistance among the present invention, improves immunity; Ramulus Cinnamomi, Fructus Evodiae warming the meridian expansion facial vessels; Agkistrodon, Ramulus Uncariae Cum Uncis, Fructus Viticis dispelling wind and removing obstruction in the collateral are removed facial spasm; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Puerariae are invigorated blood circulation, microcirculation improvement; Rhizoma Curcumae Longae, Rhizoma Curcumae antiinflammatory alleviate edema; Fructus Arctii prevents the nerve fiber degeneration; Pheretima can promote acetylcholine to discharge, and muscular strength and muscular tension are improved; Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Rhizoma Paridis, Herba Salviae Chinensis heat-clearing and toxic substances removing, antibacterium, virus; Cooperate Magnetitum can improve nervus facialis blood circulation and nutritional status, diminish inflammation, adjust nervous function, promote the functional recovery of nervus facialis, alleviate face muscle spasm, improve the irritability of nervus facialis, the atrophy of prevention facial muscle.Facial palsy correcting paste of the present invention has changed internal treatment's administration and has been subjected to decompose in administration kind, time, dosage and the body excretory the influence, make the blood drug level instability; the diseased region drug level is low; thus the defective of the curative effect of facial paralysis influenced; be administered to the part; so the drug level of local organization is apparently higher than haemoconcentration; make Chinese medicine effect performance fully; the drug effect performance is rapidly; evident in efficacy; medicine sticks on relevant acupuncture point of internal organs body surface and the meridians and imposes certain optimal stimulation simultaneously, make neurally in power conversion, information cataloged procedure, to change; Can activate again, strengthen, weaken or as killed cells in some enzymes, by nerve and endocrine approach, promote the key to exercises of body self and repair ability and treat disease, eliminate symptom.Therefore instant effect and lasting.In addition, because facial palsy correcting paste is by the meridional point medication, its selectivity, specific aim are stronger, thereby can avoid the toxic and side effects of medicine to liver and other organs, thereby safe and reliable.Have wide range of applications, men and women, old and young adapt to, and are therefore owned by France in the external treatment category, do not have misery to be easy to be accepted by the patient.And the medicine external treatment generally needs dosage less, can save the medicine source, cuts down expenses, and some medicine can be gathered materials on the spot, easy easy victory, and expense is cheap.
The specific embodiment
Embodiment one:
Facial palsy correcting paste, it is made up of medicine and medicament-carried paster, and medicine is made by principal agent and accessory drugs, and described principal agent is made up of the medicine of following weight: the Radix Astragali 15 grams; Ramulus Cinnamomi 8 grams; Ramulus Uncariae Cum Uncis 12 grams; Radix Paeoniae Rubra 12 grams; Radix Salviae Miltiorrhizae 15 grams; Rhizoma Chuanxiong 10 grams; Radix Puerariae 12 grams; Fructus Arctii 10 grams; Pheretima 8 grams; Fructus Forsythiae 10 grams; Radix Scutellariae 10 grams; Flos Lonicerae 10 grams; Fructus Evodiae 8 grams; Rhizoma Curcumae 8 grams; Rhizoma Curcumae Longae 10 grams; Radix Saposhnikoviae 10 grams; Magnetitum 25 grams; Agkistrodon 8 grams; Herba Salviae Chinensis 15 grams; Fructus Viticis 12 grams; Rhizoma Paridis 15 grams, described accessory drugs is: 150 milliliters of 1% laurocapram.
The Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Radix Puerariae, Fructus Arctii, Pheretima, Agkistrodon, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Fructus Evodiae, Rhizoma Curcumae, Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Salviae Chinensis, Fructus Viticis, Magnetitum after the processing process of preparing Chinese medicine are taken by weighing by required weight, and pulverized sieve No. six, (sieve aperture internal diameter (meansigma methods) 150 μ m ± 6.6 μ m) add 1% laurocapram mix homogeneously paste making agent then, it is standby to have carried out sponge ring on the non-woven fabrics paster in advance, then the unguentum made is put into sponge ring according to the weight of each plaster 5 gram.
Embodiment two
Facial palsy correcting paste, it is made up of medicine and medicament-carried paster, and medicine is made by principal agent and accessory drugs, and described principal agent is made up of the medicine of following weight: the Radix Astragali 20 grams; Ramulus Cinnamomi 12 grams; Ramulus Uncariae Cum Uncis 16 grams; Radix Paeoniae Rubra 16 grams; Radix Salviae Miltiorrhizae 15 grams; Rhizoma Chuanxiong 15 grams; Radix Puerariae 16 grams; Fructus Arctii 15 grams; Pheretima 12 grams; Fructus Forsythiae 16 grams; Radix Scutellariae 15 grams; Flos Lonicerae 16 grams; Fructus Evodiae 12 grams; Rhizoma Curcumae 12 grams; Rhizoma Curcumae Longae 16 grams; Radix Saposhnikoviae 16 grams; Magnetitum 50 grams; Agkistrodon 12 grams; Herba Salviae Chinensis 20 grams; Fructus Viticis 16 grams; Rhizoma Paridis 20 grams, described accessory drugs is: 200 milliliters of 1% laurocapram.
The Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Radix Puerariae, Fructus Arctii, Lumbricus, Agkistrodon, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Fructus Evodiae, Rhizoma Curcumae, Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Salviae Chinensis, Fructus Viticis, Magnetitum after the processing process of preparing Chinese medicine are taken by weighing by required weight, and pulverized sieve No. six, (sieve aperture internal diameter (meansigma methods) 150 μ m ± 6.6 μ m) add 1% laurocapram mix homogeneously paste making agent then, it is standby to have carried out sponge ring on the non-woven fabrics paster in advance, then the unguentum made is put into sponge ring according to the weight of each plaster 5 gram.
Embodiment three
Facial palsy correcting paste, it is made up of medicine and medicament-carried paster, and medicine is made by principal agent and accessory drugs, and described principal agent is made up of the medicine of following weight: the Radix Astragali 18 grams; Ramulus Cinnamomi 10 grams; Ramulus Uncariae Cum Uncis 14 grams; Radix Paeoniae Rubra 14 grams; Radix Salviae Miltiorrhizae 13 grams; Rhizoma Chuanxiong 13 grams; Radix Puerariae 14 grams; Fructus Arctii 13 grams; Pheretima 10 grams; Fructus Forsythiae 13 grams; Radix Scutellariae 13 grams; Flos Lonicerae 13 grams; Fructus Evodiae 10 grams; Rhizoma Curcumae 10 grams; Rhizoma Curcumae Longae 13 grams; Radix Saposhnikoviae 13 grams; Magnetitum 37 grams; Agkistrodon 10 grams; Herba Salviae Chinensis 18 grams; Fructus Viticis 14 grams; Rhizoma Paridis 18 grams, described accessory drugs is: 180 milliliters of 1% laurocapram.
The Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Radix Puerariae, Fructus Arctii, Pheretima, Agkistrodon, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Fructus Evodiae, Rhizoma Curcumae, Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Salviae Chinensis, Fructus Viticis, Magnetitum after the processing process of preparing Chinese medicine are taken by weighing by required weight, and pulverized sieve No. six, (sieve aperture internal diameter (meansigma methods) 150 μ m ± 6.6 μ m) add 1% laurocapram mix homogeneously paste making agent then, it is standby to have carried out sponge ring on the non-woven fabrics paster in advance, then the unguentum made is put into sponge ring according to the weight of each plaster 5 gram.
Usage and dosage
Before each plaster, earlier local skin is cleaned on the mid point that degrease then is affixed on disease side " ShiShimonoseki " and " cheek car " two cave lines.Changed once in per three days, each one pastes.
The facial palsy correcting paste advantage has four:
1, through sick institute, curative effect is rapid and lasting:
Facial palsy correcting paste has changed the defective of internal treatment's administration, owing to be subjected to decompose in administration kind, time, dosage and the body excretory the influence, make the blood drug level instability; the diseased region drug level is low, thereby influence the curative effect of facial paralysis, facial palsy correcting paste is administered to the part; so the drug level of local organization is apparently higher than haemoconcentration; and make traditional Chinese medical science effect performance fully, the drug effect performance is rapidly, and is evident in efficacy.Medicine sticks on relevant acupuncture point of internal organs body surface and the meridians and imposes certain optimal stimulation, and nerve is changed in power conversion, information cataloged procedure; Can activate again, strengthen, weaken or as killed cells in some enzymes, by nerve and endocrine approach, promote the key to exercises of body self and repair ability and treat disease, eliminate symptom.Therefore instant effect and lasting.
2. safe and reliable:
Facial palsy correcting paste is by the meridional point medication, and its selectivity, specific aim are stronger, thereby can avoid the toxic and side effects of medicine to liver and other organs, thereby safe and reliable.
3. be widely used:
Facial palsy correcting paste has wide range of applications, and men and women, old and young adapt to, and is therefore owned by France in the external treatment category, do not have misery to be easy to be accepted by the patient.
4. economic and practical:
The medicine external treatment generally needs dosage less, can save the medicine source, cuts down expenses, and some medicine can be gathered materials on the spot, easy easy victory, and expense is cheap.
Facial palsy correcting paste absorbs approach and principle
Facial palsy correcting paste belongs to the external treatment medicine, points out in the late Qing Dynasty external treatment expert Wu Shiji " Li Yue Pianwen, Rhymed Discourse for Topical Remedies ": " medicine of external treatment is the medicine of treatment by oral administration of medicines, different person's method ear for the reason of external treatment, the i.e. reason of treatment by oral administration of medicines.The reason medicine does not have two, and the magical change of rule ".Based on this theory, external treatment and treatment by oral administration of medicines are identical on this cause of disease, pathogenesis, dialectical, medication scheduling theory, it is the medication difference, absorption approach difference, but all be that to administer opinion with the organic conception of Chinese medicine and dialectical opinion be guidance, use different maneuvers, different medicines impose on face skin through the cave, position such as meridians muscles and bones, with the performance drug effect, reach the purpose of curing the disease, study carefully its principle and can be divided into general action and local directly or indirectly effect.
Motherland's medical science thinks that each is main to some extent for internal organs, respectively has and has one's ideas straightened out, each is logical to some extent, and each is will to some extent, respectively have its " 12 warps; 365 networks, all row in face and the key of making excessive money by giving performance ", link to each other with the skin flesh natural fibre line of meat outward, in communicate with the vital organs of the human body, operation whole body QI and blood, link up up and down inside and outside, so the internal organs disease by lead, place, its China, have one's ideas straightened out, meridianal reflection in outside, this what is called " Zhu Nei is arranged and shape all outer ", same external treatment also can make the efficacy of a drug reach in interior by meridians, acupuncture points on the human body, hole key, body surface.Treat as the special acupuncture points on the human body (Xiache point) at facial paralysis, facial spasm and lung, spleen, kidney channel network traveling position etc. and reach corresponding curative effect.In a word, the reason of external treatment is exactly by the getting in touch of internal organs meridians and body surface, by physics or medicine directly, indirect action and curing the disease in reaching.This what is called " just sick and cure the disease, skin every and the hair key is logical, lose internal organs and just through internal organs ".
Modern medicine thinks that external treatment absorption approach is that medicine sees through epiderm skin and enters corium, absorbed by blood capillary to enter the body circulation, and the general action of performance medicine reaches therapeutic purposes.
The mechanism of action of inner disease outer treat medicine or method is more complicated in a word, is by three kinds of effects once but conclude, and directly or indirectly produces curative effect.
1. local irritant effect
After having the medicine irritation acupuncture point of certain stimulation, make local vascular dilation, accelerate blood circulates and improves surrounding tissue nutrition, can play the effect of antiinflammatory detumescent; The medicine that some zest is strong is regulated body function by the strong stimulation neural reflex, and the formation of enhancing antibody improves immunity.
2. drug absorption
Medicine enters blood circulation, lymphsystem by skin absorbs, and then reaches in the body, produces the drug effect of general.As plastering therapy treatment facial paralysis, facial spasm is to utilize the general action of medicine to reach the purpose of curing the disease.
3. meridians are transferred the weighing apparatus effect
Utilize warm performances medicine or non-medicine medium to acupoint stimulation, the effect of can produce promoting the flow of QI in the collateral by warming the meridian, promoting flow of QI and blood, expellingging wind and relieving convulsion.Adjustment by meridians reaches reinforce insufficiency and reduce excessiveness, promotes the effect of equilibrium between yin and yang, YIN and YANG in a relative equilibrium, life activities being normally maintained.
Correlation test:
One pharmacodynamics test
1, test objective
According to the attending effectiveness of facial palsy correcting paste, study its main pharmacodynamics, for clinical practice provides foundation.
2, test material
Tried thing: title: " facial palsy correcting paste ", content 5g cream/open
Source: provide by Beijing state dragon hospital
Positive control drug: title: big blood circulation activating plaster
Lot number: the ZZ-3053-Ji is defended the accurate word (1995) 4042 of medicine
The source: pharmaceutcal corporation, Ltd provides by the Tonghua, Jilin Province
Animal: title: Kunming mouse
Source: available from Chinese Academy of Medical Sciences's Experimental Animal Center
The quality certification number: the moving word 06-3001 of doctor
Instrument:
Ultraviolet spectrophotometer model UV-265 Japan produces
Microscope model OlympusCH-2 Germany produces
Electronic balance model JP-300 Japan produces
3, method and result
(1), collagen protein-epinephrine being brought out inhibitory action that the mice thrombus in vivo forms, to get the Kunming kind healthy little 66, body weight 18-20g is divided into 5 groups at random by body weight, be respectively blank group, model group, positive controls, tried the heavy dose of group of thing, tried the thing low dose group, every group 12, male and female half and half.Modeling in first day: aseptic condition extracts the mouse ascites that went down to posterity the 7th day down, after normal saline dilution in 1: 2, gets the 0.2ml injection and respectively organizes the right axil of mice subcutaneous (except the blank group).After one week of modeling, each organizes preserved skin: with the right oxter of mice inoculation position preserved skin, receive depilation with 8% sulfuration, and the area equalization (4 square centimeters) of losing hair or feathers, topical administration, the blank group is to consubstantiality hydrops gauze; The big blood circulation activating plaster 4cm of positive controls external application
2Tried the thing group respectively by 0.44g/4cm
2, 0.11g/4cm
2The external application administration, and fix with suitable method.Change dressings once one week of successive administration every day.After the administration the 8th day, see the death toll of mice, the mice hemiplegia was recovered number and was not recovered number in the 9th day, the results are shown in Table 1,2,3.
The inhibitory action (first result of the test) that table 1 facial palsy correcting paste forms the mice thrombus in vivo
| Group | Number of animals (only) | Dosage (g/cm 2) | Specimen amount (g) | Suppression ratio (%) |
| The model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 | 10ml/kgN.S 4cm 2 0.12g/cm 2 0.03g/cm 2 | 0.259±0.124 1.007±0.512 ** 2.206±0.17 ** 1.49±0.198 ** | 21.93 34.7 39.7 |
The t check: compare with model group,
*P＜0.01
The inhibitory action (second batch of result of the test) that table 2 facial palsy correcting paste forms the mice thrombus in vivo
| Group | Number of animals (only) | Dosage (g/cm 2) | Specimen amount (g) | Suppression ratio (%) |
| The model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 | 10ml/kgN.S 4cm 2 0.12g/cm 2 0.03g/cm 2 | 0.259±0.124 1.007±0.512 ** 2.206±0.17 ** 1.49±0.198 ** | 21.93 34.7 39.7 |
The t check: compare with model group,
*P＜0.01
The inhibitory action (the 3rd batch of result of the test) that table 3 facial palsy correcting paste forms the mice thrombus in vivo
| Group | Number of animals (only) | Dosage (g/cm 2) | Specimen amount (g) | Suppression ratio (%) |
| The model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 | 10ml/kgN.S 4cm 2 0.12g/cm 2 0.03g/cm 2 | 0.259±0.124 1.007±0.512 ** 2.206±0.17 ** 1.49±0.198 ** | 21.93 34.7 39.7 |
The t check: compare with model group,
*P＜0.01
The result shows: compare with model group, each administration group all has certain inhibitory action to the formation of mice thrombus in vivo in the kunming mice body.
(2) analgesic activity
Get 66 of above-mentioned healthy mices, body weight 18-20g is divided into 5 groups at random by body weight, and be respectively blank group, model group, positive controls, tried the heavy dose of group of thing, tried the thing low dose group, 12 every group, male and female half and half.Modeling in first day: get peritoneal fluid with normal saline 1: 2 dilution after, get 0.2ml and inject and respectively organize the right axil of mice subcutaneous (except the blank group).After one week, dissect several, confirm the model success.Each organizes preserved skin: the right oxter of mice inoculation position is lost hair or feathers depilation area equalization (4 square centimeters), the external drug of topical application with 8% sodium sulfide; The blank group same volume that feeds water; The big blood circulation activating plaster 4cm of positive controls external application
2Tried the thing group respectively by 0.44g/4cm
2, 0.11g/4cm
2The external application administration, and fix with suitable method.Change dressings once one week of successive administration every day.After the administration the 18 day, weigh, each treated animal is placed on the metallic plate that is heated to 55 ℃ in advance, serve as the pain indicator reaction to add metapedes, the pain response time prolongs person more than a times after the administration, as effective analgesic activity.The results are shown in Table 4
The hot plate test result of table 4 experiment mice
| Group | Number of animals (only) | Dosage (g/cm 2) | Occur licking the sufficient time (x ± sd) |
| Blank group model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 12 | 10ml/kgN.S 10ml/kgN.S 4cm 2 0.12 0.03 | 2.68±0.21 ** 0.259±0.124 1.007±0.512 ** 2.206±0.17 ** 1.49±0.198 ** |
Compare with model group
*P＜0.01
The result shows, with the blank group relatively. four groups of model group etc. are licked the foot time and are obviously shortened (P＜0.01); Compare positive controls, " facial palsy correcting paste " heavy dose of group and subtotal amount group with model group; Can obviously prolong and add foot reaction time of occurrence (P＜0.01); Compare with positive group, tried the large and small dosage group of thing and can obviously prolong antihistamine reaction time of occurrence (p＜0.01).
(3), the influence that the mice acetic acid twisting is reacted
Get 66 of above-mentioned healthy mices, body weight 18-20g is divided into 5 groups at random by body weight, and be respectively blank group, model group, positive controls, tried the heavy dose of group of thing, tried the thing low dose group, 12 every group, male and female half and half.Modeling in first day: get peritoneal fluid with normal saline 1: 2 dilution after, get 0.2ml and inject and respectively organize the right axil of mice subcutaneous (except the blank group).After one week, dissect several, confirm the model success.Each organizes preserved skin: the right oxter of mice inoculation position is lost hair or feathers depilation area equalization (4 square centimeters), the external drug of topical application with 8% sodium sulfide; The blank group same volume that feeds water; The big blood circulation activating plaster 4cm of positive controls external application
2Tried the thing group respectively by 0.44g/4cm
2, 0.11g/4cm
2The external application administration, and fix with suitable method.Change dressings once one week of successive administration every day.Behind the last medicine 30 minutes. lumbar injection 0.6% acetic acid 0.2ml/ only,, observe each treated animal in 15 minutes and turn round the body number of times by what acetic acid caused.The results are shown in Table 3
The writhing test result of table 5 experiment mice
| Group | Number of animals (only) | Dosage (g/cm 2) | (x ± SD) (branch) appears licking the sufficient time |
| Blank group model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 12 | 10ml/kgN.S 10ml/kgN.S 4cm 2 0.12 0.03 | 21.4±2.221″ ** 36.5±2.221 25.8±2.394 ** 23±2.261 ** 28.3±214 ** |
The t check: compare with model group,
*P＞001
The result shows, compare with the blank group, the body number of times of turning round that model group, positive controls, " facial palsy correcting paste " small dose group acetic acid cause obviously increases (P＜0.01), " facial palsy correcting paste " dosage group is turned round the body number of times and is turned round the body number of times near normal mouse, and as seen being tried the thing heavy dose has tangible antitussive and antiasthmatic effect; Compare with model group, positive controls, " facial palsy correcting paste " large and small dosage group have significant difference (P＜0.01); Compare between " facial palsy correcting paste " large and small dosage group (P＜0.01).
(4), to the microcirculatory influence of mouse ear
Get 66 of above-mentioned healthy mices, body weight 18-20g is divided into 5 groups at random by body weight, is respectively the blank group, model group, and positive controls is tried the heavy dose of group of thing, is tried the thing low dose group, and 12 every group, male and female half and half.Modeling in first day: get peritoneal fluid with normal saline 1: 2 dilution after. get 0.2ml and inject and respectively organize the right axil of mice subcutaneous (except the blank group).After one week, dissect several, confirm the model success; Each organizes preserved skin: with the right oxter of mice inoculation position preserved skin, and with the depilation of 8% sodium sulfide, the area equalization (4 square centimeters) of losing hair or feathers, the external drug of topical application. the blank group same volume that feeds water; The big blood circulation activating plaster 4cm of positive controls external application
2: tried the thing group respectively by 0.44g/4cm
2, 0.11g/cm
2, the external application administration, and fix with suitable method.Change dressings once one week of successive administration every day.The 8th day, with 1% pentobarbital sodium lumbar injection 0.1ml/ only, after the anesthesia, be fixed on to drip with the adhesive plaster slice and have on the slide of paraffin oil making ear, micrometer is fixed on the microscope ocular, 10 times of amplifications, unified terminal crotch microvascular diameter of left auricle median vein and the blood flow rate situation of observing.The results are shown in Table 6
The auricular microcirculation of table 6.1 experiment mice
| Group | Number of animals (only) | Dosage (g/cm 2) | (x ± SD) (um) appears licking the sufficient time |
| Blank group model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 12 | 10ml/kgN.S 10ml/kgN.S 4cm 2 0.12 0.03 | 21.4±2.221″ ** 36.5±2.221 25.8±2.394 ** 23±2.261 ** 28.3±214 ** |
Annotate:
*P＜0.01 #P＜0.01 $P＜0.01
The result shows, compares model group, " facial palsy correcting paste " small dose group obvious difference (P＜0.01) with the blank group; Compare " facial palsy correcting paste " heavy dose of group obvious difference (P＜0.01) with model group; Compare P＜0.01 between " facial palsy correcting paste " large and small dosage group.
The auricular microcirculation of table 6.2 experiment mice
| Group | Animal (only) | Dosage (g/cm 2) | The flow classification | Gradit | |||
| I | II | III | IV | ||||
| Blank group model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 12 | 10ml/kgN.S 10ml/kgN.S 4cm 2 0.12 0.03 | 12 | 1 2 4 12 | 11 10 8 | * # ** ## | |
Remarks: #p＜0.01 ##P＜0.05 P＜0.01
*P＜0.05
I: blood flow is fast; II: blood flow is slow, granular sensation is arranged; III: blood flow is full, as silt; IV: blood flow comes to a halt;
The result shows, positive controls, and heavy dose of group of " facial palsy correcting paste " ointment and small dose group all can obviously be improved the Mice Auricle microcirculation, with blank group comparing difference remarkable (p＜0.01, p＜005), function of promoting blood circulation to disperse blood clots are arranged.
(5), to the influence of mice non-specific immunity
Get 66 of above-mentioned healthy mices, body weight 18-20g is divided into 5 groups at random by body weight, is respectively the blank group, model group, and positive controls is tried the heavy dose of group of thing, is tried the thing low dose group, and 12 every group, male and female half and half.Modeling in first day: get peritoneal fluid with normal saline 1: 2 dilution after. get 0.2ml and inject and respectively organize the right axil of mice subcutaneous (except the blank group).After one week, dissect several, confirm the model success; Each organizes preserved skin: with the right oxter of mice inoculation position preserved skin, and with the depilation of 8% sodium sulfide, the area equalization (4 square centimeters) of losing hair or feathers, the external drug of topical application. the blank group same volume that feeds water; The big blood circulation activating plaster 4cm of positive controls external application
2: tried the thing group respectively by 0.44g/4cm
2, 0.11g/cm
2, the external application administration, and fix with suitable method.Change dressings once one week of successive administration every day.The 8th day, with india ink dilution in 1: 2, get the 0.2ml mouse tail vein injection, 2min, behind the 10min, eye socket is got blood, surveys its OD value in ultraviolet 600nm.The results are shown in Table 7
The carbon clearance test result of table 7 experiment mice
| Group | Number of animals (only) | Dosage (g/cm 2) | Blood carbon clearance rate (k value) (x ± SD) | The liver spleen is engulfed coefficient (a) (x ± SD) |
| Blank group model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 12 | 10ml/kgN.S 10ml/kgN.S 4cm 2 0.12 0.03 | 0.035±0.022 0.020±0.012 0.029±0.008 0.032±0.022 3.537±1.065 | 4.026±1.792 1.379±0.62 2.918±0.472 3.537±1.065 2.757±0.669 |
Annotate:
*P＞0.05
The result shows that the blood carbon clearance rate regulating liver-QI spleen reticuloendothelial system phagocytic coefficient of experiment mice all is starkly lower than normal mouse, and " facial palsy correcting paste " heavy dose of group and small dose group, positive controls can make it to return near normal.
(6), " facial palsy correcting paste " is to the influence of mouse immune organ
Get 66 of above-mentioned healthy mices, body weight 18～20g is divided into 5 groups at random by body weight, and be respectively blank group, model group, positive controls, tried the heavy dose of group of thing, tried the thing low dose group, 12 every group, male and female half and half.Modeling in first day: get peritoneal fluid with normal saline 1: 2 dilution after, get 0.2ml and inject and organize the right axil of mice subcutaneous (except the blank group) fully.After one week, dissect several, confirm the model success; Each organizes preserved skin: the right axil of mice is foretold the inoculation position preserved skin, and with the depilation of 8% sodium sulfide, each group depilation area equalization (4 square centimeters), the external drug of topical application, blank group feedwater consubstantiality (4 square centimeters), the big blood circulation activating plaster 4cm of positive controls external application
2Tried the thing group respectively by 0.44g/4cm
2, 0.11g/cm
2, the external application administration, and fixed together with suitable method.It is one joyous to change dressings every day, one week of successive administration.The 8th day. put to death the back of weighing, and gets thymus, spleen.The results are shown in Table 8.
The influence of table 8 pair mice breast, spleen index
| Group | Number of animals (only) | Dosage (g/cm 2) | Thymus index (mg/g value) (x ± SD) | Spleen index (mg/g) (x ± SD) |
| Blank group model group positive controls is tried the heavy dose of group of thing and is tried the thing small dose group | 12 12 12 12 12 | 10ml/kgN.S 10ml/kgN.S 4cm 2 0.12 0.03 | 3.359±2.459 2.659±1.118 1.984±0.468 1.751±0.99 1.187±0.642 | 2.524±1.928 7.065±0.88 6.247±2.001 5.94±1.674 6.561±1.657 |
The result shows that the positive control of experiment mice, " facial palsy correcting paste " heavy dose of group, small dose group and model group compare, significant difference.
4, conclusion
The facial damaged tissues model of mice is selected in test for use, with " facial palsy correcting paste " the outer mouse skin position that spreads on, studies show that through a course of therapy main pharmacodynamics: " facial palsy correcting paste " heavy dose of group, the thrombosis that can significantly suppress experiment mice is with model group comparing difference remarkable (P＜0.05); Pain to the damage induced mice has analgesic activity; Can promote the Mice Auricle microcirculation, with model control group comparing difference remarkable (P＜0.05), prompting has function of promoting blood circulation to disperse blood clots; Can obviously improve is the thymus index of experiment mice, and prompting has certain immunoregulation effect (P＜0.05).
Two, facial palsy correcting paste skin acute toxicity test
1, test objective
Observation animal intact skin and damaged skin contact in short-term and are tried toxic reaction and the death condition that thing produces.
2, experiment material
Be subjected to the reagent thing: title: " facial palsy correcting paste " external-applied ointment
Source: Beijing state dragon hospital
Content: 5g crude drug/whenever put up cream
Excipient: title: Oleum Ricini
Source: Hubei Province's Tianmen City second pharmaceutical factory
No. 002177 lot number 980502 of the accurate word (1981) of medicine defended in Hubei Province
Animal origin: kind: Cavia porcellus (white)
The quality certification number: the moving word 01-3001 of doctor
Quantity: 40
Body weight: 0.20～0.25kg
Sex: male and female half and half
Source: available from Chinese Academy of Medical Sciences's animal center
3, method and result
Get above-mentioned healthy guinea pig (white), male and female half and half are weighed, and are divided into four groups of intact skin groups, damaged skin group, intact skin blank group, damaged skin blank group at random; With spinal column both sides, back unhairing (using 8% sodium sulfide), the unhairing area was about 20% (the about 40cm of Cavia porcellus of body surface area in preceding 24 hours of administration
2), the damaged skin group rubs with 300 order tissue papers, the degree of being with the oozing of blood.(left side is for being tried the thing district, and the right side is the check plot).
To be tried thing, figuration jasmine and be coated on each treated animal depilation district equably, and be fixed with proper method.Dosage is 20.8g/kg (excipient tie up to the volume excipient). applies and tried thing after 24 hours, remove the residual thing that tried with warm water, at once with observe reaction of animals every day: body weight, hair, skin, extremity activity, ingest, symptom such as drainage, and observe once continuous seven days every day.After weighing in the 8th day, put to death.When the naked eyes pathological changes is arranged, draw materials and do pathology.The results are shown in Table 1 table 2.
Table 1. facial palsy correcting adhesive plaster intact skin administration acute experiment result
| Group | Number of animals (only) | Body weight (kg) X ± SD before the administration | Body weight kg after the administration) X ± SD | Reaction of animals after the administration | Complete skin | ||||
| Hair | The extremity activity | Ingest | Drain | Dead | |||||
| Skin combination medicine group intact skin blank group | 4 4 | 253.5±17.48 253±15.846 | 298.33±26.45 279±20.79 | - - | - - | - - | - - | 0 0 | |
Annotate: "-" expression is normal
Table 2. " facial palsy correcting paste " ointment damaged skin administration acute experiment result
| Group | Number of animals (only) | Body weight (kg) X ± SD before the administration | Body weight kg after the administration) X ± SD | Reaction of animals after the administration | ||||
| Hair | The extremity activity | Ingest | Drain | Dead | ||||
| Damaged skin administration group damaged skin blank group | 4 4 | 335.56±13.33 307.778±13.94 | 356±28.36 353±23.59 | - - | - - | - - | - - | 0 0 |
Annotate: "-" is normal
4, conclusion
By this result of the test, illustrate that intact skin administration group, damaged skin administration group Cavia porcellus tried thing with Cmax through skin, be administered once in one day.Agent is 20g/kg the most, and the blank group is given the equivalent excipient, and administration was used the warm water flush away after 24 hours.At once with observe Cavia porcellus reaction every day: skin, hair, extremity activity, ingest, symptom such as drainage, continuous 7 days, Cavia porcellus no abnormality seen as a result, all survivals, weight increase is not seen the overt toxicity reaction with the blank group.
Three, facial palsy correcting paste administration skin anaphylactic test
1, purpose
After repeating contact and tried thing by animal skin, observe the reaction of body immune system on skin.
2. material
Animal: kind: albino guinea-pig, body weight 0.2-0.25kg male and female half and half
Source: provide by Chinese Academy of Medical Sciences's animal center
The animal quality certification number: the moving word O1-3001 of doctor
Quantity: 30
Tried thing: title: facial palsy correcting paste
Source: provide by Beijing state dragon hospital
Content: 1 a gram crude drug/cream
Excipient: title: Oleum Ricini
Source: skies, Hubei Province city second pharmaceutical factory
No. 002177 lot number 980502 of the accurate word (1981) of medicine defended in Hubei Province
Positive sensitizer: title: 2,4-dinitro-chloro-benzene
The source: grinding institute by consonance medical university medicine provides.
3, method and result
Get 30 of above-mentioned Cavia porcelluss, be divided into 3 groups (being tried thing group, excipient, positive controls) 10 every group at random.Each is organized Cavia porcellus and the spinal column diamond wool is taken off 10% (about 40cm of the suitable body surface area of unhairing scope in preceding 24 hours of administration with 8% sodium sulfide solution
2), the left side is for being tried the thing district, and the right side is the check plot.
Sensitization contact: facial palsy correcting paste 1g is coated in uniformly tried thing group left side depilation district, vehicle group Cavia porcellus left of spine is coated with the Oleum Ricini of equivalent, the positive controls left side is coated with positive sensitizer 1%2,4-dinitro-chloro-benzene, continue after 6 hours, the water flush away: the 7th day, the 14th day in kind repeats once, amounts to three times.
Excite contact: in last administration 14 days. repeat coating. positive control forms a cabinet 0.1%2, the 4-dinitro-chloro-benzene, after 6 hours the water flush away in remove residual tried thing after, 24, observe the administration district in 48,72 hours and have or not irritations such as erythema, edema, with the check plot, right side relatively, the results are shown in Table 1, table 2.
Table 1 facial palsy correcting paste skin anaphylactic test result
| n | Skin allergy (score value) | ||||||
| Erythema | Edema | ||||||
| 24h | 48h | 72h | 24h | 48h | 72h | ||
| Tried the positive sensitizer group of thing group blank group | 10 10 10 | 0 2 0 | 0 2 0 | 0 2 0 | 0 2 0 | 0 2 0 | 0 2 0 |
Annotate: the skin allergy score value is pressed new drug research guide " skin allergy standards of grading " scoring 0 negative reaction
The evaluation of table 2 sensitization of skin
| Group | Sensitization incidence rate (%) | The sensitization of skin evaluation |
| Tried the thing group | 0 | No sensitization |
| Plastic property group positive controls | 0 80 | No sensitization height sensitization |
4, conclusion
Result of the test shows, " facial palsy correcting paste " group, vehicle group are through Cavia porcellus (1,7,14 day) after skin is administered three times, unhairing district, left side gives and is tried thing, depilation district, right side is the check plot, after stimulating contact, observed three days, irritant reaction such as show speckle, edema not, positive group has obvious anaphylaxis.
Four, facial palsy correcting paste multiple dosing skin irritation test
1, purpose
After repeating contact and tried thing by animal skin, observe the local response that intact skin and damaged skin produced.
2, material section
Animal: kind: albino guinea-pig, body weight 0.2-one 0.25kg, male and female half and half
Source: provide by Chinese Academy of Medical Sciences's animal center
The animal quality certification number: the moving word 01-3001 of doctor
Quantity: 30
Tried thing: title: " facial palsy correcting paste "
Source: provide by Beijing state dragon hospital
Content: 5 a gram crude drugs/cream
Excipient: title: Oleum Ricini
Source: skies, Hubei Province city second pharmaceutical factory
No. 002177 lot number 980502 of the accurate word (1981) of medicine defended in Hubei Province
Positive sensitizer: 2,4-dinitro-chloro-benzene, grinding institute by consonance medical university medicine provides.
3, method and result
Get 30 of above-mentioned Cavia porcelluss, be divided into 3 groups (close set, damaged skin group, excipient) 10 every group at random.
The intact skin model: each is organized Cavia porcellus and the spinal column diamond wool is taken off with 8% sodium sulfide solution in preceding 24 hours of administration, 10% (about 40cm) of the suitable body surface area of unhairing scope, and side is for being tried the thing district, and the right side is the check plot.
The damaged skin model: the skin degerming that will lose hair or feathers, rub skin the degree of being with the oozing of blood with 300 order sand paper.The left side is for being tried the thing district, and the right side is the check plot.
Vehicle group: preserved skin is the same.
With facial palsy correcting paste medicine 5g be coated in the intact skin group uniformly, damaged skin group Cavia porcellus left of spine is tried the thing district, the check plot, right side is coated with the volume excipient.Once a day, continuous seven days, the last administration is the residual thing that tried of water flush away after 24 hours, residually observed the administration district in 1,2,4,72 hour after being tried thing and had or not irritations such as erythema edema in removing.Compare with the blank district, the results are shown in Table 1.
Table 1 facial palsy correcting paste multiple dosing intact skin irritant test result
| Group | Number of animals (only) | Skin irritation reaction (score value) | |||||||
| Erythema | Edema | ||||||||
| 1h | 24h | 48h | 72h | 1h | 24h | 48h | 72h | ||
| Intact skin administration district, blank district | 10 10 | 0 0 | 0 0 | 0 0 | 0 0 | 0 0 | 0 0 | 0 0 | 0 0 |
Annotate: 0 negative reaction
4, conclusion
Result of the test shows that " facial palsy correcting paste " is through Cavia porcellus intact skin, damaged skin multiple dosing, once a day, only unhairing district, left side is to being tried thing for each 10g/kg/, and unhairing district in right side gives excipient, successive administration 7 days, observe a week, not irritant reaction such as show speckle, edema after the drug withdrawal.
Claims (5)
1. facial palsy correcting paste, it is characterized in that: it is made up of medicine and medicament-carried paster, and described medicine is made by principal agent and accessory drugs, and described principal agent is made up of the medicine of following weight: the Radix Astragali 15～20 grams; Ramulus Cinnamomi 8～12 grams; Ramulus Uncariae Cum Uncis 12～16 grams; Radix Paeoniae Rubra 12～16 grams; Radix Salviae Miltiorrhizae 10～15 grams; Rhizoma Chuanxiong 10～15 grams; Radix Puerariae 12～16 grams; Fructus Arctii 10～15 grams; Pheretima 8～12 grams; Fructus Forsythiae 10～16 grams; Radix Scutellariae 10～15 grams; Flos Lonicerae 10～16 grams; Fructus Evodiae 8～12 grams; Rhizoma Curcumae 8～12 grams; Rhizoma Curcumae Longae 10～16 grams; Radix Saposhnikoviae 10～16 grams; Magnetitum 25～50 grams; Agkistrodon 8～12 grams; Herba Salviae Chinensis 15～20 grams; Fructus Viticis 12～16 grams; Rhizoma Paridis 15～20 grams, described accessory drugs is: 150～200 milliliters of 1% laurocapram.
2. facial palsy correcting paste according to claim 1 is characterized in that: described principal agent is made up of the medicine of following weight: the Radix Astragali 15 grams; Ramulus Cinnamomi 8 grams; Ramulus Uncariae Cum Uncis 12 grams; Radix Paeoniae Rubra 12 grams; Radix Salviae Miltiorrhizae 15 grams; Rhizoma Chuanxiong 10 grams; Radix Puerariae 12 grams; Fructus Arctii 10 grams; Pheretima 8 grams; Fructus Forsythiae 10 grams; Radix Scutellariae 10 grams; Flos Lonicerae 10 grams; Fructus Evodiae 8 grams; Rhizoma Curcumae 8 grams; Rhizoma Curcumae Longae 10 grams; Radix Saposhnikoviae 10 grams; Magnetitum 25 grams; Agkistrodon 8 grams; Herba Salviae Chinensis 15 grams; Fructus Viticis 12 grams; Rhizoma Paridis 15 grams, described accessory drugs is: 150 milliliters of 1% laurocapram.
3. facial palsy correcting paste according to claim 1 is characterized in that: described principal agent is made up of the medicine of following weight: the Radix Astragali 20 grams; Ramulus Cinnamomi 12 grams; Ramulus Uncariae Cum Uncis 16 grams; Radix Paeoniae Rubra 16 grams; Radix Salviae Miltiorrhizae 15 grams; Rhizoma Chuanxiong 15 grams; Radix Puerariae 16 grams; Fructus Arctii 15 grams; Pheretima 12 grams; Fructus Forsythiae 16 grams; Radix Scutellariae 15 grams; Flos Lonicerae 16 grams; Fructus Evodiae 12 grams; Rhizoma Curcumae 12 grams; Rhizoma Curcumae Longae 16 grams; Radix Saposhnikoviae 16 grams; Magnetitum 50 grams; Agkistrodon 12 grams; Herba Salviae Chinensis 20 grams; Fructus Viticis 16 grams; Rhizoma Paridis 20 grams, described accessory drugs is: 200 milliliters of 1% laurocapram.
4. facial palsy correcting paste according to claim 1 is characterized in that: described principal agent is made up of the medicine of following weight: the Radix Astragali 18 grams; Ramulus Cinnamomi 10 grams; Ramulus Uncariae Cum Uncis 14 grams; Radix Paeoniae Rubra 14 grams; Radix Salviae Miltiorrhizae 13 grams; Rhizoma Chuanxiong 13 grams; Radix Puerariae 14 grams; Fructus Arctii 13 grams; Pheretima 10 grams; Fructus Forsythiae 13 grams; Radix Scutellariae 13 grams; Flos Lonicerae 13 grams; Fructus Evodiae 10 grams; Rhizoma Curcumae 10 grams; Rhizoma Curcumae Longae 13 grams; Radix Saposhnikoviae 13 grams; Magnetitum 37 grams; Agkistrodon 10 grams; Herba Salviae Chinensis 18 grams; Fructus Viticis 14 grams; Rhizoma Paridis 18 grams, described accessory drugs is: 180 milliliters of 1% laurocapram.
5. the method for preparing the described facial palsy correcting card of claim 1, it is characterized in that: will process the Radix Astragali after concocting, Cortex cinnamomi japonici (Ramulus Cinnamomi), Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Rhizoma Chuanxiong, Radix Puerariae, Fructus Arctii, Pheretima, Agkistrodon, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Fructus Evodiae, Rhizoma Curcumae, Rhizoma Curcumae Longae, Rhizoma Paridis, Herba Salviae Chinensis, Fructus Viticis, Magnetitum takes by weighing by required weight, and pulverized sieve No. six, add 1% laurocapram mix homogeneously paste making agent then, it is standby to have carried out sponge ring on the non-woven fabrics paster in advance, then the unguentum made is put into sponge ring according to the weight of each plaster 5 gram.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579720A (en) * | 2012-02-28 | 2012-07-18 | 卢卫平 | Medicament for treating facial paralysis and preparation method thereof |
| CN102836412A (en) * | 2012-09-26 | 2012-12-26 | 杨高林 | Chinese medicinal composition for treating idiopathic facial paralysis and preparation method thereof |
| CN105616480A (en) * | 2016-03-08 | 2016-06-01 | 昆明市中医医院 | Facial paralysis aright-pulling mask and preparation method thereof |
| CN105687434A (en) * | 2016-03-25 | 2016-06-22 | 伦国爱 | Traditional Chinese medicine for treating wind and cold invasion type prosopospasm |
-
2007
- 2007-11-26 CN CNA2007101937651A patent/CN101181603A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579720A (en) * | 2012-02-28 | 2012-07-18 | 卢卫平 | Medicament for treating facial paralysis and preparation method thereof |
| CN102836412A (en) * | 2012-09-26 | 2012-12-26 | 杨高林 | Chinese medicinal composition for treating idiopathic facial paralysis and preparation method thereof |
| CN105616480A (en) * | 2016-03-08 | 2016-06-01 | 昆明市中医医院 | Facial paralysis aright-pulling mask and preparation method thereof |
| CN105687434A (en) * | 2016-03-25 | 2016-06-22 | 伦国爱 | Traditional Chinese medicine for treating wind and cold invasion type prosopospasm |
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