CN1301109C - 钙锌铁口服液及其制备方法 - Google Patents
钙锌铁口服液及其制备方法 Download PDFInfo
- Publication number
- CN1301109C CN1301109C CNB2004100468075A CN200410046807A CN1301109C CN 1301109 C CN1301109 C CN 1301109C CN B2004100468075 A CNB2004100468075 A CN B2004100468075A CN 200410046807 A CN200410046807 A CN 200410046807A CN 1301109 C CN1301109 C CN 1301109C
- Authority
- CN
- China
- Prior art keywords
- calcium
- zinc
- solubility
- soluble
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 22
- 239000011575 calcium Substances 0.000 title claims abstract description 22
- 239000011701 zinc Substances 0.000 title claims abstract description 18
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract description 17
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract description 9
- 229910052725 zinc Inorganic materials 0.000 title abstract description 9
- 239000002131 composite material Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 238000002360 preparation method Methods 0.000 claims abstract description 29
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 238000003756 stirring Methods 0.000 claims abstract description 16
- JYMOQWNEIZBVFC-UHFFFAOYSA-N [Fe].[Zn].[Ca] Chemical compound [Fe].[Zn].[Ca] JYMOQWNEIZBVFC-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 10
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 6
- 238000009835 boiling Methods 0.000 claims abstract description 3
- 239000000126 substance Substances 0.000 claims abstract description 3
- 230000001954 sterilising effect Effects 0.000 claims abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract 2
- 229960005069 calcium Drugs 0.000 claims description 18
- 229930003270 Vitamin B Natural products 0.000 claims description 15
- 239000011720 vitamin B Substances 0.000 claims description 15
- 235000019156 vitamin B Nutrition 0.000 claims description 15
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 11
- 239000004227 calcium gluconate Substances 0.000 claims description 11
- 235000013927 calcium gluconate Nutrition 0.000 claims description 11
- 229960004494 calcium gluconate Drugs 0.000 claims description 11
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 11
- 229960000306 zinc gluconate Drugs 0.000 claims description 10
- 235000011478 zinc gluconate Nutrition 0.000 claims description 10
- 239000011670 zinc gluconate Substances 0.000 claims description 10
- 238000013019 agitation Methods 0.000 claims description 8
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 claims description 6
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 6
- 239000001527 calcium lactate Substances 0.000 claims description 6
- 235000011086 calcium lactate Nutrition 0.000 claims description 6
- 229960002401 calcium lactate Drugs 0.000 claims description 6
- 235000013924 ferrous gluconate Nutrition 0.000 claims description 6
- 239000004222 ferrous gluconate Substances 0.000 claims description 6
- 229960001645 ferrous gluconate Drugs 0.000 claims description 6
- 235000013925 ferrous lactate Nutrition 0.000 claims description 6
- 239000004225 ferrous lactate Substances 0.000 claims description 6
- 229940037907 ferrous lactate Drugs 0.000 claims description 6
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 6
- 239000011790 ferrous sulphate Substances 0.000 claims description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 6
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims description 6
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 4
- 229960001781 ferrous sulfate Drugs 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229940050168 zinc lactate Drugs 0.000 claims description 4
- 235000000193 zinc lactate Nutrition 0.000 claims description 4
- 239000011576 zinc lactate Substances 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 8
- 238000010438 heat treatment Methods 0.000 abstract description 8
- 238000002156 mixing Methods 0.000 abstract description 7
- 229910052742 iron Inorganic materials 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 238000011049 filling Methods 0.000 abstract description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 2
- 229930003471 Vitamin B2 Natural products 0.000 abstract 2
- 229960002477 riboflavin Drugs 0.000 abstract 2
- 239000011716 vitamin B2 Substances 0.000 abstract 2
- 235000019164 vitamin B2 Nutrition 0.000 abstract 2
- 230000002349 favourable effect Effects 0.000 abstract 1
- 229940023492 oral liquid product Drugs 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 206010006956 Calcium deficiency Diseases 0.000 description 2
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- 102000002070 Transferrins Human genes 0.000 description 2
- 108010015865 Transferrins Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 206010022971 Iron Deficiencies Diseases 0.000 description 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- 102000036675 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910001447 ferric ion Inorganic materials 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 230000009645 skeletal growth Effects 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940091251 zinc supplement Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100468075A CN1301109C (zh) | 2004-09-24 | 2004-09-24 | 钙锌铁口服液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100468075A CN1301109C (zh) | 2004-09-24 | 2004-09-24 | 钙锌铁口服液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1634069A CN1634069A (zh) | 2005-07-06 |
CN1301109C true CN1301109C (zh) | 2007-02-21 |
Family
ID=34846008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100468075A Ceased CN1301109C (zh) | 2004-09-24 | 2004-09-24 | 钙锌铁口服液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1301109C (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102960566B (zh) * | 2012-12-06 | 2014-12-24 | 乌鲁木齐市金蟾兽药有限公司 | 一种母羊和羔羊专用液态的饲料添加剂及其制备方法和应用 |
CN105030781B (zh) * | 2015-07-28 | 2017-11-24 | 海南葫芦娃药业集团股份有限公司 | 一种复方锌铁钙颗粒及其制备方法 |
CN105125579A (zh) * | 2015-09-10 | 2015-12-09 | 重庆布尔动物药业有限公司 | 钙镁维生素注射液 |
CN112451543A (zh) * | 2020-12-28 | 2021-03-09 | 浙江大学医学院附属儿童医院 | 一种硫酸锌和硫酸亚铁口服液及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061154A (zh) * | 1990-11-03 | 1992-05-20 | 周先毅 | 一种微量元素浓缩原浆制造方法 |
US5215750A (en) * | 1991-09-04 | 1993-06-01 | Keane Ii Michael A | L-glutamine and vitamin-containing compositions effective for inducing weight loss and for weight control |
US6214373B1 (en) * | 1999-10-07 | 2001-04-10 | Snowden-Sutton Associates, Inc. | Nutritional composition for treating inflammatory bowel diseases |
CN1449691A (zh) * | 2002-04-05 | 2003-10-22 | 中国人民解放军总后勤部军需装备研究所 | 一种抗中暑泡腾饮料 |
-
2004
- 2004-09-24 CN CNB2004100468075A patent/CN1301109C/zh not_active Ceased
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061154A (zh) * | 1990-11-03 | 1992-05-20 | 周先毅 | 一种微量元素浓缩原浆制造方法 |
US5215750A (en) * | 1991-09-04 | 1993-06-01 | Keane Ii Michael A | L-glutamine and vitamin-containing compositions effective for inducing weight loss and for weight control |
US6214373B1 (en) * | 1999-10-07 | 2001-04-10 | Snowden-Sutton Associates, Inc. | Nutritional composition for treating inflammatory bowel diseases |
CN1449691A (zh) * | 2002-04-05 | 2003-10-22 | 中国人民解放军总后勤部军需装备研究所 | 一种抗中暑泡腾饮料 |
Also Published As
Publication number | Publication date |
---|---|
CN1634069A (zh) | 2005-07-06 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: YUEYANG XINHUADA PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: GUO LINGYUN Effective date: 20090814 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090814 Address after: Wujiang bridge, Yueyang economic and Technological Development Zone, Hunan, China Patentee after: Yueyang Xinhuada Pharmaceutical Co., Ltd. Address before: Hunan province Yueyang City baling road Real Estate Hotel 6 buildings Yueyang Huada Pharmaceutical Co. Ltd. Patentee before: Guo Lingyun |
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C35 | Partial or whole invalidation of patent or utility model | ||
IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 20140414 Decision number of declaring invalidation: 22367 Granted publication date: 20070221 |
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CI01 | Publication of corrected invention patent application |
Correction item: invalidation announcement of patent right Correct: All invalid, not announced False: All invalid announcement Number: 07 Volume: 31 |
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ERR | Gazette correction |
Free format text: CORRECT: INVALIDATION OF PATENT RIGHT; FROM: ALL INVALIDATION ANNOUNCEMENT TO: ALL INVALIDATION WITHOUT PROCLAMATION |
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IW01 | Full invalidation of patent right | ||
IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 20140414 Decision number of declaring invalidation: 22367 Granted publication date: 20070221 |