CN1265309A - Medicine for rheumatism and aploplexy and its preparation - Google Patents
Medicine for rheumatism and aploplexy and its preparation Download PDFInfo
- Publication number
- CN1265309A CN1265309A CN00100161A CN00100161A CN1265309A CN 1265309 A CN1265309 A CN 1265309A CN 00100161 A CN00100161 A CN 00100161A CN 00100161 A CN00100161 A CN 00100161A CN 1265309 A CN1265309 A CN 1265309A
- Authority
- CN
- China
- Prior art keywords
- radix aconiti
- medicine
- radix
- boil
- high temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The medicine of the present invention is prepared with aconite 30%, Radix aconiti 20%, Radix Polygoni Multiflori 15%, frankincense 1%, Rhizoma typhonii 9%, mankkshood 5%, pig feet 17% and crystal sugar 3%. The preparation is a short process and the product has low production cost and high cure effect.
Description
The present invention relates to medical technical field.
Anemofrigid-damp arthralgia and apoplectic hemiplegia are the common stubborn diseases of two classes.Wind and cold wet as rheumatic numbness, joint swell and ache, waist foot pain, rheumatic arthritis etc.; The later stage recovery of apoplexy such as cerebral hemorrhage, cerebral thrombosis, cerebral embolism etc. and traumatic fracture, soft tissue contusion etc.
At present, the Chinese patent medicine that is used to cure the rheumatism class has ZHUANGGU GUANJIE WAN, GUXIAN PIAN, XIAOHUOLUO WAN, FENGSHIBIKANG JIAONANG, SHANGSHI ZHITONG GAO, rheumatism panacea SUANTONG LING liniment, history Guogong liquor etc.; The medicine of curing the apoplexy class has the glad medicine such as logical of XUESHUANXINMAINING, XUESAITONG ZHUSHEYE, network; But the result through long-term clinical application and observation proves that their curative effect is not good enough.Taking effect of having is slow, and Time of Administration is long, thereby stomach is had stimulation; What have costs an arm and a leg, and patient's dosage is big, and can not reach treating both the principal and secondary aspects of a disease, thereby is difficult to popularize.
The patent of invention ZL 86108904.9 that the applicant has assigned discloses a kind of " the gluey preparation method of specially controlling the arthromyodynia Chinese patent medicine ".It is that the infusion in 98~115 ℃ boiling water of Radix Aconiti Kusnezoffii, Radix Aconiti, Radix Polygoni Multiflori, Radix Aconiti Lateralis Preparata, Rhizoma Typhonii, Radix Angelicae Sinensis is filtered 12 times, boil whole process of the time of putting forward and need 50~60 hours even longer, after the slagging-off of gained medicinal liquid, adding pig's feet, Olibanum, Colla Corii Asini, crystal sugar, leaf fat are gone into pot and are concentrated into the dope shape, and cooling curing is a blob of viscose.This preparation method since infusion to extract the medicinal liquid time oversize, time and effort consuming, the active ingredient of drug products reduces significantly, and has increased production cost.In addition, the prescription Chinese crude drug is too much, has also reduced drug effect.
The present invention proposes the preparation technology of a kind of improved treatment rheumatism, apoplexy class disease medicament, and it has shortened preparation process greatly, effectively reduces production cost, and makes the drug effect of product obtain bigger raising.
Purpose of the present invention reaches by the following technical programs: it comprises Radix Aconiti Kusnezoffii, Radix Aconiti, Radix Polygoni Multiflori, Olibanum, Rhizoma Typhonii, Radix Aconiti Lateralis Preparata, Ungula Sus domestica, crystal sugar, and the percentage of each material is Radix Aconiti Kusnezoffii 30%, Radix Aconiti 20%, Radix Polygoni Multiflori 15%, Olibanum 1%, Rhizoma Typhonii 9%, Radix Aconiti Lateralis Preparata 5%, Ungula Sus domestica 17%, crystal sugar 3%.
The preparation technology of said medicine is that all medicine inspections in the prescription are selected roguing, cleaned up, and weigh batching is standby in proportion, comprises the steps:
A. water system and cutting.Each medical material was soaked 11 hours, and it is thick to hack or be broken into 2~3mm sheet,
B. detoxification is extracted in hydrolysis.For the first time, add deionized water, under 0.12MPa, 140 ℃ of high temperature, boil and carry 1~2 hour in 1: 1 ratio, decocting liquid filters through 40 mesh sieves, for the second time, add deionized water, under normal pressure, 94 ℃ of high temperature, boil and carry 1~2 hour in 1: 1 ratio, decocting liquid filters through 40 mesh sieves, for the third time, add deionized water, under normal pressure, 94 ℃ of high temperature, boil and carry 1~2 hour in 1: 1 ratio, decocting liquid filters through 40 mesh sieves
C. concentrate and receive cream.Three times filtrate merges, and is evaporated to proportion after 1: 1.30, and being concentrated into water content again under normal pressure is 20%, promptly gets thick paste.
Embodiment
The present invention's prescription is made up of Radix Aconiti Kusnezoffii 900g, Radix Aconiti 600g, Radix Polygoni Multiflori 450g, Olibanum 30g, Rhizoma Typhonii 300g, Radix Aconiti Lateralis Preparata 150g, Ungula Sus domestica 500g, crystal sugar 90g.
Roguing, weighing are in accordance with regulations selected in all medicine inspections of supplementary material in will writing out a prescription.Wherein Olibanum and water filter by 1: 1 water mill and make Olibanum water to fly liquid standby; Fresh Ungula Sus domestica checks that the odorless unhairing is clean.All the other all medicines are cleaned and are soaked after 11 hours, hack or fragmentation.Fresh Ungula Sus domestica, Radix Aconiti Kusnezoffii, Radix Aconiti, Radix Aconiti Lateralis Preparata, all materials of Rhizoma Typhonii and water were in 1: 1 ratio, under 140 ℃ of high temperature, extract detoxification, 2 hours time, decocting liquid filters standby, medicinal residues add Radix Polygoni Multiflori and carry out three extractions under 94 ℃ of temperature, each time is 2 hours, merging filtrate filters through 40 mesh sieves afterwards, concentrates again, once concentration was to proportion 1: 1.30, after the secondary concentration (moisture content 20%), add Olibanum water and fly liquid and candy sugar powder, add an amount of coating of coating powder again, passed examination, packing gets product.
The used prescription of the present invention, principal agent Radix Aconiti Kusnezoffii, Radix Aconiti are the product to poison, have big using warming therapy medicine, have the effect of expelling wind and cold, removing damp and stopping pain.Selected multiple famous and precious accessory drugs material such as Olibanum have the effect of blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, removing toxicity for eliminating carbuncles.Rhizoma Typhonii has drying dampness to eliminate phlegm, expelling wind to relieve convulsion, pursues the effect of cold pain relieving.Radix Aconiti Lateralis Preparata, warming middle-JIAO recuperating depleted YANG, dispersing cold for relieving pain.
The adjuvant drug Radix Polygoni Multiflori has the effect that nourishing the liver and kidney, nourishing blood to expel wind, beneficial essence are moisturized.
Dispel the wind cold-damp heresy, clearing away phlegm of Quan Fangju searched wind, stasis-dispelling and pain-killing, nourishing the liver and kidney in a side, tool reinforcement and elimination in combination, the effect for the treatment of both the principal and secondary aspects of a disease, coordination of YIN and YANG.Significant blood circulation promoting and blood stasis dispelling, dredge the meridian passage effect are arranged.
According to diseases such as the medicine of the present invention preparation is used for the treatment of that rheumatism, numbness, joint swell and ache, lumbago and skelalgia, rheumatic arthritis, rheumatoid arthritis, hyperosteogeny, scapulohumeral periarthritis, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, blood granularity height, arteriosclerosis etc. cause treatment rheumatism, apoplexy.Later stage recovery to traumatic fracture, soft tissue contusion also has significant antiinflammatory, analgesia effect.
The present invention compares with 86108904.9, and the hydrolysis detoxification is extracted filtrate and shortened to for 3 steps from former 12 road steps; Extraction time needs 6 hours by only shortening in original 50~60 hours, and raw material is reduced to 8 flavors from 11 flavor medicines, but drug effect improved more originally, and has reduced production cost, and pure extractum one goes on foot pill, and technology is easy.
Drug products safety non-toxic provided by the invention.Acute toxicity test: press Cmax, maximum administration volume.Irritated stomach on the 1st three times, press body surface area and convert, mice day irritate the stomach amount and reached 60g/kg, for Coming-of-Age Day 85 times of dosing, all can not measure the half of mice and measure till death, the mice of taking medicine is all healthy, shows that the mice maximum tolerated dose is above 60g/kg, i.e. MTD>60g/kg.
The drug products long term toxicity test: with 4 times of the clinical consumption of being grown up and 20 times (pressing body surface area converts), 60 days (4 courses of treatment) of gastric infusion continuously, to growth promoter, the hematology of rat, every leading indicator that blood biochemical is learned; To liver, renal function, the result of histopathologic examination of organ coefficient and important organ and matched group be no significant difference relatively all.Show: clinical patient prolonged and repeated use under routine dose is safe.
The drug products effect experiment: " dense, sticking, coagulate, poly-" that can significantly reduce " blood stasis " rat model blood waits state, makes unusual blood flow index obtain correction, shows the effect of its invigorate blood circulation passive stasis of blood, dredge the meridian passage.
Usage and dosage: the each 5g of tablet, every day secondary, molten is converted wine clothes after meal.The each 5g of pill, every day secondary, boiled water is swallowed.7~14 days is a course of treatment, and old man, child are cut down according to the circumstance, and serious symptom pertinacious disease meal with wine adds or follows the doctor's advice.
Cold, fever, anemia of pregnant woman and newborn child prohibit clothes, and it is cold that period in a medicine is avoided clothes acid.
Claims (2)
1, a kind of medicine for the treatment of rheumatism, apoplexy class disease, it comprises Radix Aconiti Kusnezoffii, Radix Aconiti, Radix Polygoni Multiflori, Olibanum, Rhizoma Typhonii, Radix Aconiti Lateralis Preparata, Ungula Sus domestica, crystal sugar, it is characterized in that: the percentage of each material is Radix Aconiti Kusnezoffii 30%, Radix Aconiti 20%, Radix Polygoni Multiflori 15%, Olibanum 1%, Rhizoma Typhonii 9%, Radix Aconiti Lateralis Preparata 5%, Ungula Sus domestica 17%, crystal sugar 3%.
2, a kind of preparation technology of medicine according to claim 1, all medicine inspections are selected roguing, are cleaned up in will writing out a prescription, and weigh batching is standby in proportion, it is characterized in that comprising the steps:
A. water system and cutting.Each medical material was soaked 11 hours, and it is thick to hack or be broken into 2~3mm sheet,
B. detoxification is extracted in hydrolysis.For the first time, add deionized water, under 0.12MPa, 140 ℃ of high temperature, boil and carry 1~2 hour in 1: 1 ratio, decocting liquid filters through 40 mesh sieves, for the second time, add deionized water, under normal pressure, 94 ℃ of high temperature, boil and carry 1~2 hour in 1: 1 ratio, decocting liquid filters through 40 mesh sieves, for the third time, add deionized water, under normal pressure, 94 ℃ of high temperature, boil and carry 1~2 hour in 1: 1 ratio, decocting liquid filters through 40 mesh sieves
C. concentrate and receive cream.Three times filtrate merges, and is evaporated to proportion after 1: 1.30, and being concentrated into water content again under normal pressure is 20%, promptly gets thick paste.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN00100161A CN1114418C (en) | 2000-01-14 | 2000-01-14 | Medicine for rheumatism and aploplexy and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN00100161A CN1114418C (en) | 2000-01-14 | 2000-01-14 | Medicine for rheumatism and aploplexy and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1265309A true CN1265309A (en) | 2000-09-06 |
CN1114418C CN1114418C (en) | 2003-07-16 |
Family
ID=4575280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN00100161A Expired - Lifetime CN1114418C (en) | 2000-01-14 | 2000-01-14 | Medicine for rheumatism and aploplexy and its preparation |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1114418C (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102507781A (en) * | 2011-11-09 | 2012-06-20 | 云南金乌黑药制药有限公司 | Method for controlling quality of medicine for treating rheumatism and apoplexy diseases |
CN106421239A (en) * | 2016-11-27 | 2017-02-22 | 莫泽庸 | Medicine for treating stroke and preparation method thereof |
CN107213295A (en) * | 2017-06-28 | 2017-09-29 | 云南金乌黑药制药有限公司 | It is a kind of to treat rheumatism, medicine of apoplexy diseases and preparation method thereof |
CN114259530A (en) * | 2022-01-11 | 2022-04-01 | 云南金乌黑药制药有限公司 | Application of traditional Chinese medicine preparation in intervention of acute ischemic stroke |
CN114767744A (en) * | 2022-04-29 | 2022-07-22 | 云南金乌黑药制药有限公司 | Preparation method of traditional Chinese medicine preparation |
-
2000
- 2000-01-14 CN CN00100161A patent/CN1114418C/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102507781A (en) * | 2011-11-09 | 2012-06-20 | 云南金乌黑药制药有限公司 | Method for controlling quality of medicine for treating rheumatism and apoplexy diseases |
CN102507781B (en) * | 2011-11-09 | 2014-03-19 | 云南金乌黑药制药有限公司 | Method for controlling quality of medicine for treating rheumatism and apoplexy diseases |
CN106421239A (en) * | 2016-11-27 | 2017-02-22 | 莫泽庸 | Medicine for treating stroke and preparation method thereof |
CN107213295A (en) * | 2017-06-28 | 2017-09-29 | 云南金乌黑药制药有限公司 | It is a kind of to treat rheumatism, medicine of apoplexy diseases and preparation method thereof |
CN107213295B (en) * | 2017-06-28 | 2018-06-22 | 云南金乌黑药制药有限公司 | It is a kind of treat rheumatism, apoplexy diseases drug and preparation method thereof |
CN114259530A (en) * | 2022-01-11 | 2022-04-01 | 云南金乌黑药制药有限公司 | Application of traditional Chinese medicine preparation in intervention of acute ischemic stroke |
CN114767744A (en) * | 2022-04-29 | 2022-07-22 | 云南金乌黑药制药有限公司 | Preparation method of traditional Chinese medicine preparation |
Also Published As
Publication number | Publication date |
---|---|
CN1114418C (en) | 2003-07-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101066303A (en) | Medicine for treating cerebral thrombus, cerebral angiosclerosis, apoplexy and hemiplegia and its prepn | |
CN101632750B (en) | Chinese medicinal composition for replenishing essence, filling marrow, boosting kidney and strengthening yang and preparation method thereof | |
CN1814215A (en) | Medicine for treating gout and gout arthritis | |
CN102772712A (en) | Traditional Chinese medicine composition for treating heat-toxicity, flourishing and blood stasis type diabetic foot | |
CN1114418C (en) | Medicine for rheumatism and aploplexy and its preparation | |
CN1718211A (en) | Traditional Chinese emdicine compounding prepns. for treating fracture | |
CN1091027A (en) | Blood-pressure reducing plaster sticking on acupoint and preparation method thereof | |
CN101607067B (en) | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof | |
CN103007159B (en) | Chinese medicinal preparation for correcting pancreas islet function | |
CN105999058B (en) | Bidens bipinnata lipid-lowering tablet | |
CN100360161C (en) | Chinese medicine for treating diabets and nephritis | |
CN102512548A (en) | Toxin-removing and fat-dispelling capsule | |
CN102552812B (en) | Traumatic injury curative for external use and production method thereof | |
CN101450189A (en) | Medicine for curing angiocardiopathy and cerebrovascular disease and its preparing method | |
CN1883626A (en) | Capsule for treating gout and preparation process thereof | |
CN1212149C (en) | Cinese material medical preparation for curing children' hyperkinetic symptom and the preparation process thereof | |
CN1286515C (en) | Medicinal composition for treating cyst | |
CN1618439A (en) | Broad-specturm medicine for treating snake venom poisoning | |
CN100398143C (en) | Medicament for treating vitiligo | |
CN1718218A (en) | Medicine for treating osteoarthritis, and its prepn. method | |
CN1270822A (en) | Chinese medicine for treating puerperal diseases | |
CN1326548C (en) | Medicine for treating gonorrhoea | |
CN110215474B (en) | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and application thereof | |
CN101961481A (en) | Traditional Chinese medicine for treating liver-gallbladder qi stagnation type cholecystitis and preparation method thereof | |
CN101181441A (en) | Medicine for treating premature ovarian failure and preparation process thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20030716 |