CN1276761C - Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof - Google Patents
Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof Download PDFInfo
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- CN1276761C CN1276761C CN 03133768 CN03133768A CN1276761C CN 1276761 C CN1276761 C CN 1276761C CN 03133768 CN03133768 CN 03133768 CN 03133768 A CN03133768 A CN 03133768A CN 1276761 C CN1276761 C CN 1276761C
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Abstract
The present invention relates to a combined modern compound preparation of Chinese and western medicaments for treating rheumatism and osteoarthritis and a preparation method thereof. The combined modern compound preparation mainly contains the following components (measured by weight) of 145 to 165 portions of prepared kusnezoff monkshood roots, 145 to 165 portions of angelica, 145 to 165 portions of olibanum (preparation), 145 to 165 portions of myrrh (preparation), 145 to 165 portions of twotoothed achyranthes roots, 145 to 165 portions of pawpaw, 130 to 150 portions of notopterygium roots and 15 to 20 portions of profenid. The combined modern compound preparation of Chinese and western medicaments for treating rheumatism aims to cure the disease symptoms of the rheumatism, rheumatoid, osteoarthritis, etc., overcome the defects of slow effect of the traditional Chinese medicaments, easy 'rebounding', no obvious side effect, etc. of pharmaceutical chemicals, and attain the purposes of treating both manifestation and root causes of diseases. The present invention can dispel coldness, remove dampness, promote blood circulation to remove meridian obstruction, disperse swelling and relieve pains, and the present invention is used for treating arthromyodynia, namely rheumatic diseases which mainly relates to the rheumatoid and the osteoarthritis.
Description
One, technical field: medical technical field under the present invention particularly relates to a kind of prescription and preparation method and indication for the treatment of the bonded modern compound preparation of Chinese medicine and western medicine of rheumatism and osteoarthritis.
Two, background technology: rheumatism is the acquired chronic disease of a class, belongs to motherland's medical science arthromyodynia category.Pain, swelling, dysfunction is three big primary symptoms of rheumatism.The most existence of the Chinese medicine preparation of treatment primary disease at present are difficult to rapid lenitive symptom in a short time, and wherein analgesic activity mainly is Radix Aconiti Lateralis Preparata, Herba Asari, Radix Aconiti, but toxicity is stronger, and unsuitable consumption is excessive.Though and chemicals effect is very fast, exist the treatment later stage to occur symptom " knock-on " easily, weak point such as side reaction is more obvious.
Three, summary of the invention:
1, goal of the invention: the invention provides a kind of Chinese medicine and western medicine compound drug and production method thereof for the treatment of rheumatism and osteoarthritis, its objective is in order to solve diseases such as treatment rheumatism, rheumatoid and osteoarthritis, overcome the slow and chemical medicine of Chinese medicine onset weak points such as easily " knock-on " and side reaction be obvious, reach the purpose for the treatment of both the principal and secondary aspects of a disease.
2, technical scheme: the present invention is achieved through the following technical solutions:
A kind of Chinese medicine and western medicine compound medicament composition for the treatment of rheumatism and osteoarthritis, mainly prepare by following components by weight percent by following raw material:
145～165 parts of Radix Aconiti Kusnezoffii Preparatas, 145～165 parts of Radix Angelicae Sinensis, 145～165 parts of Olibanum (processed with vinegar), 145～165 parts of Myrrha (processed with vinegar), 145～165 parts of Radix Achyranthis Bidentataes, 145～165 parts of Fructus Chaenomeliss, 130～150 parts of Rhizoma Et Radix Notopterygiis, 15～20 parts of ketoprofens.
With above-mentioned weight portion, Radix Angelicae Sinensis, Olibanum (processed with vinegar), Myrrha (processed with vinegar), Rhizoma Et Radix Notopterygii are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby, and volatile oil is made clathrate; It is 60%～80% ethanol extraction three times that Radix Achyranthis Bidentatae, Fructus Chaenomelis add 6～8 times of amount concentration, filters filtrate recycling ethanol and to be concentrated into relative density be 1.10～1.30; Get Radix Aconiti Kusnezoffii Preparata and add 8～10 times of water gagings extraction secondaries, each 2 hours, merge with standby medicinal residues for the third time, add 8～10 times of water gagings and extracted 2 hours, filter, the aqueous solution after filtrate and the distillation merges, concentrating clear liquid to relative density is 1.10～1.30, merge drying with the alcohol extraction concentrated solution again, add volatile oil clathrate compound, ketoprofen and adjuvant, mixing, granulate, compacting in flakes, or bag film-coat or sugar-coat are promptly, also can be made into capsule preparations.
The preparation method of Olibanum (processed with vinegar) is: gets clean Olibanum, mixes thoroughly with vinegar, and vexed, to put and fry in the pot to smooth surface, every 100kg Olibanum is used vinegar 5kg.
The preparation method of Myrrha (processed with vinegar) is: gets clean Myrrha, mixes thoroughly with vinegar, and vexed, to put and fry in the pot to smooth surface, every 100kg Myrrha is used vinegar 5kg.
The application of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment rheumatoid and osteoarthritis.
3, advantage and effect: technical solutions according to the invention are on the clinical experience basis of Chinese medicine arthromyodynia, in conjunction with the modern pharmacy achievement develop with the bonded modern Chinese medicine compound preparation of Chinese medicine and western medicine.This medicine is based on Chinese medicines such as the Radix Aconiti Kusnezoffii Preparata of expelling cold and dampness, promoting blood circulation to remove obstruction in the collateral, Radix Angelicae Sinensis; it is auxilliary strengthening its analgesic and anti-inflammatory effects with the NSAID (non-steroidal anti-inflammatory drug) ketoprofen; be used for the treatment of diseases such as rheumatoid arthritis and osteoarthritis; can improve symptom rapidly, effectively control inflammation, stop course of disease development; the protection function of joint; reduce the joint deformity rate, overcome weak points such as slow and chemical medicine of Chinese medicine onset easy " knock-on " and side reaction be obvious, reach the purpose for the treatment of both the principal and secondary aspects of a disease.
Four, the specific embodiment:
[prescription]: 155 parts of Radix Aconiti Kusnezoffii Preparatas, 155 parts of Radix Angelicae Sinensis, 155 parts of Olibanum (processed with vinegar), 155 parts of Myrrha (processed with vinegar), 155 parts of Radix Achyranthis Bidentataes, 155 parts of Fructus Chaenomeliss, 140 parts of Rhizoma Et Radix Notopterygiis, 16.7 parts of ketoprofens.
[method for making]: above 8 flavors, Radix Angelicae Sinensis, Olibanum (processed with vinegar), Myrrha (processed with vinegar), Rhizoma Et Radix Notopterygii add 10 times of water gagings and extract volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Volatile oil is made the betacyclodextrin clathrate.Radix Achyranthis Bidentatae, Fructus Chaenomelis add 6 times of amount 70% ethanol extractions three times, each 1.5 hours, filter filtrate recycling ethanol and to be concentrated into relative density be 1.15～1.18 (50 ℃).Get Radix Aconiti Kusnezoffii Preparata and add 10 times of water gagings extraction secondaries, each 2 hours, merge with standby medicinal residues for the third time, add 10 times of water gagings and extracted 2 hours, filter, the aqueous solution after filtrate and the distillation merges, it is 1.15～1.18 (50 ℃) that concentrated clear liquid is concentrated into relative density, merges spray drying with the alcohol extraction concentrated solution again, adds the betacyclodextrin clathrate of volatile oil, ketone network sweet smell and adjuvant, mixing is granulated, and is pressed into 1000,0.4g/ sheet, bag film-coat or sugar-coat are promptly.Also can be made into the capsule preparations of 0.4g/ grain.So-called adjuvant, for starch, Icing Sugar etc. as disintegrating agent, be used in flakes or sugar-coat prescription bonding.
The preparation method of Olibanum (processed with vinegar) is: gets clean Olibanum, mixes thoroughly with vinegar, and vexed, to put and fry in the pot to smooth surface, every 100kg Olibanum is used vinegar 5kg.
The preparation method of Myrrha (processed with vinegar) is: gets clean Myrrha, mixes thoroughly with vinegar, and vexed, to put and fry in the pot to smooth surface, every 100kg Myrrha is used vinegar 5kg.
[function cures mainly]: dispelling cold and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain.Being used for the treatment of arthromyodynia is that rheumatism comprises: rheumatic arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, scapulohumeral periarthritis, sciatica, prolapse of lumbar intervertebral disc, diseases such as rheumatism of muscles disease.
[drug efficacy study]: 1, analgesic activity: mice hot plate method and writhing method analgesic experiment result show that the present invention has significant analgesic activity.
2, antiinflammatory action: the present invention has the ear swelling effect due to significant inhibition capillary permeability and the increase of inhibition capillary permeability, and the effect that suppresses granulation tissue hyperplasia.
3, immunosuppressive action: the present invention has immunosuppressive action (suppressing humoral immunization, cellular immunization, antagonism delayed hypersensitivity, adjuvant Secondary cases swollen joint) preferably.
[pharmacokinetic]:
The binary cycle trial design is adopted in test, has studied the pharmacokinetics behavior of the present invention and ketoprofen.
The result shows: the pharmacokinetic parameter C of ketoprofen between two preparations
MaxSignificant difference is arranged, but T
MaxWith t
1/2There was no significant difference.Further using two one-side t methods of inspection and (1-2 α) confidence interval method to carry out bioequivalence judges.The result shows: AUC and C
MaxAll can't refuse biological inequivalence hypothesis.Be subjected to test preparation AUC
0-t90% confidence interval be 93.9%～148.8% of reference preparation relevant parameter; C
Max90% confidence interval for participating in 121.3%～326.5% of preparation relevant parameter.
[clinical research]:
Use technical scheme proposed by the invention 30 routine rheumatoid arthritis, osteoarthritis (syndrome of cold-dampness blocking collaterals) patient have been carried out Preliminary Clinical Observation.Male's 14 examples wherein; Women's 16 examples.Age: the longest 65 years old, minimum 26 years old, 44.2 years old mean age.The course of disease: the longest 19 years, the shortest 6 months, average course of disease 3.9 years.Medication: every 0.4g of wind bone-recovering tablets, each 2,3 times on the one oral.The course of treatment: January.The results are shown in Table 1, table 2.
Table 1, general curative effect
| The example number | Clinic control (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Effective percentage (%) |
| 30 | 6(20.00) | 11(36.36) | 9(30.00) | 4(13.33) | 86.67％ |
As seen from Table 1, the sick syndrome of cold-dampness blocking collaterals patient of wind bone-recovering tablets treatment numbness 30 examples are significantly improved after its general curative effect treatment treatment (P＜0.01).
The comparison of erythrocyte sedimentation rate before and after table 2, the treatment
| The example number | Before the treatment | After the treatment | T | P |
| 13 | 28.00±7.76 | 8.83±7.22 | 15.39 | ＜0.01 |
As seen from Table 2, the sick syndrome of cold-dampness blocking collaterals patient of wind bone-recovering tablets treatment numbness 30 examples are significantly improved after its erythrocyte sedimentation rate treatment (P＜0.01).
Untoward reaction: have 1 example to take medicine among the 30 routine patients and occurred in back 17 days feeling sick, stomach discomfort adheres to taking omnidistance medicine.
Other patients find no allergy and untoward reaction.Safety detects (blood, urine, just conventional, hepatic and renal function, electrocardiogram) treatment all no abnormal change in front and back.
Claims (5)
1, a kind of Chinese medicine and western medicine compound medicament composition for the treatment of rheumatism and osteoarthritis, mainly prepare by following components by weight percent by following raw material:
145～165 parts of Radix Aconiti Kusnezoffii Preparatas, 145～165 parts of Radix Angelicae Sinensis, 145～165 parts of Olibanum (processed with vinegar), 145～165 parts of Myrrha (processed with vinegar), 145～165 parts of Radix Achyranthis Bidentataes, 145～165 parts of Fructus Chaenomeliss, 130～150 parts of Rhizoma Et Radix Notopterygiis, 15～20 parts of ketoprofens.
2, the preparation method of the described Chinese medicine and western medicine compound medicament composition of claim 1 is characterized in that:
With the described weight portion of claim 1, Radix Angelicae Sinensis, Olibanum (processed with vinegar), Myrrha (processed with vinegar), Rhizoma Et Radix Notopterygii are extracted volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby, and volatile oil is made clathrate; It is 60%～80% ethanol extraction three times that Radix Achyranthis Bidentatae, Fructus Chaenomelis add 6～8 times of amount concentration, filters filtrate recycling ethanol and to be concentrated into relative density be 1.10～1.30; Get Radix Aconiti Kusnezoffii Preparata and add 8～10 times of water gagings extraction secondaries, each 2 hours, merge with standby medicinal residues for the third time, add 8～10 times of water gagings and extracted 2 hours, filter, the aqueous solution after filtrate and the distillation merges, concentrating clear liquid to relative density is 1.10～1.30, merge drying with the alcohol extraction concentrated solution again, add volatile oil clathrate compound, ketoprofen and adjuvant, mixing, granulate, compacting in flakes, or bag film-coat or sugar-coat are promptly, also can be made into capsule preparations.
3, method according to claim 2 is characterized in that: the preparation method of Olibanum (processed with vinegar) is: get clean Olibanum, mix thoroughly with vinegar, and vexed, to put and fry in the pot to smooth surface, every 100kg Olibanum is used vinegar 5kg.
4, method according to claim 2 is characterized in that: the preparation method of Myrrha (processed with vinegar) is: get clean Myrrha, mix thoroughly with vinegar, and vexed, to put and fry in the pot to smooth surface, every 100kg Myrrha is used vinegar 5kg.
5, the application of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment rheumatoid and osteoarthritis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03133768 CN1276761C (en) | 2003-07-21 | 2003-07-21 | Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03133768 CN1276761C (en) | 2003-07-21 | 2003-07-21 | Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1483452A CN1483452A (en) | 2004-03-24 |
| CN1276761C true CN1276761C (en) | 2006-09-27 |
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| CN 03133768 Expired - Fee Related CN1276761C (en) | 2003-07-21 | 2003-07-21 | Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof |
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| CN112402584A (en) * | 2019-08-23 | 2021-02-26 | 魏县魏州冀南医院 | Chinese and western medicine compound medicine for treating osteoarthritis and preparation method thereof |
| CN113694149A (en) * | 2021-09-19 | 2021-11-26 | 谢亮 | Traditional Chinese medicine composition, preparation method and application |
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