CN109331043A - A kind of pharmaceutical composition and preparation method thereof for treating ulcer malignant boil furuncle - Google Patents
A kind of pharmaceutical composition and preparation method thereof for treating ulcer malignant boil furuncle Download PDFInfo
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- CN109331043A CN109331043A CN201811375336.0A CN201811375336A CN109331043A CN 109331043 A CN109331043 A CN 109331043A CN 201811375336 A CN201811375336 A CN 201811375336A CN 109331043 A CN109331043 A CN 109331043A
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- malignant boil
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/28—Mercury; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
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- Inorganic Chemistry (AREA)
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- Biotechnology (AREA)
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- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition and preparation method thereof for treating ulcer malignant boil furuncle, the pharmaceutical composition of the treatment ulcer malignant boil furuncle is made of the raw material components of following parts by weight: 2-18 parts of calomel mercurous chloride, 12-24 parts of pearl powder, 6-36 parts of alum, 12-33 parts of alumen, 1-36 parts of Moschus, 9-30 parts of borax, 9-27 parts of borneol, excipient is added to 1000 parts in 6-21 parts of realgar.The present invention is only with 8 taste medicinal material listed by the Pharmacopoeia of the People's Republic of China, new preparation is formed by reasonable compatibility, it can be used for treating the proliferation of mammary gland, ulcer malignant boil furuncle, shingles zoster, scald, ulcer, mastitis, exanthemv, the proliferation of mammary gland, hemorrhoid etc., purposes is wide.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of pharmaceutical composition for treating ulcer malignant boil furuncle and its preparation side
Method.
Background technique
Ulcer malignant boil furuncle is four kinds of common surgical diseases, easily betides body surface, they respectively have different pathological variation and shape
Shape feature.
Theory of traditional Chinese medical science thinks: carbuncle is that infection poison is evil, qi and blood obstruction, so as to cause part suppurate, the disease incidence
Rapidly, easy purulence is easily burst, is easily held back, and falls ill soft without a head from the beginning of lesion local light, agglomerates quickly, and Biao Pi inflammation redness is swollen, pain, and
It can be gradually expanded, presentation is high, swollen and hard, and touching has burning heat sensation.
Subcutaneous ulcer be because of malicious evil retardance, so as to cause purulent disease, Chinese medicine often refer to that local skin swelling is hard and color of the leather not
The carbuncle of change, the disease are divided into carbuncle and deep abscess two major classes.It is fallen ill from the beginning of Ru Li, distending pain of not generating heat, and is easy to expand around
Greatly.After festering, honeycomb sample is presented in shape, which can all occur in the thick and tough and tensile place of skin, but is mainly in after item and carries on the back
Portion.
Malignant boil, name furunculosis, topical manifestations are red, swollen, hot, pain, are in lesser tubercle, and can be gradually increased, tapered protuberance, then
Center softens, and the small purulent core of white occurs.The disease is quickly grown, and the state of an illness is heavier, and root foot is as followed closely due to its is hard, therefore named, malignant boil
Sore hair can give birth to everywhere without institute is determined, generally more common with head and four limbs, and name is also different and different with given birth to position, common
There are furuncle on renzhong point, mouthblocking boil, felon, boil on the toe.
Furuncle, name furuncle sore are the infection of a kind of suppurative hair follicle and hair follicle deep surrounding tissue, adjoining multiple hair follicle senses
Dye, inflammation merge to be formed be carbuncle.The disease is sent out in skin superficial, can be given birth to everywhere, is born in head, face, neck, item and arm stern etc. more.
Locally there is red, swollen, pain lesser tubercle, later gradually enlargement, tapered protuberance in early stage.After a few days, tubercle center is because of group
It knits necrosis and softens, the small purulent core of yellow-white occur；Red, swollen, pain range is gradually expanded, and pain increases severely, and thereafter, purulent core falls off, stream
Pus out, inflammation just fade away and are cured.
The formula of ancient prescription " Jin Sudan " is as follows: 1 part of realgar, 6 parts of alum, 3 parts of alumen, ulcer can be treated, carrion is not gone,
The disease that new meat is not given birth to has good curative effect to above-mentioned ulcer malignant boil furuncle.But it is somebody's turn to do " Jin Sudan " pulverulence, it is easy from skin
Surface slides, and is unfavorable for directly coating.
Summary of the invention
The present invention provides a kind of pharmaceutical compositions and preparation method thereof for treating ulcer malignant boil furuncle, solve in the prior art
" Jin Sudan " pulverulence, be easy from skin surface slide, be unfavorable for the problem of directly coating.
The first purpose of the invention is to provide a kind of pharmaceutical compositions for treating ulcer malignant boil furuncle, by the original of following parts by weight
Material component is made: 6-21 parts of realgar, 2-18 parts of calomel mercurous chloride, 12-24 parts of pearl powder, 6-36 parts of alum, 12-33 parts of alumen, Moschus 1-
36 parts, 9-30 parts of borax, 9-27 parts of borneol, be added excipient to 1000 parts.
Preferably, the excipient is the mixture of yellow petroleum jelly or atoleine and yellow petroleum jelly.
Preferably, when the excipient is the mixture of atoleine, yellow petroleum jelly, the dosage of atoleine is 30-
45 parts, the surplus of excipient is yellow petroleum jelly.
Based on same inventive concept, the present invention also provides the pharmaceutical compositions of the treatment ulcer malignant boil furuncle described in one kind
Preparation method, comprising the following steps:
S1 weighs each component by following parts by weight: 6-21 parts of realgar, 2-18 parts of calomel mercurous chloride, 12-24 parts of pearl powder, alum 6-
36 parts, 12-33 parts of alumen, 1-36 parts of Moschus, 9-30 parts of borax, 9-27 parts of borneol, be added excipient to 1000 parts；
S2, pearl through boiling, dry, crushing obtain pearl powder, it is spare；
Moschus after crushed, is sterilized using high-temperature heat sterilization method, obtains medicinal Moschus, spare；
Realgar, calomel mercurous chloride, pearl powder, alum, alumen, Moschus, borax, borneol are ground into powder, respectively mistake by S3 respectively
Sieve, respectively obtains realgar powder, calomel mercurous chloride powder, Pearl, alum powder, alumen powder, Moschus powder, borax powder, ice
Piece powder；The medicinal powder obtained after the powder of above-mentioned each drug is mixed carries out high-temperature sterilization, adds the excipient of formula metering,
After mixing evenly, the yellow paste finished product for the treatment of ulcer malignant boil furuncle is made.
Preferably, alumen used is prepared using the method for fumed dehydration in S1, and the method for fumed dehydration is specific as follows: being taken net
Alum, pounds blocking, and investment is forged in medicine pot, and heating is evaporated to the crystallization water to the greatest extent, when white blocks of solid, takes out, puts to room temperature,
Alumen is obtained, it is spare.
Preferably, forge the technological parameter of medicine pot: set temperature is 240 DEG C, each fumed amount 10kg, each fumed 4h.
Preferably, in a nitrogen atmosphere, high-temperature sterilization is carried out to mixed powder using hot-air sterilization, temperature is set as
160 DEG C, the sterilizing duration is 2h.
Preferably, the excipient is put into hot air sterilizer and sterilizes, 160 DEG C of sterilizing 2h of sterilising conditions；By xeothermic
After sterilizing, it is cooled to 40 DEG C, then prepares raw material as pharmaceutical composition and use.
Preferably, Moschus uses autoclaving: under 103.4kPa vapour pressure, making temperature up to 121.3 DEG C, maintains
15-20min。
Preferably, Chinese medicine external ointment is made in the yellow paste finished product of the treatment ulcer malignant boil furuncle according to pharmacy mode
Agent.
Compared with prior art, a kind of pharmaceutical composition and preparation method thereof for treating ulcer malignant boil furuncle provided by the invention,
With following curative effect:
The present invention only with 8 taste medicinal materials listed by the Pharmacopoeia of the People's Republic of China (referred to as " Chinese Pharmacopoeia " version in 2015),
New preparation is formed by reasonable compatibility, can be used for treating the proliferation of mammary gland, ulcer malignant boil furuncle, shingles zoster, scald, ulcer, mastitis,
Exanthemv, the proliferation of mammary gland, hemorrhoid etc., purposes is wide.
Detailed description of the invention
Fig. 1 is the therapeutic effect of 1 different time of case.
Wherein, Figure 1A, Figure 1B, Fig. 1 C, Fig. 1 D, Fig. 1 E are that the formula of embodiment 1 is treated 1 day, 3 days, 5 days, 10 days respectively
With 15 days effects.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
The test method of actual conditions is not specified in following embodiments, according to conventional methods in the art with condition into
Row, if material used is commercially available without specified otherwise.
The present invention provides a kind of pharmaceutical compositions for treating ulcer malignant boil furuncle, are made of the raw material components of following parts by weight:
6-21 parts of realgar, 2-18 parts of calomel mercurous chloride, 12-24 parts of pearl powder, 6-36 parts of alum, 12-33 parts of alumen, 1-36 parts of Moschus, borax 9-
30 parts, 9-27 parts of borneol, be added excipient to 1000 parts.
The pharmacological property of each drug of pharmaceutical composition provided by the invention is as follows:
1, realgar: being Red Arsenic Glass (As4S4) be commonly called as, also referred to as orpiment, gold stone, realgar, usually crocus
Granular solids or orange-yellow powder, matter is soft, and property is crisp.Often and orpiment, i.e. orpiment (As2S3), stibnite, cinnabar symbiosis；Add
Hypertoxic ingredient arsenic trioxide, i.e. arsenic can be oxidized to after heat to certain temperature in air.
Realgar medicine: (1) having antitumor action, can inhibit the growth of Transplantable Murine sarcoma S-180, and have corrosion to cell
Effect.(2) after absorbing, there are antispastic, analgesic effect to nerve；There is insecticidal action in inside and outside.(3) can cause after intestinal absorption
It spits, rush down, dizziness even convulsions, slow poisoning can damage the physiological function of liver, kidney.(4) realgar has the function of inhibiting pathogenic bacteria.
(5) shingles zoster is treated.
2, calomel mercurous chloride: Chinese medicine name.Its ingredient is calogreen (Hg2Cl2).External application has desinsection, attacks poison, the function of sore；It is for oral administration
With eliminating the phlegm disperse accumulation, relieve oedema or abdominal distension through diuresis or purgation defaecation the benefits of.It controls outside calomel mercurous chloride for scabies, stubborn dermatitis, ulcer on the shank, syphilis, sore, the illness such as eczema；It is interior
Take, oedema tympanites stagnant in treatment sputum, the illnesss such as difficulty in urination and defecation.
3, pearl powder: pearl typically exhibits similar spherical shape, oblong, oval or stick, and diameter is between 1.5~8mm.
There are off-white color, baby pink, chartreuse or the form and aspect such as light blue in its surface, and present it is translucent, micro- have it is concave-convex, smooth and
Colored gloss.Quality is hard, and the plane of disruption shows laminated striation.Gas is micro-, lightly seasoned, and pearl powder is obtained after processing.
The effect of pearl powder has arresting convulsion of calming the nerves, and improving eyesight disappears screen, solves taking poison and growing muscle due, moistening skin and eliminating spot.For insomnia of palpitating with fear, infantile convulsion
Epilepsy, cataract, sore are not held back, skin splash.
4, alum: main chemical compositions are KAl (SO4)2·12H2O.Minerals Chinese medicine, external application can detoxify desinsection, and eliminating dampness is stopped
Itch；Interior hemostasis, antidiarrheal, resolving sputum.Scabies wet sore, swollen ulcer drug, scald, aphthae, rotten string are used in Chinese traditional treatment
The eye of wind, Ting discharging ear, in nose polyp, sore hemorrhoid pains and other diseases treatment.Alum nature and flavor are sour and astringent, tremble with fear, have micro- poison, can eat on a small quantity
With having antibacterial, Thyme Extract.
5, alumen: also known as forging alum, takes the alum for picking net, fumed and obtain.Its is hard and crisp, easily smashes, it is slightly sweet and
Puckery, white with color, transparent, matter is hard and crisp, free from admixture person is preferred, alumen is soluble easily in water or glycerol, does not dissolve in alcohol.
Alumen is used for dissolving phlegm, antidiarrheal, hemostasis, removing toxic substances, desinsection, aphthae, the diseases such as sore hemorrhoid scabies in Chinese traditional treatment
Treatment.
6, Moschus: this product is the secretion in the buck scent gland capsule of animal in deer family musk deer.Major function are as follows: have one's ideas straightened out, ward off it is dirty, lead to
Network dissipates the stasis of blood.Treatment in Chinese traditional treatment for diseases such as apoplexy, frightened epilepsy, trusted subordinate sudden and violent pain, traumatic injury, swollen ulcer drugs.
7, borneol: also known as piece brain, orange slices, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing
Deng through steam distillation and being recrystallized and obtained by composite family Blumea balsamifera cauline leaf or lauraceae plant borneol camphor tree branches and leaves.Also useful turpentine
Oil is obtained through a series of chemical method techniques.With inducing resuscitation of having one's ideas straightened out, the effect of clearing away heat to and alleviating pain.For pyreticosis mind in Chinese traditional treatment
Dusk, convulsions, chest impediment and cardialgia, hot eyes, aphtha, abscess of throat, purulent ear canal, sore swell and ache curative, burst after the diseases such as do not hold back.
8, borax: Chinese medicine name, scientific name are sodium tetraborate, contain Na2B4O7·10H2O.With heat-clearing and phlegm-dissolving, detoxifying and anticorrosive it
Effect.It is taken orally in Chinese traditional treatment for treating the illness such as phlegm-heat cough and dysphagic accumulation, all bone sticking larynxs；External application can be used for treating pharynx
The illnesss such as larynx swelling and pain, aphthae, cataract, pudendal ulcer.
The pharmaceutical composition for the treatment of ulcer malignant boil furuncle of the invention includes following embodiment.
Embodiment 1
A kind of pharmaceutical composition for treating ulcer malignant boil furuncle, is made of the raw material components of following parts by weight: 6 parts of realgar, calomel mercurous chloride 3
Part, 12 parts of pearl powder, 6 parts of alum, 12 parts of alumen, 1 part of Moschus, 9 parts of borax, 9 parts of borneol, 942 parts of excipient.The excipient
For atoleine, the mixture of yellow petroleum jelly, and the dosage of atoleine is 45 parts, and the dosage of yellow petroleum jelly is 897 parts.
Embodiment 2
A kind of pharmaceutical composition for treating ulcer malignant boil furuncle, is made of the raw material components of following parts by weight: 21 parts of realgar, calomel mercurous chloride
18 parts, 24 parts of pearl powder, 36 parts of alum, 33 parts of alumen, 36 parts of Moschus, 30 parts of borax, 27 parts of borneol, 775 parts of excipient.It is described
Excipient is the mixture of atoleine, yellow petroleum jelly, and the dosage of atoleine is 30 parts, and the dosage of yellow petroleum jelly is 745
Part.
Embodiment 3
A kind of pharmaceutical composition for treating ulcer malignant boil furuncle, is made of the raw material components of following parts by weight: 6 parts of realgar, calomel mercurous chloride 2
Part, 4 parts of pearl powder, 36 parts of alum, 18 parts of alumen, 3 parts of Moschus, 6 parts of borax, 9 parts of borneol, 916 parts of excipient.The excipient
For atoleine, the mixture of yellow petroleum jelly, and the dosage of atoleine is 44 parts, and the dosage of yellow petroleum jelly is 872 parts.
Embodiment 4
A kind of pharmaceutical composition for treating ulcer malignant boil furuncle, is made of the raw material components of following parts by weight: 12 parts of realgar, calomel mercurous chloride
3 parts, 36 parts of pearl powder, 24 parts of alum, 12 parts of alumen, 3 parts of Moschus, 12 parts of borax, 12 parts of borneol, 886 parts of excipient.The tax
Shape agent is the mixture of atoleine, yellow petroleum jelly, and the dosage of atoleine is 41 parts, and the dosage of yellow petroleum jelly is 845 parts.
Embodiment 5
A kind of pharmaceutical composition for treating ulcer malignant boil furuncle, is made of the raw material components of following parts by weight: 12 parts of realgar, calomel mercurous chloride
6 parts, 18 parts of pearl powder, 12 parts of alum, 22 parts of alumen, 1 part of Moschus, 15 parts of borax, 9 parts of borneol, 905 parts of excipient.The tax
Shape agent is yellow petroleum jelly.
Based on same inventive concept, the present invention also provides a kind of preparation sides of pharmaceutical composition for treating ulcer malignant boil furuncle
Method, including following embodiment.
Embodiment 6
A kind of preparation method of pharmaceutical composition that treating ulcer malignant boil furuncle, comprising the following steps:
S1 weighs each component by the formula of pharmaceutical composition for the treatment of ulcer malignant boil furuncle: 6-21 parts of realgar, 2-18 parts of calomel mercurous chloride,
12-24 parts of pearl powder, 12-33 parts of alumen, 1-36 parts of Moschus, 9-30 parts of borax, 9-27 parts of borneol, is added and assigns 6-36 parts of alum
Shape agent is to 1000 parts；
S2, pearl through boiling, dry, crushing obtain pearl powder, it is spare；
Moschus is sterilized using high-temperature heat sterilization method (autoclaving), dry, obtains medicinal Moschus, standby
With；
Alumen used is prepared using the method for fumed dehydration in S1, and the method for fumed dehydration is specific as follows: taking net alum, pounds
At fritter, investment is forged in medicine pot, and heating is evaporated to the crystallization water to the greatest extent, when white blocks of solid, is taken out, is put to room temperature, obtain
Alumen, it is spare；Forge the technological parameter of medicine pot: set temperature is 240 DEG C, each fumed amount 10kg, fumed 4 hours every time.
Realgar, calomel mercurous chloride, pearl powder, alum, alumen, Moschus, borax, borneol are ground into powder, respectively mistake by S3 respectively
100 meshes respectively obtain realgar powder, calomel mercurous chloride powder, Pearl, alum powder, alumen powder, Moschus powder, borax powder
End, borneol powder；By realgar powder, calomel mercurous chloride powder, Pearl, alum powder, alumen powder, borax powder, borneol powder
Mixed mixed powder carries out high-temperature sterilization, and sterilized Moschus powder is added, and adds the excipient of formula dosage, and stirring is equal
After even, the yellow paste finished product for the treatment of ulcer malignant boil furuncle is made.Finished product is orange-yellow ointment；Gas is fragrant, there is refrigerant sense.
In S3, in a nitrogen atmosphere, high-temperature sterilization is carried out using hot-air sterilization, temperature is set as 160 DEG C, and sterilizing continues
Time is 2h.The reason of temperature and time is arranged is after avoiding being heated to certain temperature, and in air atmosphere, realgar is oxidized
For hypertoxic ingredient arsenic trioxide.The excipient first passes through hot air sterilization, filters and is cooled to 40 DEG C, is then used as pharmaceutical composition
Object prepares raw material use.
Moschus carries out sterilization treatment using autoclaving: under 103.4 kPas of vapour pressures, making temperature up to 121.3
DEG C, maintain 15-20min.Muskone loss late can be made less than 2.40% after sterilizing using this method, it is spare after sterilizing.
It should be noted that other existing dewatering preparations can also be used in medicinal alumen.
Applicating modern times technology of the present invention is made into paste, convenient for smearing and drug absorption.It can treat the proliferation of mammary gland, carbuncle
Subcutaneous ulcer malignant boil furuncle, shingles zoster, scald, ulcer, mastitis, cure rate reach 96%-100%；Treat skin caused by ulcer malignant boil furuncle, diabetes
Skin, which festers, special efficacy, has in treatments such as the proliferation of mammary gland, shingles zoster, ulcer, mastitis, hemorrhoid effective；Without scar after treatment scald.
Below made of the preparation method of the formula prepared of embodiment 1 and embodiment 6 for pharmaceutical composition, illustrate this
The clinical effectiveness of invention:
Case 1
More than 80 years old diabetics, hand, which festers, not to be controlled, as shown in Figure 1, hospital, which sees a doctor, needs amputation, by example 1 drug
Composition treatment, smears primary for 24 hours when treatment, and dosage all standing area of festering is limited, and fully recovers after 15 days, Figure 1A, Figure 1B,
Fig. 1 C, Fig. 1 D, Fig. 1 E are that the formula of embodiment 1 treats 1 day, 3 days, 5 days, 10 days and 15 days effect respectively.
Case 2
It is husky certain, female, 40 years old, symptom was the proliferation of mammary gland, breast lump pain before medication, small with example 1 drug composition 24
When smear chest hyperplasia position it is primary, after 7 days breast lump disappear, recovery from illness.
Case 3
The Qin, female, 25 years old, symptom lymph inflammation before medication, lymph enlargement were had a fever with pain, night, with embodiment 2
It after pharmaceutical composition, smears within every 24 hours once, coating swelling and pain position, fever number is reduced, and pain disappearance is fully recovered for 5 days.
Case 4
Poplar, male, 30 years old, medical history phlebothrombosis, symptom was full foot swelling, walks and ache before medication, with 3 medicine group of embodiment
After closing object, primary, coating swelling position is smeared within every 24 hours, 10 days, full foot swelling disappearance, treatment results were almost recovered.
Case 5
The Qin, male, 38 years old, the raw scabies of medical history neck, skin cracks, epidermis festered after symptom operation before medication, with implementation
The same day, pain slowed down after 3 pharmaceutical composition of example, was gradually recovered at rear exanthemv twice, purulence blood adheres to medication 15 days from exhausting
Afterwards, treatment results are fully recovered.
Case 6
Jiang, female, 29 years old, the medical history proliferation of mammary gland, symptom breast lump was more before medication and aches, and smeared one within every 24 hours
It is secondary, painful area is coated, is substantially reduced with lump after 4 pharmaceutical composition of embodiment 3 days, medication January, breast lump disappears completely
It loses, and has no adverse reaction, check treatment results recovery from illness through hospital.
Case 7
Xue, female, 30 years old, medical history cholecystitis, dysmenorrhea before medication smeared underbelly, rear dysmenorrhea with 4 pharmaceutical composition of embodiment
It disappears, treatment results are almost recovered.
Case 8
Cui, male, 3 years old, medical history foreskin was red and swollen, before medication symptom foreskin redness issue, pain, smear one within every 24 hours
It is secondary, red and swollen position is coated, is disappeared with pain after 5 pharmaceutical composition of embodiment 4 hours, black subsides, and medication is fully recovered after 4 days.
Case 9
Certain is made pottery, male, 9 years old, medical history scrotal swelling, symptom scrotal swelling before medication smeared primary, coating swelling for every 24 hours
Position is disappeared with red and swollen after 3 days after 5 pharmaceutical composition of embodiment, treatment results recovery from illness.
Comparative example 1
Number of patent application is a kind of Dressed medicine powder for treating ulcer malignant boil furuncle of 201410392394.X, disclosed formula are as follows:
30-90 parts of the dried venom of toads, 10-50 parts of calomel mercurous chloride, 10-40 parts of alum, 15-45 parts of verdigris, 15-40 parts of olibanum, 10-40 parts of myrrh, blue stone
10-50 parts, 15-45 parts of Moschus, 30-90 parts of realgar, 70-100 parts of cinnabar.Preparation method is to be ground into a powder raw material altogether, uses vinegar
Dress affected part.The effect reached is that all medicines share has resolution carbuncle, convergence eliminating dampness, blood circulation promoting and dispersing pathogen accumulation and other effects, effectively
Treat various ulcer malignant boil furuncles.Although there is four traditional Chinese medicine mutually to repeat with of the invention, its treatment for being only limitted to " carbuncle " is treated than the present invention
Effect is few.
Comparative example 2
Number of patent application is a kind of external application Chinese medicine and preparation method thereof of 200710026665.X, disclosed formula are as follows: in
1-15 parts of medicine fine powder, 5-30 parts of menthol, 5-30 parts of borneol, 920-990 parts of matrix；Wherein traditional Chinese medicine fine powder is by the dried venom of toads, snail, musk deer
Perfume, olibanum, myrrh, verdigris, blue stone, alum, gypsum rubrum, cinnabar, realgar are made.Preparation method be using vaseline, ointment or
Chinese medicine is made externally applied drug or powder base is made using talcum powder, Paris white by person's gel.The effect reached is treatment skin
Skin stubborn dermatitis, ulcer, malignant boil furuncle, boil and various malignant sores etc..There are three taste medicinal materials mutually to repeat with the present invention, but it is refined by high temperature,
And it is only limitted to the treatment of " ulcer, malignant boil furuncle, boil and various malignant sores ", it is fewer than curative effect of the present invention.
Comparative example 3
A kind of hydrargyrum chloratum compositum and preparation method thereof that number of patent application is 201710184170.3, disclosed formula are as follows: mercury
25-30g, alum 20-25g, nitre 18-20g, salt 8-10g, melanterite 8-10g, cinnabar 15-20g, borax 8-10g, realgar 3-
5g, pearl powder 15-20g, official's powder 15-20g.Preparation method include test tank, seat tire, sealed cans, upper furnace, mill, take pellet and etc..It reaches
To effect be treatment ulcer carbuncle on the back serious case of furuncle, the diffusion of negative subcutaneous ulcer, sore head is flat to collapse, and necrosis is difficult to fall off, and purulence of bursting in sore is not perforated long.
There is four traditional Chinese medicine material mutually to repeat with the present invention, but its treatment for being only limitted to " ulcer ", it is fewer than curative effect of the present invention.
By above-mentioned comparative example 1-3 it will be seen that the present invention can be used to treatment mammary gland and increase only with 8 taste medicinal materials
Life, ulcer malignant boil furuncle, shingles zoster, scald, ulcer, mastitis, exanthemv, the proliferation of mammary gland, fibroma, hemorrhoid etc., purposes is wide, and
Comparative example 1-3 is all made of more than medicinal materials more than 10 tastes, and is simply possible to use in the various skin ulcer malignant boil furuncles for the treatment of.Drug of the invention
Composition is significant in efficacy to be better than the prior art.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, since the step method of use is identical as embodiment,
It repeats in order to prevent, description of the invention preferred embodiment, once a person skilled in the art knows basic wounds
The property made concept, then additional changes and modifications may be made to these embodiments.So the following claims are intended to be interpreted as includes
Preferred embodiment and all change and modification for falling into the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (10)
1. a kind of pharmaceutical composition for treating ulcer malignant boil furuncle, which is characterized in that be made of the raw material components of following parts by weight: realgar
6-21 parts, 2-18 parts of calomel mercurous chloride, 12-24 parts of pearl powder, 6-36 parts of alum, 12-33 parts of alumen, 1-36 parts of Moschus, 9-30 parts of borax,
Excipient is added to 1000 parts in 9-27 parts of borneol.
2. the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 1, which is characterized in that the excipient is yellow all
The mixture of intellectual circle or atoleine and yellow petroleum jelly.
3. the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 1, which is characterized in that when the excipient is liquid
Body paraffin, yellow petroleum jelly mixture when, the dosage of atoleine is 30-45 part, and the surplus of excipient is yellow petroleum jelly.
4. it is according to claim 1 treatment ulcer malignant boil furuncle pharmaceutical composition preparation method, which is characterized in that including with
Lower step:
S1 weighs each component by following parts by weight: 6-21 parts of realgar, 2-18 parts of calomel mercurous chloride, 12-24 parts of pearl powder, 6-36 parts of alum,
1-36 parts of Moschus, 9-30 parts of borax, 9-27 parts of borneol, excipient is added to 1000 parts in 12-33 parts of alumen；
S2, pearl through boiling, dry, crushing obtain pearl powder, it is spare；
Moschus after crushed, is sterilized using high-temperature heat sterilization method, obtains medicinal Moschus, spare；
Realgar, calomel mercurous chloride, pearl powder, alum, alumen, Moschus, borax, borneol are ground into powder respectively, are sieved respectively by S3, point
Realgar powder, calomel mercurous chloride powder, Pearl, alum powder, alumen powder, Moschus powder, borax powder, borneol powder are not obtained
End；The mixed powder obtained after the powder of above-mentioned each drug is mixed carries out high-temperature sterilization, adds the excipient of formula metering,
After mixing evenly, the yellow paste finished product for the treatment of ulcer malignant boil furuncle is made.
5. the preparation method of the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 4, which is characterized in that institute in S1
It is prepared with alumen using the method for fumed dehydration, the method for fumed dehydration is specific as follows: taking net alum, pound blocking, investment forges medicine
In pot, heating is evaporated to the crystallization water to the greatest extent, when white blocks of solid, takes out, puts to room temperature, obtain alumen, spare.
6. the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 5, which is characterized in that forge the technique ginseng of medicine pot
Number: set temperature is 240 DEG C, each fumed amount 10kg, each fumed 4h.
7. the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 4, which is characterized in that in S3, in nitrogen atmosphere
Under, high-temperature sterilization is carried out to mixed powder using hot-air sterilization, temperature is set as 160 DEG C, and the sterilizing duration is 2h.
8. the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 4, which is characterized in that the excipient is put into dry
Heat sterilization device sterilizes, 160 DEG C of sterilizing 2h of sterilising conditions；After hot air sterilization, it is cooled to 40 DEG C, is then used as pharmaceutical composition
Object prepares raw material use.
9. the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 4, which is characterized in that Moschus uses high steam
Sterilization: under 103.4kPa vapour pressure, making temperature up to 121.3 DEG C, maintains 15-20min.
10. the manufacturing method of the pharmaceutical composition for the treatment of ulcer malignant boil furuncle according to claim 4, which is characterized in that according to
Chinese medicine external ointment is made in the yellow paste finished product of the treatment ulcer malignant boil furuncle by pharmacy mode.
Priority Applications (1)
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| CN110123869A (en) * | 2019-05-21 | 2019-08-16 | 许张留 | It is a kind of to treat dermopathic Chinese medicine composition, preparation method and its application method |
| CN114767769A (en) * | 2022-05-19 | 2022-07-22 | 曹俊生 | A Chinese medicinal composition for treating furunculosis and dermatoses, and its preparation method |
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Cited By (2)
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|---|---|---|---|---|
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| CN114767769A (en) * | 2022-05-19 | 2022-07-22 | 曹俊生 | A Chinese medicinal composition for treating furunculosis and dermatoses, and its preparation method |
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Application publication date: 20190215 |